Akhilraj Pillai
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View article: Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands
Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands Open
Mutations in the PKD2 gene, which encodes the polycystin-2 (PC2, also called TRPP2) protein, lead to autosomal dominant polycystic kidney disease (ADPKD). As a member of the transient receptor potential (TRP) channel superfamily, PC2 funct…