Abigail Ortiz
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View article: Feasibility, efficacy, and perceptions of an online writing intervention in patients with depressive disorders: A randomized, multi-methods pilot study
Feasibility, efficacy, and perceptions of an online writing intervention in patients with depressive disorders: A randomized, multi-methods pilot study Open
Barriers to accessing treatment for Depressive Disorders highlight a need for scalable interventions. Expressive writing (EW), which involves daily writing about a personal issue, has been shown to alleviate depressive symptoms in various …
View article: Day-to-day variability in activity levels detects transitions to depressive symptoms in bipolar disorder earlier than changes in sleep and mood
Day-to-day variability in activity levels detects transitions to depressive symptoms in bipolar disorder earlier than changes in sleep and mood Open
Anticipating clinical transitions in bipolar disorder (BD) is essential for the development of clinically actionable predictions. Our aim was to determine what is the earliest indicator of the onset of depressive symptoms in BD. We hypothe…
View article: Descriptive analysis of the Application of Electroconvulsive Therapy in patients with acute psychiatric pathology admitted to a Psychiatric Hospitalization Unit
Descriptive analysis of the Application of Electroconvulsive Therapy in patients with acute psychiatric pathology admitted to a Psychiatric Hospitalization Unit Open
Introduction Electroconvulsive therapy (ECT) is a recognized treatment for various psychiatric conditions (Bernardo et al., 2018). However, there is a lack of recent studies describing the clinical characteristics of patients undergoing EC…
View article: Narrative enhancement and cognitive therapy for self-stigma among youth with bipolar disorder or multiple mental health conditions: protocol for a pilot randomised basket trial
Narrative enhancement and cognitive therapy for self-stigma among youth with bipolar disorder or multiple mental health conditions: protocol for a pilot randomised basket trial Open
Introduction Self-stigma occurs when individuals internalise negative stereotypes about their mental health conditions. Self-stigma is common among those with serious mental illnesses, including youth, and is considered a major barrier to …
View article: Referee report. For: Forecasting the course of bipolar disorder using rest-activity rhythms: Protocol for a multi-study modelling project [version 1; peer review: 1 approved with reservations]
Referee report. For: Forecasting the course of bipolar disorder using rest-activity rhythms: Protocol for a multi-study modelling project [version 1; peer review: 1 approved with reservations] Open
View article: Mood regulation in euthymic patients with a history of antidepressant‐induced mania
Mood regulation in euthymic patients with a history of antidepressant‐induced mania Open
Introduction The use of antidepressants in bipolar disorder (BD) remains contentious, in part due to the risk of antidepressant‐induced mania (AIM). However, there is no information on the architecture of mood regulation in patients who ha…
View article: Multidimensional analysis of heart rate variability and burden of illness in bipolar disorder
Multidimensional analysis of heart rate variability and burden of illness in bipolar disorder Open
Introduction: Patients with bipolar disorder (BD) face disproportionate rates of cardiovascular disease. While several mechanisms have been proposed for this association, both are multifactorial and heterogeneous illnesses, and it is unlik…
View article: Beyond Step Count: Are We Ready to Use Digital Phenotyping to Make Actionable Individual Predictions in Psychiatry?
Beyond Step Count: Are We Ready to Use Digital Phenotyping to Make Actionable Individual Predictions in Psychiatry? Open
Some models for mental disorders or behaviors (eg, suicide) have been successfully developed, allowing predictions at the population level. However, current demographic and clinical variables are neither sensitive nor specific enough for m…
View article: The Use of Text Messaging as an Adjunct to Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder in Youth: Secondary Analysis
The Use of Text Messaging as an Adjunct to Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder in Youth: Secondary Analysis Open
Background As an established treatment for major depressive disorder (MDD), cognitive behavioral therapy (CBT) is now implemented and assessed in internet-based formats that, when combined with smartphone apps, enable secure text messaging…
View article: A Novel Unsupervised Machine Learning Approach to Assess Postural Dynamics in Euthymic Bipolar Disorder
A Novel Unsupervised Machine Learning Approach to Assess Postural Dynamics in Euthymic Bipolar Disorder Open
Bipolar disorder (BD) is a mood disorder with different phases alternating between euthymia, manic or hypomanic episodes, and depressive episodes. While motor abnormalities are commonly seen during depressive or manic episodes, not much at…
View article: Prescribed psychostimulants and other pro‐cognitive medications in bipolar disorder: A systematic review and meta‐analysis of recurrence of manic symptoms
Prescribed psychostimulants and other pro‐cognitive medications in bipolar disorder: A systematic review and meta‐analysis of recurrence of manic symptoms Open
Objectives Clinicians are often hesitant to prescribe psychostimulants in bipolar disorder (BD) due to concerns of inducing (hypo)mania, despite limited published evidence on associations between prescribed psychostimulant use and recurren…
View article: Not missing at random: Missing data are associated with clinical status and trajectories in an electronic monitoring longitudinal study of bipolar disorder
Not missing at random: Missing data are associated with clinical status and trajectories in an electronic monitoring longitudinal study of bipolar disorder Open
View article: Examining the feasibility, efficacy, and perceptions of an online writing intervention in patients with Major Depressive Disorder: A multi-methods study (Preprint)
Examining the feasibility, efficacy, and perceptions of an online writing intervention in patients with Major Depressive Disorder: A multi-methods study (Preprint) Open
BACKGROUND Barriers to accessing treatment for Major Depressive Disorder (MDD) highlight a need for scalable interventions that can be administered online. One such intervention is expressive writing (EW), which typically involves daily s…
View article: Challenges in defining treatment‐resistant mania in adults: A systematic review
Challenges in defining treatment‐resistant mania in adults: A systematic review Open
Objectives To review the definitions of treatment‐resistant mania (TRM) in the literature and propose criteria for an operationalized definition. Methods A systematic search of five databases (MEDLINE, EMBASE, PsychInfo, Cochrane Central, …
View article: Protocol for a systematic review and meta-analysis of coordinate-based network mapping of brain structure in bipolar disorder across the lifespan
Protocol for a systematic review and meta-analysis of coordinate-based network mapping of brain structure in bipolar disorder across the lifespan Open
Background Studies about brain structure in bipolar disorder have reported conflicting findings. These findings may be explained by the high degree of heterogeneity within bipolar disorder, especially if structural differences are mapped t…
View article: The Role of Daily Steps in the Treatment of Major Depressive Disorder: Secondary Analysis of a Randomized Controlled Trial of a 6-Month Internet-Based, Mindfulness-Based Cognitive Behavioral Therapy Intervention for Youth
The Role of Daily Steps in the Treatment of Major Depressive Disorder: Secondary Analysis of a Randomized Controlled Trial of a 6-Month Internet-Based, Mindfulness-Based Cognitive Behavioral Therapy Intervention for Youth Open
Background Current evidence supports physical activity (PA) as an adjunctive treatment for major depressive disorder (MDD). Few studies, however, have examined the relationship between objectively measured PA and MDD treatment outcomes usi…
View article: A History of Suicide Attempt Is Associated with Increased Sympathetic Activation in Bipolar Disorder: Des antécédents de tentatives de suicide dans le trouble bipolaire sont associés à une activation sympathique accrue dans le trouble bipolaire
A History of Suicide Attempt Is Associated with Increased Sympathetic Activation in Bipolar Disorder: Des antécédents de tentatives de suicide dans le trouble bipolaire sont associés à une activation sympathique accrue dans le trouble bipolaire Open
Objective Suicide risk in bipolar disorder (BD) is estimated to be up to 20 times higher than in the general population. While there is a large body of evidence suggesting that increased sympathetic activation is associated with disease an…
View article: Multi-resolution Time-frequency Spectral Derivative Spike Detection for Episode Onset Detection using Passively Collected Sensor Data
Multi-resolution Time-frequency Spectral Derivative Spike Detection for Episode Onset Detection using Passively Collected Sensor Data Open
We analyzed data from 145 participants, the majority of which were diagnosed with BD I (92 (63.4%) and 53 (36.6%) with BD II. The participants have been enrolled in the study for a duration of 449±224 days until June 23, 2023. Participants…
View article: Multi-resolution Time-frequency Spectral Derivative Spike Detection for Episode Onset Detection using Passively Collected Sensor Data
Multi-resolution Time-frequency Spectral Derivative Spike Detection for Episode Onset Detection using Passively Collected Sensor Data Open
We analyzed data from 145 participants, the majority of which were diagnosed with BD I (92 (63.4%) and 53 (36.6%) with BD II. The participants have been enrolled in the study for a duration of 449±224 days until June 23, 2023. Participants…
View article: Psilocybin for treatment-resistant depression without psychedelic effects: study protocol for a 4-week, double-blind, proof-of-concept randomised controlled trial
Psilocybin for treatment-resistant depression without psychedelic effects: study protocol for a 4-week, double-blind, proof-of-concept randomised controlled trial Open
Background Randomised controlled trials (RCTs) of psilocybin have reported large antidepressant effects in adults with major depressive disorder and treatment-resistant depression (TRD). Given psilocybin's psychedelic effects, all publishe…
View article: A new approach to assess postural dynamics and its association with higher illness burden in bipolar disorder
A new approach to assess postural dynamics and its association with higher illness burden in bipolar disorder Open
We recruited 53 BD participants at two Canadian academic psychiatric hospitals (the Centre for Addiction and Mental Health, Toronto; the Royal Ottawa Hospital, Ottawa) between April 2016 and December 2019. Participants were provided with a…
View article: A new approach to assess postural dynamics and its association with higher illness burden in bipolar disorder
A new approach to assess postural dynamics and its association with higher illness burden in bipolar disorder Open
We recruited 53 BD participants at two Canadian academic psychiatric hospitals (the Centre for Addiction and Mental Health, Toronto; the Royal Ottawa Hospital, Ottawa) between April 2016 and December 2019. Participants were provided with a…
View article: Predictors of adherence to electronic self-monitoring in patients with bipolar disorder: a contactless study using Growth Mixture Models
Predictors of adherence to electronic self-monitoring in patients with bipolar disorder: a contactless study using Growth Mixture Models Open
View article: Associations between peripheral inflammation and clinical phenotypes of bipolar depression in a lower-middle income country
Associations between peripheral inflammation and clinical phenotypes of bipolar depression in a lower-middle income country Open
Objective There has been increased interest in repurposing anti-inflammatories for the treatment of bipolar depression. Evidence from high-income countries suggests that these agents may work best for specific depressive symptoms in a subs…
View article: A systematic review on the effectiveness of dialectical behavior therapy for improving mood symptoms in bipolar disorders
A systematic review on the effectiveness of dialectical behavior therapy for improving mood symptoms in bipolar disorders Open
View article: A cross-sectional study of cognitive performance in bipolar disorder across the lifespan: the cog-BD project
A cross-sectional study of cognitive performance in bipolar disorder across the lifespan: the cog-BD project Open
Background Neuroprogressive models of the trajectory of cognitive dysfunction in patients with bipolar disorder (BD) have been proposed. However, few studies have explored the relationships among clinical characteristics of BD, cognitive d…
View article: A critical evaluation of dynamical systems models of bipolar disorder
A critical evaluation of dynamical systems models of bipolar disorder Open
Bipolar disorder (BD) is a mood disorder involving recurring (hypo)manic and depressive episodes. The inherently temporal nature of BD has inspired its conceptualization using dynamical systems theory, which is a mathematical framework for…
View article: Assessment of Objective and Subjective Cognitive Function in Patients With Treatment-Resistant Depression Undergoing Repeated Ketamine Infusions
Assessment of Objective and Subjective Cognitive Function in Patients With Treatment-Resistant Depression Undergoing Repeated Ketamine Infusions Open
Background Subanesthetic ketamine infusions can elicit rapid and sustained antidepressant effects, yet the potential cognitive impact of ketamine has not been thoroughly examined. This study measured changes in objective and subjective cog…
View article: The Use of Text Messaging as an Adjunct to Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder in Youth: Secondary Analysis (Preprint)
The Use of Text Messaging as an Adjunct to Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder in Youth: Secondary Analysis (Preprint) Open
BACKGROUND As an established treatment for major depressive disorder (MDD), cognitive behavioral therapy (CBT) is now implemented and assessed in internet-based formats that, when combined with smartphone apps, enable secure text messagin…
View article: Identifying patient-specific behaviors to understand illness trajectories and predict relapses in bipolar disorder using passive sensing and deep anomaly detection: protocol for a contactless cohort study
Identifying patient-specific behaviors to understand illness trajectories and predict relapses in bipolar disorder using passive sensing and deep anomaly detection: protocol for a contactless cohort study Open