Richard B. Thompson
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View article: Margins to account for cardiac and respiratory motion in cardiac radioablation
Margins to account for cardiac and respiratory motion in cardiac radioablation Open
Background Cardiac radioablation (CR) is an emerging treatment for ventricular tachycardia, a rapid abnormal heart rhythm. Effectively delivering radiation to CR targets requires understanding and accounting for geometric uncertainties. On…
View article: Zinc in eye health, retinal biology and disease
Zinc in eye health, retinal biology and disease Open
Zinc is an essential trace mineral that plays a crucial role in numerous bodily functions, including immune response, wound healing, and protein synthesis. Regarding eye health, zinc is particularly important due to its high concentration,…
View article: 3D Cartesian ultrashort double half‐echo imaging of the lung parenchyma for water density imaging
3D Cartesian ultrashort double half‐echo imaging of the lung parenchyma for water density imaging Open
Purpose Develop and illustrate a 3D double half‐echo Cartesian UTE method for spin‐density weighted imaging of the lung parenchyma and calculation of lung water density (LWD). Methods A 3D gradient‐echo pulse sequence was modified to acqui…
View article: Intermittent Electrical Stimulation‐Induced Contractions Accelerate Pro‐Regenerative Processes in Muscles With Deep Tissue Injury in Rats
Intermittent Electrical Stimulation‐Induced Contractions Accelerate Pro‐Regenerative Processes in Muscles With Deep Tissue Injury in Rats Open
The goal of this study was to investigate the effects of an intermittent electrical stimulation (IES) paradigm on the healing of deep tissue pressure injury (DTPI). Electrical stimulation has been extensively studied for the treatment of o…
View article: Looking beyond LVEF: cardiac and skeletal muscle function in long-term breast cancer survivors with normal versus reduced peak oxygen uptake
Looking beyond LVEF: cardiac and skeletal muscle function in long-term breast cancer survivors with normal versus reduced peak oxygen uptake Open
Background Peak oxygen uptake (VO2peak) is a marker of cardiovascular disease (CVD) and heart failure (HF) risk that is gaining interest in breast cancer survivors (BCS) treated with cardiotoxic therapy. However, the factors contributing t…
View article: Prevention of radiation induced cardiotoxicity in patients with left sided breast cancer: results from a phase 2 clinical trial
Prevention of radiation induced cardiotoxicity in patients with left sided breast cancer: results from a phase 2 clinical trial Open
Background Adjuvant radiotherapy (RT) is an essential component of the optimal management of breast cancer (BC). However, RT-induced risk of cardiac toxicity is a major concern for patients with left sided BC as they are at twice the risk …
View article: <scp>MRI</scp> Assessment of Lung Water Density in Individuals Previously Infected With <scp>COVID</scp>‐19: A Cross‐Sectional Study
<span>MRI</span> Assessment of Lung Water Density in Individuals Previously Infected With <span>COVID</span>‐19: A Cross‐Sectional Study Open
Background Lung damage in post‐acute COVID‐19 is a common clinical finding. Lung water density (LWD) imaging using ultrashort echo time (UTE) MRI with proton‐density weighting is sensitive to edema and fibrosis. Purpose To characterize LWD…
View article: Decreased ventricular reserve in individuals with thoracic aortic disease
Decreased ventricular reserve in individuals with thoracic aortic disease Open
Background Thoracic aortic disease (TAD) – including aortic aneurysm and dissection – are life-threatening conditions. In addition to causing acute aortic syndromes, TAD may chronically increase left-ventricular (LV) -arterial loading and …
View article: Validation of magnetic resonance imaging-derived venous oxygen saturation and oxygen consumption measurements during exercise
Validation of magnetic resonance imaging-derived venous oxygen saturation and oxygen consumption measurements during exercise Open
Noninvasive MRI susceptometry-based [Formula: see text] measurements demonstrated excellent repeatability and validity against established direct blood sampling during localized handgrip exercise. The technique’s accuracy for determining V̇…
View article: Long-term cardiac MRI follow up of MANTICORE (Multidisciplinary Approach to Novel Therapies in Cardio-Oncology REsearch)
Long-term cardiac MRI follow up of MANTICORE (Multidisciplinary Approach to Novel Therapies in Cardio-Oncology REsearch) Open
The findings suggest that in a selected population receiving trastuzumab-based chemotherapy, extended cardiac imaging surveillance beyond one-year post-treatment may be unnecessary. We posit that the presence of HER2 overexpressing breast …
View article: Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation
Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation Open
Clinicaltrials.gov ID: NCT05579678.
View article: Reference Values for Water‐Specific <scp>T1</scp>, Intermuscular and Intramuscular Fat Content in Skeletal Muscle at 2.<scp>89 T</scp>
Reference Values for Water‐Specific <span>T1</span>, Intermuscular and Intramuscular Fat Content in Skeletal Muscle at 2.<span>89 T</span> Open
Background MRI offers quantification of proton density fat fraction (PDFF) and tissue characteristics with T1 mapping. The influence of age, sex, and the potential confounding effects of fat on T1 values in skeletal muscle in healthy adult…
View article: Accuracy of resting energy expenditure predictive equations in coronavirus disease 2019 (COVID-19) survivors
Accuracy of resting energy expenditure predictive equations in coronavirus disease 2019 (COVID-19) survivors Open
Summary: Background & Aims: Coronavirus disease 2019 (COVID-19) may be associated with abnormal energy metabolism and lead to inaccurate resting energy expenditure (REE) estimations by predictive equations. Here, we report measured REE (mR…
View article: Protocol for a pilot study: Feasibility of a web-based platform to improve nutrition, mindfulness, and physical function in people living with Post COVID-19 condition (BLEND)
Protocol for a pilot study: Feasibility of a web-based platform to improve nutrition, mindfulness, and physical function in people living with Post COVID-19 condition (BLEND) Open
Individuals with Post COVID-19 condition (PCC), or long COVID, experience symptoms such as fatigue, muscle weakness, and psychological distress, including anxiety, depression, or sleep disorders that persist after recovery from COVID-19. T…
View article: Aorta Wall Stress during Exercise in Patients with an Ascending Thoracic Aortic Aneurysm: Insights from a Case Series
Aorta Wall Stress during Exercise in Patients with an Ascending Thoracic Aortic Aneurysm: Insights from a Case Series Open
Individuals with ascending thoracic aortic aneurysm (ATAA) are recommended to avoid intense exercise for fear of marked increases in aortic wall stress (AWS). However, no study has measured AWS during exercise. The aim of this case series …
View article: Rationale and design of the multi organ inflammation with serial testing study: a comprehensive assessment of functional and structural abnormalities in patients with recovered COVID-19
Rationale and design of the multi organ inflammation with serial testing study: a comprehensive assessment of functional and structural abnormalities in patients with recovered COVID-19 Open
Introduction Short-term clinical outcomes from SARS-CoV-2 infection are generally favorable. However, 15–20% of patients report persistent symptoms of at least 12 weeks duration, often referred to as long COVID. Population studies have als…
View article: Lung water density is increased in patients at risk of heart failure and is largely independent of conventional cardiovascular magnetic resonance measures
Lung water density is increased in patients at risk of heart failure and is largely independent of conventional cardiovascular magnetic resonance measures Open
Aims Non-invasive methods to quantify pulmonary congestion are lacking in clinical practice. Cardiovascular magnetic resonance (CMR) lung water density (LWD) mapping is accurate and reproducible and has prognostic value. However, it is not…
View article: Feasibility of exercise cardiac magnetic resonance imaging for the concurrent assessment of oxygen uptake and its Fick determinants
Feasibility of exercise cardiac magnetic resonance imaging for the concurrent assessment of oxygen uptake and its Fick determinants Open
Background The concurrent assessment of oxygen uptake (VO2) and it’s Fick determinants (cardiac output x arterio-venous oxygen content difference [Qc x a-vO2diff]) provides key insights into the physiologic underpinnings of exercise intole…
View article: Lung water density is increased in patients at risk of heart failure and is largely independent of conventional CMR measures
Lung water density is increased in patients at risk of heart failure and is largely independent of conventional CMR measures Open
Aims Non-invasive methods to quantify pulmonary congestion are lacking in clinical practice. Cardiovascular magnetic resonance (CMR) lung water density (LWD) mapping is accurate, reproducible, and has prognostic value. However, it is not k…
View article: Cardiac MRI evaluation of aortic biophysical properties in paediatric Turner syndrome
Cardiac MRI evaluation of aortic biophysical properties in paediatric Turner syndrome Open
Background: Aortopathy in Turner syndrome is associated with aortic dilation, and the risk of dissection is increased when the aortic size index is ≥ 2–2.5 cm/m 2 . We evaluated the aortic biophysical properties in paediatric Turner syndro…
View article: Analysis of left ventricle regional myocardial motion for cardiac radioablation
Analysis of left ventricle regional myocardial motion for cardiac radioablation Open
Purpose Left ventricle (LV) regional myocardial displacement due to cardiac motion was assessed using cardiovascular magnetic resonance (CMR) cine images to establish region‐specific margins for cardiac radioablation treatments. Methods CM…
View article: Effect of lower body negative pressure on cardiac and cerebral function in postural orthostatic tachycardia syndrome: A pilot <scp>MRI</scp> assessment
Effect of lower body negative pressure on cardiac and cerebral function in postural orthostatic tachycardia syndrome: A pilot <span>MRI</span> assessment Open
Postural orthostatic tachycardia syndrome (POTS) is characterized by an excessive heart rate (HR) response upon standing and symptoms indicative of inadequate cerebral perfusion. We tested the hypothesis that during lower body negative pre…
View article: Left ventricle segment-specific motion assessment for cardiac-gated radiosurgery
Left ventricle segment-specific motion assessment for cardiac-gated radiosurgery Open
Purpose. Cardiac radiosurgery is a non-invasive treatment modality for ventricular tachycardia, where a linear accelerator is used to irradiate the arrhythmogenic region within the heart. In this work, cardiac magnetic resonance (CMR) cine…
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View article: Reference Values for Water‐Specific T1 of the Liver at <scp>3 T</scp>: T2*‐Compensation and the Confounding Effects of Fat
Reference Values for Water‐Specific T1 of the Liver at <span>3 T</span>: T2*‐Compensation and the Confounding Effects of Fat Open
Background T1 mapping of the liver is confounded by the presence of fat. Multiparametric T1 mapping combines fat‐water separation with T1‐weighting to enable imaging of water‐specific T1 (T1 Water ), proton density fat fraction (PDFF), and…
View article: Dynamic changes in lung water density and volume following supine body positioning
Dynamic changes in lung water density and volume following supine body positioning Open
Purpose Measure the changes in relative lung water density (rLWD), lung volume, and total lung water content as a function of time after supine body positioning. Methods An efficient ultrashort‐TE pulse sequence with a yarnball k‐space tra…
View article: Cardiac-induced motion of the pancreas and its effect on image quality of ultrahigh-resolution CT
Cardiac-induced motion of the pancreas and its effect on image quality of ultrahigh-resolution CT Open
Recent advancements in diagnostic CT detector technology have made it possible to resolve anatomical features smaller than 20 LP/cm, referred to as ultra-high-resolution (UHR) CT. Subtle biological motions that did not affect standard-reso…
View article: Lung Water Density Is Increased in Patients at Risk of Heart Failure and Is Largely Independent of Conventional CMR Measures
Lung Water Density Is Increased in Patients at Risk of Heart Failure and Is Largely Independent of Conventional CMR Measures Open
View article: Determinants of Impaired Peak Oxygen Uptake in Breast Cancer Survivors: JACC: CardioOncology Primer
Determinants of Impaired Peak Oxygen Uptake in Breast Cancer Survivors: JACC: CardioOncology Primer Open
View article: Prognostic Utility of Cardiovascular Magnetic Resonance–Based Phenotyping in Patients With Muscular Dystrophy
Prognostic Utility of Cardiovascular Magnetic Resonance–Based Phenotyping in Patients With Muscular Dystrophy Open
Background The prognostic utility of cardiovascular magnetic resonance imaging, including strain analysis and tissue characterization, has not been comprehensively investigated in adult patients with muscular dystrophy. Methods and Results…