Christian R. Baumann
YOU?
Author Swipe
View article: The role of electrode placement in subthalamic nucleus deep brain stimulation for improving gait in Parkinson’s Disease
The role of electrode placement in subthalamic nucleus deep brain stimulation for improving gait in Parkinson’s Disease Open
These findings support precision targeting of stimulation sites to optimize patient-specific gait outcomes, advancing personalized DBS therapy in Parkinson's disease.
View article: Circadian Modulation of Sleep-Wake Behavior in Patients with Narcolepsy Type 1 and Idiopathic Hypersomnia
Circadian Modulation of Sleep-Wake Behavior in Patients with Narcolepsy Type 1 and Idiopathic Hypersomnia Open
These findings argue against circadian disruption as a primary mechanism in idiopathic hypersomnia and point toward other underlying causes, such as altered sleep homeostasis or neurochemical dysregulation.
View article: Sleep phenotypes of α-synucleinopathies and tauopathies with Parkinsonism
Sleep phenotypes of α-synucleinopathies and tauopathies with Parkinsonism Open
Distinct sleep phenotypes characterize neurodegenerative Parkinsonism with Syn or Tau. Pending pathological confirmation, our data suggests that neurodegeneration could affect sleep-wake regulatory brain systems in a proteinopathy-dependen…
View article: Brain Drain for Brain Gain: Potential Applications of Robotic-assisted Lymphatic Microsurgery in the Management of Neurological Disorders
Brain Drain for Brain Gain: Potential Applications of Robotic-assisted Lymphatic Microsurgery in the Management of Neurological Disorders Open
Background: The central nervous system (CNS) was long believed to be devoid of lymphatic drainage. However, the discovery of the glymphatic system and meningeal lymphatics has revolutionized our understanding of cerebrospinal fluid homeost…
View article: Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia
Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia Open
Objective Impaired ability to induce stepping after incomplete spinal cord injury (SCI) can limit the efficacy of locomotor training, often leaving patients wheelchair‐bound. The cuneiform nucleus (CNF), a key mesencephalic locomotor contr…
View article: Thalamic Deep Brain Stimulation Versus Magnetic Resonance–Guided Focused Ultrasound in Tremor Patients: A Retrospective Single‐Surgeon Comparison
Thalamic Deep Brain Stimulation Versus Magnetic Resonance–Guided Focused Ultrasound in Tremor Patients: A Retrospective Single‐Surgeon Comparison Open
Background Bilateral deep brain stimulation (DBS) and unilateral magnetic resonance–guided focused ultrasound (MRgFUS), with potential future second‐side treatment targeting the thalamic ventral intermediate nucleus (VIM), are currently th…
View article: Auditory Enhancement of Sleep Slow Waves in People with Parkinson’s Disease: A Proof-of-Concept Study
Auditory Enhancement of Sleep Slow Waves in People with Parkinson’s Disease: A Proof-of-Concept Study Open
Deep sleep supports several restorative functions and has emerged as a potential therapeutic target in neurodegenerative disorders, such as Parkinson’s disease (PD). Phase-targeted auditory stimulation (PTAS) is a non-invasive method for e…
View article: Longitudinal changes in hippocampal morphology before and after temporal lobe epilepsy surgery
Longitudinal changes in hippocampal morphology before and after temporal lobe epilepsy surgery Open
Temporal lobe epilepsy (TLE) is associated with progressive neocortical thinning that may be prevented by resective surgery, but little knowledge exists on dynamic changes in the hippocampus. Here, we assessed progressive morphological cha…
View article: Sleep Fragmentation as a Diagnostic Biomarker of Traumatic Brain Injury
Sleep Fragmentation as a Diagnostic Biomarker of Traumatic Brain Injury Open
Sleep disturbances are among the most prevalent and persistent consequences of traumatic brain injury (TBI), yet they remain underutilized as clinical indicators of injury status. In this perspective, we propose that sleep fragmentation-de…
View article: Brain Hypertrophy in Patients With Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis and Its Clinical Correlates
Brain Hypertrophy in Patients With Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis and Its Clinical Correlates Open
Unilateral mTLE due to hippocampal sclerosis is associated with hypertrophy of the contralateral amygdala. This may represent plasticity to compensate for verbal memory deficits or may be the consequence of seizure spread to the contralate…
View article: Predicting MDS-UPDRS-III score changes using mobile device biomarkers
Predicting MDS-UPDRS-III score changes using mobile device biomarkers Open
Digital biomarkers derived from mobile sensors could enable more frequent and objective monitoring of motor disorder symptoms. In this study, we examined the sensitivity of five tablet-based tests in predicting changes in the MDS-UPDRS-III…
View article: Spiral volumetric optoacoustic tomography of reduced oxygen saturation in the spinal cord of M83 mouse model of Parkinson’s disease
Spiral volumetric optoacoustic tomography of reduced oxygen saturation in the spinal cord of M83 mouse model of Parkinson’s disease Open
Purpose Metabolism and bioenergetics in the central nervous system play important roles in the pathophysiology of Parkinson’s disease (PD). Here, we employed a multimodal imaging approach to assess oxygenation changes in the spinal cord of…
View article: T2 MRI visible perivascular spaces in Parkinson’s disease: clinical significance and association with polysomnography measured sleep
T2 MRI visible perivascular spaces in Parkinson’s disease: clinical significance and association with polysomnography measured sleep Open
Poor sleep quality might contribute to the risk and progression of neurodegenerative disorders via deficient cerebral waste clearance functions during sleep. In this retrospective cross-sectional study, we explore the link between enlarged…
View article: Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration
Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration Open
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we esta…
View article: mCLAS adaptively rescues disease-specific sleep and wake phenotypes in neurodegeneration
mCLAS adaptively rescues disease-specific sleep and wake phenotypes in neurodegeneration Open
Sleep alterations are hallmarks of prodromal Alzheimer’s (AD) and Parkinson’s disease (PD), with fundamental neuropathological processes of both diseases showing susceptibility of change upon deep sleep modulation. However, promising pharm…
View article: Should asleep deep brain stimulation in Parkinson’s disease be preferred over the awake approach? – Cons
Should asleep deep brain stimulation in Parkinson’s disease be preferred over the awake approach? – Cons Open
No abstract available.
View article: Visualizing alpha‐synuclein and iron deposition in <scp>M83</scp> mouse model of Parkinson's disease in vivo
Visualizing alpha‐synuclein and iron deposition in <span>M83</span> mouse model of Parkinson's disease in vivo Open
Abnormal alpha‐synuclein (αSyn) and iron accumulation in the brain play an important role in Parkinson's disease (PD). Herein, we aim to visualize αSyn inclusions and iron deposition in the brains of M83 (A53T) mouse models of PD in vivo. …
View article: Exploring the local field potential signal from the subthalamic nucleus for phase-targeted auditory stimulation in Parkinson's disease
Exploring the local field potential signal from the subthalamic nucleus for phase-targeted auditory stimulation in Parkinson's disease Open
Our findings suggest the feasibility of implementing PTAS using solely STN-LFP signal for slow wave detection, thus without a need for an external EEG device alongside the implanted neurostimulator. Moreover, we propose options for more ef…
View article: Neurofeedback-enabled beta power control with a fully implanted DBS system in patients with Parkinson’s disease
Neurofeedback-enabled beta power control with a fully implanted DBS system in patients with Parkinson’s disease Open
Fully-implanted DBS electrode-guided neurofeedback is feasible and can now be explored over extended timespans.
View article: Continuous and Unconstrained Tremor Monitoring in Parkinson’s Disease Using Supervised Machine Learning and Wearable Sensors
Continuous and Unconstrained Tremor Monitoring in Parkinson’s Disease Using Supervised Machine Learning and Wearable Sensors Open
Background . Accurately assessing the severity and frequency of fluctuating motor symptoms is important at all stages of Parkinson’s disease management. Contrarily to time-consuming clinical testing or patient self-reporting with uncertain…
View article: Rapid eye movement sleep, the Swiss army knife in neurodegenerative disease?
Rapid eye movement sleep, the Swiss army knife in neurodegenerative disease? Open
Journal Article Accepted manuscript REM sleep, the Swiss army knife in neurodegenerative disease? Get access Christian R Baumann, Christian R Baumann Department of Neurology University Hospital Zurich, Zurich, SwitzerlandCenter of Competen…
View article: Spinal cord perfusion impairments in the M83 mouse model of Parkinson’s disease
Spinal cord perfusion impairments in the M83 mouse model of Parkinson’s disease Open
Metabolism and bioenergetics in the central nervous system play important roles in the pathophysiology of Parkinson’s disease (PD). Here, we employed a multimodal imaging approach to assess oxygenation changes in the spinal cord of a trans…
View article: Assessment of Fitbit Charge 4 for sleep stage and heart rate monitoring against polysomnography and during home monitoring in Huntington’s disease
Assessment of Fitbit Charge 4 for sleep stage and heart rate monitoring against polysomnography and during home monitoring in Huntington’s disease Open
Doheny EP, Renerts K, Braun A, et al. Assessment of Fitbit Charge 4 for sleep stage and heart rate monitoring against polysomnography and during home monitoring in Huntington's disease. J Clin Sleep Med. 2024;20(7):1163-1171.
View article: Novel murine closed-loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration
Novel murine closed-loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration Open
Boosting slow-wave activity (SWA) by modulating slow-waves through closed-loop auditory stimulation (CLAS) might provide a powerful nonpharmacological tool to investigate the link between sleep and neurodegeneration. Nevertheless, CLAS in …
View article: NASCarD (Nanopore Adaptive Sampling with Carrier DNA): A Rapid, PCR-Free Method for SARS-CoV-2 Whole-Genome Sequencing in Clinical Samples
NASCarD (Nanopore Adaptive Sampling with Carrier DNA): A Rapid, PCR-Free Method for SARS-CoV-2 Whole-Genome Sequencing in Clinical Samples Open
Whole-genome sequencing (WGS) represents the main technology for SARS-CoV-2 lineage characterization in diagnostic laboratories worldwide. The rapid, near-full-length sequencing of the viral genome is commonly enabled by high-throughput se…
View article: Direct subthalamic nucleus stimulation influences speech and voice quality in Parkinson's disease patients
Direct subthalamic nucleus stimulation influences speech and voice quality in Parkinson's disease patients Open
STN-DBS can considerably improve both speech and voice quality based on a carefully arranged stimulation regimen along central stimulation features.
View article: Triggers for freezing of gait in individuals with Parkinson’s disease: a systematic review
Triggers for freezing of gait in individuals with Parkinson’s disease: a systematic review Open
Background Freezing of Gait (FOG) is a motor symptom frequently observed in advanced Parkinson’s disease. However, due to its paroxysmal nature and diverse presentation, assessing FOG in a clinical setting can be challenging. Before FOG ca…
View article: MRI reveals cerebral iron, calcification and spinal cord atrophy in M83 mouse model of Parkinson’s disease
MRI reveals cerebral iron, calcification and spinal cord atrophy in M83 mouse model of Parkinson’s disease Open
Background Rodent models of Parkinson’s disease have been crucial tools for understanding the pathogenic mechanisms of alpha‐synuclein‐associated alterations. Here, we employed multiparametric high‐field magnetic resonance imaging (MRI) to…