Ahmad Reza Dehpour
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View article: Investigating the Analgesic Effect of Sublingual Glycerol Trinitrate (GTN) Spray as an Alternative Treatment in Renal Colic Pain: A Triple-Blinded Randomized Controlled Trial
Investigating the Analgesic Effect of Sublingual Glycerol Trinitrate (GTN) Spray as an Alternative Treatment in Renal Colic Pain: A Triple-Blinded Randomized Controlled Trial Open
Renal colic, a severe pain caused by renal and urethral calculi, causes millions of patients to visit the emergency department (ED) worldwide each year. Based on international guidelines, NSAIDs are the first-line analgesics of choice for …
View article: From Anthelmintic to Neurotherapeutic: Exploring the Regenerative Potential of Niclosamide in Sciatic Nerve Injury
From Anthelmintic to Neurotherapeutic: Exploring the Regenerative Potential of Niclosamide in Sciatic Nerve Injury Open
Peripheral nerve injury (PNI) remains a major clinical challenge, often leading to chronic neuropathic pain and persistent motor and sensory dysfunction. Despite advances in microsurgical repair, effective pharmacological strategies to att…
View article: Exogenous phosphatidylserine protects against mesenteric ischemia-reperfusion with associated Akt/mTOR pathway upregulation
Exogenous phosphatidylserine protects against mesenteric ischemia-reperfusion with associated Akt/mTOR pathway upregulation Open
View article: Niclosamide as a Neuroprotective and Anti-Inflammatory Agent: A Potential Therapeutic Approach for Spinal Cord Injury
Niclosamide as a Neuroprotective and Anti-Inflammatory Agent: A Potential Therapeutic Approach for Spinal Cord Injury Open
Spinal cord injury (SCI) is a life-altering condition of the central nervous system resulting in permanent motor, sensory, and functional deficits. The pathophysiology involved includes: primary neuronal necrosis, secondary inflammation, o…
View article: IDO Inhibition by 1-Methyltryptophan: Unlocking New Paths to Treat Ovarian Dysfunction and Hormonal Imbalance in PCOS
IDO Inhibition by 1-Methyltryptophan: Unlocking New Paths to Treat Ovarian Dysfunction and Hormonal Imbalance in PCOS Open
Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic inflammation, as well as metabolic and reproductive dysfunction. While insulin resistance affects many tissues, ovarian tissue exhibits in…
View article: Linezolid mitigates tissue injury in experimental model of pediatric testicular torsion: TLR-4/MAPK/NF-κB involvement
Linezolid mitigates tissue injury in experimental model of pediatric testicular torsion: TLR-4/MAPK/NF-κB involvement Open
Background: Testicular torsion is a urological emergency that requires prompt surgery to prevent orchiectomy. Pharmacological interventions may slow the progression of damage and reduce reperfusion injury after surgical correction.Purpose:…
View article: Effects of Gap 26, a Connexin 43 Inhibitor, on Cirrhotic Cardiomyopathy in Rats
Effects of Gap 26, a Connexin 43 Inhibitor, on Cirrhotic Cardiomyopathy in Rats Open
[This corrects the article DOI: 10.7759/cureus.59053.].
View article: Ferroptosis as a therapeutic target in glioblastoma: Mechanisms and emerging strategies
Ferroptosis as a therapeutic target in glioblastoma: Mechanisms and emerging strategies Open
View article: Combined Forces Against Bacteria: Phages and Antibiotics
Combined Forces Against Bacteria: Phages and Antibiotics Open
Background and Aim It is now known that bacteria are highly interactive and exhibit a range of complex cooperative behaviors, including conjugal plasmid transfer, toxins, swarming, drug resistance, toxin production, biofilm development, an…
View article: Scientists Collaboration for Science Development and Peace: USERN View
Scientists Collaboration for Science Development and Peace: USERN View Open
The Article Abstract is not available.
View article: Biocompatibility and photoinactivation evaluation of zinc hydroxide chloride nanosheets against Streptococcus mutans
Biocompatibility and photoinactivation evaluation of zinc hydroxide chloride nanosheets against Streptococcus mutans Open
View article: Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ‐ and MES‐Induced Seizures in Mice via 5‐HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways
Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ‐ and MES‐Induced Seizures in Mice via 5‐HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways Open
Epilepsy, a chronic neurological disorder affecting around 65 million people globally, is characterized by recurrent, unprovoked epileptic seizures. Psilocin, the active metabolite of psilocybin, a well‐known psychedelic compound, has rece…
View article: The Effect of Heparin on Bone Metabolism and Orthodontic Tooth Movement in Rats
The Effect of Heparin on Bone Metabolism and Orthodontic Tooth Movement in Rats Open
Objectives Various attempts have been made to increase the rate of orthodontic tooth movement (OTM). The aim of this study was to determine the effect of different doses of heparin on OTM and paraclinical factors related to bone metabolism…
View article: Intra‐ and Postoperative Botulinum Toxin Injection in Postsurgical Pain Management: A Literature Review
Intra‐ and Postoperative Botulinum Toxin Injection in Postsurgical Pain Management: A Literature Review Open
Postoperative pain remains a significant challenge in surgical services, which necessitates improving analgesic strategies to enhance patient outcomes. Botulinum neurotoxin (BoNT), which was primarily approved for the treatment of strabism…
View article: Anticonvulsant effects of pentoxifylline on seizures induced by pentylenetetrazole and maximal electroshock in male mice: The role of the nitrergic pathway
Anticonvulsant effects of pentoxifylline on seizures induced by pentylenetetrazole and maximal electroshock in male mice: The role of the nitrergic pathway Open
View article: Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy
Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy Open
Onchocerciasis, commonly known as river blindness, is a neglected tropical disease caused by the parasite Onchocerca volvulus . It can lead to blindness and visual impairment. Studies have also demonstrated a link between onchocerciasis an…
View article: <b>Metoprolol Metabolites’ Ratios and/or Enantiomeric Profiles: A Simple and Low-cost Tool for Personalized Medicine through CYP2D6 Phenotyping</b>
<b>Metoprolol Metabolites’ Ratios and/or Enantiomeric Profiles: A Simple and Low-cost Tool for Personalized Medicine through CYP2D6 Phenotyping</b> Open
View article: Densitometric Evaluation Jaws and Skulls of Ovariectomized Rats Following Atorvastatin Administration: The Role of Nitric Oxide
Densitometric Evaluation Jaws and Skulls of Ovariectomized Rats Following Atorvastatin Administration: The Role of Nitric Oxide Open
Statins affect the bone metabolism. Considering the role of nitric oxide (NO) in many physiological processes, this study assessed the effects of atorvastatin (ATOR) and NO on the mandible and skull bone density (BD) in ovariectomized rats…
View article: Protective effects of sumatriptan against optic nerve injury in rats via modulation of kynurenine pathway, oxidative stress and apoptosis
Protective effects of sumatriptan against optic nerve injury in rats via modulation of kynurenine pathway, oxidative stress and apoptosis Open
Introduction: Traumatic optic neuropathy (TON) is an acute visual dysfunction subsequent to head and neck trauma. Despite immense efforts, there is no effective treatment to minimize the damage caused by TON. Due to its anti-inflammatory a…
View article: Erythrocyte Antioxidants and Hexokinase Activity Alterations in CCl4-Induced Cirrhotic Rats Through Naltrexone Treatment
Erythrocyte Antioxidants and Hexokinase Activity Alterations in CCl4-Induced Cirrhotic Rats Through Naltrexone Treatment Open
Cirrhosis is the consequence of chronic liver injury Considering the crucial role of oxidative stress in the progression of liver cirrhosis, we aimed to investigate the ameliorative effect of NTX against oxidative stress in carbon tetrachl…
View article: The Possible Involvement of KATP Channels in Cholestatic Pruritus in Mice
The Possible Involvement of KATP Channels in Cholestatic Pruritus in Mice Open
Background Cholestatic itch dramatically impairs the quality of life of affected patients; however, the therapeutic choices are limited and far from sufficient. ATP-sensitive potassium channels (KATP channels) contribute to tran…
View article: Additive Anticonvulsive Effects of Sumatriptan and Morphine on Pentylenetetrazole-Induced Clonic Seizures in Mice
Additive Anticonvulsive Effects of Sumatriptan and Morphine on Pentylenetetrazole-Induced Clonic Seizures in Mice Open
Background and Purpose: Sumatriptan protects the brain from damage and enhance the anti-seizure effect of morphine. There is evidence that nitric oxide (NO) may mediate these effects of both drugs. In the present study, we investigated the…
View article: Effects of Levothyroxine and Liothyronine on Cirrhotic Cardiomyopathy in Rats
Effects of Levothyroxine and Liothyronine on Cirrhotic Cardiomyopathy in Rats Open
In liver cirrhosis, there is low T3 syndrome associated with a decrease in total triiodothyronine (T3) and free T3 concentrations and cirrhotic cardiomyopathy (CCM) with chronotropic incompetence. Thus, we aimed to investigate the effects …
View article: “Niclosamide: A potential antipruritic agent by modulating serotonin pathway through metabotropic glutamate receptors (mGluRs)”
“Niclosamide: A potential antipruritic agent by modulating serotonin pathway through metabotropic glutamate receptors (mGluRs)” Open
View article: Social interactions and olfactory cues are required for contagious itch in mice
Social interactions and olfactory cues are required for contagious itch in mice Open
The phenomenon of contagious itch, observed in both humans and rodents, remains a topic of ongoing debate concerning its modulators and underlying pathways. This study delves into the relationship between contagious itch and familiar olfac…
View article: Effects of Gap 26, a Connexin 43 Inhibitor, on Cirrhotic Cardiomyopathy in Rats
Effects of Gap 26, a Connexin 43 Inhibitor, on Cirrhotic Cardiomyopathy in Rats Open
View article: The effect of dapsone on skin flap survival depends on modulation of inflammatory response and VEGF expression
The effect of dapsone on skin flap survival depends on modulation of inflammatory response and VEGF expression Open
The random-pattern skin flap is a common method used for reconstructing skin defects. However, flap ischemia necrosis remains a significant challenge in plastic surgery. Strategies aimed at reducing persistent inflammation and promoting bl…
View article: Lasmiditan Ameliorates Serotonergic Itch in Mice: Possible Involvement of 5-HT1F Receptors
Lasmiditan Ameliorates Serotonergic Itch in Mice: Possible Involvement of 5-HT1F Receptors Open
Purpose Previously, some allergic conditions involving pruritus have been linked to migraine, raising the possibility that migraine and itching may be governed by similar underlying mechanisms. We aimed to investigate the efficacy of lasmi…
View article: The trend of poisonings before and after the COVID-19 pandemic
The trend of poisonings before and after the COVID-19 pandemic Open
View article: Exploring the impact of naltrexone on the THBS1/eNOS/NO pathway in osteoporotic bile duct-ligated rats
Exploring the impact of naltrexone on the THBS1/eNOS/NO pathway in osteoporotic bile duct-ligated rats Open