Explanipedia

Telomere-to-telomere genome assembly of the Fraxinus mandshurica Rupr Open

Dandan Zhang, Shaofei Guo, Zicheng Zhang, Wei Gao, Mingwei Tang , et al. · 2025

Asymmetric rotations slow down diffusion under confinement Open

Zhiqiang Liu, Xun Kan, Mingbin Gao, Yi Ji, F. Ye , et al. · 2025

Solvent-Controlled Selective Synthesis of Quinazolinones and 2-Arylquinazolinones Via Copper-Catalyzed [5 + 1] Annulation Open

Min Wang, Kexin Li, Jiang-Yan Xue, Kewei Hu, Duoluo Guo , et al. · 2025

Developing a prognostic model for hepatocellular carcinoma based on MED19 and clinical stage and determining MED19 as a therapeutic target Open

Jin Xiao-jun, Yun Zhang, Wei Hu, Chang Liu, Danyang Cai , et al. · 2024

Evidence-based incorporation of key parameters into MELD score for acute-on-chronic liver failure Open

Yu Xia, Ruoqi Zhou, Wenting Tan, Xiaobo Wang, Xin Zheng , et al. · 2024

Background The model for end-stage liver disease (MELD) score is widely used for the prognostication in end-stage liver disease but has limited performance in acute-on-chronic liver failure (ACLF). In this study, we identified additional p…

Construction of a novel prognostic scoring model for HBV-ACLF liver failure based on dynamic data Open

Qun Cai, Hao Wang, Mingyan Zhu, Yixin Xiao, Tingting Zhuo · 2024

Early prognostic assessment of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is important for guiding clinical management and reducing mortality. The aim of this study was to dynamically monitor the clin…

Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure Open

Hozeifa Mohamed Hassan, Xi Liang, Jiaojiao Xin, Yingyan Lu, Qun Cai , et al. · 2024

Background The key role of thrombospondin 1 (THBS1) in the pathogenesis of acute-on-chronic liver failure (ACLF) is unclear. Here, we present a transcriptome approach to evaluate THBS1 as a potential biomarker in ACLF disease pathogenesis.…

Development of a novel lncRNA-derived immune gene score using machine learning-based ensembles for predicting the survival of HCC Open

Qun Cai, Guoqi Li, Mingyan Zhu, Tingting Zhuo, Jiaying Xiao · 2024

Influence of a Reverse Positive Hipims Pulse on the Microstructure and Mechanical Properties of Hard Coatings Open

Qun Cai, Xuebing Bai, Yuqiao Zeng, xuhai zhang · 2024

SEMA6B induces macrophage-mediated inflammation and hepatocyte apoptosis in hepatitis B virus-related acute-on-chronic liver failure Open

Hui Yang, Qun Cai, Jiaojiao Xin, Xi Liang, Hozeifa Mohamed Hassan , et al. · 2024

Rationale: Patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) have a high short-term mortality rate. Semaphorin-6B (SEMA6B) plays a crucial role in the pathogenesis of HBV-ACLF, but its molecular basis…

Modification on Flower Defects and Electronic Properties of Epitaxial Graphene by Erbium Open

Yong Duan, Xu Wenting, Wenxia Kong, Jianxin Wang, Jinzhe Zhang , et al. · 2023

Manipulating the topological defects and electronic properties of graphene has been a subject of great interest. In this work, we have investigated the influence of Er predeposition on flower defects and electronic band structures of epita…

Er intercalation and its impact on transport properties of epitaxial graphene Open

Mingmin Yang, Yong Duan, Wenxia Kong, Jinzhe Zhang, Jianxin Wang , et al. · 2023

Intercalation of atomic species is a practicable method for epitaxial graphene to adjust the electronic band structure and to tune the coupling between graphene and SiC substrate. In this work, atomically flat epitaxial graphene is prepare…

Morphological features and nanostructures generated during SiC graphitization process Open

Wenxia Kong, Yong Duan, Jinzhe Zhang, Jianxin Wang, Qun Cai · 2023

Surface morphological features and nanostructures generated during SiC graphitization process can significantly affect fabrication of high-quality epitaxial graphene on semiconductor substrates. In this work, we investigate the surface mor…

Variations in Growth and Photosynthetic Traits of Polyploid Poplar Hybrids and Clones in Northeast China Open

Luping Jiang, Xiangzhu Xu, Qun Cai, Rui Han, Mulualem Tigabu , et al. · 2022

To evaluate differences among 19 different ploidy hybrid poplar clones grown in northeast China, 21 traits related to growth traits and photosynthetic characteristics were detected and analyzed. Abundant phenotypic variations exist among a…

Author Correction: Adaptive VAlCN-Ag composite and VAlCN/VN-Ag multilayer coatings intended for applications at elevated temperature Open

Qun Cai, Xuebing Bai, Jibin Pu · 2022

Prognostic model of immune-related genes for patients with hepatocellular carcinoma Open

Qun Cai, Jinnan Duan, Liang Ding · 2022

Background Immune-related genes (IRGs) are closely connected to the occurrence and development of tumors. Their influence on the prognosis of patients with HCC, however, remains unclear. Methods From the TCGA database, we integrated 365 li…

The protective effect of MiR-27a on the neonatal hypoxic-ischemic encephalopathy by targeting FOXO1 in rats Open

Qun Cai, Xiaoqun Zhang, Liyuan Shen, Honghua Song, Ting Wang · 2022

MiR-27a plays protective roles by reducing infarct volume and brain edema, and inhibiting inflammatory factors and infiltrated peripheral immune cells by targeting FOXO1 in neonatal HIE rats.

Comprehensive Analysis of Immune-Related Prognosis of TK1 in Hepatocellular Carcinoma Open

Qun Cai, Mingyan Zhu, Jinnan Duan, Hao Wang, Jingdan Chen , et al. · 2022

Increased expression of TK1 is associated with the progression of a variety of tumors. However, the relationship of TK1 expression with immune cell infiltration and its prognostic value in hepatocellular carcinoma (HCC) are still unknown. …

Graphene oxide modified polypropylene fiber filter membrane for enhanced treatment efficiency of water-based paint wastewater Open

Yang Zhang, Hang Yang, Qun Cai, Shibin Xia · 2022

Clinical application value of serum neutrophil gelatinase-associated lipocalin in neonatal sepsis Open

Qun Cai, Xiaoqun Zhang, Liyuan Shen, Ting Wang · 2022

Increased sNGAL levels could reflect the inflammatory status in the acute stage of neonatal sepsis. When combined with other sepsis markers, such as CRP and PCT, the sNGAL is a useful marker in the rapid diagnosis and follow up of neonatal…

Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats Open

Hozeifa Mohamed Hassan, Qun Cai, Xi Liang, Jiaojiao Xin, Keke Ren , et al. · 2021

Acute-on-chronic liver failure (ACLF) is clinical syndrome with high mortality rate. This study aimed to perform detailed transcriptomic analysis in liver cirrhosis–based ACLF rats to elucidate ACLF pathogenesis. ACLF was induced by combin…

PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF Open

Jiang Li, Xi Liang, Jing Jiang, Lingling Yang, Jiaojiao Xin , et al. · 2021

Objective Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) pathophysiology remains unclear. This study aims to characterise the molecular basis of HBV-ACLF using transcriptomics. Methods Four hundred subjects with HBV-AC…

An outbreak of Coxsackievirus A6 infection in adults of a collective unit, China, 2019 Open

Yumeng Gao, Guangyuan Ma, Yong Xiao, Qun Cai, Yujun Chen , et al. · 2020

Background: Outbreaks/epidemic caused by Coxsackievirus A6 have been reported continuously since 2008. However, outbreaks caused by Coxsackievirus A6 infection in adults of a collective unit have not been reported. Methods: The nasopharyng…

AAIT: A novel prognostic model for HIV-negative patients with cryptococcal meningoencephalitis New Scoring Model for Non-HIV Patients with CM Open

Qun Cai, Hao Wang, Sihan Ruan, Mingyan Zhu, Jinnan Duan , et al. · 2020

Cryptococcal meningitis (CM) is a common opportunistic infection in HIV-negative patients, with mortality rates as high as those in the HIV-negative population. This requires accurate initial clinical decision-making, warranting the develo…

Host susceptibility to severe COVID-19: a retrospective analysis of 487 case outside Wuhan Open

Yu Shi, Xia Yu, Hong Zhao, Hao Wang, Ruihong Zhao , et al. · 2020

Background: The recent outbreak of SARS-CoV-2 infection results in a considerable morbidity and mortality, mainly in China. The study is to investigate the intrinstic features of infected patients that associated with severe type of this d…

Establishment of reference sequences of hepatitis B virus genotype B subgenotypes Open

Xiaojun Jin, Qun Cai, Zhenhua Zhang, Jifang Sheng · 2020

Hepatitis B virus (HBV) has been classified into ten genotypes (A-J). Genotype B (HBV/B) is divided into nine subgenotypes (B1-B9), each with specific geographical predominance. Some reference sequence of HBV/B subgenotypes are currently i…

An outbreak of Coxsackievirus A6 infection in adults of a collective unit, China, 2019 Open

Yumeng Gao, Guangyuan Ma, Yong Xiao, Qun Cai, Yujun Chen , et al. · 2019

Background: Outbreaks/epidemic caused by Coxsackievirus A6 have been reported continuously since 2008. However, outbreaks caused by Coxsackievirus A6 infection in adults of a collective unit have not been reported. Methods: The nasopharyng…

Establishment of prognostic scoring models for different etiologies of acute decompensation in hospitalized patients with cirrhosis Open

Qun Cai, Mingyan Zhu, Jinnan Duan, Hao Wang, Jifang Sheng · 2019

Objective Acute decompensation (AD) in liver cirrhosis has high mortality. We assessed prognostic scoring models and established prediction models for different etiologies of AD. Methods This retrospective analysis included 732 patients ho…

Microbial Infections as a Trigger for Acute-on-Chronic Liver Failure: A Review Open

Qun Cai, Wei Liu, Mingyan Zhu, Jifang Sheng · 2019

ABSTRACT Microbial infection is an important cause of acute-on-chronic liver failure (ACLF), which is a syndrome that results in multiple organ dysfunction or failure and is accompanied by an increased short-term risk of m…

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