Ruma Banerjee
YOU?
Author Swipe
View article: Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death
Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death Open
Colorectal cancer (CRC) cells are addicted to iron, which fuels nucleotide synthesis, mitochondrial respiration, and rapid proliferation. Yet paradoxically, high intracellular iron is cytotoxic to most other cells, raising the question of …
View article: Power and poison: The intersections of H2S and O2 metabolism
Power and poison: The intersections of H2S and O2 metabolism Open
The metabolic interaction between hydrogen sulfide (H2S) and oxygen (O2) exemplifies the interplay between chemical power and poison at the electron transport chain as these gases influence the conversion of nutrient …
View article: An unusual Co–S bond links B <sub>12</sub> chaperones in an interprotein complex
An unusual Co–S bond links B <sub>12</sub> chaperones in an interprotein complex Open
Chaperones in trafficking pathways ensure specificity of transition metal loading and protection against adventitious side reactions. In B 12 , an essential cofactor for humans, a cobalt ion is coordinated to a >1.3 kDa tetrapyrrolic scaff…
View article: Conformation-gated binding underlies kinetic asymmetry and negative cooperativity in ATP:cob(I)alamin adenosyltransferase
Conformation-gated binding underlies kinetic asymmetry and negative cooperativity in ATP:cob(I)alamin adenosyltransferase Open
Vitamin B12 (cobalamin) is a high-value yet scarce cofactor critical for metabolic homeostasis, necessitating efficient handling mechanisms. ATP:cob(I)alamin adenosyltransferase (MMAB) plays a central role in synthesizing, deliv…
View article: Flotilla: A scalable, modular and resilient federated learning framework for heterogeneous resources
Flotilla: A scalable, modular and resilient federated learning framework for heterogeneous resources Open
View article: Abstract 2205 Hydrogen sulfide increases intracellular oxygen to destabilize HIF and iron-sulfur cluster proteins
Abstract 2205 Hydrogen sulfide increases intracellular oxygen to destabilize HIF and iron-sulfur cluster proteins Open
View article: Abstract 2078 Installation of the trisulfide cofactor in human sulfide quinone oxidoreductase
Abstract 2078 Installation of the trisulfide cofactor in human sulfide quinone oxidoreductase Open
View article: Abstract 2185 Clinical P1173L variant of methionine synthase impairs reductive methylation
Abstract 2185 Clinical P1173L variant of methionine synthase impairs reductive methylation Open
View article: Abstract 2536 Instability of the B12 trafficking chaperone MMADHC is mitochondrially regulated
Abstract 2536 Instability of the B12 trafficking chaperone MMADHC is mitochondrially regulated Open
View article: Abstract 2095 Redox shifts in the cysteine proteome in response to sulfide
Abstract 2095 Redox shifts in the cysteine proteome in response to sulfide Open
View article: Abstract 2011 H2S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes
Abstract 2011 H2S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes Open
View article: Gut sulfide metabolism modulates behavior and brain bioenergetics
Gut sulfide metabolism modulates behavior and brain bioenergetics Open
The host-microbiome interface is rich in metabolite exchanges and exquisitely sensitive to diet. Hydrogen sulfide (H 2 S) is present at high concentrations at this interface, and is a product of both microbial and host metabolism. The mito…
View article: Conformation-gated binding drives negative cooperativity in ATP:cob(I)alamin Adenosyltransferase for optimized cobalamin handling
Conformation-gated binding drives negative cooperativity in ATP:cob(I)alamin Adenosyltransferase for optimized cobalamin handling Open
Vitamin B 12 (cobalamin) is a high-value yet scarce cofactor required for various metabolic processes, making its efficient handling important for maintaining metabolic homeostasis. While the involvement of ATP:cob(I)alamin adenosyltransfe…
View article: H<sub>2</sub>S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes
H<sub>2</sub>S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes Open
Mitochondrial form and function are intimately interconnected, responding to cellular stresses and changes in energy demand. Hydrogen sulfide, a product of amino acid metabolism, has dual roles as an electron transport chain substrate and …
View article: Extending apo-sGC to haem-sensing proteins and a landscape of haem mimetic pharmacophores with broad applications
Extending apo-sGC to haem-sensing proteins and a landscape of haem mimetic pharmacophores with broad applications Open
Haem, a fundamental prosthetic group, mediates oxygen transport and metabolism in proteins while exerting signalling functions in haemolytic disorders through its pro-oxidant, pro-inflammatory, and cytotoxic effects when unbound. In additi…
View article: Acidity of persulfides and its modulation by the protein environments in sulfide quinone oxidoreductase and thiosulfate sulfurtransferase
Acidity of persulfides and its modulation by the protein environments in sulfide quinone oxidoreductase and thiosulfate sulfurtransferase Open
Persulfides (RSSH/RSS-) participate in sulfur metabolism and are proposed to transduce hydrogen sulfide (H2S) signaling. Their biochemical properties are poorly understood. Herein, we studied the acidity and nucleophi…
View article: BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III
BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III Open
Inter-organellar communication is critical for cellular metabolic homeostasis. One of the most abundant inter-organellar interactions are those at the endoplasmic reticulum and mitochondria contact sites (ERMCS). However, a detailed unders…
View article: Intensified behavioural modernity of human: an insight into extinction crisis
Intensified behavioural modernity of human: an insight into extinction crisis Open
Human behaviour modernity causes an instantaneous advancement in language, art (Palaeolithic), and technology, including the mid-stone age discoveries of weapons such as spear throwers on Earth. In human science, self-awareness, genetic dr…
View article: H<sub>2</sub>S preconditioning induces long-lived perturbations in O<sub>2</sub>metabolism
H<sub>2</sub>S preconditioning induces long-lived perturbations in O<sub>2</sub>metabolism Open
Hydrogen sulfide exposure in moderate doses can induce profound but reversible hypometabolism in mammals. At a cellular level, H 2 S inhibits the electron transport chain (ETC), augments aerobic glycolysis, and glutamine-dependent carbon u…
View article: Incorporating chemical structures into scientific figures
Incorporating chemical structures into scientific figures Open
View article: Cobalt-sulfur coordination chemistry drives B<sub>12</sub>loading onto methionine synthase
Cobalt-sulfur coordination chemistry drives B<sub>12</sub>loading onto methionine synthase Open
Cobalt-sulfur (Co-S) coordination is labile to both oxidation and reduction chemistry and is rarely seen in Nature. Cobalamin (or vitamin B 12 ) is an essential cobalt-containing organometallic cofactor in mammals, and is escorted via an i…
View article: Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B<sub>12</sub>delivery and repair
Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B<sub>12</sub>delivery and repair Open
G-proteins function as molecular switches to power cofactor translocation and confer fidelity in metal trafficking. MMAA, a G-protein motor, together with MMAB, an adenosyltransferase, orchestrate cofactor delivery and repair of B 12 -depe…
View article: Sulfide oxidation promotes hypoxic angiogenesis and neovascularization
Sulfide oxidation promotes hypoxic angiogenesis and neovascularization Open
Angiogenic programming in the vascular endothelium is a tightly regulated process to maintain tissue homeostasis and is activated in tissue injury and the tumor microenvironment. The metabolic basis of how gas signaling molecules regulate …
View article: Abstract 2575: Hydrogen sulfide induces long-term changes in mitochondrial energy metabolism
Abstract 2575: Hydrogen sulfide induces long-term changes in mitochondrial energy metabolism Open
View article: Abstract 2601: A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent H2S oxidation
Abstract 2601: A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent H2S oxidation Open
View article: Abstract 2200: The impact of patient mutations on coenzyme B12 loading and repair
Abstract 2200: The impact of patient mutations on coenzyme B12 loading and repair Open
View article: Abstract 1608: Coordination chemistry control of coenzyme B12 synthesis
Abstract 1608: Coordination chemistry control of coenzyme B12 synthesis Open
View article: Abstract 2270: Cobalt-sulfur coordination chemistry drives B12 loading onto methionine synthase
Abstract 2270: Cobalt-sulfur coordination chemistry drives B12 loading onto methionine synthase Open
View article: The new horizon exploration in the domain of science
The new horizon exploration in the domain of science Open
Science winds the helices of knowledge with the bids of prediction, exploration, evolution and explanation to shape the nature in a specific and universal configuration. Time is precious for all the living creatures. Research is the potent…
View article: Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer
Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer Open