Richard J. Quigg
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View article: The complement system and kidney cancer: pathogenesis to clinical applications
The complement system and kidney cancer: pathogenesis to clinical applications Open
Kidney cancer poses unique clinical challenges because of its resistance to conventional treatments and its tendency to metastasize. The kidney is particularly susceptible to dysfunction of the complement system, an immune network that tum…
View article: Has ICD-10 improved identification of rapidly progressing stage 3 and stage 4 chronic kidney disease patients: A diagnostic test study
Has ICD-10 improved identification of rapidly progressing stage 3 and stage 4 chronic kidney disease patients: A diagnostic test study Open
Background: The International Classification of Diseases (ICD) coding system is the industry standard tool for billing, disease classification, and epidemiology purposes. Prior research has demonstrated ICD codes to have poor clinical and …
View article: Complement: Functions, location and implications
Complement: Functions, location and implications Open
The complement system, an arm of the innate immune system plays a critical role in both health and disease. The complement system is highly complex with dual possibilities, helping or hurting the host, depending on the location and local m…
View article: Prevalence of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) in the Greater Buffalo Region: A Retrospective Review
Prevalence of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) in the Greater Buffalo Region: A Retrospective Review Open
Background: Congenital anomalies of the kidney and urinary tract, also known as CAKUT, represents a spectrum of conditions from complete bilateral renal aplasia (i.e. agenesis), to unilateral aplasia, hypoplasia (defined as small kidneys <…
View article: Macrophage Depletion Reduces Disease Pathology in Factor H-Dependent Immune Complex-Mediated Glomerulonephritis
Macrophage Depletion Reduces Disease Pathology in Factor H-Dependent Immune Complex-Mediated Glomerulonephritis Open
Complement factor H (FH) is a key regulator of the alternative pathway of complement, in man and mouse. Earlier, our studies revealed that the absence of FH causes the C57BL6 mouse to become susceptible to chronic serum sickness (CSS) alon…
View article: Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake
Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake Open
Patients with chronic kidney disease (CKD) and end-stage renal disease suffer from increased cardiovascular events and cardiac mortality. Prior studies have demonstrated that a portion of this enhanced risk can be attributed to the accumul…
View article: Double negative T cells, a potential biomarker for systemic lupus erythematosus
Double negative T cells, a potential biomarker for systemic lupus erythematosus Open
Systemic lupus erythematosus (SLE) is an autoimmune disease that is a challenge to diagnose and treat. There is an urgent need for biomarkers to help define organ involvement, and more effective therapies. A unique population of T cells, t…
View article: Effects of conventional immunosuppressive therapy on functional and pathological features of CNS lupus in NZB/W mice
Effects of conventional immunosuppressive therapy on functional and pathological features of CNS lupus in NZB/W mice Open
Neurological involvement is one of the most devastating complications of the disease, systemic lupus erythematosus (SLE). To understand the effect of the drugs, cyclophosphamide (CY) and prednisolone (PD) on CNS manifestations, the New Zea…
View article: Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial
Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial Open
The modern Western diet is rich in advanced glycation end products (AGEs). We have previously shown an association between dietary AGEs and markers of inflammation and oxidative stress in a population of end stage renal disease (ESRD) pati…
View article: C5a induces caspase‐dependent apoptosis in brain vascular endothelial cells in experimental lupus
C5a induces caspase‐dependent apoptosis in brain vascular endothelial cells in experimental lupus Open
Summary Blood–brain barrier ( BBB ) dysfunction complicates central nervous system lupus, an important aspect of systemic lupus erythematosus. To gain insight into the underlying mechanism, vascular corrosion casts of brain were generated …
View article: Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE<sub>2</sub>production
Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE<sub>2</sub>production Open
Thrombotic microangiopathy (TMA) is a disorder characterized by microvascular occlusion that can lead to thrombocytopenia, hemolytic anemia, and glomerular damage. Complement activation is the central event in most cases of TMA. Primary fo…