Explanipedia

Transfer learning identifies bacterial signatures for cross‐regional diagnosis of type 2 diabetes and enable stage‐sensitive dietary fiber intervention Open

Qunye Zhang, Nan Wang, Fanghua Zhang, Bin Chen, Yihui Wang , et al. · 2025

<i>Bacteroides fragilis</i> and propionate synergize with low-dose methimazole to treat Graves’ disease Open

Xinjie Zhang, Q J Pan, Guixiang Yao, Danxia Kong, Haiyan Chen , et al. · 2025

Graves’ disease (GD) is a common autoimmune thyroid disease with limited treatment efficacy, high relapse rates, and severe adverse effects. Gut microbiota dysbiosis is thought to play a critical role in GD, with the potential for microbio…

Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes (Diabetes Metab J 2024;48:885-900) Open

Junfei Gu, Xinjie Zhang, Qunye Zhang, Z Wang · 2025

Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM Open

Jiaxuan Li, Zhenyu Tian, Tongxue Zhang, Jiajia Jin, Xinjie Zhang , et al. · 2024

Background Vasculopathy underlies diabetic complications, with perivascular adipose tissue (PVAT) playing crucial roles in its development. However, the changes in the cellular composition and function of PVAT, including the specific cell …

ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure Open

Xiuru Cui, Y J Wang, Hanlin Lu, Lei Wang, Xianwei Xie , et al. · 2024

Hypertension remains a major risk factor for cardiovascular diseases, but the underlying mechanisms are not well understood. Zinc finger protein 36 (ZFP36) is an RNA‐binding protein that regulates mRNA stability by binding to adenylate‐uri…

The role of dysbiotic gut mycobiota in modulating risk for abdominal aortic aneurysm Open

Guixiang Yao, Xinjie Zhang, Tongxue Zhang, Jiajia Jin, Zihan Qin , et al. · 2024

Abdominal aortic aneurysm (AAA) is a large-vessel disease with high mortality, characterized by complex pathogenic mechanisms. Current therapeutic approaches remain insufficient to halt its progression. Fungi are important members of the g…

Low molecular weight heparin promotes the PPAR pathway by protecting the glycocalyx of cells to delay the progression of diabetic nephropathy Open

Bin Zhang, Changkai Bu, Qingchi Wang, Qingqing Chen, Deling Shi , et al. · 2024

Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes Open

J. Gu, Jiajia Jin, Xiaoyu Ren, Xinjie Zhang, J. Li , et al. · 2024

Background: Metabolic dysregulation is a hallmark of type 2 diabetes mellitus (T2DM), in which the abnormalities in brown adipose tissue (BAT) play important roles. However, the cellular composition and function of BAT as well as its patho…

Identification of a distinct cluster of GDF15high macrophages induced by in vitro differentiation exhibiting anti-inflammatory activities Open

Chaochao Dai, Hongyu Zhang, Zhijian Zheng, Chun Guang Li, Mingyuan Ma , et al. · 2024

Introduction Macrophage-mediated inflammatory response may have crucial roles in the pathogenesis of a variety of human diseases. Growth differentiation factor 15 (GDF15) is a cytokine of the transforming growth factor-β superfamily, with …

Intestinal flora and pregnancy complications: Current insights and future prospects Open

Zhenyu Tian, Xinjie Zhang, Guixiang Yao, Jiajia Jin, Tongxue Zhang , et al. · 2024

Numerous studies have demonstrated the pivotal roles of intestinal microbiota in many physiopathological processes through complex interactions with the host. As a unique period in a woman's lifespan, pregnancy is characterized by changes …

Identification of a distinct cluster of GDF15<sup>high</sup>macrophages exhibiting anti-inflammatory activities Open

Chaochao Dai, Hongyu Zhang, Zhijian Zheng, Chun Guang Li, Mingyuan Ma , et al. · 2024

Macrophage-mediated inflammatory response may have crucial roles in the pathogenesis of a variety of human diseases. Growth differentiation factor 15 (GDF15) is a cytokine of the transforming growth factor-β superfamily, with potential ant…

NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post‐Myocardial Infarction via Human Antigen R Open

Chenghu Guo, Wei Ji, Wei Yang, Qiming Deng, Tengfei Zheng , et al. · 2023

Myocardial infarction (MI) remains the leading cause of death worldwide. Cardiac fibroblasts (CFs) are abundant in the heart and are responsible for cardiac repair post‐MI. NF‐κB‐repressing factor (NKRF) plays a significant role in the tra…

Author Correction: Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice Open

Hanlin Lu, Peidong Yuan, Xiaoping Ma, Xiuxin Jiang, Shaozhuang Liu , et al. · 2023

Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice Open

Hanlin Lu, Peidong Yuan, Xiaoping Ma, Xiuxin Jiang, Shaozhuang Liu , et al. · 2023

Editorial: Interactions between proteins and biomacromolecules: Tools and applications (volume II) Open

Fuming Zhang, Qunye Zhang, Lianli Chi · 2022

EDITORIAL article Front. Mol. Biosci., 09 December 2022Sec. Molecular Recognition Volume 9 - 2022 | https://doi.org/10.3389/fmolb.2022.1105486

A transcriptional program associated with cell cycle regulation predominates in the anti-inflammatory effects of CX-5461 in macrophage Open

Jie Wang, Zhijian Zheng, Xiaopei Cui, Chaochao Dai, Jiaxin Li , et al. · 2022

CX-5461, a novel selective RNA polymerase I inhibitor, shows potential anti-inflammatory and immunosuppressive activities. However, the molecular mechanisms underlying the inhibitory effects of CX-5461 on macrophage-mediated inflammation r…

Evaluating the immunogenicity of heparin and heparin derivatives by measuring their binding to platelet factor 4 using biolayer interferometry Open

Qingqing Chen, Fei Li, Haoran Wang, Changkai Bu, Feng Shi , et al. · 2022

Heparin (HP) is a polysaccharide that is widely used in the clinic as an anticoagulant. A major side effect associated with HP is the heparin-induced thrombocytopenia (HIT), which is initiated by the immune response to complex formed by HP…

Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts Open

Jiajia Jin, Liaomei Gao, Xiuli Zou, Yun Zhang, Zhijian Zheng , et al. · 2022

Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and is characterized by hypertension, inflammation, and placental dysfunction. Gut microbiota plays key roles in inflammation and hypertension. Howev…

Endothelial G protein stimulatory α-subunit is a critical regulator of post-ischemic angiogenesis Open

Lifan He, Hanlin Lu, Jianying Chu, Xiaoteng Qin, Jiangang Gao , et al. · 2022

Post-ischemic angiogenesis is a vital pathophysiological process in diseases such as peripheral arterial disease (PAD), heart ischemia, and diabetic retinopathy. The molecular mechanisms of post-ischemic angiogenesis are complicated and no…

Stimulatory G-Protein α Subunit Modulates Endothelial Cell Permeability Through Regulation of Plasmalemma Vesicle-Associated Protein Open

Lifan He, Hanlin Lu, Xuyang Ji, Jianying Chu, Xiaoteng Qin , et al. · 2022

Endothelial cell leakage occurs in several diseases. Intracellular junctions and transcellular fashion are involved. The definite regulatory mechanism is complicated and not fully elucidated. The alpha subunit of the heterotrimeric G-stimu…

Correction: Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques Open

Chongbo Yang, Ming Lu, Wenbin Chen, He Zhao, Xu Hou , et al. · 2022

MiR‐363‐5p modulates regulatory T cells through STAT4‐HSPB1‐Notch1 axis and is associated with the immunological abnormality in Graves' disease Open

Xianlun Yin, Junfeng Ge, Xiurong Ge, Jing Gao, Xinhuan Su , et al. · 2021

MiRNAs are a class of small non‐coding RNAs with ability to regulate function of Treg cells and are involved in many autoimmune diseases. Our previous study found that miR‐363‐5p expression was significantly upregulated in peripheral Treg …

Editorial: Interactions Between Proteins and Biomacromolecules: Tools and Applications Open

Qunye Zhang, Lianli Chi, Fuming Zhang · 2021

EDITORIAL article Front. Mol. Biosci., 11 June 2021Sec. Molecular Recognition https://doi.org/10.3389/fmolb.2021.708084

TSH Activates Macrophage Inflammation by G13- and G15-dependent Pathways Open

Chongbo Yang, Zhao He, Qunye Zhang, Ming Lu, Jiajun Zhao , et al. · 2021

Thyroid-stimulating hormone (TSH) treatment activates inhibitor of NF-κB/nuclear factor κB (IκB/NFκB) and extracellular signal-regulated kinase (ERK)–P38 in macrophages, but how these pathways are activated, and how they contribute to the …

Delayed Comparison and Apriori Algorithm (DCAA): A Tool for Discovering Protein–Protein Interactions From Time-Series Phosphoproteomic Data Open

Lianhong Ding, Shaoshuai Xie, Shucui Zhang, Hangyu Shen, Huaqiang Zhong , et al. · 2020

Analysis of high-throughput omics data is one of the most important approaches for obtaining information regarding interactions between proteins/genes. Time-series omics data are a series of omics data points indexed in time order and norm…

Comparison of Erythrocyte Membrane Lipid Profiles between NAFLD Patients with or without Hyperlipidemia Open

Wenbin Chen, Shanshan Shao, Hu Cai, Jie Han, Tian Guo , et al. · 2020

Objectives. Nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia (HL) are common metabolic disorders due to overnutrition and obesity. NAFLD is often associated with hyperlipidemia. The aim of this study was to identify and compare …

Gut Dysbiosis Contributes to the Imbalance of Treg and Th17 Cells in Graves’ Disease Patients by Propionic Acid Open

Xinhuan Su, Xianlun Yin, Yue Liu, Xuefang Yan, Shucui Zhang , et al. · 2020

Background Graves’ disease (GD) is a typical organ-specific autoimmune disease. Intestinal flora plays a pivotal role in immune homeostasis and autoimmune disease development. However, the association and mechanism between intestinal flora…

Progress in the seasonal variations of blood lipids: a mini-review Open

Xiaochun Ma, Haichen Yan, Haizhou Zhang, Mansen Wang, Qunye Zhang , et al. · 2020

Gut dysbiosis contributes to the imbalance of Treg and Th17 cells in Graves’ disease patients by propionic acid Open

Xinhuan Su, Xianlun Yin, Yue Liu, Xuefang Yan, Shucui Zhang , et al. · 2020

Supplementary material for manuscript "Gut dysbiosis contributes to the imbalance of Treg and Th17 cells in Graves’ disease patients by propionic acid".

Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques Open

Chongbo Yang, Ming Lu, Wenbin Chen, Zhao He, Xu Hou , et al. · 2019

Subclinical hypothyroidism is associated with cardiovascular diseases, yet the underlying mechanism remains largely unknown. Herein, in a common population (n = 1,103), TSH level was found to be independently correlated with both carotid p…

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