Qunfeng Wu
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View article: Exploring Glypican-3 targeted CAR-NK treatment and potential therapy resistance in hepatocellular carcinoma
Exploring Glypican-3 targeted CAR-NK treatment and potential therapy resistance in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer and the second leading cause of cancer-related mortality globally. Despite advancements in current HCC treatment, it remains a malignancy with poor prognosis…
View article: Exploring Glypican-3 Targeted CAR-NK Treatment and Potential Therapy Resistance in Hepatocellular Carcinoma
Exploring Glypican-3 Targeted CAR-NK Treatment and Potential Therapy Resistance in Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer and ranks as the second leading cause of cancer-related mortality globally. Despite advances in current HCC treatment, it remains a malignancy with poor prog…
View article: Interferon drives HCV scarring of the epigenome and creates targetable vulnerabilities following viral clearance
Interferon drives HCV scarring of the epigenome and creates targetable vulnerabilities following viral clearance Open
Background and Aims Chronic HCV infection is a leading etiologic driver of cirrhosis and ultimately HCC. Of the approximately 71 million individuals chronically infected with HCV, 10%‐20% are expected to develop severe liver complications …
View article: Neuroimmune/Hematopoietic Axis with Distinct Regulation by the High-Mobility Group Box 1 in Association with Tachykinin Peptides
Neuroimmune/Hematopoietic Axis with Distinct Regulation by the High-Mobility Group Box 1 in Association with Tachykinin Peptides Open
Hematopoiesis is tightly regulated by the bone marrow (BM) niche. The niche is robust, allowing for the return of hematopoietic homeostasis after insults such as infection. Hematopoiesis is partly regulated by soluble factors, such as neur…
View article: Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma
Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma Open
Disruption of epigenetic mechanisms has been intimately linked to the etiology of human cancer. Understanding how these epigenetic mechanisms (including DNA methylation [5mC], hydroxymethylation [5hmC], and histone post‐translational modif…
View article: RETRACTED: Mi<scp>RNA</scp>‐545 negatively regulates the oncogenic activity of <scp>EMS</scp>1 in gastric cancer
RETRACTED: Mi<span>RNA</span>‐545 negatively regulates the oncogenic activity of <span>EMS</span>1 in gastric cancer Open
Gastric cancer ( GC ) is a common malignant tumor of the digestive system. In addition, GC metastasis is an extremely complicated process. In this article, high expression levels of EMS 1 mRNA and protein were found to be positively correl…
View article: Breast cancer stem cells, epigenetics, and radiation
Breast cancer stem cells, epigenetics, and radiation Open
Breast cancer remains a clinical problem despite advancements in the field. Cancer stem cells (CSCs) within the breast cancer population are implicated in cancer relapse. The dormant CSCs generally resist available treatment, thus challeng…
View article: Aptamers against Cells Overexpressing Glypican 3 from Expanded Genetic Systems Combined with Cell Engineering and Laboratory Evolution
Aptamers against Cells Overexpressing Glypican 3 from Expanded Genetic Systems Combined with Cell Engineering and Laboratory Evolution Open
Laboratory in vitro evolution (LIVE) might deliver DNA aptamers that bind proteins expressed on the surface of cells. In this work, we used cell engineering to place glypican 3 (GPC3), a possible marker for liver cancer theranostics, on th…
View article: Members of the Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma
Members of the Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma Open
Hepatic stem/progenitor cells (HPC) reside quiescently in normal biliary trees and are activated in the form of ductular reactions during severe liver damage when the replicative ability of hepatocytes is inhibited. HPC niches are full of …