Qusai Al Abdallah
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View article: Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer
Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer Open
View article: Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer
Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer Open
Immune checkpoint blockade (ICB) has improved outcomes in some cancers. A major limitation of ICB is that most patients fail to respond, which is partly attributable to immunosuppression. Obesity appears to improve immune checkpoint therap…
View article: The gut mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to diet
The gut mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to diet Open
View article: The gut mycobiome of healthy mice is shaped by the environment and shapes metabolic outcomes in response to diet
The gut mycobiome of healthy mice is shaped by the environment and shapes metabolic outcomes in response to diet Open
Objective As an active interface between the host and their diet, the gut bacteriome influences host metabolic adaptation. However, the contribution of gut fungi to host metabolic outcomes is not yet understood. Therefore, we aimed to dete…
View article: SH3‐class Ras guanine nucleotide exchange factors are essential for<i>Aspergillus fumigatus</i>invasive growth
SH3‐class Ras guanine nucleotide exchange factors are essential for<i>Aspergillus fumigatus</i>invasive growth Open
Proper hyphal morphogenesis is essential for the establishment and progression of invasive disease caused by filamentous fungi. In the human pathogen Aspergillus fumigatus, signalling cascades driven by Ras and Ras-like proteins orchestrat…
View article: Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi
Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi Open
Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique …
View article: Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi
Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi Open
Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique …
View article: Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi
Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi Open
Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique …
View article: Whole-genome sequencing reveals highly specific gene targeting by in vitro assembled Cas9-ribonucleoprotein complexes in Aspergillus fumigatus
Whole-genome sequencing reveals highly specific gene targeting by in vitro assembled Cas9-ribonucleoprotein complexes in Aspergillus fumigatus Open
CRISPR/Cas9-based genome editing in A. fumigatus using in vitro assembled RNPs coupled with microhomology templates is a reliable method of gene targeting. This system is highly efficient and is not associated with increased off-tar…
View article: C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA in Aspergillus fumigatus
C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA in Aspergillus fumigatus Open
RasA is a major regulator of fungal morphogenesis and virulence in Aspergillus fumigatus. The proper localization of RasA to the plasma membrane is essential for the formation of invasive hyphae during infection. In yeast, the local…
View article: A Simple and Universal System for Gene Manipulation in Aspergillus fumigatus: <i>In Vitro</i> -Assembled Cas9-Guide RNA Ribonucleoproteins Coupled with Microhomology Repair Templates
A Simple and Universal System for Gene Manipulation in Aspergillus fumigatus: <i>In Vitro</i> -Assembled Cas9-Guide RNA Ribonucleoproteins Coupled with Microhomology Repair Templates Open
Tackling the multifactorial nature of virulence and antifungal drug resistance in A. fumigatus requires the mechanistic interrogation of a multitude of genes, sometimes across multiple genetic backgrounds. Classical fungal gene replacement…
View article: The<i>Aspergillus fumigatus</i>farnesyltransferase β-subunit, RamA, mediates growth, virulence, and antifungal susceptibility
The<i>Aspergillus fumigatus</i>farnesyltransferase β-subunit, RamA, mediates growth, virulence, and antifungal susceptibility Open
Post-translational prenylation mechanisms, including farnesylation and geranylgeranylation, mediate both subcellular localization and protein-protein interaction in eukaryotes. The prenyltransferase complex is an αβ heterodimer in which …
View article: A Fungus-Specific Protein Domain Is Essential for RasA-Mediated Morphogenetic Signaling in Aspergillus fumigatus
A Fungus-Specific Protein Domain Is Essential for RasA-Mediated Morphogenetic Signaling in Aspergillus fumigatus Open
Aspergillus fumigatus is an important fungal pathogen against which limited treatments exist. During invasive disease, A. fumigatus hyphae grow in a highly polarized fashion, forming filaments that invade blood vessels and disseminate to d…
View article: The Enzymatic Conversion of Major Algal and Cyanobacterial Carbohydrates to Bioethanol
The Enzymatic Conversion of Major Algal and Cyanobacterial Carbohydrates to Bioethanol Open
The production of fuels from biomass is categorized as first-, second- or third-generation depending upon the source of raw materials, either food crops, lignocellulosic material, or algal biomass, respectively. Thus far, the emphasis has …
View article: The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps
The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps Open
Of the over 250 Aspergillus species, Aspergillus fumigatus accounts for up to 80% of invasive human infections. A. fumigatus produces galactosaminogalactan (GAG), an exopolysaccharide composed of galactose and N-acetyl-galactosamine (GalNA…
View article: Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets
Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets Open
Ras pathway signaling is a critical virulence determinant for pathogenic fungi. Localization of Ras to the plasma membrane (PM) is required for Ras network interactions supporting fungal growth and virulence. For example, loss of Aspergill…