R. Charles Kissell
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View article: Molecular basis for the activation of the bitter taste receptor TAS2R14 by Ritonavir
Molecular basis for the activation of the bitter taste receptor TAS2R14 by Ritonavir Open
Ritonavir is a protease inhibitor used in combination with other antiretroviral drugs to treat HIV, especially in children. It enhances the effectiveness of these drugs by inhibiting the cytochrome P450-3A4 enzyme, thereby increasing their…
View article: PI(4,5)P2 regulates the gating of NaV1.4 channels
PI(4,5)P2 regulates the gating of NaV1.4 channels Open
Voltage-gated sodium (NaV) channels are densely expressed in most excitable cells and activate in response to depolarization, causing a rapid influx of Na+ ions that initiates the action potential. The voltage-dependent activation of NaV c…