D. Hewett
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View article: Mer receptor expression promotes multiple myeloma disease development via a cell-extrinsic mechanism
Mer receptor expression promotes multiple myeloma disease development via a cell-extrinsic mechanism Open
Multiple myeloma (MM) is an incurable hematologic malignancy characterized by the uncontrolled proliferation of bone marrow resident plasma cells (PCs). Two members of the TAM (TYRO3, AXL, and MER) receptor family have previously been impl…
View article: Mer receptor expression promotes multiple myeloma disease development via a cell-extrinsic mechanism
Mer receptor expression promotes multiple myeloma disease development via a cell-extrinsic mechanism Open
Multiple myeloma (MM) is an incurable haematological malignancy characterised by the uncontrolled proliferation of bone marrow resident plasma cells (PCs). Two members of the TAM (TYRO3, AXL and MER) receptor family have previously been im…
View article: Expression of the chemokine receptor CCR1 decreases sensitivity to bortezomib in multiple myeloma cell lines
Expression of the chemokine receptor CCR1 decreases sensitivity to bortezomib in multiple myeloma cell lines Open
Taken together, these studies suggest that CCR1 expression may be associated with decreased response to bortezomib in MM cell lines.
View article: Myeloperoxidase creates a permissive microenvironmental niche for the progression of multiple myeloma
Myeloperoxidase creates a permissive microenvironmental niche for the progression of multiple myeloma Open
Summary Expression of myeloperoxidase (MPO), a key inflammatory enzyme restricted to myeloid cells, is negatively associated with the development of solid tumours. Activated myeloid cell populations are increased in multiple myeloma (MM); …
View article: Supplementary Table 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Table 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
GSEA for genes upregulated by overexpression of HIF-2alpha in LP-1 cells
View article: Supplementary Table 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Table 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
GSEA for genes upregulated by overexpression of HIF-2alpha in LP-1 cells
View article: Supp Figure 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 2. Migration towards CXCL12 and cell surface CXCR4 expression is downregulated by CXCL12 treatment
View article: Supp Figure 4 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 4 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 4. CXCL12 does not inhibit response to CCL3 in human MM cell lines
View article: Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Disease progression and relapse in multiple myeloma is dependent on the ability of the multiple myeloma plasma cells (PC) to reenter the circulation and disseminate throughout the bone marrow. Increased bone marrow hypoxia is associated wi…
View article: Supp Figure 3 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 3 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 3. CCR1 expression is upregulated by hypoxia in human MM cell lines
View article: Supp Figure 5 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 5 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 5. Cell surface expression of CXCR4 and CCR1 in newly diagnosed MM patients
View article: Supp Figure 3 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 3 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 3. CCR1 expression is upregulated by hypoxia in human MM cell lines
View article: Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Disease progression and relapse in multiple myeloma is dependent on the ability of the multiple myeloma plasma cells (PC) to reenter the circulation and disseminate throughout the bone marrow. Increased bone marrow hypoxia is associated wi…
View article: Supp Figure 5 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 5 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 5. Cell surface expression of CXCR4 and CCR1 in newly diagnosed MM patients
View article: Supplementary Table 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Table 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Table of genes dysregulated with overexpression of HIF-2alpha in LP-1 cells
View article: Supp Figure 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 1. Overexpression of HIF-2α and CXCL12 in the HMCLs LP-1 and RPMI-8226
View article: Supplementary Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supplementary Figure Legends and Methods
View article: Supp Figure 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 1. Overexpression of HIF-2α and CXCL12 in the HMCLs LP-1 and RPMI-8226
View article: Supplementary Table 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Table 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Table of genes dysregulated with overexpression of HIF-2alpha in LP-1 cells
View article: Supp Figure 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 2. Migration towards CXCL12 and cell surface CXCR4 expression is downregulated by CXCL12 treatment
View article: Supplementary Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supplementary Figure Legends and Methods
View article: Supp Figure 4 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 4 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 4. CXCL12 does not inhibit response to CCL3 in human MM cell lines
View article: Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells <i>in vivo</i>
Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells <i>in vivo</i> Open
Multiple myeloma (MM) disease progression is dependent on the ability of MM plasma cells (PC) to egress from the bone marrow (BM), enter the circulation and disseminate to distal BM sites. Expression of the chemokine CXCL12 by BM stromal c…
View article: Targeted Disruption of Bone Marrow Stromal Cell-Derived Gremlin1 Limits Multiple Myeloma Disease Progression In Vivo
Targeted Disruption of Bone Marrow Stromal Cell-Derived Gremlin1 Limits Multiple Myeloma Disease Progression In Vivo Open
In most instances, multiple myeloma (MM) plasma cells (PCs) are reliant on factors made by cells of the bone marrow (BM) stroma for their survival and growth. To date, the nature and cellular composition of the BM tumor microenvironment an…
View article: Characterization of the role of Samsn1 loss in multiple myeloma development
Characterization of the role of Samsn1 loss in multiple myeloma development Open
The protein SAMSN1 was recently identified as a putative tumor suppressor in multiple myeloma, with re‐expression of Samsn1 in the 5TGM1/KaLwRij murine model of myeloma leading to a near complete abrogation of intramedullary tumor growth. …
View article: LCRF‐0006, a small molecule mimetic of the N‐cadherin antagonist peptide ADH‐1, synergistically increases multiple myeloma response to bortezomib
LCRF‐0006, a small molecule mimetic of the N‐cadherin antagonist peptide ADH‐1, synergistically increases multiple myeloma response to bortezomib Open
N‐cadherin is a homophilic cell‐cell adhesion molecule that plays a critical role in maintaining vascular stability and modulating endothelial barrier permeability. Pre‐clinical studies have shown that the N‐cadherin antagonist peptide, AD…
GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice Open
Multiple myeloma, a plasma cell malignancy, is a genetically heterogeneous disease and the genetic factors that contribute to its development and progression remain to be fully elucidated. The tumour suppressor gene GLIPR1 has previously b…