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View article: A FAIR narrative on open science: when, who, what and how of computed tomography and the NoCTURN network
A FAIR narrative on open science: when, who, what and how of computed tomography and the NoCTURN network Open
Open science, the practice of making research products and processes free and available to scientists and non-scientists alike, is transforming image-based studies using non-clinical computed tomography (CT). Recently, the National Science…
Recent Progress of Digital Reconstruction in Polycrystalline Materials Open
This study comprehensively reviews recent advances in the digital reconstruction of polycrystalline materials. Digital reconstruction serves as both a representative volume element for multiscale modelling and a source of quantitative data…
View article: Bio-inspiration from the <i>Issus</i> Nymph gear − strength analysis
Bio-inspiration from the <i>Issus</i> Nymph gear − strength analysis Open
Planthoppers are champion jumpers. Adult specimens are propelled by rapid movements of the hind legs, which can launch them a horizontal distance of 1.1 m with a take-off speed of 5.5 m/s, demonstrating high power output. The planthopper I…
View article: Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis
Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis Open
The success of checkpoint inhibitors (CPIs) for cancer has been tempered by immune-related adverse effects including colitis. CPI-induced colitis is hallmarked by expansion of resident mucosal IFNγ cytotoxic CD8+ T cells, but how these ari…
2D and 3D imaging of ‘tunnel-shaped’ weathering features in soil grains: a biological origin? Open
The evolution of the first plant-based terrestrial ecosystems some ~450 million years ago had a profound effect on the development of soils and shifts in global biogeochemical cycles, notably drawdown of CO2 from the atmosphere. In some pa…
View article: Variation and covariation of external shape and cross‐sectional geometry in the human metacarpus
Variation and covariation of external shape and cross‐sectional geometry in the human metacarpus Open
Objectives Analyses of external bone shape using geometric morphometrics (GM) and cross‐sectional geometry (CSG) are frequently employed to investigate bone structural variation and reconstruct activity in the past. However, the associatio…
Exploring the link between coffee matrix microstructure and flow properties using combined X-ray microtomography and smoothed particle hydrodynamics simulations Open
Coffee extraction involves many complex physical and transport processes extremely difficult to model. Among the many factors that will affect the final quality of coffee, the microstructure of the coffee matrix is one of the most critical…
Developmental biomechanics and age polyethism in leaf-cutter ants Open
Many social insects display age polyethism: young workers stay inside the nest, and only older workers forage. This behavioural transition is accompanied by genetic and physiological changes, but the mechanistic origin of it remains unclea…
Experimental investigation of the air blast performance of hybrid composite skinned sandwich panels with X-ray micro-CT damage assessment Open
This research investigates the performance of interlaminar hybrid composites as the skins of composite sandwich panels under blast loading with the aim of promoting delamination between dissimilar plies for energy absorption. The deformati…
Exploring the link between coffee matrix microstructure and flow properties using combined X-ray microtomography and smoothed particle hydrodynamics simulations Open
Coffee extraction involves many complex physical and transport processes extremely difficult to model. Among the many factors that will affect the final quality of coffee, the microstructure of the coffee matrix is one of the most critical…
Towards using a multi-material, pellet-fed additive manufacturing platform to fabricate novel imaging phantoms Open
The design freedom afforded by additive manufacturing (AM) is now being leveraged across multiple applications, including many in the fields of imaging for personalised medicine. This study utilises a pellet-fed, multi-material AM machine …
Developmental biomechanics and age polyethism in leaf-cutter ants Open
Many social insects display age polyethism: young workers stay inside the nest, and only older workers forage. This behavioural transition is accompanied by genetic and physiological changes, but the mechanistic origin of it remains unclea…
A biomechanical model for the relation between bite force and mandibular opening angle in arthropods Open
Bite forces play a key role in animal ecology: they affect mating behaviour, fighting success, and the ability to feed. Although feeding habits of arthropods have a significant ecological and economical impact, we lack fundamental knowledg…
CCDC 2237150: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
A biomechanical model for the relation between bite force and mandibular opening angle in arthropods Open
Bite forces play a key role in animal ecology: they affect mating behaviour, fighting success, and the ability to feed. Although feeding habits of arthropods have an enormous ecological and economical impact, we lack fundamental knowledge …
Connected Microscopy to Characterise the Dermal Denticle of <i>Raja clavata</i>, the Thornback Ray Open
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Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug–Drug Interaction Risk Profile Open
Results from recently completed clinical studies suggest the dopamine D1 receptor positive allosteric modulator (PAM) mevidalen (1) could offer unique value for lewy body dementia (LBD) patients. In nonclinical assessments, 1 was mainly el…
Indentation Plastometry of Welds Open
This investigation concerns the application of the profilometry‐based indentation plastometry (PIP) methodology to obtain stress–strain relationships for material in the vicinity of fusion welds. These are produced by The Welding Institute…
Modeling the effect of flow-induced mechanical erosion during coffee filtration Open
The espresso extraction process involves a complex transport inside a geometry-changing porous medium. Large solid grains forming the majority of the porous medium can migrate, swell, and consolidate, and they can also morphologically chan…
Correlative Microscopy: a tool for understanding soil weathering in modern analogues of early terrestrial biospheres Open
Correlative imaging provides a method of investigating complex systems by combining analytical (chemistry) and imaging (tomography) information across dimensions (2D-3D) and scales (centimetres-nanometres). We studied weathering processes …
Correlative Microscopy: a tool for understanding soil weathering in modern analogues of early terrestrial biospheres Open
Correlative imaging provides a method of investigating complex systems by combining analytical (chemistry) and imaging (tomography) information across dimensions (2D-3D) and scales (centimetres-nanometres). We studied weathering processes …
Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements Open
The mechanics of breathing is a fascinating and vital process. The lung has complexities and subtle heterogeneities in structure across length scales that influence mechanics and function. This study establishes an experimental pipeline fo…