Weihua Chen
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View article: Adrenal cavernous lymphangioma successfully treated with robot-assisted laparoscopic adrenalectomy: a case description
Adrenal cavernous lymphangioma successfully treated with robot-assisted laparoscopic adrenalectomy: a case description Open
View article: A novel deep learning model based on multimodal contrast-enhanced ultrasound dynamic video for predicting occult lymph node metastasis in papillary thyroid carcinoma
A novel deep learning model based on multimodal contrast-enhanced ultrasound dynamic video for predicting occult lymph node metastasis in papillary thyroid carcinoma Open
Objective This study aimed to evaluate the value of constructing a multimodal deep-learning video model based on 2D ultrasound and contrast-enhanced ultrasound (CEUS) dynamic video for the preoperative prediction of OLNM in papillary thyro…
View article: BOOST: a robust ten-fold expansion method on hour-scale
BOOST: a robust ten-fold expansion method on hour-scale Open
Expansion microscopy enhances the microscopy resolution by physically expanding biological specimens and improves the visualization of structural and molecular details. Numerous expansion microscopy techniques and labeling methods have bee…
View article: BEX4 inhibits the progression of clear cell renal cell carcinoma by stabilizing SH2D4A, which is achieved by blocking SIRT2 activity
BEX4 inhibits the progression of clear cell renal cell carcinoma by stabilizing SH2D4A, which is achieved by blocking SIRT2 activity Open
Clear cell renal cell carcinoma (ccRCC) is one of the most common malignancies. Recently, the role of brain-expressed X-linked 4 (BEX4) in cancer progression has received increasing attention. This study aimed to investigate the function o…
View article: UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells
UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells Open
View article: Full Field Optical Coherence Tomography (FFOCT) to analyze prostate biopsy core in-office: a new step to real-time cancer diagnosis
Full Field Optical Coherence Tomography (FFOCT) to analyze prostate biopsy core in-office: a new step to real-time cancer diagnosis Open
BACKGROUND Focal therapy for prostate cancer is rising. One of the actual challenge is the management of the margins. A real-time cancer diagnosis device could be a useful tool to control margins during focal therapy. Full Field Optical Co…
View article: Exposure to Butylparaben Induces Craniofacial Bone Developmental Toxicity in Zebrafish (Danio rerio) Embryos
Exposure to Butylparaben Induces Craniofacial Bone Developmental Toxicity in Zebrafish (Danio rerio) Embryos Open
Butylparaben (BuP) is a common antibacterial preservative utilized extensively in food, medical supplies, cosmetics, and personal care products. The current study reports the use of Zebrafish (Danio rerio) embryos to investigate potential …
View article: Red blood cell distribution width predicts gastrointestinal bleeding after coronary artery bypass grafting
Red blood cell distribution width predicts gastrointestinal bleeding after coronary artery bypass grafting Open
Background Red blood cell distribution width (RDW) is highly associated with adverse clinical outcomes in many diseases. The present study aimed to evaluate the relationship between RDW and gastrointestinal bleeding (GIB) after isolated co…
View article: Deleted in liver cancer 1 suppresses the growth of prostate cancer cells through inhibiting Rho-associated protein kinase pathway
Deleted in liver cancer 1 suppresses the growth of prostate cancer cells through inhibiting Rho-associated protein kinase pathway Open
Our results indicated that DLC1 overexpression markedly suppressed the proliferation and cell cycle progression of PCa cells and negatively correlated with ROCK expression in PCa cells and tissue.
View article: Qici Sanling Decoction Suppresses Glutamine Consumption and Bladder Cancer Cell Growth through Inhibiting c-Myc Expression
Qici Sanling Decoction Suppresses Glutamine Consumption and Bladder Cancer Cell Growth through Inhibiting c-Myc Expression Open
Traditional Chinese medicine (TCM) is widely used as an alternative therapy for cancer treatment in China. Glutamine catabolism plays an important role in cancer development. Qici Sanling decoction (QCSL) suppresses bladder cancer growth. …
View article: Platelet-to-hemoglobin ratio as a valuable predictor of long-term all-Cause mortality in coronary artery disease patients with congestive heart failure
Platelet-to-hemoglobin ratio as a valuable predictor of long-term all-Cause mortality in coronary artery disease patients with congestive heart failure Open
Background The platelet-to-hemoglobin ratio (PHR) has emerged as a prognostic biomarker in coronary artery disease (CAD) patients after PCI but not clear in CAD complicated with congestive heart failure (CHF). Hence, we aimed to assess the…
View article: A Glycolysis Gene Methylation Prediction Model Based on Explainable Machine Learning for Alzheimer's Disease
A Glycolysis Gene Methylation Prediction Model Based on Explainable Machine Learning for Alzheimer's Disease Open
View article: miR‑483‑3p promotes the osteogenesis of human osteoblasts by�targeting Dikkopf 2 (DKK2) and the Wnt signaling pathway
miR‑483‑3p promotes the osteogenesis of human osteoblasts by�targeting Dikkopf 2 (DKK2) and the Wnt signaling pathway Open
Osteoporosis is a systemic metabolic bone disease during which bone mass decreases and bone quality is reduced. Maintaining the bone formation capacity of osteoblasts is crucial for the treatment of osteoporosis. In the present study, bioi…
View article: Significant association between GPR50 hypomethylation and AD in males
Significant association between GPR50 hypomethylation and AD in males Open
Alzheimer's disease (AD) is a chronic neurodegenerative disease. G protein coupled receptor 50 (GPR50) is a candidate gene for AD. The present study was designed to determine the association between GPR50 methylation and AD. The methylatio…
View article: Rho-Associated Protein Kinase (ROCK) Promotes Proliferation and Migration of PC-3 and DU145 Prostate Cancer Cells by Targeting LIM Kinase 1 (LIMK1) and Matrix Metalloproteinase-2 (MMP-2)
Rho-Associated Protein Kinase (ROCK) Promotes Proliferation and Migration of PC-3 and DU145 Prostate Cancer Cells by Targeting LIM Kinase 1 (LIMK1) and Matrix Metalloproteinase-2 (MMP-2) Open
BACKGROUND In the pathogenesis and progression of prostate cancer, cell proliferation and cell migration results in tumor invasion and metastasis that is associated with patient morbidity and mortality. Rho-associated protein kinase (ROCK)…
View article: Qici Sanling decoction suppresses bladder cancer growth by inhibiting the Wnt/Β-catenin pathway
Qici Sanling decoction suppresses bladder cancer growth by inhibiting the Wnt/Β-catenin pathway Open
Context: Bladder cancer, which has high recurrence, is one of the most deadly cancers in the world. Astragalus propinquus Schischkin (Fabaceae) and Sagittaria sagittifolia L. (Alismataceae) are important herbs reported…
View article: Expression of ARHGAP10 correlates with prognosis of prostate cancer.
Expression of ARHGAP10 correlates with prognosis of prostate cancer. Open
Prostate cancer is one of the most common malignancies in men worldwide. Altered expression of ARHGAP10, a member of the Rho GTPase activating protein (RhoGAP) family, has been found in several human cancers. However, its clinical signific…
View article: Power Grid Development Planning Based on Small World Model
Power Grid Development Planning Based on Small World Model Open
There are two main directions of the further development of power grid. One is the construction of higher voltage power grid. The other is strengthen power grid by keeping the original voltage grade. The current research of the two power g…
View article: Mucosal-Associated Invariant T Cells Improve Nonalcoholic Fatty Liver Disease Through Regulating Macrophage Polarization
Mucosal-Associated Invariant T Cells Improve Nonalcoholic Fatty Liver Disease Through Regulating Macrophage Polarization Open
Mucosal-associated invariant T (MAIT) cells, a novel population of innate-like lymphocytes, have been involved in various inflammatory and autoimmune diseases. However, their role in the development of nonalcoholic fatty liver disease (NAF…
View article: Microwave ablation of ex vivo human undifferentiated pleomorphic sarcoma
Microwave ablation of ex vivo human undifferentiated pleomorphic sarcoma Open
Background: Many undifferentiated pleomorphic sarcoma (UPS) patients had lost the opportunity of surgical therapy. Microwave (MW) ablation of UPS can be an effective method for achieving local tumor control while preserving the relative fu…
View article: Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer
Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer Open
Prostate cancer (PCa) is the second most common male cancer worldwide and the fifth leading cause of death from cancer in men. Early detection and risk stratification is the most effective way to improve the survival of PCa patients. Curre…
View article: Decreased expression of SLC39A14 is associated with tumor aggressiveness and biochemical recurrence of human prostate cancer
Decreased expression of SLC39A14 is associated with tumor aggressiveness and biochemical recurrence of human prostate cancer Open
Decreased expression of SLC39A14 may lead to malignant phenotypes of PCa cells and aggressive tumor progression in patients with PCa. Importantly, SLC39A14 may function as a tumor suppressor and a biomarker for screening patients with bioc…
View article: High RhoA expression at the tumor front in clinically localized prostate cancer and association with poor tumor differentiation
High RhoA expression at the tumor front in clinically localized prostate cancer and association with poor tumor differentiation Open
Ras homolog gene family, member A (RhoA) has been reported as essential to the invasion process and aggressiveness of numerous cancers. However, there are only sparse data on the expression and activity of RhoA in clinically localised pros…
View article: Adaptability Among Power Source, Power Grid and Load Based on Game Theory
Adaptability Among Power Source, Power Grid and Load Based on Game Theory Open
The coordinated development of power grid and load is one of the basic factors to optimize the social resources and to improve the equipment utilization.The decision makers of power grid and load are different.And their focuses are also di…