Explanipedia

A Comparative Study of Virucidal and Virustatic Multivalent Entry Inhibitors Open

Tran Thị Thu Hien, Sujeet Pawar, Yong Zhu, Quy K. Ong, Francesco Stellacci · 2025

Viral infections, such as those caused by herpes simplex viruses (HSV) and influenza, continue to pose a significant global health challenge. We have focused on the development of multivalent entry inhibitors (MEIs) that have an irreversib…

Stabilizing effect of amino acids on protein and colloidal dispersions Open

Ting Mao, Xufeng Xu, Pamina M. Winkler, Cécilia Laetitia Carla Siri, Ekaterina Poliukhina , et al. · 2025

Proline stabilizes amphiphilic gold nanoparticles via hydrophobic interactions Open

Ting Mao, Quy K. Ong, Joachim Kohlbrecher, Ekaterina Poliukhina, Paulo Jacob Silva , et al. · 2025

Proline stabilizes gold nanoparticle dispersions. Using gold nanoparticles as a model system, we identify the scale, magnitude, and nature of the screening effect. Screening becomes stronger as the hydrophobic attraction between particles …

Amino Acids Stabilizing Effect on Protein and Colloidal Dispersions Open

Ting Mao, Xufeng Xu, Pamina M. Winkler, Cécilia Siri, Ekaterina Poliukhina , et al. · 2024

Despite being used for decades as stabilizers, amino acids (AAs) remain mysterious components of many medical and biological formulations. Hypotheses on their role vary ranging from hydrotropic to protein-specific effects (stabilization ag…

Versatile Capillary Cells for Handling Concentrated Samples in Analytical Ultracentrifugation Open

Quy K. Ong, Xufeng Xu, Francesco Stellacci · 2024

In concentrated macromolecular dispersions, far-from-ideal intermolecular interactions determine the dispersion behaviors including phase transition, crystallization, and liquid-liquid phase separation. Here, we present a novel versatile c…

Ligand concentration determines antiviral efficacy of silica multivalent nanoparticles Open

Heyun Wang, Xufeng Xu, Rémi La Polla, Paulo Jacob Silva, Quy K. Ong , et al. · 2023

Experimental Method to Distinguish between a Solution and a Suspension Open

Xufeng Xu, Quy K. Ong, Ting Mao, Paulo Jacob Silva, Seishi Shimizu , et al. · 2022

Dispersion of objects in a fluid phase can be classified as solutions (Gibbs free energy of mixing, Δ G mix < 0) or suspensions (Δ G mix > 0) depending on their thermodynamic stability. Small objects tend to form solutions, larger ones sus…

Experimental method to distinguish between a solution and a suspension Open

Xufeng Xu, Quy K. Ong, Ting Mao, Paulo Jacob Silva, Seishi Shimizu , et al. · 2022

Dispersion of objects in a fluid phase can be classified as solutions (Gibbs free energy of mixing, ΔGmix < 0) or suspensions (ΔGmix > 0) depending on their thermodynamic stability. Small objects tend to form solutions, larger ones suspens…

Monovalent ion-mediated charge–charge interactions drive aggregation of surface-functionalized gold nanoparticles Open

Emanuele Petretto, Quy K. Ong, Francesca Olgiati, Ting Mao, Pablo Campomanes , et al. · 2022

Monolayer-protected metal nanoparticles are a powerful tool to investigate the behavior of matter at nanoscales. We found that electrostatic interactions can lead to the formation of metastable NP dimers at moderate ionic strenghts.

Ion-mediated charge-charge interactions drive aggregation of surface-functionalized gold nanoparticles Open

Emanuele Petretto, Quy K. Ong, Francesca Olgiati, Ting Mao, Pablo Campomanes , et al. · 2021

Monolayer-protected metal nanoparticles (NPs) are not only promising materials with a wide range of potential industrial and biological applications, but they are also a powerful tool to investigate the behavior of matter at nanoscopic sca…

In‐situ Investigations on Gold Nanoparticles Stabilization Mechanisms in Biological Environments Containing HSA Open

Neda Iranpour Anaraki, Marianne Liebi, Quy K. Ong, Clément Blanchet, Anjani K. Maurya , et al. · 2021

Nanoparticles (NPs) developments advance innovative biomedical applications. However, complex interactions and the low colloidal stability of NPs in biological media restrict their widespread utilization. The influence of NPs properties on…

Cryogenic electron tomography to determine thermodynamic quantities for nanoparticle dispersions Open

Quy K. Ong, Ting Mao, Neda Iranpour Anaraki, Łukasz Richter, Carla Malinverni , et al. · 2021

Nanoparticle dispersions were studied by cryogenic electron tomography, which was found to allow extraction of key thermodynamic quantities.

Chemical sensing with Au and Ag nanoparticles Open

Verónica Montes‐García, Marco Squillaci, Marta Diez‐Castellnou, Quy K. Ong, Francesco Stellacci , et al. · 2020

Noble metal nanoparticles (NPs) are ideal scaffolds for the fabrication of chemical sensing devices with either optical or electrical readout combining high sensitivity and selectivity, along with fast response and full reversibility.

Multi-sulfonated ligands on gold nanoparticles as virucidal antiviral for Dengue virus Open

Antonella Zacheo, Jan Hodek, Dariusz Witt, Giuseppe Felice Mangiatordi, Quy K. Ong , et al. · 2020

Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture Open

Simona Serratì, Chiara Martinelli, Antonio J. Palazzo, Rosa Maria Iacobazzi, Mara Perrone , et al. · 2020

Reproducibility of results is essential for a well-designed and conducted experiment. Several reasons may originate failure in reproducing data, such as selective reporting, low statistical power, or poor analysis. In this study, we used P…

Determination and evaluation of the nonadditivity in wetting of molecularly heterogeneous surfaces Open

Zhi Luo, Anna Murello, David M. Wilkins, Filip Kovacik, Joachim Kohlbrecher , et al. · 2019

The interface between water and folded proteins is very complex. Proteins have “patchy” solvent-accessible areas composed of domains of varying hydrophobicity. The textbook understanding is that these domains contribute additively to inter…

Stable Ultraconcentrated and Ultradilute Colloids of CsPbX3 (X = Cl, Br) Nanocrystals Using Natural Lecithin as a Capping Ligand Open

Franziska Krieg, Quy K. Ong, Max Burian, Gabriele Rainò, Denys Naumenko , et al. · 2019

Attaining thermodynamic stability of colloids in a broad range of concentrations has long been a major thrust in the field of colloidal ligand-capped semiconductor nanocrystals (NCs). This challenge is particularly pressing for the novel N…

Determination and Evaluation of the Non-Additivity in Wetting of Molecularly Heterogeneous Surfaces Open

Zhi Luo, Anna Murello, David M. Wilkins, Filip Kovacik, Joachim Kohlbrecher , et al. · 2019

All the data relevant to the paper "Determination and Evaluation of the Non-Additivity in Wetting of Molecularly Heterogeneous Surfaces" (PNAS, 2019) are available here. The details about the data collection and analysis are available in t…

Determination and Evaluation of the Non-Additivity in Wetting of Molecularly Heterogeneous Surfaces Open

Zhi Luo, Anna Murello, David M. Wilkins, Filip Kovacik, Joachim Kohlbrecher , et al. · 2019

All the data relevant to the paper "Determination and Evaluation of the Non-Additivity in Wetting of Molecularly Heterogeneous Surfaces" (PNAS, 2019) are available here. The details about the data collection and analysis are available in t…

Reproducibility warning: The curious case of Polyethylene glycol 6000 and spheroid cell culture Open

Simona Serratì, Chiara Martinelli, Antonio J. Palazzo, Rosa Maria Iacobazzi, Mara Perrone , et al. · 2019

In this study we report about the reproducibility of three-dimensional cell culture of floating cell spheroids on PEG6000 treated cell culture dishes. Three-dimensional tumour spheroids or organoids present an interesting test platform for…

Multidimensional Characterization of Mixed Ligand Nanoparticles Using Small Angle Neutron Scattering Open

Zhi Luo, Ye Yang, Aurel Rădulescu, Joachim Kohlbrecher, Tamim A. Darwish , et al. · 2019

The properties of ligand protected gold nanoparticles are determined by the synergistic interplay of their structural components, including the metal core, the ligand shell, and the solvation layer. However, the simultaneous characterizati…

Thioether‐Functionalized Quinone‐Based Resorcin[4]arene Cavitands: Electroswitchable Molecular Actuators Open

Jovana V. Milić, Thomas Schneeberger, Michal Zalibera, Karolina Z. Milowska, Quy K. Ong , et al. · 2019

The utility of molecular actuators in nanoelectronics requires activation of mechanical motion by electric charge at the interface with conductive surfaces. We functionalized redox‐active resorcin[4]arene‐quinone cavitands with thioethers …

CCDC 1535924: Experimental Crystal Structure Determination Open

Jovana V. Milić, Thomas Schneeberger, Michal Zalibera, Karolina Z. Milowska, Quy K. Ong , et al. · 2019

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Quantitative 3D determination of self-assembled structures on nanoparticles using small angle neutron scattering Open

Zhi Luo, Domenico Marson, Quy K. Ong, Anna Loiudice, Joachim Kohlbrecher , et al. · 2018

Bimodal atomic force microscopy for the characterization of thiolated self-assembled monolayers Open

Evangelia‐Nefeli Athanasopoulou, Nikolaos Nianias, Quy K. Ong, Francesco Stellacci · 2018

In-depth analysis of self-assembled monolayers by bimodal atomic force microscopy.

Novel Sensing Strategies Based on Monolayer Protected Gold Nanoparticles for the Detection of Metal Ions and Small Molecules Open

Elif Ertem, Marta Diez‐Castellnou, Quy K. Ong, Francesco Stellacci · 2017

Monolayer protected gold nanoparticles (AuNPs) have a huge potential for the development of innovative sensing systems for the detection of metal ions and small molecules. The organic ligand shell, primarily utilized to stabilize the gold …

The van der Waals Interactions of n‐Alkanethiol‐Covered Surfaces: From Planar to Curved Surfaces Open

Fernando P. Cometto, Zhi Luo, Shun Zhao, Jimena A. Olmos‐Asar, Marcelo M. Mariscal , et al. · 2017

The van der Waals (vdW) interactions of n ‐alkanethiols (ATs) adsorbed on planar Au(111) and Au(100) surfaces and curved Au nanoparticles of different diameters are reported. By means of electrochemical measurements and molecular dynamic c…

The van der Waals Interactions of n‐Alkanethiol‐Covered Surfaces: From Planar to Curved Surfaces Open

Fernando P. Cometto, Zhi Luo, Shun Zhao, Jimena A. Olmos‐Asar, Marcelo M. Mariscal , et al. · 2017

The van der Waals (vdW) interactions of n ‐alkanethiols (ATs) adsorbed on planar Au(111) and Au(100) surfaces and curved Au nanoparticles of different diameters are reported. By means of electrochemical measurements and molecular dynamic c…

Evolution of the Ligand Shell Morphology during Ligand Exchange Reactions on Gold Nanoparticles Open

Zhi Luo, Jing Hou, Laure Menin, Quy K. Ong, Francesco Stellacci · 2017

Ligand exchange reactions are used to achieve nanoparticles coated with a mixture of ligand molecules. Currently, nothing is known on the evolution of the morphology of the ligand shell during the reaction. Here, we use a recently develope…

Characterization of Ligand Shell for Mixed-Ligand Coated Gold Nanoparticles Open

Quy K. Ong, Zhi Luo, Francesco Stellacci · 2017

Gold nanoparticles owe a large number of their properties to their ligand shell. Indeed, many researchers routinely use mixtures of ligand molecules for their nanoparticles to impart complex property sets. It has been shown that the morpho…

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