R. Dale Brown
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View article: Evaluation of a national digital pre-implantation biopsy service for deceased-donor kidney transplantation in the UK (Pithia trial): a stepped-wedge cluster randomised registry trial
Evaluation of a national digital pre-implantation biopsy service for deceased-donor kidney transplantation in the UK (Pithia trial): a stepped-wedge cluster randomised registry trial Open
NIHR Research for Patient Benefit programme (RfPB PB-PG-1215-20033).
View article: Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial Open
View article: Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload
Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload Open
This study analyzed microarray data of right ventricular (RV) tissue from rats exposed to pulmonary embolism to understand the initial dynamic transcriptional response to mechanical stress and compare it with experimental pulmonary hyperte…
View article: Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model
Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model Open
Using a large animal model and employing a comprehensive approach integrating hemodynamic, transcriptomic, proteomic, and immunohistochemical analyses, we examined the early (2 wk) effects of severe PH on the RV. We observed that RV remode…
View article: The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension
The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension Open
Hypoxia-inducible factor (HIF) has received much attention as a potential pulmonary hypertension (PH) treatment target because inhibition of HIF reduces the severity of established PH in rodent models. However, the limitations of small-ani…
View article: Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia
Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia Open
Few studies have examined lung interstitial macrophage (IM) molecular phenotypes after being exposed to hypoxia in vivo at the single-cell level, even though macrophages contribute to hypoxic pulmonary hypertension (PH). We aimed to determ…
View article: Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages
Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages Open
Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by complement-dependent, fibroblast-induced perivascular accumulation and proinflammatory activation of macrophages. We hypothesized that, in PH, nanoscale-sized…
View article: Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension
Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension Open
Pulmonary hypertension (PH) is an incurable condition in humans; driven by pulmonary vascular remodeling partially mediated by epigenetic mechanisms; and leading to right ventricular hypertrophy, failure, and death. We hypothesized that ta…
View article: Treat COVID-19, but Not Only COVID-19: Stroke Matters as Well
Treat COVID-19, but Not Only COVID-19: Stroke Matters as Well Open
Introduction: During the COVID-19 pandemic, studies reported less number of hospitalizations for acute stroke and reduction in the use of recanalization treatments. This study analyzes nationwide data on stroke admissions and…
View article: Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension
Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension Open
The recruitment and subsequent polarization of inflammatory monocytes/macrophages in the perivascular regions of pulmonary arteries is a key feature of pulmonary hypertension (PH). However, the mechanisms driving macrophage polarization wi…
View article: 17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin
17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin Open
Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are unknown. We hypothesized that 17β-estradiol (E2), through estrogen receptor α (ER…
View article: RNA-Binding Proteins in Pulmonary Hypertension
RNA-Binding Proteins in Pulmonary Hypertension Open
Pulmonary hypertension (PH) is a life-threatening disease characterized by significant vascular remodeling and aberrant expression of genes involved in inflammation, apoptosis resistance, proliferation, and metabolism. Effective therapeuti…
View article: Therapeutic Actions of the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Hypoxia-Induced Pulmonary Hypertension
Therapeutic Actions of the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Hypoxia-Induced Pulmonary Hypertension Open
View article: Fibroblast-Secreted Exosomal Complement Protein Promotes Macrophage Polarization Towards a Pro-Inflammatory Phenotype
Fibroblast-Secreted Exosomal Complement Protein Promotes Macrophage Polarization Towards a Pro-Inflammatory Phenotype Open
View article: Pulmonary Adventitial Fibroblasts Regulate Macrophage Transcriptional and Metabolic Programs in Pulmonary Hypertension
Pulmonary Adventitial Fibroblasts Regulate Macrophage Transcriptional and Metabolic Programs in Pulmonary Hypertension Open
View article: Timing of Community Mitigation and Changes in Reported COVID-19 and Community Mobility ― Four U.S. Metropolitan Areas, February 26–April 1, 2020
Timing of Community Mitigation and Changes in Reported COVID-19 and Community Mobility ― Four U.S. Metropolitan Areas, February 26–April 1, 2020 Open
Community mitigation activities (also referred to as nonpharmaceutical interventions) are actions that persons and communities can take to slow the spread of infectious diseases. Mitigation strategies include personal protective measures (…
View article: Band on the run: insights into right ventricular reverse remodelling
Band on the run: insights into right ventricular reverse remodelling Open
View article: Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases <i>in vitro</i>
Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases <i>in vitro</i> Open
Hydrolytically stable, phototunable hybrid-hydrogels containing clickable decellularized extracellular matrix enable spatiotemporal control over fibroblast activation.
View article: Characterizing the impact of altitude and finishing system on mean pulmonary arterial pressure and carcass characteristics in Angus cattle
Characterizing the impact of altitude and finishing system on mean pulmonary arterial pressure and carcass characteristics in Angus cattle Open
View article: Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension
Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension Open
Most published studies addressing the role of hypoxia inducible factors (HIFs) in hypoxia-induced pulmonary hypertension development employ models that may not recapitulate the clinical setting, including the use of animals with pre-existi…
View article: The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation
The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation Open
These data suggest that paracrine factor(s) released by Cfib from the PH calf signal a phenotypic transformation in a population of cardiomyocytes that likely contributes to RV dysfunction. Therapies targeting this process, such as inhibit…
View article: Cardiopulmonary remodeling in fattened beef cattle: a naturally occurring large animal model of obesity‐associated pulmonary hypertension with left heart disease
Cardiopulmonary remodeling in fattened beef cattle: a naturally occurring large animal model of obesity‐associated pulmonary hypertension with left heart disease Open
The obesity epidemic in developed societies has led to increased cardiovascular diseases including pulmonary hypertension associated with left heart disease (PH‐LHD), the largest and fastest‐growing class of PH. Similar to obese humans, PH…
View article: The beta-adrenergic agonist zilpaterol hydrochloride may predispose feedlot cattle to cardiac remodeling and dysfunction
The beta-adrenergic agonist zilpaterol hydrochloride may predispose feedlot cattle to cardiac remodeling and dysfunction Open
Background: The aim of this study was to address producer concerns that the β2-adrenergic agonist zilpaterol hydrochloride, a bovine growth promotant, predisposes cattle to cardiac disease and death. Our objectives were to evaluate the eff…
View article: TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension
TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension Open
View article: Static and dynamic components of right ventricular afterload are negatively associated with calf survival at high altitude1
Static and dynamic components of right ventricular afterload are negatively associated with calf survival at high altitude1 Open
The purposes of this study were to evaluate mean, systolic, and diastolic pulmonary arterial pressures; pulmonary arterial pulse pressures; and systemic oxygen extraction fraction as risk factors for the survival of suckling calves on one …
View article: Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension
Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension Open
BACKGROUND: Pulmonary hypertension and resulting right ventricular (RV) dysfunction are associated with significant perioperative morbidity and mortality. Although echocardiography permits real-time, noninvasive assessment of RV function, …
View article: The altitude at which a calf is born and raised influences the rate at which mean pulmonary arterial pressure increases with age1
The altitude at which a calf is born and raised influences the rate at which mean pulmonary arterial pressure increases with age1 Open
Right heart failure secondary to pulmonary hypertension is a leading cause of mortality among suckling beef calves in the Rocky Mountain region. The objective of this study was to track changes in pulmonary arterial pressures (PAP) in heal…
View article: Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension
Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension Open
View article: HIGH ALTITUDE DISEASE, PAP, FEEDLOT HYPERTENSION, AND RESPIRATORY ISSUES
HIGH ALTITUDE DISEASE, PAP, FEEDLOT HYPERTENSION, AND RESPIRATORY ISSUES Open
Right-heart failure (RHF) due to pulmonary hypertension, more commonly known as brisket disease or high altitude disease, is a complex disease that is becomingly increasing problematic for the cattle industry–regardless of altitude. The di…