Quinton Smith
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Development of a 3D Human Colon Model Along with Bioelectronics for the Induction and Monitoring of Diseases Open
Conventional in vitro and animal models do not reproduce the geometry, mechanics, or transport physics of the human colon, limiting their fidelity for disease studies and drug screening. A patient‐derived, freeform reversible embedding of …
Geometrically Controlled WNT Activation Drives Intestinal Morphogenesis Open
Morphogenesis is a multifaceted process that integrates biochemical signals with mechanical and architectural cues to drive tissue formation. Here, the modulation of WNT signaling and engineered microenvironments synergistically drive cryp…
Racial discrimination and other adverse childhood experiences as risk factors for internalizing mental health concerns among Black youth Open
Adverse childhood experiences (ACEs) have been consistently linked to a reduction in healthy psychological adjustment among youth. Emergent evidence suggests that there are culturally specific ACEs, such as racial discrimination, that are …
Advances in engineered models of peri-gastrulation Open
Studying human development presents significant ethical and technical challenges. Yet, the integration of stem cell technology and engineering tools has provided unprecedented insights into early lineage specification and the morphogenetic…
YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution Open
Tumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive. Here we employ spatiotemporally…
View article: Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver
Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver Open
Background & Aims Aging is associated with a significant decline in mitochondrial function in the liver, leading to an increased risk of liver disease. This study examines age-related changes in the mitochondrial structure of human and mur…
View article: The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney
The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney Open
The kidney filters nutrient waste and bodily fluids from the bloodstream, in addition to secondary functions of metabolism and hormone secretion, requiring an astonishing amount of energy to maintain its functions. In kidney cells, mitocho…
Gelatin‐Mediated Vascular Self‐Assembly via a YAP‐MMP Signaling Axis Open
Tissue self‐assembly relies on the interplay between structural cues imparted by the extracellular matrix (ECM) and instructive chemical factors that guide cellular signaling pathways. Here, it is reported that endothelial cell‐laden gelat…
Vascularized liver-on-a-chip model to investigate nicotine-induced dysfunction Open
The development of physiologically relevant in vitro systems for simulating disease onset and progression and predicting drug metabolism holds tremendous value in reducing drug discovery time and cost. However, many of these platforms lack…
YAP-Driven Malignant Reprogramming of Epithelial Stem Cells at Single Cell Resolution Open
Tumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive. Here we employ cell tracing app…
‘Chip’-ing away at morphogenesis – application of organ-on-chip technologies to study tissue morphogenesis Open
Emergent cell behaviors that drive tissue morphogenesis are the integrated product of instructions from gene regulatory networks, mechanics and signals from the local tissue microenvironment. How these discrete inputs intersect to coordina…
YAP-Driven Oral Epithelial Stem Cell Malignant Reprogramming at Single Cell Resolution Open
Tumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive. Here we employ spatiotemporally…
View article: Juneteenth in STEMM and the barriers to equitable science
Juneteenth in STEMM and the barriers to equitable science Open
We are 52 Black scientists. Here, we establish the context of Juneteenth in STEMM and discuss the barriers Black scientists face, the struggles they endure, and the lack of recognition they receive. We review racism's history in science an…
Strategies for Regenerative Vascular Tissue Engineering (Adv. Biology 5/2023) Open
Regenerative Vascular Tissue Engineering In article number 2200050, Quinton Smith and co-workers review strategies for regenerative vascular tissue engineering. The vasculature is a conduit that links various organ systems, guiding develop…
A Systematic Review of the Effectiveness of Children’s Behavioral Health Interventions in Psychiatric Residential Treatment Facilities Open
Objective The purpose of this systematic review was to synthesize quantitative or mixed-method studies that evaluate the efficacy of interventions with youth in the context of psychiatric residential treatment facilities (PRTFs) in the Uni…
Strategies for Regenerative Vascular Tissue Engineering Open
Vascularization remains one of the key challenges in creating functional tissue‐engineered constructs for therapeutic applications. This review aims to provide a developmental lens on the necessity of blood vessels in defining tissue funct…
Ileo‐ileal intussusception: a rare manifestation of metastatic synovial sarcoma Open
A 24-year-old female presented to the emergency department (ED) with a two-day history of worsening colicky central abdominal pain and watery, non-bloody diarrhoea. Her only past medical history includes right thigh synovial sarcoma with o…
Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds Open
Adv. Sci. 2022, 9, 2102698 DOI: 10.1002/advs.202102698 Several key pieces of information are inadvertently missing in the original manuscript. Please find below the updated Figure 4 caption in which the gel conditions are given and a new m…
Home Away From Home: Bioengineering Advancements to Mimic the Developmental and Adult Stem Cell Niche Open
The inherent self-organizing capacity of pluripotent and adult stem cell populations has advanced our fundamental understanding of processes that drive human development, homeostasis, regeneration, and disease progression. Translating thes…
Racial discrimination and other adverse childhood experiences as risk factors for internalizing mental health concerns among Black youth Open
Adverse childhood experiences (ACEs) have been consistently linked to a reduction in healthy psychological adjustment among youth. Emergent evidence suggests that there are culturally specific ACEs, such as racial discrimination, that are …
Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds Open
Patients with Alagille syndrome carry monogenic mutations in the Notch signaling pathway and face complications such as jaundice and cholestasis. Given the presence of intrahepatic ductopenia in these patients, Notch2 receptor signaling is…
Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds Open
Patients with Alagille syndrome carry monogenic mutations in the Notch signaling pathway and face complications such as jaundice and cholestasis. Given the presence of intrahepatic ductopenia in these patients, Notch2 receptor signaling ha…