Kent R. Bailey
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View article: Maternal and Perinatal Outcomes in Pregnancies With Type 1 Diabetes and Controls During a 15-Year Period (2006-2020)
Maternal and Perinatal Outcomes in Pregnancies With Type 1 Diabetes and Controls During a 15-Year Period (2006-2020) Open
Pregnancies with T1D continue to be associated with suboptimal glycemic control and higher maternal and perinatal morbidity, as compared to pregnancies in women without T1D, reinforcing the urgent need for the development of interventions …
View article: Transcatheter Versus Surgical Aortic Valve Replacement in Patients Aged 50 to 64 Years in the United States
Transcatheter Versus Surgical Aortic Valve Replacement in Patients Aged 50 to 64 Years in the United States Open
This nationwide observational analysis found that TAVR is increasingly performed among patients aged 50-64 years with lower in-hospital mortality and resource utilization but higher readmissions than SAVR.
View article: Long-term effects of 4 years of menopausal hormone therapy on white matter integrity
Long-term effects of 4 years of menopausal hormone therapy on white matter integrity Open
Objectives: To assess the long-term effects of 4 years of menopausal hormone therapy (mHT) on the brain’s white matter architecture in women who initiated mHT within 3 years of menopause onset. Methods: The Kronos Early Estrogen Prevention…
View article: Assessment of adverse childhood experiences in women: a study of reliability and predictive validity of self-reporting versus medical records abstraction in an American population
Assessment of adverse childhood experiences in women: a study of reliability and predictive validity of self-reporting versus medical records abstraction in an American population Open
Objective To study the reliability and validity of adverse childhood experiences (ACE) scores measured using a questionnaire versus abstraction of medical records, and to test whether the scores vary by history of bilateral oophorectomy, o…
View article: Constipation in a Large Online Cohort of Persons with Parkinson's Disease
Constipation in a Large Online Cohort of Persons with Parkinson's Disease Open
Background Small studies suggest that constipation is a common symptom associated with a worse prognosis in patients with Parkinson's disease (PD). Objectives The aim was to compare the association between constipation, motor, and other no…
View article: Development and Validation of a Bowel Diary for Fecal Incontinence: Comparison With a Questionnaire
Development and Validation of a Bowel Diary for Fecal Incontinence: Comparison With a Questionnaire Open
Background and Aims Bowel diaries are used to characterize the severity of fecal incontinence (FI) but have not been adequately validated for this purpose. Our aims were to validate a new bowel diary and to compare the characteristics of F…
View article: Baseline Fasting Glucose Level, Age, Sex, and Body Mass Index and the Development of Diabetes in US Adults
Baseline Fasting Glucose Level, Age, Sex, and Body Mass Index and the Development of Diabetes in US Adults Open
Importance Understanding the interplay between diabetes risk factors and diabetes development is important to develop individual, practice, and population-level prevention strategies. Objective To evaluate the progression from normal and i…
View article: Abnormal Glucagon Secretion Contributes to a Longitudinal Decline in Glucose Tolerance
Abnormal Glucagon Secretion Contributes to a Longitudinal Decline in Glucose Tolerance Open
Context Defects in insulin secretion and action contribute to the progression of prediabetes to diabetes. However, the contribution of α-cell dysfunction to this process has been unclear. Objective This work aimed to understand the relativ…
View article: Associations of blood pressure with white matter hyperintensities later in life; influence of short-term menopausal hormone therapy
Associations of blood pressure with white matter hyperintensities later in life; influence of short-term menopausal hormone therapy Open
Objective To assess the association of systolic and diastolic blood pressure (SBP and DBP) in recently menopausal women with white matter hyperintensity (WMH) volume later in life and determine whether short-term menopausal hormone therapy…
View article: Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life
Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life Open
INTRODUCTION Premenopausal bilateral oophorectomy (PBO) before the age of 46 years is associated with an increased risk of dementia. We investigated the long‐term effects of PBO performed before age 50 years on amyloid beta (Aβ), tau, and …
View article: Effect of disclosing a polygenic risk score for coronary heart disease on adverse cardiovascular events: 10-year follow-up of the MI-GENES randomized clinical trial
Effect of disclosing a polygenic risk score for coronary heart disease on adverse cardiovascular events: 10-year follow-up of the MI-GENES randomized clinical trial Open
Background The MI-GENES clinical trial ( NCT01936675 ), in which participants at intermediate risk of coronary heart disease (CHD) were randomized to receive a Framingham risk score (FRS g , n=103), or an integrated risk score (IRS g , n=1…
View article: Diabetes-associated Genetic Variation in <i>MTNR1B</i> and Its Effect on Islet Function
Diabetes-associated Genetic Variation in <i>MTNR1B</i> and Its Effect on Islet Function Open
Context Multiple common genetic variants have been associated with type 2 diabetes, but the mechanism by which they predispose to diabetes is incompletely understood. One such example is variation in MTNR1B, which implicates melatonin and …
View article: Effects of ondansetron on symptoms during a gastric emptying study and enteral lipid challenge and on daily symptoms in diabetic gastroenteropathy
Effects of ondansetron on symptoms during a gastric emptying study and enteral lipid challenge and on daily symptoms in diabetic gastroenteropathy Open
Background This study compared the effects of ondansetron and placebo in patients with diabetes mellitus and symptoms of dyspepsia (diabetic gastroenteropathy [DGE]). Methods We performed a randomized, double‐blinded, placebo‐controlled st…
View article: The Longitudinal Effect of Diabetes-Associated Variation in <i>TCF7L2</i> on Islet Function in Humans
The Longitudinal Effect of Diabetes-Associated Variation in <i>TCF7L2</i> on Islet Function in Humans Open
The T allele at rs7903146 in TCF7L2 increases the rate of conversion from prediabetes to type 2 diabetes. This has been associated with impaired β-cell function and with defective suppression of α-cell secretion by glucose. However, the te…
View article: Concordance of Blood Glucose and CGM During a Pilot Trial of Automated Insulin Delivery in Type 1 Diabetes Pregnancies
Concordance of Blood Glucose and CGM During a Pilot Trial of Automated Insulin Delivery in Type 1 Diabetes Pregnancies Open
Background Customized and standard automated insulin delivery (AID) systems for use in pregnancies of women with preexisting type 1 diabetes (T1D) are being developed and tested to achieve pregnancy appropriate continuous glucose monitorin…
View article: 466 Development of Machine Learning Algorithms to Predict Symptomatic VTE at Time of Admission and Time of Discharge after Severe Traumatic Injury
466 Development of Machine Learning Algorithms to Predict Symptomatic VTE at Time of Admission and Time of Discharge after Severe Traumatic Injury Open
OBJECTIVES/GOALS: Clinical indicators predictive of venous thromboembolism (VTE) in trauma patients at multiple time points are not well outlined, particularly at time of discharge. We aimed to describe and predict inpatient and post-disch…
View article: MANP: A natriuretic peptide-based therapy for cardiometabolic disease
MANP: A natriuretic peptide-based therapy for cardiometabolic disease Open
Introduction Hypertension (HTN) and metabolic syndrome (MetS) are leading and frequently coexisting risk factors for major cardiovascular diseases. The cardiac hormone atrial natriuretic peptide (ANP) plays a key role in blood pressure (B…
View article: INHIBITORS OF INORGANIC POLYPHOSPHATE AND NUCLEIC ACIDS ATTENUATE IN VITRO THROMBIN GENERATION IN PLASMA FROM TRAUMA PATIENTS
INHIBITORS OF INORGANIC POLYPHOSPHATE AND NUCLEIC ACIDS ATTENUATE IN VITRO THROMBIN GENERATION IN PLASMA FROM TRAUMA PATIENTS Open
Background: Inorganic polyphosphate (polyP) is a procoagulant polyanion. We assessed the impact of polyP inhibition on thrombin generation after trauma using the novel polyP antagonists, macromolecular polyanion inhibitor 8 (MPI 8), and un…
View article: Effect of clinical decision support for severe hypercholesterolemia on low-density lipoprotein cholesterol levels
Effect of clinical decision support for severe hypercholesterolemia on low-density lipoprotein cholesterol levels Open
Severe hypercholesterolemia/possible familial hypercholesterolemia (FH) is relatively common but underdiagnosed and undertreated. We investigated whether implementing clinical decision support (CDS) was associated with lower low-density li…
View article: Most patients with disorders of gut‐brain interaction receive pharmacotherapy with major or moderate drug‐gene interactions
Most patients with disorders of gut‐brain interaction receive pharmacotherapy with major or moderate drug‐gene interactions Open
Background How variations predicted by pharmacogenomic testing to alter drug metabolism and therapeutic response affect outcomes for patients with disorders of gut‐ brain interaction is unclear. Aims To assess the prevalence of pharmacogen…
View article: Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation
Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation Open
Background Higher blood pressure (BP) is associated with greater white matter hyperintensity (WMH) volume, but research is limited in recently menopausal and postmenopausal women. Postmenopausal women have a greater burden of WMH than men …
View article: Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation
Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation Open
Background Higher blood pressure (BP) is associated with greater white matter hyperintensity (WMH) volume, but research is limited in recently menopausal and postmenopausal women. Postmenopausal women have a greater burden of WMH than men …
View article: A murine multiple-injury model for the study of thromboinflammation
A murine multiple-injury model for the study of thromboinflammation Open
INTRODUCTION Neutrophil extracellular traps (NETs) contribute to trauma-induced coagulopathy. We aimed to develop a murine multiple-injury model that induces thrombo-inflammatory response, that is, NETosis and accelerated thrombin generati…
View article: Cardiovascular and metabolic effects of MANP. a novel GC-A activator, in human hypertension with metabolic syndrome
Cardiovascular and metabolic effects of MANP. a novel GC-A activator, in human hypertension with metabolic syndrome Open
Background/Introduction Hypertension (HTN) and metabolic syndrome (MetS) are both leading risk factors for major cardiovascular diseases, which frequently coexist as a complicated cardiometabolic disorder. The cardiac hormone atrial natriu…
View article: A randomized <scp>double‐blind</scp> trial of clonidine and colesevelam for women with fecal incontinence
A randomized <span>double‐blind</span> trial of clonidine and colesevelam for women with fecal incontinence Open
Background Diarrhea and rectal urgency are risk factors for fecal incontinence (FI). The effectiveness of bowel modifiers for improving FI is unclear. Methods In this double‐blind, parallel‐group, randomized trial, women with urge FI were …
View article: Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans
Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans Open
BACKGROUNDProglucagon can be processed to glucagon-like peptide1 (GLP-1) within the islet, but its contribution to islet function in humans remains unknown. We sought to understand whether pancreatic GLP-1 alters islet function in humans a…