Queralt Vallmajó-Martín
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View article: LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment
LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment Open
Triple-negative breast cancer (TNBC) is a highly aggressive and metastatic form of breast cancer that lacks an effective targeted therapy. To identify potential therapeutic targets, we investigated the phosphohistidine phosphatase, LHPP, w…
View article: The molecular chronology of mammary epithelial cell fate switching
The molecular chronology of mammary epithelial cell fate switching Open
Summary The adult mammary gland is maintained by lineage-restricted progenitor cells through pregnancy, lactation, involution, and menopause. Injury resolution, transplantation-associated mammary gland reconstitution, and tumorigenesis are…
View article: LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment
LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment Open
Triple-negative breast cancer (TNBC) is a highly aggressive and metastatic form of breast cancer that lacks an effective targeted therapy. To identify new therapeutic targets, we investigated the phosphohistidine phosphatase, LHPP, which h…
View article: Engineered Platelet‐Derived Growth Factor‐Releasing Hydrogels Promote Fetal Membrane Healing In Vivo
Engineered Platelet‐Derived Growth Factor‐Releasing Hydrogels Promote Fetal Membrane Healing In Vivo Open
Fetoscopic interventions to treat fetal anomalies are currently performed for a variety of conditions. Depending on the procedure, preterm rupture of the fetal membranes (FMs) happens in around 30% of the cases, potentially leading to pret…
View article: Amnion Cells in Tailored Hydrogels Deposit Human Amnion Native Extracellular Matrix
Amnion Cells in Tailored Hydrogels Deposit Human Amnion Native Extracellular Matrix Open
Fetal therapies regularly result in iatrogenic preterm premature rupture of the fetal membranes (iPPROM), which is associated with preterm birth. Biomaterials that promote the healing of traumatized fetal membranes (FMs) may prevent iPPROM…
View article: In Vitro and Ectopic In Vivo Studies toward the Utilization of Rapidly Isolated Human Nasal Chondrocytes for Single-Stage Arthroscopic Cartilage Regeneration Therapy
In Vitro and Ectopic In Vivo Studies toward the Utilization of Rapidly Isolated Human Nasal Chondrocytes for Single-Stage Arthroscopic Cartilage Regeneration Therapy Open
Nasal chondrocytes (NCs) have a higher and more reproducible chondrogenic capacity than articular chondrocytes, and the engineered cartilage tissue they generate in vitro has been demonstrated to be safe in clinical applications. Here, we …
View article: PEG/HA Hybrid Hydrogels for Biologically and Mechanically Tailorable Bone Marrow Organoids
PEG/HA Hybrid Hydrogels for Biologically and Mechanically Tailorable Bone Marrow Organoids Open
Bone marrow (BM) organoids provide powerful tools to study the vital interplay between the BM microenvironment and resident cells. Current biomaterials, however, are limited in terms of versatility for independently studying the biochemica…
View article: Extracellular Matrix Production by Mesenchymal Stromal Cells in Hydrogels Facilitates Cell Spreading and Is Inhibited by FGF‐2
Extracellular Matrix Production by Mesenchymal Stromal Cells in Hydrogels Facilitates Cell Spreading and Is Inhibited by FGF‐2 Open
In native tissues, the interaction between cells and the surrounding extracellular matrix (ECM) is reciprocal, as cells not only receive signals from the ECM but also actively remodel it through secretion of cell‐derived ECM. However, very…
View article: Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment
Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment Open
The treatment of bone defects with recombinant bone morphogenetic protein‐2 (BMP‐2) requires high doses precluding broad clinical application. Here, a bioengineering approach is presented that strongly improves low‐dose BMP‐2‐based bone re…
View article: A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues
A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues Open
For creating functional tissue analogues in tissue engineering, stem cells require very specific 3D microenvironments to thrive and mature. Demanding (stem) cell types that are used nowadays can find such an environment in a heterogeneous …
View article: Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche
Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche Open
The bone marrow (BM) microenvironment, or niche, significantly affects behaviors of its resident stem cell populations. Disruptions in the BM niche contribute to a number of severe clinical pathologies. Discovery of novel therapeutic strat…
View article: Polyisocyanopeptide hydrogels: A novel thermo-responsive hydrogel supporting pre-vascularization and the development of organotypic structures
Polyisocyanopeptide hydrogels: A novel thermo-responsive hydrogel supporting pre-vascularization and the development of organotypic structures Open
Molecular and mechanical interactions with the surrounding environment are essential for cell functions. Although 2D culture systems greatly contributed to our understanding of complex biological phenomena, they cannot substitute for cruci…
View article: Single cell-laden protease-sensitive microniches for long-term culture in 3D
Single cell-laden protease-sensitive microniches for long-term culture in 3D Open
We present a powerful strategy for evading Poisson encapsulation statistics and for cell centering in single cell-laden synthetic microniches to facilitate long-term culture in protease-sensitive 3D microenvironments.