Rolf F. Barth
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View article: Evaluation of sodium borocaptate (BSH) and boronophenylalanine (BPA) as boron delivery agents for neutron capture therapy (NCT) of cancer: an update and a guide for the future clinical evaluation of new boron delivery agents for NCT
Evaluation of sodium borocaptate (BSH) and boronophenylalanine (BPA) as boron delivery agents for neutron capture therapy (NCT) of cancer: an update and a guide for the future clinical evaluation of new boron delivery agents for NCT Open
Boron neutron capture therapy (BNCT) is a cancer treatment modality based on the nuclear capture and fission reactions that occur when boron‐10, a stable isotope, is irradiated with neutrons of the appropriate energy to produce boron‐11 in…
View article: Boron neutron capture therapy of cancer: where do we stand now?
Boron neutron capture therapy of cancer: where do we stand now? Open
This is the third Editorial/Commentary that one of us (R. F. Barth) has written relating to boron neutron capture therapy (BNCT) [1, 2]. For those readers who are unfamiliar with BNCT we would refer them to several recent comprehensive rev…
View article: Amyloid Coronary Artery Disease, Primary Systemic Amyloidosis and Paraproteinemia
Amyloid Coronary Artery Disease, Primary Systemic Amyloidosis and Paraproteinemia Open
A patient had primary systemic amyloidosis with severe cardiac involvement and IgG paraproteinemia. Numerous intramural coronary arteries were occluded by amyloid deposits, but arteriosclerosis of the extramural arteries was absent. The am…
View article: Data from Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy
Data from Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy Open
Thymidine analogs containing o-carboranylalkyl groups at the 3-position were screened as potential substrates for human thymidine kinase 1 (TK1), an enzyme that is selectively expressed in a variety of rapidly proliferating cells, includin…
View article: Data from Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy
Data from Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy Open
Thymidine analogs containing o-carboranylalkyl groups at the 3-position were screened as potential substrates for human thymidine kinase 1 (TK1), an enzyme that is selectively expressed in a variety of rapidly proliferating cells, includin…
View article: Supplementary Methods from Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy
Supplementary Methods from Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy Open
Supplementary Methods from Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy
View article: Supplementary Methods from Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy
Supplementary Methods from Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy Open
Supplementary Methods from Evaluation of Human Thymidine Kinase 1 Substrates as New Candidates for Boron Neutron Capture Therapy
View article: Rat and Mouse Brain Tumor Models for Experimental Neuro-Oncology Research
Rat and Mouse Brain Tumor Models for Experimental Neuro-Oncology Research Open
Rodent brain tumor models have been useful for developing effective therapies for glioblastomas (GBMs). In this review, we first discuss the 3 most commonly used rat brain tumor models, the C6, 9L, and F98 gliomas, which are all induced by…
View article: A Comparison of the Clinical, Viral, Pathologic, and Immunologic Features of Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Coronavirus 2019 (COVID-19) Diseases
A Comparison of the Clinical, Viral, Pathologic, and Immunologic Features of Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Coronavirus 2019 (COVID-19) Diseases Open
Context.— The purpose of this review was to compare 3 coronavirus diseases, including severe acute respiratory syndrome, Middle East respiratory syndrome, and COVID-19 caused by SARS-CoV, MERS-CoV, and SARS-CoV-2 viruses, respectively. Obj…
View article: Phase I trial of intracerebral convection-enhanced delivery of carboplatin for treatment of recurrent high-grade gliomas
Phase I trial of intracerebral convection-enhanced delivery of carboplatin for treatment of recurrent high-grade gliomas Open
Background Carboplatin is a potent cytoreductive agent for a variety of solid tumors. However, when delivered systemically, clinical efficacy for the treatment of high grade gliomas is poor due to limited penetration across the blood-brain…
View article: A realistic appraisal of boron neutron capture therapy as a cancer treatment modality
A realistic appraisal of boron neutron capture therapy as a cancer treatment modality Open
Boron neutron capture therapy (BNCT) is a binary therapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope boron‐10 is irradiated with neutrons to produce high‐energy alpha particles and rec…
View article: Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget's disease with curative responses
Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget's disease with curative responses Open
Background Although the most commonly recommended treatment for melanoma and extramammary Paget's disease (EMPD) of the genital region is wide surgical excision of the lesion, the procedure is highly invasive and can lead to functional and…
View article: Boron delivery agents for neutron capture therapy of cancer
Boron delivery agents for neutron capture therapy of cancer Open
Boron neutron capture therapy (BNCT) is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope, boron‐10, is irradiated with neutrons to produce high energy alpha particles.…
View article: Design, synthesis, and evaluation of cisplatin-containing EGFR targeting bioconjugates as potential therapeutic agents for brain tumors
Design, synthesis, and evaluation of cisplatin-containing EGFR targeting bioconjugates as potential therapeutic agents for brain tumors Open
The aim of this study was to evaluate four different platinated bioconjugates containing a cisplatin (cis-diamminedichloroplatinum [cis-DDP]) fragment and epidermal growth factor receptor (EGFR)-targeting moieties as potential therapeutic …
View article: Gadolinium nanoparticles and contrast agent as radiation sensitizers
Gadolinium nanoparticles and contrast agent as radiation sensitizers Open
The goal of the present study was to evaluate and compare the radiosensitizing properties of gadolinium nanoparticles (NPs) with the gadolinium contrast agent (GdCA) Magnevist(®) in order to better understand the mechanisms by which they a…