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View article: Apoptotic metabolites synthesize and inherit unique de novo L2a/L2b RNAs to prevent virus infection
Apoptotic metabolites synthesize and inherit unique de novo L2a/L2b RNAs to prevent virus infection Open
View article: The mechanism and application of Scrophulariae Radix in the treatment of endocrine disorders: focusing on thyroid diseases and diabetes mellitus
The mechanism and application of Scrophulariae Radix in the treatment of endocrine disorders: focusing on thyroid diseases and diabetes mellitus Open
Endocrine disorders are prevalent worldwide, with particularly high incidence rates of thyroid diseases and diabetes mellitus (DM), which impose a substantial burden on healthcare systems. Life-long medication is often required to manage t…
View article: USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage
USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage Open
Astrocyte transformation into a neurotoxic phenotype is a hallmark pathological feature of intracerebral hemorrhage (ICH) and a key contributor to exacerbating secondary brain injury. Understanding the underlying mechanisms that regulate t…
View article: Fatty acid-binding protein 4 drives microglia-mediated neuroinflammation through promoting S100A9 expression and lipid droplet accumulation after intracerebral hemorrhage
Fatty acid-binding protein 4 drives microglia-mediated neuroinflammation through promoting S100A9 expression and lipid droplet accumulation after intracerebral hemorrhage Open
Background As primary immune sentinels of the central nervous system (CNS), microglia respond rapidly to acute brain injury and engage in dynamic crosstalk with infiltrating peripheral immune cells. This interplay critically shapes the neu…
View article: Associations of serum pepsinogen and Gastrin-17 with Helicobacter pylori infection, sex, and age, in an asymptomatic coastal population: A cross-sectional study in Rizhao, China
Associations of serum pepsinogen and Gastrin-17 with Helicobacter pylori infection, sex, and age, in an asymptomatic coastal population: A cross-sectional study in Rizhao, China Open
Background Pepsinogen (PG) and gastrin-17 (G-17) are widely used in the screening of gastric diseases. Our cross-sectional clinical study investigates the relationship between Helicobacter pylori (HP) infection, sex, and age on serum level…
View article: Comorbidity Network of Self-Stigma, Insomnia, and Mental Health in Chronic Disease Patients: A Network Analysis
Comorbidity Network of Self-Stigma, Insomnia, and Mental Health in Chronic Disease Patients: A Network Analysis Open
This network analysis identified self-stigma cognition and sleep quality as central symptoms within the self-stigma-insomnia network structure. It pinpointed a lack of interest and pleasure in activities, along with the inability to stop o…
View article: Exosomal programmed death-ligand 1 is associated with post-intracerebral hemorrhage pneumonia
Exosomal programmed death-ligand 1 is associated with post-intracerebral hemorrhage pneumonia Open
BACKGROUND: Post-stroke immunosuppression elevates the risk of stroke-associated pneumonia (SAP). Our earlier research indicated that perihematomal neuron-derived PD-L1 may play a role in peripheral immunosuppression following intracerebra…
View article: Root-centered sodium sequestration and transcriptomic regulation under salt and alkali stress in wild soybean (Glycine soja)
Root-centered sodium sequestration and transcriptomic regulation under salt and alkali stress in wild soybean (Glycine soja) Open
Salt and alkali stress are major constraints on soybean productivity, but their distinct impacts during early development remain insufficiently understood. Wild soybean ( Glycine soja ), a valuable genetic resource for stress tolerance, wa…
View article: On the pair correlation function of the Sine$_β$ process
On the pair correlation function of the Sine$_β$ process Open
We study the Sine$_β$ process, the bulk point process scaling limit of beta-ensembles. We provide a representation of its pair correlation function for all $β>0$ via a stochastic differential equation. We show that the pair correlation fun…
View article: Accuracy of new-generation and traditional IOL power calculation formulas in pediatric primary implantation
Accuracy of new-generation and traditional IOL power calculation formulas in pediatric primary implantation Open
Purpose: To compare the prediction accuracy of new-generation and traditional intraocular lens (IOL) power calculation formulas in pediatric primary IOL implantation and identify factors influencing refractive prediction errors. Setting: Z…
View article: School-level prediction and management of myopia in children and adolescents
School-level prediction and management of myopia in children and adolescents Open
View article: Deep Brain Stimulation in Parkinson's Disease Patients Over 75 Years of Age: A Single‐Institution Retrospective Analysis
Deep Brain Stimulation in Parkinson's Disease Patients Over 75 Years of Age: A Single‐Institution Retrospective Analysis Open
Aim Elderly patients (aged 75 years and older) with Parkinson's disease (PD) are commonly considered unsuitable for deep brain stimulation (DBS) because of its limited benefits for this population and high risk. Understanding therapeutic h…
View article: Risk factors for motor decline following parasagittal and falx meningioma resection in the middle third
Risk factors for motor decline following parasagittal and falx meningioma resection in the middle third Open
Objective The resection of parasagittal and falx meningiomas in the middle third superior sagittal sinus (SSS) is associated with a high risk of postoperative motor deficits. This study discusses the risk factors affecting postoperative mo…
View article: Supramolecular Structure and Circularly Polarized Luminescence Property of Chiral Perylene Diimide Derivatives
Supramolecular Structure and Circularly Polarized Luminescence Property of Chiral Perylene Diimide Derivatives Open
View article: Mitochondrial acetyl-CoA reprogramming by the SIRT3–ACSS2–OPA1 axis confers resistance to ferroptosis in Parkinson's disease
Mitochondrial acetyl-CoA reprogramming by the SIRT3–ACSS2–OPA1 axis confers resistance to ferroptosis in Parkinson's disease Open
View article: Glycerophospholipids, Sphingolipids, and Unsaturated Fatty Acid Content are Main Factors Affecting Viscosity of Torreya grandis Seed Oil
Glycerophospholipids, Sphingolipids, and Unsaturated Fatty Acid Content are Main Factors Affecting Viscosity of Torreya grandis Seed Oil Open
View article: Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion
Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion Open
Accumulation of nanoplastics (NPs) poses a severe threat to the homeostasis of the internal environment in patients with chronic diseases. The effects of NP contamination on health in chronically ill populations must urgently be elucidated…
View article: Multicentre prospective, randomised open-label, endpoint-blinded study to evaluate the safety and efficacy of propranolol for the prevention of stroke-associated pneumonia in patients with intracerebral haemorrhage (PROCHASE): rationale and design
Multicentre prospective, randomised open-label, endpoint-blinded study to evaluate the safety and efficacy of propranolol for the prevention of stroke-associated pneumonia in patients with intracerebral haemorrhage (PROCHASE): rationale and design Open
Background Stroke-induced transient immune suppression is believed to contribute to post-stroke infections. The β-adrenergic receptor antagonist, propranolol, has been shown to prevent stroke-associated pneumonia (SAP) via reversing post-s…
View article: Progress and Prospects for Titanium Extraction from Titanium-Bearing Blast Furnace Slag
Progress and Prospects for Titanium Extraction from Titanium-Bearing Blast Furnace Slag Open
The composition of TBFS is complex. It is categorized into low (W(TiO2) < 5%), medium (5% < W(TiO2) < 20%), and high-titanium slag (W(TiO2) > 20%) based on Ti content. The titanium in the slag is underutilized, causing it to accumulate and…
View article: Astrocyte–neuron crosstalk through extracellular vesicle-shuttled miRNA-382-5p promotes traumatic brain injury
Astrocyte–neuron crosstalk through extracellular vesicle-shuttled miRNA-382-5p promotes traumatic brain injury Open
View article: circUBE2G1 interacts with hnRNPU to promote VEGF-C-mediated lymph node metastasis of lung adenocarcinoma
circUBE2G1 interacts with hnRNPU to promote VEGF-C-mediated lymph node metastasis of lung adenocarcinoma Open
Background Patients with lymph node(LN)metastasis-positive Lung adenocarcinoma(LUAD)suffer from a significantly reduced five-year survival rate. Increasing evidence indicates circular RNAs(circRNAs)play crucial roles in regulating cancer p…
View article: Study on the influencing mechanism of biochar and ethylenediaminetetraacetic acid combination on the remediation of Cd polluted soil by Sedum alfredii Hance
Study on the influencing mechanism of biochar and ethylenediaminetetraacetic acid combination on the remediation of Cd polluted soil by Sedum alfredii Hance Open
View article: Apoptotic vesicles rescue impaired mesenchymal stem cells and their therapeutic capacity for osteoporosis by restoring miR-145a-5p deficiency
Apoptotic vesicles rescue impaired mesenchymal stem cells and their therapeutic capacity for osteoporosis by restoring miR-145a-5p deficiency Open
View article: Ninety percent circular polarization detected in a repeating fast radio burst
Ninety percent circular polarization detected in a repeating fast radio burst Open
Fast radio bursts (FRBs) are extra-galactic sources with unknown physical mechanisms. They emit millisecond-duration radio pulses with isotropic equivalent energy of $10^{36}\sim10^{41}$ ergs. This corresponds to a brightness temperature o…
View article: Correction: FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control
Correction: FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control Open
In this article typos have been corrected:1. Consistently, the protective effects of FNDC5 on mitochondrial bioenergetics were counteracted in SIRT3 cKO mice.2. Figure legends: Fig. 1: a, Serum irisin levels were decreased in patients with…
View article: Apoptotic vesicles rescue impaired mesenchymal stem cells and their therapeutic capacity for osteoporosis by restoring miR-145a-5p deficiency
Apoptotic vesicles rescue impaired mesenchymal stem cells and their therapeutic capacity for osteoporosis by restoring miR-145a-5p deficiency Open
Apoptotic vesicles (apoVs) play a vital role in various pathological conditions; however, we have yet to fully understand their precise biological effects in rescuing impaired mesenchymal stem cells (MSCs) and regulating tissue homeostasis…
View article: FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control
FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control Open
View article: Optimal range of systolic blood pressure in the emergent phase that reduces the negative outcomes of traumatic brain injury surgery
Optimal range of systolic blood pressure in the emergent phase that reduces the negative outcomes of traumatic brain injury surgery Open
Blood pressure management is critical for the treatment of traumatic brain injury (TBI). The purpose of this study was to determine the safe systolic blood pressure (SBP) range during the emergent phase that reduces negative outcomes after…
View article: Risk factors for hemorrhage in patients with long-term aspirin therapy undergoing emergency external ventricular drainage/intracranial pressure probe placement
Risk factors for hemorrhage in patients with long-term aspirin therapy undergoing emergency external ventricular drainage/intracranial pressure probe placement Open
View article: Spatiotemporal heterogeneity and protective polarization of astrocytes depending on intercellular interaction after intracerebral hemorrhage
Spatiotemporal heterogeneity and protective polarization of astrocytes depending on intercellular interaction after intracerebral hemorrhage Open
Multiple cells and their interactions in the perihematomal lesions play crucial roles in the progression of intracerebral hemorrhage (ICH), but full dynamics of intercellular interactions among the resident and peripheral cells remain inco…