Qunwei Dong
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View article: Isorhynchophylline Mitigates Bone Loss in OVX Mice by Modulating Inflammatory Responses, Oxidative Stress, Gut Microbiota Composition and SCFAs Production
Isorhynchophylline Mitigates Bone Loss in OVX Mice by Modulating Inflammatory Responses, Oxidative Stress, Gut Microbiota Composition and SCFAs Production Open
Osteoporosis (OP) is a systemic skeletal disorder characterized by reduced bone mass and deteriorated bone architecture. Isorhynchophylline (IRN), an active alkaloid derived from the plant Uncaria rhynchophylla , is known for its significa…
View article: Lumbar spine infection caused by candida albicans: A case report
Lumbar spine infection caused by candida albicans: A case report Open
Introduction: Lumbar spine infection caused by Candida albicans is a rare condition in clinical practice that often presents as chronic lower back pain. The combination of imaging and laboratory tests can aid in the accurate diagnosis of t…
View article: Gut microbiota and short-chain fatty acids signatures in postmenopausal osteoporosis patients: A retrospective study
Gut microbiota and short-chain fatty acids signatures in postmenopausal osteoporosis patients: A retrospective study Open
Studies have shown that gut microbiota (GM) and its metabolites, short-chain fatty acids (SCFAs), are associated with the development of postmenopausal osteoporosis (PMO). This study explored the clinical and laboratory evidence of the rel…
View article: Clinical effect analysis of vertebroplasty with high viscosity and standard bone cement for Kummell disease
Clinical effect analysis of vertebroplasty with high viscosity and standard bone cement for Kummell disease Open
This study aims to observe and compare the effects of high-viscosity bone cement versus standard bone cement on the postoperative outcomes of percutaneous vertebroplasty (PVP) in patients with Kummell disease. A retrospective analysis was …
View article: Investigating the protective effect of loganin in ovariectomy‑induced bone loss through network pharmacology and molecular docking
Investigating the protective effect of loganin in ovariectomy‑induced bone loss through network pharmacology and molecular docking Open
Loganin, a major iridoid glycoside derived from Cornus officinalis, exerts strong anti-inflammatory property. The present study aimed to investigate the underlying mechanism of loganin to reduce estrogen deficiency-induced bone loss…
View article: Ziyuglycoside II attenuated OVX mice bone loss via inflammatory responses and regulation of gut microbiota and SCFAs
Ziyuglycoside II attenuated OVX mice bone loss via inflammatory responses and regulation of gut microbiota and SCFAs Open
Our data indicated that ZGS II attenuated bone loss in OVX mice by relieving inflammation and regulating gut microbiota and SCFAs.
View article: Decoding the mechanism of Eleutheroside E in treating osteoporosis via network pharmacological analysis and molecular docking of osteoclast-related genes and gut microbiota
Decoding the mechanism of Eleutheroside E in treating osteoporosis via network pharmacological analysis and molecular docking of osteoclast-related genes and gut microbiota Open
Objective Eleutheroside E (EE) is an anti-inflammatory natural compound derived from the edible medicinal herb Acanthopanax senticosus . This study aims to investigate the underlying mechanism of the anti-osteoporosis action of EE through …
View article: Fufang Zhenshu Tiaozhi Capsule Enhances Bone Formation and Safeguards against Glucocorticoid-Induced Osteoporosis through Innovative Mekk2-Mediated β-Catenin Deubiquitination
Fufang Zhenshu Tiaozhi Capsule Enhances Bone Formation and Safeguards against Glucocorticoid-Induced Osteoporosis through Innovative Mekk2-Mediated β-Catenin Deubiquitination Open
Background The homeostasis of bone is reliant on the regulation of β-catenin activity in osteoblasts. Glucocorticoids (GC) have been found to reduce β-catenin activity through Wnt pathway signaling, leading to osteoporotic pathology. On th…
View article: The therapeutic effect of Fufang Zhenshu Tiaozhi (FTZ) on osteoclastogenesis and ovariectomized-induced bone loss: evidence from network pharmacology, molecular docking and experimental validation
The therapeutic effect of Fufang Zhenshu Tiaozhi (FTZ) on osteoclastogenesis and ovariectomized-induced bone loss: evidence from network pharmacology, molecular docking and experimental validation Open
Fufang Zhenshu Tiaozhi (FTZ) has been widely used in clinical practice and proven to be effective against aging-induced osteoporosis in mice. This study aimed to explore the mechanism of FTZ against osteoclastogenesis and ovariectomized-in…