Explanipedia

Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2 Open

Marlena Mucha, Zhihao Lai, Nicholas Mckenzie, Francesca Matrà, Marion Boudes , et al. · 2025

Polycomb Repressive Complex 2 (PRC2) is an essential chromatin regulator responsible for mono-, di- and tri-methylating H3K27. Control of PRC2 activity is a critical process in development and disease, yet no inhibitory cofactor has been i…

A multi-tissue single-cell expression atlas in cattle Open

Bo Han, Houcheng Li, Weijie Zheng, Qi Zhang, Ao Chen , et al. · 2025

Corrigendum to Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis Open

Dongxue Su, Shuai Ma, Lin Shan, Yue Wang, Yuejiao Wang , et al. · 2025

Fungal community structure and viability in biofilms on wall paintings of the Maijishan Grottoes Open

Wenxia Ma, Fasi Wu, Dongpeng He, Ji-Dong Gu, Yuxin Chen , et al. · 2025

High‐Performance, Strain‐Stable Electromagnetic Shielding Materials Enabled by Magnetic Elastic Fiber Networks Pinning Liquid Metal Open

Qi Zhang, Yuanzhao Wu, Xilai Bao, Shengbin Li, Xueheng Zhuang , et al. · 2025

Stretchable electromagnetic interference (EMI) shielding materials are critical for the reliability of wearable electronic devices in complex electromagnetic environments. However, achieving compatibility between ultra‐thinness, high shiel…

Integrated analysis of WGCNA and machine learning identified diagnostic biomarkers in trauma-induced coagulopathy Open

Qingsong Chen, Tao Li, Tao Zhang, Yue Zhou, Wei-Feng Huang , et al. · 2025

Despite advancements in trauma care, uncontrolled hemorrhage and trauma-induced coagulopathy (TIC) remain the leading causes of preventable deaths after trauma. Understanding the genetic underpinnings and molecular mechanisms of TIC is cru…

Development and validation of simultaneous quantitative analytical method for emerging contaminants in animal-derived foods using ultra performance liquid chromatography-tandem mass spectrometry Open

Bolin Liu, Zi-Yue Zhan, Qi Zhang, Yu Liu, Yan-Yu Dai , et al. · 2025

Regulation of the PKD2 channel function and associated disease phenotypes by RASSF4 Open

Xing‐Zhen Chen, Rui Tian, Wenbin Yuan, Wanyi Fang, Li Shi , et al. · 2025

ADPKD is caused by mutations in receptor PKD1 and ion channel PKD2. As no effective treatment is available for ADPKD, further studies on the function and regulation of PKD1 and PKD2 are required. Using biotin-neighborhood labeling in HEK29…

Liver Transcriptome Analysis Reveals a Potential Mechanism of Heat Stress Increasing Susceptibility to Salmonella Typhimurium in Chickens Open

Qi Zhang, Yiping Zhu, Zixuan Wang, Qinghe Li, Guiping Zhao , et al. · 2025

Salmonella infection poses a serious threat to the poultry industry, causing significant economic losses. Under global warming conditions, the underlying molecular mechanisms by which heat stress affects bacterial infections in poultry rem…

Comparative evaluation of four new immunoassays and LC-MS/MS for the measurement of urinary free cortisol in Cushing's syndrome diagnosis Open

Qi Zhang, Danni Mu, Yichen Ma, Yuemeng Li, Yumeng Gao , et al. · 2025

Native Massenspektrometrie erleichtert die Hit‐Validierung in der DNA‐Encoded Library Technologie Open

Philipp Bittner, Andreas Gloger, Michelle Keller, Sebastian Oehler, Alice Lessing , et al. · 2025

Zusammenfassung Die DNA‐encoded Library (DEL) Technologie hat sich als zentrales Instrument der Wirkstoffentwicklung etabliert und wird sowohl in der Industrie als auch in der akademischen Forschung breit eingesetzt. Eine zunehmende Anzahl…

A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis Open

Qi Zhang, Shengchao Ma, Kang Xue, Yi Liu, Fei Ma , et al. · 2025

Hyperhomocysteinemia (HHy) can lead to vascular endothelial cell dysfunction, progressive inflammation and lipid metabolism disorder, which finally result in the onset and development of atherosclerosis, a major contributor to cardiovascul…

Anti-tumor and cellular mechanisms of HfIV tetra-(8-hydroxyquinolinato) complexes Open

Tiankun Zhao, Dikui Mei, Jing Ma, Nan Liu, Qi Zhang , et al. · 2025

Three 8-hydroxyquinoline-stabilized hafnium complexes, [Hf^IV(oxinate)₄], were synthesized with good aqueous stability and solubility by reacting Hf^IVCl₄ with 8-hydroxyquinoline (HL₁), …

A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis Open

Qi Zhang, Shengchao Ma, Kang Xue, Yi Liu, Fei Ma , et al. · 2025

Hyperhomocysteinemia (HHy) can lead to vascular endothelial cell dysfunction, progressive inflammation and lipid metabolism disorder, which finally result in the onset and development of atherosclerosis, a major contributor to cardiovascul…

Exploration of Multi-Element Collaborative Research and Application for Modern Power System Based on Generative Large Models Open

Lu Cheng, Qi Zhang, Beibei Xu, Zhiwei Huang, Cirun Zhang , et al. · 2025

The transition to intelligent, low-carbon power systems necessitates advanced optimization strategies for managing renewable energy integration, energy storage, and carbon emissions. Generative Large Models (GLMs) provide a data-driven app…

Causal Associations of Epigenetic Age Acceleration With Stroke and Its Functional Outcome: A Two‐Sample, Two‐Step Mendelian Randomization Study Open

Baizhi Qiu, Shuyang Wen, Zifan Li, Yuxin Cai, Qi Zhang , et al. · 2025

Background Emerging evidence from observational studies suggested that epigenetic age acceleration may result in an increased incidence of stroke and poorer functional outcomes after a stroke. However, the causality of these associations r…

c-JUN: a chromatin repressor that limits mesoderm differentiation in human pluripotent stem cells Open

Ran Zhang, Guihuan Li, Qi Zhang, Zhenhua Wang, Dan Xiang , et al. · 2025

Cell fate determination at the chromatin level is not fully comprehended. Here, we report that c-JUN acts on chromatin loci to limit mesoderm cell fate specification as cells exit pluripotency. Although c-JUN is widely expressed across var…

Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates Open

Michael Uckelmann, Vita Levina, Cyntia Taveneau, Xiao Han Ng, Varun Pandey , et al. · 2025

The compaction of chromatin is a prevalent paradigm in gene repression. Chromatin compaction is commonly thought to repress transcription by restricting chromatin accessibility. However, the spatial organization and dynamics of chromatin c…

Inhomogeneous Flow Characteristics of Pressurised Hydrogen Leakage in Arc-Shaped Tube Open

Yunyu Li, Xuhai Pan, Min Hua, Qi Zhang, Langqing Lu · 2025

Cell cycle proteins: Linking the cell cycle to tumors Open

Jie Zhong, Jiayi Liu, Xing Tang, Weidong Zhou, Song Guang-ming , et al. · 2025

The cell cycle is a tightly coupled series of events that enable cells to grow and proliferate. Cyclin-dependent kinases (CDKs) play crucial roles in the cell cycle by enabling cells to transition between different phases when they are act…

Development of a DNA-encoded library screening method “DEL Zipper” to empower the study of RNA-targeted chemical matter Open

Zhongyao Ma, Bin Zou, Jiannan Zhao, Rui Zhang, Qiaoqiao Zhu , et al. · 2024

To date, RNA-targeted chemical matter is under explored due to a lack of robust screening assays. In this study, we present a novel RNA-targeted small molecule screening approach using a specialized DNA-encoded library (DEL). Our findings …

[FER-1 inhibits methylglyoxal-induced ferroptosis in mouse alveolar macrophages <i>in vitro</i>]. Open

Qi Zhang, Zhixing Ji, Abai Jiashaer, Youda Wang, Abuduxukuer Abulimiti · 2024

Methylglyoxal can induce ferroptosis in MH-S cells in a dose-dependent manner, and FER-1 can rescue the cells from methylglyoxal-induced ferroptosis.

Exploring distinct modes of inter-spike cross-linking for enhanced neutralization by SARS-CoV-2 antibodies Open

Xuanyu Nan, Yujie Li, Rui Zhang, Ruoke Wang, Nonghua Lv , et al. · 2024

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its Omicron subvariants drastically amplifies transmissibility, infectivity, and immune escape, mainly due to their resistance to most neutralizing antibodie…

Prevalence, trends, and outcomes of hematological malignancies in patients with hemophagocytic lymphohistiocytosis Open

Qi Zhang, Qiuyan Yu, Qian Chen, Hongjing Dong, Min Fang , et al. · 2024

Despite the increasing awareness and diagnosis of HLH, the prognosis of patients with HLH associated with hematological malignancies remains poor, highlighting the urgent need for improved management strategies and therapeutic intervention…

340 Efficacy and safety of conditionally-activated CAR-T cells against gastrointestinal tumors Open

Qi Zhang, Yanqing Yang, Jiang Cao, Shengnan Liu, Qian Lu , et al. · 2024

DISCO: A Hierarchical Disentangled Cognitive Diagnosis Framework for Interpretable Job Recommendation Open

Xiaoshan Yu, Chuanbo Qin, Qi Zhang, Hongda Chen, Haiping Ma , et al. · 2024

The rapid development of online recruitment platforms has created unprecedented opportunities for job seekers while concurrently posing the significant challenge of quickly and accurately pinpointing positions that align with their skills …

Radical-Mediated N–C Crosslinking in the Biosynthesis of Dynobactin A, a Ribosomally-Derived Peptide Targeting Gram-Negative Bacteria Open

Yuanjun Han, He Li, Xinhui Li, Wei Ding, Qi Zhang · 2024

Single-Atom Ce-N-C Nanozyme Ameliorates Type 2 Diabetes Mellitus by Improving Glucose Metabolism Disorders and Reducing Oxidative Stress Open

Yitong Lin, Yanan Wang, Qi Zhang, Ruxin Gao, Chang Fei , et al. · 2024

Type 2 diabetes mellitus (T2DM) as a chronic metabolic disease has become a global public health problem. Insulin resistance (IR) is the main pathogenesis of T2DM. Oxidative stress refers to an imbalance between free radical production and…

Endogenous retroviral ERVH48-1 promotes human urine cell reprogramming Open

Yuling Peng, Jieying Zhu, Qi Zhang, Ran Zhang, Zhenhua Wang , et al. · 2024

Endogenous retroviruses (ERVs), once thought to be mere remnants of ancient viral integrations in the mammalian genome, are now recognized for their critical roles in various physiological processes, including embryonic development, innate…

A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development Open

Ran Zhang, Menghua Wu, Dan Xiang, Jieying Zhu, Qi Zhang , et al. · 2024

Endogenous retroviruses (ERVs) occupy a significant part of the human genome, with some encoding proteins that influence the immune system or regulate cell-cell fusion in early extra-embryonic development. However, whether ERV-derived prot…

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