Explanipedia

Sex Differences in Atherosclerotic Coronary Artery Disease Patterns Open

Kazumasa Ikeda, Daniel Munhoz, Sofie Brouwers, Hitoshi Matsuo, Toshiro Shinke , et al. · 2025

Background Sex differences in coronary artery disease (CAD) have been increasingly recognized, as women present with distinct clinical characteristics and outcomes compared with men. This study investigated the impact of sex on pathophysio…

Vessel‐Specific Myocardial Mass in Patients With Stable Coronary Artery Disease Open

Nikolaos Stalikas, Takuya Mizukami, Frédéric Bouisset, Kazumasa Ikeda, Atomu Tajima , et al. · 2025

Background Assessing the myocardial mass at risk is essential in evaluating patients with coronary artery disease. This study aims to establish reference values for vessel‐specific myocardial mass derived from coronary computed tomography …

Randomized Comparison of Fractional Flow Reserve and Instantaneous Wave Free Ratio in Serial Disease Open

Matthew Li Kam Wa, Saad Ezad, Bhavik Modi, Ozan M. Demir, Jonathan Hinton , et al. · 2025

FFR and iFR pullback gradients overestimate the benefit of target lesion PCI and can miss residual ischemia in one-third of patients. FFR or iFR should be routinely repeated post-PCI in serial disease.

Angiography‐Based Blood Flow Quantification After Revascularization in Acute Coronary Syndromes Open

Koshiro Sakai, Takuya Mizukami, Hirofumi Ohashi, Frédéric Bouisset, Giulia Botti , et al. · 2025

Background In patients presenting with acute coronary syndromes (ACS), impaired coronary blood flow (CBF) after percutaneous coronary interventions (PCI) is linked to mortality. We developed a novel angiography‐based approach for blood flo…

Exploring the association between coronary vascular anatomical features and future myocardial infarction through statistical shape modelling Open

Bianca Griffo, Maurizio Lodi Rizzini, Alessandro Candreva, Carlos Collet, Takuya Mizukami , et al. · 2025

Considering the intricate interplay among coronary anatomy and hemodynamics in coronary artery disease (CAD), anatomy-based descriptors have been employed as surrogates of local aberrant hemodynamics and, ultimately, as clinical markers fo…

Coronary computed tomography angiography to guide percutaneous coronary intervention: Expert opinion from a SCAI/SCCT roundtable Open

Yader Sandoval, Jonathon Leipsic, Carlos Collet, Ziad A. Ali, Lorenzo Azzalini , et al. · 2025

Coronary computed tomography angiography (CCTA) has emerged as an important tool for planning percutaneous coronary intervention (PCI). While it has traditionally been employed for diagnostic purposes, increasing evidence and real-world ex…

Coronary Computed Tomography Angiography to Guide Percutaneous Coronary Intervention: Expert Opinion from a SCAI/SCCT Roundtable Open

Yader Sandoval, Jonathon Leipsic, Carlos Collet, Ziad A. Ali, Lorenzo Azzalini , et al. · 2025

Coronary computed tomography angiography (CCTA) has emerged as an important tool for planning percutaneous coronary intervention (PCI). While it has traditionally been employed for diagnostic purposes, increasing evidence and real-world ex…

The Pullback Pressure Gradient Open

Pedro E P Carvalho, Carlos Collet, Bernard De Bruyne, Daniel Munhoz, Jeroen Sonck , et al. · 2025

Fractional flow reserve is the most widely used physiologic index to establish the functional significance of epicardial coronary artery disease (CAD). Fractional flow reserve guides clinical decisions toward or against coronary revascular…

Hemoglobin-to-Creatinine Ratio Predicts One-Year Adverse Clinical Outcomes in ST-Elevation Myocardial Infarction: Retrospective and Propensity Score Matched Analysis Open

Luigi Spadafora, Stefano Cacciatore, Mattía Galli, Carlos Collet, Matteo Betti , et al. · 2025

Background/Objectives: Anemia and renal impairment are key predictors of adverse outcomes in acute coronary syndromes (ACSs). The hemoglobin-to-creatinine (Hb/Cr) ratio combines these parameters into a simple index. This study aimed to eva…

Left Ventricular Unloading in Nonischemic Dilated Cardiomyopathy Improves Coronary Haemodynamic Reserve Open

Samer Fawaz, Rohini Ramaseshan, Sarosh Khan, John R. Davies, Carlos Collet , et al. · 2025

Background The Impella CP is a catheter‐based ventricular assist device used in the management of cardiogenic shock and to support high‐risk percutaneous coronary interventions (PCI). Despite its growing use, the effects of Impella CP on c…

A Diffusion Model for Simulation Ready Coronary Anatomy with Morpho-Skeletal Control Open

Karim Kadry, Shreya Gupta, Jonas Sogbadji, Michiel Schaap, Kersten Petersen , et al. · 2024

A Diffusion Model for Simulation Ready Coronary Anatomy with Morpho-skeletal Control Open

Karim Kadry, Shreya Gupta, Jonas Sogbadji, Michiel Schaap, Kersten Petersen , et al. · 2024

Virtual interventions enable the physics-based simulation of device deployment within coronary arteries. This framework allows for counterfactual reasoning by deploying the same device in different arterial anatomies. However, current meth…

Novel diagnostic approaches and management of coronary microvascular dysfunction Open

Graziella Pompei, Nandine Ganzorig, Christos P. Kotanidis, Mohammad Alkhalil, Carlos Collet , et al. · 2024

The mechanism underlying ischaemic heart disease (IHD) has been primarily attributed to obstructive coronary artery disease (CAD). However, non-obstructive coronary arteries are identified in >50% of patients undergoing elective coronary a…

Influence of Pathophysiologic Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes Open

Carlos Collet, Daniel Munhoz, Takuya Mizukami, Jeroen Sonck, Hitoshi Matsuo , et al. · 2024

BACKGROUND: Diffuse coronary artery disease affects the safety and efficacy of percutaneous coronary intervention (PCI). Pathophysiologic coronary artery disease patterns can be quantified using fractional flow reserve (FFR) pullbacks inco…

A Systematic Approach to the Evaluation of the Coronary Microcirculation Using Bolus Thermodilution: CATH CMD Open

Carlos Collet, A. Yong, Daniel Munhoz, Takashi Akasaka, Colin Berry , et al. · 2024

Coronary microvascular dysfunction (CMD) can cause myocardial ischemia in patients presenting with angina without obstructive coronary artery disease (ANOCA). Evaluating for CMD by using the thermodilution technique offers a widely accessi…

Association Between Automated 3D Measurement of Coronary Luminal Narrowing and Risk of Future Myocardial Infarction Open

Alessandro Candreva, Maurizio Lodi Rizzini, Karol Calò, Mattia Pagnoni, Daniel Munhoz , et al. · 2024

Advanced CT Imaging for the Assessment of Calcific Coronary Artery Disease and PCI Planning Open

Atomu Tajima, Frédéric Bouisset, Hirofumi Ohashi, Koshiro Sakai, Takuya Mizukami , et al. · 2024

Vascular calcification is a hallmark of atherosclerosis and adds considerable challenges for percutaneous coronary intervention (PCI). This review underscores the critical role of coronary computed tomography (CT) angiography in assessing …

Intravascular Imaging Findings After PCI in Patients With Focal and Diffuse Coronary Artery Disease Open

Hirofumi Ohashi, Takuya Mizukami, Jeroen Sonck, Frédéric Bouisset, Brian Ko , et al. · 2024

Background Following percutaneous coronary intervention (PCI), optical coherence tomography provides prognosis information. The pullback pressure gradient is a novel index that discriminates focal from diffuse coronary artery disease based…

Measuring Absolute Coronary Flow and Microvascular Resistance by Thermodilution Open

Marta Belmonte, Emanuele Gallinoro, Nico H.J. Pijls, Dario Tino Bertolone, Danielle Keulards , et al. · 2024

Diagnosing coronary microvascular dysfunction remains challenging, primarily due to the lack of direct measurements of absolute coronary blood flow (Q) and microvascular resistance (R_μ). However, there has been recent progress w…

Head-to-head comparison of two angiography-derived fractional flow reserve techniques in patients with high-risk acute coronary syndrome: A multicenter prospective study Open

Ioannis Skalidis, Nathalie Noirclerc, David Meier, Wongsakorn Luangphiphat, Aurelien Cagnina , et al. · 2023

Differential Impact of Fractional Flow Reserve Measured After Coronary Stent Implantation by Left Ventricular Dysfunction Open

Ki Hong Choi, Woochan Kwon, Doosup Shin, Seung Hun Lee, Doyeon Hwang , et al. · 2023

Coronary CT Angiography in the Cath Lab: Leveraging Artificial Intelligence to Plan and Guide Percutaneous Coronary Intervention Open

Hirofumi Ohashi, Frédéric Bouisset, Dimitri Buytaert, Ruiko Seki, Jeroen Sonck , et al. · 2023

The role of coronary CT angiography for the diagnosis and risk stratification of coronary artery disease is well established. However, its potential beyond the diagnostic phase remains to be determined. The current review focuses on the in…

Can Coronary Flow Reserve After Stenting Be a Useful Predictor of Target Vessel Failure? Open

Hirohiko Ando, Carlos Collet, Tetsuya Amano · 2023

Artificial Intelligence–based Coronary Stenosis Quantification at Coronary CT Angiography versus Quantitative Coronary Angiography Open

James Dundas, Jonathon Leipsic, Stephanie Sellers, Philipp Blanke, Patrícia Miranda , et al. · 2023

Purpose To evaluate the performance of a new artificial intelligence (AI)-based tool by comparing the quantified stenosis severity at coronary CT angiography (CCTA) with a reference standard derived from invasive quantitative coronary angi…

Endotypes of coronary microvascular dysfunction in patients with and without Diabetes Mellitus Open

Emanuele Gallinoro, Pasquale Paolisso, Dario Tino Bertolone, Marta Belmonte, Giuseppe Esposito , et al. · 2023

Background Coronary microvascular dysfunction (CMD) is an early feature of diabetic cardiomyopathy, which usually precedes the onset of ventricular dysfunction. Continuous intracoronary thermodilution allows an accurate and reproducible as…

Microvascular Resistance Reserve assessed by bolus and continuous thermodilution Open

Emanuele Gallinoro, Dario Tino Bertolone, Marta Belmonte, Pasquale Paolisso, Takuya Mizukami , et al. · 2023

Aim The main limitation of Coronary flow reserve (CFR) as an index to assess coronary microvascular function, is that it is influenced by epicardial resistance. Microvascular Resistance Reserve (MRR) has been recently introduced as a metri…

Impact of coronary physiological phenotypes on the immediate angiography-derived hemodynamic results of percutaneous coronary intervention Open

Bei Wang, Tzung‐Yi Tsai, X Q Hery, Nozomi Kotoku, Sumit Garg , et al. · 2023

Background Angiography-based technologies can evaluate the physiological phenotypes of coronary artery disease (CAD) and the functional results of percutaneous coronary intervention (PCI), however, few studies have combined these to assess…

Cost-effectiveness analysis of PCI in focal and diffuse coronary artery disease Open

D M Munhoz, Mark A. Hlatky, Damien Collison, Colin Berry, K Oldroy , et al. · 2023

Aims The pattern of CAD predicts angina relief after PCI. Our aim was to evaluate the cost-effectiveness of PCI in diffuse coronary artery disease (CAD) to deferral from PCI in these patients. Methods This is a sub-analysis of the TARGET-F…

Comparison of two angiography-based FFR techniques in NSTEMI Patients: A Multicenter Study Open

Ioannis Skalidis, David Meier, O Luangphiphat, Sarah Mauler‐Wittwer, Nathalie Noirclerc , et al. · 2023

Background Recently, non-invasive methods ("wire free") to functionally assess the hemodynamic severity of a coronary artery have emerged. FFRangio and QFR are angiography-based technologies that have been validated in patients with chroni…

Gender-related differences in absolute coronary flow and microvascular resistance in patients with angina and non-obstructed coronary arteries (ANOCA) Open

Marta Belmonte, Emanuele Gallinoro, Dario Tino Bertolone, Pasquale Paolisso, Michele Mattia Viscusi , et al. · 2023

Background Women with angina more often have non-obstructive coronary artery disease (ANOCA) compared to males. Coronary microvascular dysfunction (CMD) is responsible for angina in a sizable proportion of ANOCA patients. Intracoronary con…

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