Roberta Bulla
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View article: P-491 Multimerin-2 dysregulation in preeclampsia and oocyte donation pregnancies: insights into vascular remodeling and disease susceptibility
P-491 Multimerin-2 dysregulation in preeclampsia and oocyte donation pregnancies: insights into vascular remodeling and disease susceptibility Open
Study question Does the homeostatic molecule Multimerin-2 (MMRN2) undergo alterations in preeclampsia (PE) and oocyte donation (OD) pregnancies, potentially contributing to the increased PE risk in OD? Summary answer Multimerin-2, is profo…
View article: Anti-miRNA therapeutics for uterine fibroids
Anti-miRNA therapeutics for uterine fibroids Open
Anti-miR-148a-3p LNA inhibits the proliferation of patient-derived leiomyoma cells and tumor growth in vivo, by suppressing miR-148a-3p levels and increasing TXNIP and Nrp1 gene expression. The highest therapeutic effect was observed with …
View article: A possible association between low MBL/lectin pathway functionality and microbiota dysbiosis in endometriosis patients
A possible association between low MBL/lectin pathway functionality and microbiota dysbiosis in endometriosis patients Open
A lower functionality of LP in the uterine mucosa may contribute to an unbalanced bacterial environment that could activate endometrial cells. Not only the genotype and the inflammatory condition, but also the estrogen pathway can cause al…
View article: Enhancing Composite Performance: Hydrothermally Treated Wood Reinforcement in Recycled Polypropylene
Enhancing Composite Performance: Hydrothermally Treated Wood Reinforcement in Recycled Polypropylene Open
The low thermal stability of cellulose presents unique technological challenges to the formulation of wood and plastic composites that are compatible and processable. For this, hydrothermal modification is a well-established technology for…
View article: Epigenetic regulation of complement C1Q gene expression
Epigenetic regulation of complement C1Q gene expression Open
Human C1q is a multifaceted complement protein whose functions range from activating the complement classical pathway to immunomodulation and promoting placental development and tumorigenesis. It is encoded by the C1QA , C1QB , and C1QC ge…
View article: The proline-rich antimicrobial peptide B7-005: low bacterial resistance, safe for human cells and effective in zebrafish embryo bacteraemia model
The proline-rich antimicrobial peptide B7-005: low bacterial resistance, safe for human cells and effective in zebrafish embryo bacteraemia model Open
Proline-rich antimicrobial peptides (PrAMPs) have gained attention due to their antimicrobial properties and low cytotoxicity. B7-005, a small optimized PrAMP, exhibits a broader spectrum of activity than native PrAMPs, due to an antimicro…
View article: Proangiogenic properties of complement protein C1q can contribute to endometriosis
Proangiogenic properties of complement protein C1q can contribute to endometriosis Open
Endometriosis (EM) is defined as the engraftment and proliferation of functional endometrial-like tissue outside the uterine cavity, leading to a chronic inflammatory condition. While the precise etiology of EM remains elusive, recent stud…
View article: Systematic review of the complement components as potential biomarkers of pre-eclampsia: pitfalls and opportunities
Systematic review of the complement components as potential biomarkers of pre-eclampsia: pitfalls and opportunities Open
The complement system (C) is a crucial component of the innate immune system. An increasing body of research has progressively shed light on the pivotal role of C in immunological tolerance at the feto-maternal interface. Excessive C activ…
View article: In Vitro and In Vivo Evaluation of the Effects of Drug 2c and Derivatives on Ovarian Cancer Cells
In Vitro and In Vivo Evaluation of the Effects of Drug 2c and Derivatives on Ovarian Cancer Cells Open
Background: The identification of novel therapeutic strategies for ovarian cancer (OC), the most lethal gynecological neoplasm, is of utmost urgency. Here, we have tested the effectiveness of the compound 2c (4-hydroxy-2,6-bis(4-nitrobenzy…
View article: In Vitro and In Vivo Evaluation of the Effects of Drug 2c and Derivatives on Ovarian Cancer Cells
In Vitro and In Vivo Evaluation of the Effects of Drug 2c and Derivatives on Ovarian Cancer Cells Open
Background: The identification of novel therapeutic strategies for Ovarian cancer (OC), the most lethal gynecological neoplasm, is of utmost urgency. Here, we have tested the effectiveness of the compound 2c (4-Hydroxy-2,6-bis(4-nitrobenzy…
View article: Protective role of complement factor H against the development of preeclampsia
Protective role of complement factor H against the development of preeclampsia Open
Pregnancy is an immunologically regulated, complex process. A tightly controlled complement system plays a crucial role in the successful establishment of pregnancy and parturition. Complement inhibitors at the feto-maternal interface are …
View article: The role of complement component C1q in angiogenesis
The role of complement component C1q in angiogenesis Open
The complement component C1q plays a role as a pro-angiogenic factor in different contexts, acting in a complement-independent way. For example, this molecule is able to foster the remodeling of the spiral arteries for a physiological preg…
View article: Neutrophil-derived complement factor P induces cytotoxicity in basal-like cells via caspase 3/7 activation in pancreatic cancer
Neutrophil-derived complement factor P induces cytotoxicity in basal-like cells via caspase 3/7 activation in pancreatic cancer Open
Due to profound heterogeneity within stromal immune tumor microenvironment (TME), pancreatic ductal adenocarcinoma (PDAC) remains a hard to treat disease, with the lowest 5-year survival below 10%. Large-scale transcriptomic analysis has r…
View article: A likely association between low mannan-binding lectin level and brain fog onset in long COVID patients
A likely association between low mannan-binding lectin level and brain fog onset in long COVID patients Open
Brain fog can be described as a constellation of new-onset neuropsychiatric sequelae in the post-acute phase of COVID-19 (long COVID). The symptoms include inattention, short-term memory loss, and reduced mental acuity, which may undermine…
View article: Complement protein C1q stimulates hyaluronic acid degradation via gC1qR/HABP1/p32 in malignant pleural mesothelioma
Complement protein C1q stimulates hyaluronic acid degradation via gC1qR/HABP1/p32 in malignant pleural mesothelioma Open
Complement component C1q can act as a pro-tumorigenic factor in the tumor microenvironment (TME). The TME in malignant pleural mesothelioma (MPM) is rich in C1q and hyaluronic acid (HA), whose interaction enhances adhesion, migration and p…
View article: Genetic bases of C7 deficiency: systematic review and report of a novel deletion determining functional hemizygosity
Genetic bases of C7 deficiency: systematic review and report of a novel deletion determining functional hemizygosity Open
Primary complement system (C) deficiencies are rare but notably associated with an increased risk of infections, autoimmunity, or immune disorders. Patients with terminal pathway C-deficiency have a 1,000- to 10,000-fold-higher risk of Nei…
View article: Editorial: Updates on the complement system in kidney diseases
Editorial: Updates on the complement system in kidney diseases Open
EDITORIAL article Front. Immunol., 06 April 2023Sec. Molecular Innate Immunity Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1196487
View article: Anti-Spike Antibodies Present in the Milk of SARS-CoV-2 Vaccinated Mothers Are Complement-Activating
Anti-Spike Antibodies Present in the Milk of SARS-CoV-2 Vaccinated Mothers Are Complement-Activating Open
Although only 0.8–1% of SARS-CoV-2 infections are in the 0–9 age-group, pneumonia is still the leading cause of infant mortality globally. Antibodies specifically directed against SARS-CoV-2 spike protein (S) are produced during severe COV…
View article: Ischemic wound revascularization by the stromal vascular fraction relies on host-donor hybrid vessels
Ischemic wound revascularization by the stromal vascular fraction relies on host-donor hybrid vessels Open
Nonhealing wounds place a significant burden on both quality of life of affected patients and health systems. Skin substitutes are applied to promote the closure of nonhealing wounds, although their efficacy is limited by inadequate vascul…
View article: A longitudinal study of C1q and anti-C1q autoantibodies in homologous and heterologous pregnancies for predicting pre-eclampsia
A longitudinal study of C1q and anti-C1q autoantibodies in homologous and heterologous pregnancies for predicting pre-eclampsia Open
C1q, the recognition molecule of the classical pathway of the complement system, plays a central role in pregnancy. Lack of C1q is characterized by poor trophoblast invasion and pregnancy failure. C1q can be the target of an antibody respo…
View article: SARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeability
SARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeability Open
SARS-CoV-2 is a devastating virus that induces a range of immunopathological mechanisms including cytokine storm, apoptosis, inflammation and complement and coagulation pathway hyperactivation. However, how the infection impacts pregnant m…
View article: A non-redundant role of complement protein C1q in normal and adverse pregnancy
A non-redundant role of complement protein C1q in normal and adverse pregnancy Open
Complement component 1q (C1q) is the recognition molecule of the classical pathway of the complement system that can bind to an array of closely spaced antigen-bound immunoglobulin G (IgG) and IgM antibodies. In addition to its involvement…
View article: Effective re-vascularization of non-healing wounds by the Stromal Vascular Fraction relies on the formation of hybrid vessels between host and transplanted cells.
Effective re-vascularization of non-healing wounds by the Stromal Vascular Fraction relies on the formation of hybrid vessels between host and transplanted cells. Open
With the increased prevalence of chronic diseases, non-healing wounds place a significant burden on both the quality of life of affected patients and health systems. Skin substitutes are applied to promote the closure of non-healing wounds…
View article: Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation
Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation Open
Lung surfactant protein D (SP-D) and Dendritic cell-specific intercellular adhesion molecules-3 grabbing non-integrin (DC-SIGN) are pathogen recognising C-type lectin receptors. SP-D has a crucial immune function in detecting and clearing …
View article: Distinct Roles of Classical and Lectin Pathways of Complement in Preeclamptic Placentae
Distinct Roles of Classical and Lectin Pathways of Complement in Preeclamptic Placentae Open
Pre-eclampsia is a pregnancy complication characterized by defective vascular remodeling in maternal decidua responsible for reduced blood flow leading to functional and structural alterations in the placenta. We have investigated the cont…