Liqun Lu
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View article: PirB Inhibition Mitigates Neonatal White Matter Injury via Regulating Nlrp3-Driven PANoptosis in Oligodendrocyte Precursor Cells
PirB Inhibition Mitigates Neonatal White Matter Injury via Regulating Nlrp3-Driven PANoptosis in Oligodendrocyte Precursor Cells Open
Background: White matter injury (WMI) is a major cause of neurological impairment in preterm infants, characterized by demyelination due to disrupted oligodendrocyte precursor cell (OPC) maturation. Currently, no effective treatment exists…
View article: A rapid and portable dual-mode RAA-CRISPR/Cas12a system for one-pot detection of spring viraemia of carp virus (SVCV)
A rapid and portable dual-mode RAA-CRISPR/Cas12a system for one-pot detection of spring viraemia of carp virus (SVCV) Open
Spring viraemia of carp virus (SVCV), a pathogen with significant economic impacts on global aquaculture, necessitates the development of rapid, sensitive diagnostic tools for effective disease management. This study presents two innovativ…
View article: Investigating E3 ubiquitin ligase activity of ORF150 in fish herpesvirus pathogenesis
Investigating E3 ubiquitin ligase activity of ORF150 in fish herpesvirus pathogenesis Open
Fish herpesviruses, members of the family Alloherpesviridae , infect aquatic species. The host’s ubiquitin-proteasome system (UPS) serves as the major intracellular pathway for protein degradation and plays a crucial role in the viral repl…
View article: A Rapid and Portable Dual-Mode Raa-Crispr/Cas12a System For One-Pot Detection of Spring Viraemia of Carp Virus (Svcv)
A Rapid and Portable Dual-Mode Raa-Crispr/Cas12a System For One-Pot Detection of Spring Viraemia of Carp Virus (Svcv) Open
View article: A Rapid and Portable Dual-Mode Raa-Crispr/Cas12a System for One-Pot Detection of Spring Viraemia of Carp Virus (Svcv)
A Rapid and Portable Dual-Mode Raa-Crispr/Cas12a System for One-Pot Detection of Spring Viraemia of Carp Virus (Svcv) Open
View article: Optimization of iron flocculation for enrichment of CyHV-2 in aquaculture water
Optimization of iron flocculation for enrichment of CyHV-2 in aquaculture water Open
Cyprinid herpesvirus 2 (CyHV-2) is an important infectious virus endangering the farmed Carassius species industry. The enrichment and identification of CyHV-2 in the water is a vital means of early warning diagnostics, which is helpful to…
View article: Development of cross monoclonal antibodies for cyprinid herpesvirus 3 and cyprinid herpesvirus 2
Development of cross monoclonal antibodies for cyprinid herpesvirus 3 and cyprinid herpesvirus 2 Open
Cyprinid herpesvirus 3 (CyHV-3) and Cyprinid herpesvirus 2 (CyHV-2) both belong to Alloherpesviridae family and bring great harm to koi carp, goldfish and crucian carp industry worldwide. In order to prepare a cross monoclonal antibody (MA…
View article: Genomic and molecular characterization of a cyprinid herpesvirus 2 YC-01 strain isolated from gibel carp
Genomic and molecular characterization of a cyprinid herpesvirus 2 YC-01 strain isolated from gibel carp Open
Cyprinid herpesvirus 2 (CyHV-2) is the pathogen of herpesviral hematopoietic necrosis (HVHN), causing the severe economic losses in farmed gibel carp (Carassius gibelio). Further exploration of the genome structure and potential mol…
View article: Effect of Heat Shock Treatment on the Virulence of Grass Carp Reovirus in Rare Minnow Gobiocypris rarus
Effect of Heat Shock Treatment on the Virulence of Grass Carp Reovirus in Rare Minnow Gobiocypris rarus Open
The mode and outcome of fish–virus interactions are influenced by many abiotic factors, among which water temperature is especially important in poikilothermic fish. Rare minnow Gobiocypris rarus is a eurythermal small cyprinid fish that i…
View article: Probing the nanomechanics of interfacial interactions between hydrophobic surfaces
Probing the nanomechanics of interfacial interactions between hydrophobic surfaces Open
Hydrophobic interactions are widely applied in diverse fields, yet the effect of the degree of hydrophobicity on the interactions between hydrophobic surfaces is still unaddressed, limiting the development of functional hydrophobic surface…
View article: Prediction of Hydration Heat for Diverse Cementitious Composites through a Machine Learning-Based Approach
Prediction of Hydration Heat for Diverse Cementitious Composites through a Machine Learning-Based Approach Open
Hydration plays a crucial role in cement composites, but the traditional methods for measuring hydration heat face several limitations. In this study, we propose a machine learning-based approach to predict hydration heat at specific time …
View article: Optimization of Iron Flocculation for Enrichment of Cyhv-2 in Aquaculture Water
Optimization of Iron Flocculation for Enrichment of Cyhv-2 in Aquaculture Water Open
View article: Generation and Characterization of ORF55/ORF57-Deleted Recombinant Cyprinid herpesvirus 2 Mutants with Chimeric Capsid Protein Gene of Grouper Nervous Necrosis Virus
Generation and Characterization of ORF55/ORF57-Deleted Recombinant Cyprinid herpesvirus 2 Mutants with Chimeric Capsid Protein Gene of Grouper Nervous Necrosis Virus Open
Cyprinid herpesvirus 2 (CyHV-2) is a pathogen that causes significant losses to the global aquaculture industry due to mass mortality in crucian carp and goldfish. This study demonstrates that the ORF55/ORF57 deletion mutants CyHV-2-Δ55-CP…
View article: Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia Open
White matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused by excessive apoptosis of oligodendrocyte precursor cells (OPCs). In recent years, studies have found that excessive autophagy and apoptosis are hig…
View article: Rapamycin attenuates pyroptosis by suppressing mTOR phosphorylation and promoting autophagy in LPS-induced bronchopulmonary dysplasia
Rapamycin attenuates pyroptosis by suppressing mTOR phosphorylation and promoting autophagy in LPS-induced bronchopulmonary dysplasia Open
Rapamycin reduces pyroptosis in neonatal rats with LPS-induced BPD by inhibiting mTOR phosphorylation and inducing autophagy; hence, it may represent a potential therapeutic for treating BPD.
View article: Regulating NLRP3 Inflammasome–Induced Pyroptosis via Nrf2: TBHQ Limits Hyperoxia-Induced Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia
Regulating NLRP3 Inflammasome–Induced Pyroptosis via Nrf2: TBHQ Limits Hyperoxia-Induced Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia Open
View article: Identification of serum immunoglobulin M (IgM) of crucian carp (Carassius auratus gibelio) and immune response to cyprinid herpesvirus 2 infection
Identification of serum immunoglobulin M (IgM) of crucian carp (Carassius auratus gibelio) and immune response to cyprinid herpesvirus 2 infection Open
Crucian carp (Carassius auratus gibelio), an extensively cultivated freshwater fish, was one of the model species for the study of fish immunology. Polyclonal antibodies were advantageous molecular tools for studying teleost immune system.…
View article: Isolation and characterization of the lytic Aeromonas phage HJ05,a new member of Caudovirales
Isolation and characterization of the lytic Aeromonas phage HJ05,a new member of Caudovirales Open
Phages are proposed for treating and preventing bacteria diseases largely due to their narrow spectrum of activity and capacity to multiply at the site of infection. Aeromonas hydrophila , a gram-negative and facultatively anaerobic bacter…
View article: The identification of viral ribonucleotide reductase encoded by ORF23 and ORF141 genes and effect on CyHV-2 replication
The identification of viral ribonucleotide reductase encoded by ORF23 and ORF141 genes and effect on CyHV-2 replication Open
Introduction Ribonucleotide reductase (RR) is essential for the replication of the double-stranded DNA virus CyHV-2 due to its ability to catalyze the conversion of ribonucleotides to deoxyribonucleotides, and is a potential target for the…
View article: Screening and identification of cyprinid herpesvirus 2 (CyHV-2) ORF55-interacting proteins by phage display
Screening and identification of cyprinid herpesvirus 2 (CyHV-2) ORF55-interacting proteins by phage display Open
View article: Regulating NLRP3 Inflammasome-Induced Pyroptosis via Nrf2: TBHQ Limits Hyperoxia-Induced Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia
Regulating NLRP3 Inflammasome-Induced Pyroptosis via Nrf2: TBHQ Limits Hyperoxia-Induced Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia Open
Background Nuclear factor e2-related factor 2 (Nrf2) plays a key role in cellular resistance to oxidative stress injury. Oxidative stress injury caused by Nrf2 imbalance leads to cellular abnormalities, such as increased pyroptosis, DNA da…
View article: Combination of iron flocculation and qPCR for quantitative evaluation of virus-shedding intensity of goldfish Carassius auratus infected with cyprinid herpesvirus 2 in the water and the effect of sodium chlorite powder in blocking waterborne horizontal viral transmission
Combination of iron flocculation and qPCR for quantitative evaluation of virus-shedding intensity of goldfish Carassius auratus infected with cyprinid herpesvirus 2 in the water and the effect of sodium chlorite powder in blocking waterborne horizontal viral transmission Open
Cyprinid herpesvirus 2 (CyHV-2), a member of the Alloherpesviridae family belonging to the genus Cyprinivirus, was initially isolated from goldfish (Carassius auratus) and has been recently emerging as a virulent pathogen for cultured prus…
View article: Complete Genome and Molecular Characterization of a New Cyprinid Herpesvirus 2 (CyHV-2) SH-01 Strain Isolated from Cultured Crucian Carp
Complete Genome and Molecular Characterization of a New Cyprinid Herpesvirus 2 (CyHV-2) SH-01 Strain Isolated from Cultured Crucian Carp Open
Cyprinid herpesvirus 2 (CyHV-2) is a causative factor of herpesviral hematopoietic necrosis (HVHN) in farmed crucian carp (Carassius carassius) and goldfish (Carassius auratus). In this study, we analyzed the genomic characteristics of a n…
View article: The transcriptomic responses of blunt snout bream (Megalobrama amblycephala) to acute hypoxia stress alone, and in combination with bortezomib
The transcriptomic responses of blunt snout bream (Megalobrama amblycephala) to acute hypoxia stress alone, and in combination with bortezomib Open
Background Blunt snout bream ( Megalobrama amblycephala ) is sensitive to hypoxia. A new blunt snout bream strain, “Pujiang No.2”, was developed to overcome this shortcoming. As a proteasome inhibitor, bortezomib (PS-341) has been shown to…
View article: Induction of Reactive Oxygen Species Is Necessary for Efficient Onset of Cyprinid Herpesvirus 2 Replication: Implications for Novel Antiviral Strategy With Antioxidants
Induction of Reactive Oxygen Species Is Necessary for Efficient Onset of Cyprinid Herpesvirus 2 Replication: Implications for Novel Antiviral Strategy With Antioxidants Open
Cyprinid herpesvirus 2 (CyHV-2) has caused great economic loss to the crucian carp breeding industry. Upon viral stimulation, eukaryotic cells generally activate the expression of anti-oxidative genes to maintain the intracellular oxidativ…
View article: Additional file 4 of The transcriptomic responses of blunt snout bream (Megalobrama amblycephala) to acute hypoxia stress alone, and in combination with bortezomib
Additional file 4 of The transcriptomic responses of blunt snout bream (Megalobrama amblycephala) to acute hypoxia stress alone, and in combination with bortezomib Open
Additional file 4.
View article: Additional file 6 of The transcriptomic responses of blunt snout bream (Megalobrama amblycephala) to acute hypoxia stress alone, and in combination with bortezomib
Additional file 6 of The transcriptomic responses of blunt snout bream (Megalobrama amblycephala) to acute hypoxia stress alone, and in combination with bortezomib Open
Additional file 6.
View article: Additional file 5 of The transcriptomic responses of blunt snout bream (Megalobrama amblycephala) to acute hypoxia stress alone, and in combination with bortezomib
Additional file 5 of The transcriptomic responses of blunt snout bream (Megalobrama amblycephala) to acute hypoxia stress alone, and in combination with bortezomib Open
Additional file 5.
View article: Additional file 3 of The transcriptomic responses of blunt snout bream (Megalobrama amblycephala) to acute hypoxia stress alone, and in combination with bortezomib
Additional file 3 of The transcriptomic responses of blunt snout bream (Megalobrama amblycephala) to acute hypoxia stress alone, and in combination with bortezomib Open
Additional file 3.
View article: Susceptibility of Goldfish to Cyprinid Herpesvirus 2 (CyHV-2) SH01 Isolated from Cultured Crucian Carp
Susceptibility of Goldfish to Cyprinid Herpesvirus 2 (CyHV-2) SH01 Isolated from Cultured Crucian Carp Open
Cyprinid herpesvirus 2 (CyHV-2), a member of the Alloherpesviridae family belonging to the genus Cyprinivirus, is a fatal contagious aquatic pathogen that affects goldfish (Carassius auratus) and crucian carp (Carassius carassius). Althoug…