Explanipedia

Effects of ulinastatin on therapeutic outcomes and inflammatory markers in pediatric septic shock patients Open

Shan Gao, Suk Hang Cheng, Qunwei Zhang, Zhizhong Cheng, Le Chen , et al. · 2025

Long Noncoding RNA NR_030777 Alleviates Cobalt Nanoparticles-Induced Neurodegenerative Damage by Promoting Autophagosome–Lysosome Fusion Open

Xinpei Lin, Cheng Chen, Jinxiang Chen, Canlin Zhu, Jiajun Zhang , et al. · 2024

Potential exposure to cobalt nanoparticles (CoNPs) occurs in various fields, including hard alloy industrial production, the increasing use of new energy lithium-ion batteries, and millions of patients with metal-on-metal joint prostheses.…

MMP-3 mediates copper oxide nanoparticle-induced pulmonary inflammation and fibrosis Open

Yuanbao Zhang, Zhenyu Zhang, Yiqun Mo, Yue Zhang, Jiali Yuan , et al. · 2024

Background The increasing production and usage of copper oxide nanoparticles (Nano-CuO) raise human health concerns. Previous studies have demonstrated that exposure to Nano-CuO could induce lung inflammation, injury, and fibrosis. However…

ROS/mtROS promotes TNTs formation via the PI3K/AKT/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials Open

Xinpei Lin, Wei Wang, Xiangyu Chang, Cheng Chen, Zhenkun Guo , et al. · 2024

Background As the demand and application of engineered nanomaterials have increased, their potential toxicity to the central nervous system has drawn increasing attention. Tunneling nanotubes (TNTs) are novel cell–cell communication that p…

The pulmonary effects of nickel-containing nanoparticles: cytotoxicity, genotoxicity, carcinogenicity, and their underlying mechanisms Open

Yiqun Mo, Yue Zhang, Qunwei Zhang · 2024

This review summarized the cytotoxic, genotoxic, and carcinogenic effects of Ni-containing NPs on humans, lung cells in vitro , and rodent lungs in vivo , and the underlying mechanisms. Their extra-pulmonary effects were also briefly menti…

High glucose enhances the activation of NLRP3 inflammasome by ambient fine particulate matter in alveolar macrophages Open

Yiqun Mo, Luke Mo, Yue Zhang, Yuanbao Zhang, Jiali Yuan , et al. · 2023

ROS/mtROS promotes TNTs formation via PI3K/AKT/mTOR pathway to protect against mitochondrial damages induced by engineering nanomaterialsin human glial cells Open

Xinpei Lin, Wei Wang, Xiangyu Chang, Cheng Chen, Zhenkun Guo , et al. · 2023

Background As the demand and application of engineering nanomaterials rise, their potential toxicity in the central nervous system has drawn increasing concerns. As a novel cell-cell communication, tunneling nanotubes (TNTs) plays a crucia…

MMP-3-mediated cleavage of OPN is involved in copper oxide nanoparticle-induced activation of fibroblasts Open

Yuanbao Zhang, Yiqun Mo, Yue Zhang, Jiali Yuan, Qunwei Zhang · 2023

Background Copper oxide nanoparticles (Nano-CuO) are one of the most produced and used nanomaterials. Previous studies have shown that exposure to Nano-CuO caused acute lung injury, inflammation, and fibrosis. However, the mechanisms under…

Nickel nanoparticles induce autophagy and apoptosis via HIF-1α/mTOR signaling in human bronchial epithelial cells Open

Jiali Yuan, Yiqun Mo, Yue Zhang, Yuanbao Zhang, Qunwei Zhang · 2023

Overview of Internet of Medical Things Security Based on Blockchain Access Control Open

Yikai Liu, Feng-lan Ju, Qunwei Zhang, Meng Zhang, Zezhong Ma , et al. · 2023

The Internet of Things provides convenience to health systems, especially for remote monitoring of patient physical indicators. While providing convenience, there may be more security vulnerabilities in protecting patient and doctor inform…

Solving and Numerical Simulations of Fractional-Order Governing Equation for Micro-Beams Open

Aimin Yang, Qunwei Zhang, Jingguo Qu, Yuhuan Cui, Yiming Chen · 2023

This paper applies a recently proposed numerical algorithm to discuss the deflection of viscoelastic micro-beams in the time domain with direct access. A nonlinear-fractional order model for viscoelastic micro-beams is constructed. Before …

Numerical solutions of the viscoelastic plate of fractional variable order Open

Yuhuan Cui, Qi Zhang, Jingguo Qu, Aimin Yang, Qunwei Zhang , et al. · 2023

The fractional variable-order constitutive model for the viscoelastic plate is analyzed. The fractional variable-order constitutive equations for the plates are solved numerically using the shifted Bernstein polynomials directly in time do…

Prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deacetylation Open

Yu Zhang, Linhu Du, Jinhua Yan, Qianxiang Bai, Qiao Niu , et al. · 2022

Nickel nanoparticles induce epithelial-mesenchymal transition in human bronchial epithelial cells via the HIF-1α/HDAC3 pathway Open

Jiali Yuan, Yiqun Mo, Yuanbao Zhang, Yue Zhang, Qunwei Zhang · 2022

We and others have previously demonstrated that exposure to nickel nanoparticles (Nano-Ni) caused fibrogenic and carcinogenic effects; however, the underlying mechanisms are still not fully understood. This study aimed to investigate the e…

The Improvement of DV-Hop Model and Its Application in the Security Performance of Smart Campus Open

Aimin Yang, Qunwei Zhang, Yikai Liu, Ji Zhao · 2022

In the smart campus, sensors are the basic units in the whole the Internet of Things structure, which play the role of collecting information and transmitting it. How to transmits more information at a certain power level has attracted the…

A protective role of autophagy in fine airborne particulate matter-induced apoptosis in LN-229 cells Open

Jiali Yuan, Luke Mo, Yiqun Mo, Yuanbao Zhang, Yue Zhang , et al. · 2022

Editorial: Epigenetic and Related Signaling Pathways in Response to Ionizing Radiation and Nano-Particles Open

Ruixue Huang, Qunwei Zhang, Ping‐Kun Zhou · 2022

EDITORIAL article Front. Cell Dev. Biol., 27 May 2022Sec. Signaling https://doi.org/10.3389/fcell.2022.932757

MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells Open

Yuanbao Zhang, Yiqun Mo, Jiali Yuan, Yue Zhang, Luke Mo , et al. · 2021

Copper oxide nanoparticles (Nano-CuO) are widely used in medical and industrial fields and our daily necessities. However, the biosafety assessment of Nano-CuO is far behind their rapid development. Here, we investigated the adverse effect…

Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway Open

Yiqun Mo, Yue Zhang, Yuanbao Zhang, Jiali Yuan, Luke Mo , et al. · 2021

Enhanced Skin Incisional Wound Healing With Intracellular ATP Delivery via Macrophage Proliferation and Direct Collagen Production Open

Harshini Sarojini, Alexander Bajorek, Rong Wan, Kai Wang, Qunwei Zhang , et al. · 2021

This study sought to use a newly developed intracellular ATP delivery to enhance incisional wound healing to reduce surgical wound dehiscence and to explore possible mechanism for this effect. Thirty-five adult New Zealand white rabbits we…

miR-770–5p inhibits the activation of pulmonary fibroblasts and silica-induced pulmonary fibrosis through targeting TGFBR1 Open

Jiali Yuan, Ping Li, Honghong Pan, Qi Xu, Tiantian Xu , et al. · 2021

Silicosis is a devastating interstitial lung disease arising from long-term exposure to inhalable silica. Regrettably, no therapy currently can effectively reverse the silica-induced fibrotic lesion. Emerging evidence has indicated that th…

Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes Open

Jiali Yuan, Yue Zhang, Yuanbao Zhang, Yiqun Mo, Qunwei Zhang · 2021

K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice Open

Jing Xie, Yong Shao, Jin Liu, Meilan Cui, Xiuxiao Xiao , et al. · 2020

miR-21 mediates nickel nanoparticle-induced pulmonary injury and fibrosis Open

Yiqun Mo, Yue Zhang, Rong Wan, Mizu Jiang, Youqiong Xu , et al. · 2020

We and other groups have demonstrated that exposure to nickel nanoparticles (Nano-Ni) results in severe and persistent lung inflammation and fibrosis, but the underlying mechanisms remain unclear. Here, we propose that miR-21 may play an i…

The role of miR-21 in nickel nanoparticle-induced MMP-2 and MMP-9 production in mouse primary monocytes: In vitro and in vivo studies Open

Yiqun Mo, Yue Zhang, Luke Mo, Rong Wan, Mizu Jiang , et al. · 2020

Intracellular ATP Delivery Causes Rapid Tissue Regeneration via Upregulation of Cytokines, Chemokines, and Stem Cells Open

Yiqun Mo, Harshini Sarojini, Rong Wan, Qunwei Zhang, Kai Wang , et al. · 2020

We have reported accelerated wound healing induced by intracellular ATP delivery in rabbits, through early massive accumulation, in situ proliferation, and M2 polarization of macrophages. Granulation tissue started to grow within fi…

Adverse effects of subchronic exposure to cooking oil fumes on the gonads and the GPR30-mediated signaling pathway in female rats Open

Xiaoyang Zhang, Yonghua He, Quanhui Lin, Lili Huang, Qunwei Zhang , et al. · 2019

Background Cooking oil fumes (COFs) are composed of particulate matter, polycyclic aromatic hydrocarbons, volatile organic compounds, aldehydes, and ketones, and are currently a global health concern. Some agents in COFs are mutagenic and …

Nrf2-regulated miR-380-3p Blocks the Translation of Sp3 Protein and Its Mediation of Paraquat-Induced Toxicity in Mouse Neuroblastoma N2a Cells Open

Zhipeng Cai, Fuli Zheng, Yan Ding, Yanting Zhan, Ruijie Gong , et al. · 2019

Laboratorial and epidemiological research has established a relationship between paraquat (PQ) exposure and a risk for Parkinson’s disease. Previously, we have investigated the effects of nuclear factor erythroid 2 related factor 2 (Nrf2) …

Comparative mouse lung injury by nickel nanoparticles with differential surface modification Open

Yiqun Mo, Mizu Jiang, Yue Zhang, Rong Wan, Jing Li , et al. · 2019

Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2 Open

Qingqing Wang, Nan Ren, Zhipeng Cai, Qingxia Lin, Zhangjing Wang , et al. · 2017

Both transcription factors (TFs) and microRNAs (miRNAs) can exert a widespread impact on gene expression. In the present study, we investigated the role of Nrf2 in paraquat-induced intracorporeal neurodegeneration and miRNA expression by e…

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