Charles R. Thomas
YOU?
Author Swipe
View article: Systematic review and consensus conceptual model of meaningful symptoms and functional impacts in early Parkinson’s Disease
Systematic review and consensus conceptual model of meaningful symptoms and functional impacts in early Parkinson’s Disease Open
A comprehensive, patient-centered conceptual model of early Parkinson’s is lacking and is greatly needed. A systematic review and meta-synthesis of qualitative and quantitative research was conducted by a multi-stakeholder taskforce using …
View article: Postprogression therapy and confounding for the estimated treatment effect on overall survival in phase III oncology trials
Postprogression therapy and confounding for the estimated treatment effect on overall survival in phase III oncology trials Open
Objective Estimations of the treatment effect on overall survival (OS) may be influenced by post-progression therapies (PPTs). It is unclear how often OS analyses account for PPT effects. The purpose of this cross-sectional analysis was to…
View article: Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect
Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect Open
The skin FLASH sparing effect is significantly reduced when using oxygen during anesthesia rather than room air. FLASH sparing was also reduced in female mice compared to male mice. Both tissue oxygenation and sex are likely sources of var…
View article: Empirically Derived Principles for Research Funding Success: A Primer for Early Career Academic Investigators
Empirically Derived Principles for Research Funding Success: A Primer for Early Career Academic Investigators Open
Radiation oncology is unique among oncologic specialties due to its high exposure to scientific research. Notably, most radiation oncology residents spend 9 to 12 months of training conducting research, and a considerable number become aca…
View article: Clinical value of random esophageal biopsies in patients with dysphagia and normal endoscopy who are treated with a proton pump inhibitor
Clinical value of random esophageal biopsies in patients with dysphagia and normal endoscopy who are treated with a proton pump inhibitor Open
Summary Rome IV recommended esophageal biopsies in patients with dysphagia and normal endoscopy to exclude mucosal disease. Thus far, studies evaluating the utility of this recommendation remain scarce. The aims of this study were to deter…
View article: Variables associated with admission rates among cancer patients presenting to emergency departments: a CONCERN group study
Variables associated with admission rates among cancer patients presenting to emergency departments: a CONCERN group study Open
Background Patients with cancer visit the emergency department often and have a high rate of admission compared to other patients. Admission rates by institution may vary widely, even after accounting for patient and hospital-specific char…
View article: Anesthetic oxygen use and sex are critical factors in the FLASH sparing effect
Anesthetic oxygen use and sex are critical factors in the FLASH sparing effect Open
Introduction Ultra-high dose-rate (UHDR) radiation has been reported to spare normal tissue compared to conventional dose-rate (CDR) radiation. However, reproducibility of the FLASH effect remains challenging due to varying dose ranges, ra…
View article: Disparities in outcomes and access to therapy options in hepatocellular carcinoma
Disparities in outcomes and access to therapy options in hepatocellular carcinoma Open
Background Hepatocellular carcinoma (HCC) disproportionately impacts racial and ethnic minorities and patients with lower socioeconomic status. These social determinants of health (SDH) lead to disparities in access to care and outcomes. W…
View article: Effects of UHDR and Conventional Irradiation on Behavioral and Cognitive Performance and the Percentage of Ly6G+ CD45+ Cells in the Hippocampus
Effects of UHDR and Conventional Irradiation on Behavioral and Cognitive Performance and the Percentage of Ly6G+ CD45+ Cells in the Hippocampus Open
We assessed the effects of conventional and ultra-high dose rate (UHDR) electron irradiation on behavioral and cognitive performance one month following exposure and assessed whether these effects were associated with alterations in the nu…
View article: Incidence of Primary End Point Changes Among Active Cancer Phase 3 Randomized Clinical Trials
Incidence of Primary End Point Changes Among Active Cancer Phase 3 Randomized Clinical Trials Open
Importance Primary end point (PEP) changes to an active clinical trial raise questions regarding trial quality and the risk of outcome reporting bias. It is unknown how the frequency and transparency of the reported changes depend on repor…
View article: Effects of UHDR and Conventional Irradiation on Behavioral and Cognitive Performance and the Percent Ly6G+ CD45+ Cells in the Hippocampus
Effects of UHDR and Conventional Irradiation on Behavioral and Cognitive Performance and the Percent Ly6G+ CD45+ Cells in the Hippocampus Open
In the current study, we assessed the effects of conventional and Ultra High Dose Rate (UHDR) irradiation on behavioral and cognitive performance one month following exposure and assessed whether these effects were associated with alterati…
View article: Phase 2 study of preoperative chemotherapy with nab‐paclitaxel and gemcitabine followed by chemoradiation for borderline resectable or node‐positive pancreatic ductal adenocarcinoma
Phase 2 study of preoperative chemotherapy with nab‐paclitaxel and gemcitabine followed by chemoradiation for borderline resectable or node‐positive pancreatic ductal adenocarcinoma Open
Background Neoadjuvant treatment with nab‐paclitaxel and gemcitabine for potentially operable pancreatic adenocarcinoma has not been well studied in a prospective interventional trial and could down‐stage tumors to achieve negative surgica…
View article: Association of fall rate and functional status by <i>APOE</i> genotype in cancer survivors after exercise intervention
Association of fall rate and functional status by <i>APOE</i> genotype in cancer survivors after exercise intervention Open
APOE genotype may modulate cancer treatment related side effects and symptoms and response to exercise intervention.
View article: Angiotensin receptor blockade and stereotactic body radiation therapy for early stage lung cancer ARB & SBRT for early stage lung cancer
Angiotensin receptor blockade and stereotactic body radiation therapy for early stage lung cancer ARB & SBRT for early stage lung cancer Open
Stereotactic body radiotherapy (SBRT) demonstrates excellent local control in early stage lung cancer, however a quarter of patients develop recurrence or distant metastasis. Transforming growth factor-beta (TGF-β) supports metastasis and …
View article: Oncologic emergencies and urgencies: A comprehensive review
Oncologic emergencies and urgencies: A comprehensive review Open
Patients with advanced cancer generate 4 million visits annually to emergency departments (EDs) and other dedicated, high‐acuity oncology urgent care centers. Because of both the increasing complexity of systemic treatments overall and the…
View article: Palliative Care Needs and Clinical Outcomes of Patients with Advanced Cancer in the Emergency Department
Palliative Care Needs and Clinical Outcomes of Patients with Advanced Cancer in the Emergency Department Open
Background: Older adults with cancer use the emergency department (ED) for acute concerns. Objectives: Characterize the palliative care needs and clinical outcomes of advanced cancer patients in the ED. Design: A planned secondary data ana…
View article: Neoadjuvant Therapy Is Associated with Improved Chemotherapy Delivery and Overall Survival Compared to Upfront Resection in Pancreatic Cancer without Increasing Perioperative Complications
Neoadjuvant Therapy Is Associated with Improved Chemotherapy Delivery and Overall Survival Compared to Upfront Resection in Pancreatic Cancer without Increasing Perioperative Complications Open
The role of neoadjuvant chemoradiotherapy and/or chemotherapy (neoCHT) in patients with pancreatic ductal adenocarcinoma (PDAC) is poorly defined. We hypothesized that patients who underwent neoadjuvant therapy (NAT) would have improved sy…
View article: Observation unit use among patients with cancer following emergency department visits: Results of a multicenter prospective cohort from CONCERN
Observation unit use among patients with cancer following emergency department visits: Results of a multicenter prospective cohort from CONCERN Open
Purpose Emergency department (ED) visits by patients with cancer frequently end in hospitalization. As concerns about ED and hospital crowding increase, observation unit care may be an important strategy to deliver safe and efficient treat…
View article: Three-Year Experience of a Multidisciplinary Central Nervous System Clinic Model for Radiation Oncology and Neurosurgery (RADIANS) in a Community Hospital Setting
Three-Year Experience of a Multidisciplinary Central Nervous System Clinic Model for Radiation Oncology and Neurosurgery (RADIANS) in a Community Hospital Setting Open
Background: As academic centers partner and establish healthcare systems with community hospitals, delivery of subspecialty, multidisciplinary care in community hospital settings remains a challenge. Improving outcomes for central nervous …
View article: Examining pain among non‐Hispanic Black and non‐Hispanic White patients with cancer visiting emergency departments: CONCERN (Comprehensive Oncologic Emergencies Research Network)
Examining pain among non‐Hispanic Black and non‐Hispanic White patients with cancer visiting emergency departments: CONCERN (Comprehensive Oncologic Emergencies Research Network) Open
Pain is common in patients with cancer1 seeking emergency department (ED) care.2 Fifty percent of ED patients with cancer present with pain and 39% report pain at final ED pain assessment.3 Thus, ED practitioners seemingly remain challenge…
View article: Mitigating Implicit Bias in Radiation Oncology
Mitigating Implicit Bias in Radiation Oncology Open
Implicit bias is one of the most insidious and least recognizable mechanisms that can cause inequity and disparities. There is increasing evidence that both implicit and explicit biases have a negative effect on patient outcomes and patien…
View article: Radiation-Induced Toxicity in the Era of Stereotactic Body Radiation Therapy—Lessons From NRG-BR001
Radiation-Induced Toxicity in the Era of Stereotactic Body Radiation Therapy—Lessons From NRG-BR001 Open
Steve Chmura, MD, PhD; Kathryn A. Winter, MS; Clifford Robinson, MD; Thomas M. Pisansky, MD; Virginia Borges, MD; Hania Al-Hallaq, PhD; Martha Matuszak, PhD; Sean S. Park, MD; Sun Yi, MD; Yasmin Hasan, MD; Jose Bazan, MD; Philip Wong, MD; …