Carlos Brites
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View article: Dolutegravir use is related to lower HTLV-1 proviral load in people co-infected by HIV-1
Dolutegravir use is related to lower HTLV-1 proviral load in people co-infected by HIV-1 Open
Background Infection by human T-cell lymphotropic virus type 1 (HTLV-1) affects millions of people worldwide and causes severe diseases. To date, no specific treatment is available for HTLV infection. The purpose of this study was to deter…
View article: A national cross-sectional analysis of surveillance drug resistance mutations among recently diagnosed antiretroviral naïve Brazilian people with HIV
A national cross-sectional analysis of surveillance drug resistance mutations among recently diagnosed antiretroviral naïve Brazilian people with HIV Open
FAPESP and CNPq.
View article: The spatiotemporal ecology of Oropouche virus across Latin America: a multidisciplinary, laboratory-based, modelling study
The spatiotemporal ecology of Oropouche virus across Latin America: a multidisciplinary, laboratory-based, modelling study Open
For the Spanish and Portuguese translations of the abstract see Supplementary Materials section.
View article: Multicenter cross-sectional study of HTLV-1 prevalence and associated risk factors in epidemiologically relevant groups across Brazil
Multicenter cross-sectional study of HTLV-1 prevalence and associated risk factors in epidemiologically relevant groups across Brazil Open
Background Human T cell lymphotropic virus type 1 (HTLV-1) is highly endemic in Brazil, necessitating surveillance studies to understand its epidemiology. While previous research has focused on either specific cities or populations, there …
View article: Effects of physical rehabilitation interventions on exercise performance, dyspnea, and health-related quality of life in acute and post-acute COVID-19 patients: Systematic review and meta-analysis
Effects of physical rehabilitation interventions on exercise performance, dyspnea, and health-related quality of life in acute and post-acute COVID-19 patients: Systematic review and meta-analysis Open
Objective To analyze the published randomized controlled trials (RCTs) that investigated the effects of physical rehabilitation interventions provided directly (face to face) and by telerehabilitation on exercise performance, dyspnea, and …
View article: 4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection
4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection Open
Since late 2021, Omicron variants have dominated the epidemiological scenario as the most successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sublineages, driving new and breakthrough infections globally over the past t…
View article: Ancient origins and global spread of domestic cat hepatitis B virus
Ancient origins and global spread of domestic cat hepatitis B virus Open
Mammalian hepadnaviruses have likely been evolving alongside their hosts for millions of years. Domestic cat HBV (DCHBV) has been detected in cats from several countries, but its genealogy, epidemiology, and host range remain unclear. Besi…
View article: Efficacy and Safety of DTG/3TC for Prophylaxis of HIV Perinatal Transmission: A Pilot Study (PREGNANCY)
Efficacy and Safety of DTG/3TC for Prophylaxis of HIV Perinatal Transmission: A Pilot Study (PREGNANCY) Open
Background The prevention of perinatal human immunodeficiency virus (HIV) transmission depends on the safe and effective use of antiretroviral therapy (ART). Simplifying treatment reduces drug exposure for both mother and child. We evaluat…
View article: Mass Spectrometry-Based Metabolomics Reveals a Salivary Signature for Low-Severity COVID-19
Mass Spectrometry-Based Metabolomics Reveals a Salivary Signature for Low-Severity COVID-19 Open
Omics approaches were extensively applied during the coronavirus disease 2019 (COVID-19) pandemic to understand the disease, identify biomarkers with diagnostic and prognostic value, and discover new molecular targets for medications. COVI…
View article: Genetic signatures of AKT1 variants associated with worse COVID-19 outcomes – a multicentric observational study
Genetic signatures of AKT1 variants associated with worse COVID-19 outcomes – a multicentric observational study Open
Introduction The COVID-19, triggered by the SARS-CoV-2 virus, has varied clinical manifestations, ranging from mild cases to severe forms such as fatal pneumonia and acute respiratory distress syndrome (ARDS). Disease severity is influence…
View article: Cognitive Assessment in HTLV-1 Patients Followed Up at a Reference Center in Salvador, Brazil
Cognitive Assessment in HTLV-1 Patients Followed Up at a Reference Center in Salvador, Brazil Open
Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) is endemic to Brazil, and there is still no specific treatment for these patients. The literature shows that few studies have described the cognitive impairment associated with …
View article: Patient-Reported Outcomes After Switching to a 2-Drug Regimen of Fixed-Dose Combination Dolutegravir/Lamivudine: 48-Week Results from the SALSA Study
Patient-Reported Outcomes After Switching to a 2-Drug Regimen of Fixed-Dose Combination Dolutegravir/Lamivudine: 48-Week Results from the SALSA Study Open
Patient-reported outcomes (PROs) facilitate communication between patients and providers, enhancing patient-centered care. We report PROs for virologically suppressed people living with HIV-1 who switched to dolutegravir/lamivudine (DTG/3T…
View article: A Systematical Review on ART Use in HTLV Infection: Clinical, Virological, and Immunological Outcomes
A Systematical Review on ART Use in HTLV Infection: Clinical, Virological, and Immunological Outcomes Open
Human T-cell lymphotropic virus (HTLV) infection affects over ten million people worldwide, but there is no effective treatment so far. This review describes the virological, immunological, and clinical outcomes of antiretroviral therapy (…
View article: Distinctive genomic features of human T-lymphotropic virus type 1-related adult T-cell leukemia-lymphoma in Western populations
Distinctive genomic features of human T-lymphotropic virus type 1-related adult T-cell leukemia-lymphoma in Western populations Open
Adult T-cell leukemia-lymphoma (ATLL) is an aggressive Human T-cell Leukemia Virus Type 1 (HTLV-1)-driven malignancy. Although Western hemisphere (Afro-Caribbean and South American) patients face worse prognoses, our understanding of ATLL …
View article: A Systematical Review on ART Use in HTLV Infection: Clinical, Virological, and Immunological Outcomes
A Systematical Review on ART Use in HTLV Infection: Clinical, Virological, and Immunological Outcomes Open
Human T-cell lymphotropic virus (HTLV) infection lacks effective treatment. This review describes the virological, immunological and clinical outcomes of antiretroviral therapy (ART) in people with HTLV infection. This systematic review fo…
View article: Detection of cytokines in cervicovaginal lavage in HIV-infected women and its association with high-risk human papillomavirus
Detection of cytokines in cervicovaginal lavage in HIV-infected women and its association with high-risk human papillomavirus Open
Background Women living with HIV/AIDS (WLHA) have an increased prevalence of high-risk HPV infection (HR-HPV) and cervical intraepithelial neoplasia (CIN) and a greater risk of cervical cancer despite access to a new generation of antiretr…
View article: Development of RT-RPA-based point-of-care tests for epidemic arthritogenic alphaviruses
Development of RT-RPA-based point-of-care tests for epidemic arthritogenic alphaviruses Open
Chikungunya (CHIKV), o’nyong-nyong (ONNV), and Mayaro (MAYV) viruses are transmitted by mosquitoes and known to cause a debilitating arthritogenic syndrome. These alphaviruses have emerged and re-emerged, leading to outbreaks in tropical a…
View article: Autochtonal case of chronic, unifocal, pulmonary paracoccidioidomycosis with methotrexate use, in Salvador ‒ Brazil
Autochtonal case of chronic, unifocal, pulmonary paracoccidioidomycosis with methotrexate use, in Salvador ‒ Brazil Open
We report an autochthonous case of mild unifocal chronic pulmonary paracoccidioidomycosis in a 48-year-old previously healthy woman with no history of possible environmental exposures in endemic rural areas, supposedly resulting from react…
View article: Factors associated with hepatitis A susceptibility among men who have sex with men using HIV pre-exposure prophylaxis in Northeastern Brazil: A cross-sectional study
Factors associated with hepatitis A susceptibility among men who have sex with men using HIV pre-exposure prophylaxis in Northeastern Brazil: A cross-sectional study Open
Hepatitis A virus (HAV) infection has disproportionately affected more men who have sex with men (MSM), occurring in outbreaks, despite being vaccine-preventable. We determined the prevalence and factors associated with HAV susceptibility …
View article: Outcomes of severely ill patients with AIDS treated with efavirenz or dolutegravir: a multicenter, observational study
Outcomes of severely ill patients with AIDS treated with efavirenz or dolutegravir: a multicenter, observational study Open
Background Currently, integrase inhibitors (INIs)-based ART regimens are the preferred initial therapy for AIDS patients. There is scarce information on the use of dolutegravir (DTG) among late-presenter people living with HIV (PLHIV). Obj…
View article: Description of the new HIV-1 intersubtype B/C circulating recombinant form (CRF146_BC) detected in Brazil
Description of the new HIV-1 intersubtype B/C circulating recombinant form (CRF146_BC) detected in Brazil Open
Thus, the new HIV-1 CRF146_BC is circulating in three different Brazilian regions: South, Southeast and Northeast.
View article: Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions
Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions Open
In the past few decades, several emerging/re-emerging mosquito-borne flaviviruses have resulted in disease outbreaks of public health concern in the tropics and subtropics. Due to cross-reactivities of antibodies recognizing the envelope p…
View article: Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions
Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions Open
In the past few decades, several emerging/re-emerging mosquito-borne flaviviruses have resulted in disease outbreaks of public health concern in the tropics and subtropics. Due to cross-reactivities of antibodies recognizing the envelope p…