Rachael A Evans
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View article: Corrigendum to: Chronic breathlessness is associated with much longer lengths of hospital stay
Corrigendum to: Chronic breathlessness is associated with much longer lengths of hospital stay Open
View article: Effect of 8-Week Exercise-Based Rehabilitation on Immune Cell Counts in Post-COVID Syndrome Following Hospitalisation: An RCT
Effect of 8-Week Exercise-Based Rehabilitation on Immune Cell Counts in Post-COVID Syndrome Following Hospitalisation: An RCT Open
View article: Morphine for chronic breathlessness (MABEL) in the UK: a health economic evaluation of a multisite, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial
Morphine for chronic breathlessness (MABEL) in the UK: a health economic evaluation of a multisite, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial Open
Objectives To compare costs and health consequences and to assess the cost-effectiveness of using low-dose oral long-acting morphine in people with chronic breathlessness. Design Within-trial planned cost-consequences and cost-effectivenes…
View article: Immunological associations in post-infective fatigue syndromes including Long COVID—a systematic review and meta-analysis
Immunological associations in post-infective fatigue syndromes including Long COVID—a systematic review and meta-analysis Open
ARL is supported by a National Health and Medical Research Council Practitioner Fellowship (Grant 1041897). CXS is supported by a Cancer Institute New South Wales Early Career Fellowship (2021/ECF1310). BZK is supported by the National Ins…
View article: Long-Term Efficacy and Safety of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disorder From the SAkuraMoon Open-Label Extension Study
Long-Term Efficacy and Safety of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disorder From the SAkuraMoon Open-Label Extension Study Open
View article: Clinical and cost-effectiveness of diverse posthospitalisation pathways for COVID-19: a UK evaluation using the PHOSP-COVID cohort
Clinical and cost-effectiveness of diverse posthospitalisation pathways for COVID-19: a UK evaluation using the PHOSP-COVID cohort Open
Background Long covid has emerged as a complex health condition for millions of people worldwide following the COVID-19 pandemic. Previously, we have categorised healthcare pathways for patients after discharge from hospital with COVID-19 …
View article: Morphine for chronic breathlessness (MABEL) in the UK: a multi-site, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial
Morphine for chronic breathlessness (MABEL) in the UK: a multi-site, parallel-group, dose titration, double-blind, randomised, placebo-controlled trial Open
NIHR Health Technology Assessment programme (HTA Project 17/34/01).
View article: Personalised exercise-rehabilitation for people with multiple long-term conditions (PERFORM): a randomised feasibility study
Personalised exercise-rehabilitation for people with multiple long-term conditions (PERFORM): a randomised feasibility study Open
Objective Existing exercise-based rehabilitation services, such as cardiac and pulmonary rehabilitation, are traditionally commissioned around single long-term conditions (LTCs) and therefore may not meet the complex needs of adults with m…
View article: Personalised Exercise Rehabilitation FOR people with Multiple long-term conditions (PERFORM): findings from a process evaluation of a randomised feasibility study
Personalised Exercise Rehabilitation FOR people with Multiple long-term conditions (PERFORM): findings from a process evaluation of a randomised feasibility study Open
Objective The number of people living with multiple long-term conditions (MLTCs or ‘multimorbidity’) is growing. Evidence indicates that exercise-based rehabilitation can improve health-related quality of life and reduce hospital admission…
View article: Impact of pulmonary rehabilitation programme design on effectiveness in COPD: a systematic review and component network meta-analysis
Impact of pulmonary rehabilitation programme design on effectiveness in COPD: a systematic review and component network meta-analysis Open
This research was funded through a National Institute for Health and Care Research (NIHR) Applied Research Collaboration East Midlands grant (2.12) and carried out at the NIHR Leicester Biomedical Research Centre (BRC).
View article: Co-design and development of a Personalised Exercise-based Rehabilitation and self-management programme FOR people with Multiple long-term conditions: The PERFORM intervention
Co-design and development of a Personalised Exercise-based Rehabilitation and self-management programme FOR people with Multiple long-term conditions: The PERFORM intervention Open
Background Exercise and self-management support may be clinically effective and cost-effective treatments for a range of individual long-term conditions (LTCs), as they activate multiple beneficial physiological and psychological mechanism…
View article: Long-Term Efficacy and Safety of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disorder From the SAkuraMoon Open-Label Extension Study
Long-Term Efficacy and Safety of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disorder From the SAkuraMoon Open-Label Extension Study Open
This study provides Class IV evidence that SAT is safe and effective in patients with NMOSD.
View article: Breathlessness intensity recorded in general practice is associated with shorter times to unplanned hospital admissions and longer lengths of stay: a UK cohort study
Breathlessness intensity recorded in general practice is associated with shorter times to unplanned hospital admissions and longer lengths of stay: a UK cohort study Open
Background and objective Breathlessness is associated with higher rates of unplanned health service utilisation. We aimed to evaluate any associations between the severity of breathlessness limiting exertion (hereafter breathlessness ), ti…
View article: Large-scale psychometric assessment and validation of the Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) patient-reported outcome measure for Long COVID or Post-COVID syndrome
Large-scale psychometric assessment and validation of the Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) patient-reported outcome measure for Long COVID or Post-COVID syndrome Open
Background The C19-YRS was the first condition-specific scale for Long COVID/Post-COVID syndrome. Although the original C19-YRS evolved to the modified version (C19-YRSm) based on psychometric evidence, clinical content relevance and feedb…
View article: The safety, physiological response, and repeatability of the incremental shuttle walk test in survivors of COVID-19
The safety, physiological response, and repeatability of the incremental shuttle walk test in survivors of COVID-19 Open
Introduction The incremental shuttle walk test (ISWT) may be a valuable tool for measuring exercise tolerance in patients after a hospital admission with COVID-19. However, the safety, physiological response, and repeatability of the ISWT …
View article: eLife Assessment: A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning
eLife Assessment: A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning Open
View article: Health Economic Evaluation of a Double-Blind, Randomised, Placebo-Controlled Trial of Low-Dose Oral Morphine (MABEL)
Health Economic Evaluation of a Double-Blind, Randomised, Placebo-Controlled Trial of Low-Dose Oral Morphine (MABEL) Open
Objectives To compare costs and health consequences and to assess the cost-effectiveness of using low-dose oral long-acting morphine in people with chronic breathlessness. Design Within-trial planned cost-consequences and cost-effectivenes…
View article: The risk of Long Covid symptoms: a systematic review and meta-analysis of controlled studies
The risk of Long Covid symptoms: a systematic review and meta-analysis of controlled studies Open
View article: Validation of artificial intelligence spirometry diagnostic support software in primary care: a blinded diagnostic accuracy study
Validation of artificial intelligence spirometry diagnostic support software in primary care: a blinded diagnostic accuracy study Open
Objective and design The objective of the present study was to assess the discriminative accuracy of artificial intelligence (AI) software to identify COPD and other chronic respiratory diseases from primary care spirometry. This was a dia…
View article: Determining the minimum important differences for field walking tests in adults with long–term conditions: a systematic review and meta-analysis
Determining the minimum important differences for field walking tests in adults with long–term conditions: a systematic review and meta-analysis Open
Importance The minimum important difference (MID) for field walking tests aims to improve interpretation of outcomes, but the volume and heterogeneity of MIDs for these tests is challenging. We aimed to determine the MID for the 6-min walk…
View article: Readability and complexity of written information presented to hospitalised patients for trial consent during the COVID-19 pandemic in the UK: a retrospective document analysis
Readability and complexity of written information presented to hospitalised patients for trial consent during the COVID-19 pandemic in the UK: a retrospective document analysis Open
Objectives Patient information sheets (PISs) and informed consent forms (ICFs) are essential tools to communicate and document informed consent for clinical trial participation. These documents need to be easily understandable, especially …
View article: Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation
Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation Open
Objective Post-COVID syndrome involves prolonged symptoms with multisystem and functional impairment lasting ≥12 weeks after acute coronavirus disease 2019 (COVID-19). We aimed to determine the efficacy of exercise-based rehabilitation int…
View article: Investigating a structured diagnostic approach for chronic breathlessness in primary care: a mixed-methods feasibility cluster randomised controlled trial
Investigating a structured diagnostic approach for chronic breathlessness in primary care: a mixed-methods feasibility cluster randomised controlled trial Open
Background There is a need to reduce delays to diagnosis for chronic breathlessness to improve patient outcomes. Objective To conduct a mixed-methods feasibility study of a larger cluster randomised controlled trial (cRCT) investigating a …
View article: Immunocompromised individuals remain at risk of COVID-19: 2023 results from the observational INFORM study
Immunocompromised individuals remain at risk of COVID-19: 2023 results from the observational INFORM study Open
Beyond three years since the start of the COVID-19 pandemic, immunocompromised individuals remain disproportionately impacted from COVID-19 despite increased vaccination. These findings highlight a persistent need for additional COVID-19 i…
View article: P-2006. Individuals on Immunosuppressive or Immunomodulatory Therapies Remain at Increased Risk of COVID-19 Hospitalization, Despite Vaccination: Findings from INFORM, a Retrospective Health Database Study in England
P-2006. Individuals on Immunosuppressive or Immunomodulatory Therapies Remain at Increased Risk of COVID-19 Hospitalization, Despite Vaccination: Findings from INFORM, a Retrospective Health Database Study in England Open
Background Use of immunosuppressive or immunomodulatory therapies (IITs) may be a risk factor for severe COVID-19 outcomes. The INFORM (INvestigation oF cOvid-19 Risk among iMmunocompromised populations) study (ISRCTN53375662) uses routine…
View article: P-1989. COVID-19 Mortality Among Immunocompromised Individuals is Consistently High Compared with Non-Immunocompromised Individuals: Results of the INFORM Study 2022, England
P-1989. COVID-19 Mortality Among Immunocompromised Individuals is Consistently High Compared with Non-Immunocompromised Individuals: Results of the INFORM Study 2022, England Open
Background The INFORM study showed the disproportionate risk of COVID-19 hospitalization and mortality among immunocompromised (IC) versus non-immunocompromised (non-IC) individuals. This analysis aimed to describe the relationship between…
View article: Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts
Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts Open
Background Identifying clusters of multiple long-term conditions (MLTCs), also known as multimorbidity, and their associated burden may facilitate the development of effective and cost-effective targeted healthcare strategies. This study a…
View article: An immunomodulatory encapsulation system to deliver human iPSC-derived dopaminergic neuron progenitors for Parkinson's disease treatment
An immunomodulatory encapsulation system to deliver human iPSC-derived dopaminergic neuron progenitors for Parkinson's disease treatment Open
A multi-component immunomodulatory encapsulation system has potential to improve the survival of therapeutic hiPSC-derived dopaminergic neuron progenitors, for the treatment of Parkinson’s disease.
View article: Lower Airway and Oral Microbiome Dysbiosis in Patients with Long COVID Post-Hospitalisation: A UK Multicentre, Prospective Cohort Study
Lower Airway and Oral Microbiome Dysbiosis in Patients with Long COVID Post-Hospitalisation: A UK Multicentre, Prospective Cohort Study Open
View article: Physical activity guidelines for adults with type 2 Diabetes: Systematic review
Physical activity guidelines for adults with type 2 Diabetes: Systematic review Open
While guidelines consistently recommended aerobic exercise, there was limited emphasis on strength and flexibility exercises. Significant limitations in methodological and reporting quality were noted, especially in stakeholder involvement…