Richard E. Olson
YOU?
Author Swipe
View article: Physics of laser direct-drive liquid deuterium–tritium wetted foam capsules for inertial confinement fusion
Physics of laser direct-drive liquid deuterium–tritium wetted foam capsules for inertial confinement fusion Open
Laser direct-drive liquid deuterium–tritium (DT) wetted foam capsules hold substantial promise for future advancements in inertial confinement fusion (ICF). For this new class of ICF capsules, additive manufacturing (AM) techniques are use…
View article: Exploration of polar direct drive wetted foam concepts for neutron sources on the National Ignition Facility laser
Exploration of polar direct drive wetted foam concepts for neutron sources on the National Ignition Facility laser Open
A multi-laboratory collaborative effort is currently exploring the feasibility of laser direct drive liquid deuterium–tritium (DT) wetted foam inertial confinement fusion concepts being considered for novel neutron sources on the National …
View article: An Ensemble Approach for Brain Tumor Segmentation and Synthesis
An Ensemble Approach for Brain Tumor Segmentation and Synthesis Open
The integration of machine learning in magnetic resonance imaging (MRI), specifically in neuroimaging, is proving to be incredibly effective, leading to better diagnostic accuracy, accelerated image analysis, and data-driven insights, whic…
View article: Evaluation of the relative importance of preheat from hohlraum x rays and a radiative shock on a low-density foam
Evaluation of the relative importance of preheat from hohlraum x rays and a radiative shock on a low-density foam Open
Indirectly driven shock-tube experiments were performed on the Omega Laser Facility to evaluate the relative importance of hohlraum x ray and radiative shock preheat sources on a low-density foam. X rays emitted from the hohlraum and a sub…
View article: The dynamics, mixing, and thermonuclear burn of compressed foams with varied gas fills
The dynamics, mixing, and thermonuclear burn of compressed foams with varied gas fills Open
Inertial confinement fusion (ICF) implosions involve highly coupled physics and complex hydrodynamics that are challenging to model computationally. Due to the sensitivity of such implosions to small features, detailed simulations require …
View article: Yield degradation mechanisms for two-shock capsules evaluated through simulations
Yield degradation mechanisms for two-shock capsules evaluated through simulations Open
An investigation of twenty two-shock campaign indirectly driven capsules on the National Ignition Facility was conducted using the xRAGE computer code. The two-shock platform was developed to look at the sensitivity of fuel–ablator mix wit…
View article: Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features
Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features Open
Antisense oligonucleotides are a relatively new therapeutic modality and safety evaluation is still a developing area of research. We have observed that some oligonucleotides can produce acute, nonhybridization dependent, neurobehavioral s…
View article: Experimental quantification of the impact of heterogeneous mix on thermonuclear burn
Experimental quantification of the impact of heterogeneous mix on thermonuclear burn Open
In inertial confinement fusion, deuterium–tritium (DT) fuel is brought to densities and temperatures where fusion ignition occurs. However, mixing of the ablator material into the fuel may prevent ignition by diluting and cooling the fuel.…
View article: A P(V) platform for oligonucleotide synthesis
A P(V) platform for oligonucleotide synthesis Open
Platform for the synthesis of diverse oligos DNA is primarily viewed as a carrier of information encoded in the sequence of bases, but the chemistry of the phosphodiester backbone is crucial to oligonucleotide stability and structure. Buil…
View article: A P(V)-Platform for Oligonucleotide Synthesis
A P(V)-Platform for Oligonucleotide Synthesis Open
The early promise of gene-based therapies is currently being realized at an accelerated pace with over 155 active clinical trials for antisense compounds and multiple FDA-approved oligonucleotide therapeutics. Fundamental advances in this …
View article: A P(V)-Platform for Oligonucleotide Synthesis
A P(V)-Platform for Oligonucleotide Synthesis Open
The early promise of gene-based therapies is currently being realized at an accelerated pace with over 155 active clinical trials for antisense compounds and multiple FDA-approved oligonucleotide therapeutics. Fundamental advances in this …
View article: Experimental quantification of the impact of heterogeneous mix on thermonuclear burn
Experimental quantification of the impact of heterogeneous mix on thermonuclear burn Open
In inertial confinement fusion (ICF), deuterium-tritium (DT) fuel is brought to densities and temperatures where fusion ignition occurs. Mix of ablator material into the fuel may prevent ignition by diluting and cooling the fuel. MARBLE ex…
View article: Experimental validation of shock propagation through a foam with engineered macro-pores
Experimental validation of shock propagation through a foam with engineered macro-pores Open
The engineered macro-pore foam provides a new way to study thermonuclear burn physics by utilizing capsules containing deuterated (D) foam and filling tritium (T) gas in the engineered macro-pores. The implosion of a thermonuclear capsule …
View article: Preparations for a European R&D roadmap for an inertial fusion demo reactor
Preparations for a European R&D roadmap for an inertial fusion demo reactor Open
A European consortium of 15 laboratories across nine nations have worked together under the EUROFusion Enabling Research grants for the past decade with three principle objectives. These are: (a) investigating obstacles to ignition on mega…
View article: Development of the Marble experimental platform at the National Ignition Facility
Development of the Marble experimental platform at the National Ignition Facility Open
The Marble experimental platform at the National Ignition Facility (NIF) was developed to quantify the influence of heterogeneous mix on fusion burn. The platform utilizes a plastic capsule filled with a deuterated plastic foam of controll…
View article: The rate of development of atomic mixing and temperature equilibration in inertial confinement fusion implosions
The rate of development of atomic mixing and temperature equilibration in inertial confinement fusion implosions Open
The MARBLE project is a novel inertial confinement fusion platform for studying the development of atomic mixing and temperature equilibration in inertial confinement fusion implosions and their impact on thermonuclear burn. Experiments in…
View article: Radiation driven <i>Hohlraum</i> using 2<i>ω</i> for ICF implosions at the NIF
Radiation driven <i>Hohlraum</i> using 2<i>ω</i> for ICF implosions at the NIF Open
Radiation flux symmetry in laser-irradiated Hohlraum environments is difficult to model and control and relies on the details of plasma evolution and laser energy deposition in the harsh plasma-filled Hohlraum over the duration of the lase…
View article: Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides
Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides Open
Hundreds of dominant-negative myosin mutations have been identified that lead to hypertrophic cardiomyopathy, and the biomechanical link between mutation and disease is heterogeneous across this patient population. To increase the therapeu…