Richard D. Pearson
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Understanding the global rise of artemisinin resistance: Insights from over 100,000 Plasmodium falciparum samples Open
Artemisinin partial resistance (ART-R) in Plasmodium falciparum is a major challenge to malaria control globally. Over the last two decades, ART-R has spread widely across Southeast Asia, undermining public health strategies and hindering …
View article: An expanded method for malaria parasite genetic surveillance using targeted nanopore sequencing
An expanded method for malaria parasite genetic surveillance using targeted nanopore sequencing Open
Malaria causes around 250 million cases and over 600,000 deaths annually, with the heaviest burden falling on young children living in sub-Saharan Africa. Molecular surveillance of Plasmodium parasites and Anopheles mosquito vectors are ke…
View article: Pf8: an open dataset of Plasmodium falciparum genome variation in 33,325 worldwide samples
Pf8: an open dataset of Plasmodium falciparum genome variation in 33,325 worldwide samples Open
We describe the Pf8 data resource, the latest MalariaGEN release of curated genome variation data on over 33,000 Plasmodium falciparum samples from 99 partner studies and 122 locations over more than 50 years. This release provides open ac…
Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at dhfr and dhps genes across Africa Open
Sulfadoxine-pyrimethamine (SP), despite emergence of mutations in dhfr and dhps genes associated with lower treatment efficacy, is still recommended for preventive malaria treatment. Therefore, it is important to understand the evolution o…
View article: T-cell activation and senescence in asymptomatic HIV/Leishmania infantum co-infection
T-cell activation and senescence in asymptomatic HIV/Leishmania infantum co-infection Open
Background Leishmania infantum can be an opportunistic pathogen, with an immunocompromised status increasing the risk of converting asymptomatic infection to symptomatic visceral leishmaniasis (VL). VL has approximately 5% fatality rate; a…
View article: Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at <i>dhfr</i> and <i>dhps</i> genes across Africa
Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at <i>dhfr</i> and <i>dhps</i> genes across Africa Open
Sulfadoxine-pyrimethamine (SP), despite the emergence and spread of mutations in dhfr and dhps genes associated with lower treatment efficacy, is still recommended alone or in combination by the WHO for preventive treatment in pregnant wom…
Pf-HaploAtlas: an interactive web app for spatiotemporal analysis of <i>Plasmodium falciparum</i> genes Open
Motivation Monitoring the genomic evolution of Plasmodium falciparum—the most widespread and deadliest of the human-infecting malaria species—is critical for making decisions in response to changes in drug resistance, diagnostic test failu…
View article: Microhaplotype deep sequencing assays to capture <i>Plasmodium vivax</i> infection lineages
Microhaplotype deep sequencing assays to capture <i>Plasmodium vivax</i> infection lineages Open
The elimination of Plasmodium vivax is challenged by dormant liver stages (hypnozoites) that can reactivate months after initial infection resulting in relapses that enhance transmission. Relapsing infections confound antimalarial clinical…
View article: Microhaplotype deep sequencing assays to capture Plasmodium vivax infection lineages
Microhaplotype deep sequencing assays to capture Plasmodium vivax infection lineages Open
The elimination of Plasmodium vivax is challenged by dormant liver stages (hypnozoites) that can reactivate months after initial infection resulting in relapses that enhance transmission. Relapsing infections confound antimalarial clinical…
Understanding the Global Spread of Artemisinin Resistance: Insights from over 100K <i>Plasmodium falciparum</i> Samples Open
Artemisinin partial resistance (ART-R) in Plasmodium falciparum is one of the most pressing threats to global malaria control. Over the last two decades, ART-R has spread widely across Southeast Asia, compromising public health strategies …
Pf-HaploAtlas: an interactive web app for spatiotemporal analysis of <i>P. falciparum</i> genes Open
Monitoring the genomic evolution of Plasmodium falciparum - the most widespread and deadliest of the human-infecting malaria species - is critical for making decisions in response to changes in drug resistance, diagnostic test failures, an…
View article: Genetic surveillance of <i>Plasmodium falciparum</i> populations following treatment policy revisions in the Greater Mekong Subregion
Genetic surveillance of <i>Plasmodium falciparum</i> populations following treatment policy revisions in the Greater Mekong Subregion Open
Genetic surveillance of Plasmodium falciparum ( Pf ) can track antimalarial-resistant strains, to inform decision-making by National Malaria Control Programmes (NMCPs). The GenRe-Mekong project prospectively collected 5,982 samples in the …
View article: Issue Information
Issue Information Open
Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries and…
View article: A complex <i>Plasmodium falciparum</i> cryptotype circulating at low frequency across the African continent
A complex <i>Plasmodium falciparum</i> cryptotype circulating at low frequency across the African continent Open
The population structure of the malaria parasite Plasmodium falciparum can reveal underlying demographic and adaptive evolutionary processes. Here, we analyse population structure in 4,376 P. falciparum genomes from 21 countries across Afr…
View article: Genomic analysis of Plasmodium vivax describes patterns of connectivity and putative drivers of adaptation in Ethiopia
Genomic analysis of Plasmodium vivax describes patterns of connectivity and putative drivers of adaptation in Ethiopia Open
Ethiopia has the greatest burden of Plasmodium vivax in Africa, but little is known about the epidemiological landscape of parasites across the country. We analysed the genomic diversity of 137 P. vivax isolates collected nine Ethiopian di…
View article: Genomic analysis of Plasmodium vivax identifies putative drivers of adaptation and connectivity across diverse districts in Ethiopia
Genomic analysis of Plasmodium vivax identifies putative drivers of adaptation and connectivity across diverse districts in Ethiopia Open
Ethiopia has the greatest burden of Plasmodium vivax in Africa, but little is known about the epidemiological landscape of parasites across the country. We analysed the genomic diversity of 137 P. vivax isolates collected nine Ethiopian di…
Genomics of Plasmodium vivax in Colombia: evidence of local bottle-necking and inter-country connectivity in the Americas Open
Colombia aims to eliminate malaria by 2030 but remains one of the highest burden countries in the Americas. Plasmodium vivax contributes half of all malaria cases, with its control challenged by relapsing parasitaemia, drug resistance and …
View article: Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1
Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1 Open
Malaria parasites break down host haemoglobin into peptides and amino acids in the digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is central to the mode of action of several antimalarial drugs.…
Potential decline in the distribution and food provisioning services of the mopane worm (Gonimbrasia belina) in southern Africa Open
The mopane worm (Gonimbrasia belina) is an edible insect distributed across southern Africa. As a culturally important source of food, the mopane worm provides nutrition, livelihoods and improves wellbeing for rural communities across its …
View article: T-cell activation, senescence, and exhaustion in asymptomatic HIV/Leish <i>mania infantum</i> co-infection
T-cell activation, senescence, and exhaustion in asymptomatic HIV/Leish <i>mania infantum</i> co-infection Open
Background Leishmania infantum is an opportunistic parasitic infection. An immunocompromised state increases the risk of converting asymptomatic infection to symptomatic visceral leishmaniasis (VL), which has a ∼5% fatality rate even with …
Nanopore sequencing for real-time genomic surveillance of <i>Plasmodium falciparum</i> Open
Malaria is a global public health priority causing over 600,000 deaths annually, mostly young children living in Sub-Saharan Africa. Molecular surveillance can provide key information for malaria control, such as the prevalence and distrib…
Malaria outbreak in Laos driven by a selective sweep for Plasmodium falciparum kelch13 R539T mutants: a genetic epidemiology analysis Open
For the Lao translation of the abstract see Supplementary Materials section.
Generation of a mutator parasite to drive resistome discovery in <i>Plasmodium falciparum</i> Open
In vitro evolution of drug resistance is a powerful approach for identifying antimalarial targets, however key obstacles to eliciting resistance are the parasite inoculum size and mutation rate. Here we sought to increase parasite genetic …