Explanipedia

Combined heart-liver transplantation and Acute Kidney Injury: Risk factors and outcomes from CARDHEPAT registry Open

R. Guillemain, Fabiano Perdigão, Adrien Bouglé, Pascal Leprince, Eric Savier , et al. · 2025

Acute respiratory failure due to pulmonary exacerbation in children with cystic fibrosis admitted in a pediatric intensive care unit: outcomes and factors associated with mortality Open

David Drummond, Charlotte Le Roy, Matthieu Cornet, Julie Bucher, V. Boussaud , et al. · 2024

Blood MMP-9 measured at 2 years after lung transplantation as a prognostic biomarker of chronic lung allograft dysfunction Open

Adrien Tissot, Eugénie Durand, Thomas Goronflot, Benjamin Coiffard, B. Renaud-Picard , et al. · 2024

Acute respiratory failure due to pulmonary exacerbation in children with cystic fibrosis admitted in a pediatric intensive care unit: outcomes and factors associated with mortality Open

David Drummond, Charlotte Roy, Matthieu Cornet, Julie Bucher, V. Boussaud , et al. · 2024

Background. Children with advanced pulmonary disease due to cystic fibrosis (CF) are at risk of acute respiratory failure due to pulmonary exacerbations leading to their admission to pediatric intensive care units (PICU). The objectives of…

Diuretic dose is a strong prognostic factor in ambulatory patients awaiting heart transplantation Open

Guillaume Baudry, Guillaume Coutance, Richard Dorent, Fabrice Bauer, Katrien Blanchart , et al. · 2023

Aims The prognostic value of ‘high dose’ loop diuretics in advanced heart failure outpatients is unclear. We aimed to assess the prognosis associated with loop diuretic dose in ambulatory patients awaiting heart transplantation (HT). Metho…

Sudden cardiac death after heart transplantation: a population-based study Open

Guillaume Bonnet, Guillaume Coutance, Olivier Aubert, Victor Waldmann, Marc Raynaud , et al. · 2023

Aims The epidemiology of sudden cardiac death (SCD) after heart transplantation (HTx) remains imprecisely described. We aimed to assess the incidence and determinants of SCD in a large cohort of HTx recipients, compared with the general po…

Transcatheter Tricuspid Repair for Tricuspid Regurgitation After Heart Transplantation Open

Tania Puscas, Charles-Henri Gautier, Anne‐Céline Martin, Louis Pechmajou, Leonora Du Puy-Montbrun , et al. · 2023

A 67-year-old patient with history of heart transplantation was referred for symptomatic severe tricuspid regurgitation. Diagnostic workup showed chordal ruptures on the septal and anterior leaflets, most likely related to endomyocardial b…

Pre-exposure prophylaxis with tixagevimab and cilgavimab (Evusheld) for COVID-19 among 1112 severely immunocompromised patients Open

Yann Nguyen, Adrien Flahault, Nathalie Chavarot, Cléa Melenotte, Morgane Cheminant , et al. · 2022

Targeted SARS-CoV-2 treatment is associated with decreased mortality in immunocompromised patients with COVID-19 Open

Emmanuel Lafont, Hélène Péré, David Lebeaux, Geoffrey Cheminet, Éric Thervet , et al. · 2022

Background Little is known about targeted (antiviral or monoclonal antibody) anti-SARS-CoV-2 treatment in immunocompromised patients with COVID-19. Objectives To assess the real-life efficacy and tolerance of targeted treatment of COVID-19…

Prognosis value of Forrester's classification in advanced heart failure patients awaiting heart transplantation Open

Guillaume Baudry, Guillaume Coutance, Richard Dorent, Fabrice Bauer, Katrien Blanchart , et al. · 2022

Aims The value of Forrester's perfusion/congestion profiles assessed by invasive catheter evaluation in non‐inotrope advanced heart failure patients listed for heart transplant (HT) is unclear. We aimed to assess the value of haemodynamic …

Pulmonary toxicity of mTOR inhibitors. Comparisons of two populations: Solid organ recipients and cancer patients Open

S. Gendarme, Jean Pastré, Eliane M. Billaud, Laure Gibault, R. Guillemain , et al. · 2022

Toxic optic neuropathy due to voriconazole: possible potentiation by reduction of CYP2C19 activity Open

Christophe Orssaud, R. Guillemain, A. Lillo Le Louet · 2021

OBJECTIVE: Voriconazole is an antifungal treatment with central neurotoxicity. Modifications of the electroretinogram can explain some of its visual complications: visual hallucination, blurred vision, altered visual perception or photopho…

Study design and rationale of the pAtients pResenTing with cOngenital heaRt dIseAse Register (ARTORIA‐R) Open

Christoph Sinning, Elvin Zengin, Gerhard‐Paul Diller, Francesco Onorati, M. Castel , et al. · 2021

Aim Due to improved therapy in childhood, many patients with congenital heart disease reach adulthood and are termed adults with congenital heart disease (ACHD). ACHD often develop heart failure (HF) as a consequence of initial palliative …

Death Rate in Heart Transplant Recipients during the COVID-19 Outbreak in France Open

Camille Legeai, Carine Jasseron, C. Cantrelle, Shaïda Varnous, Marylou Para , et al. · 2021

Heart Transplant Activity in France during the COVID-19 Outbreak Open

C. Cantrelle, Camille Legeai, Carine Jasseron, Pascal Leprince, Marylou Para , et al. · 2021

A Case of Phage Therapy against Pandrug-Resistant Achromobacter xylosoxidans in a 12-Year-Old Lung-Transplanted Cystic Fibrosis Patient Open

David Lebeaux, Maia Merabishvili, Éric Caudron, Damien Lannoy, Leen Van Simaey , et al. · 2021

Bacteriophages are a promising therapeutic strategy among cystic fibrosis and lung-transplanted patients, considering the high frequency of colonization/infection caused by pandrug-resistant bacteria. However, little clinical data are avai…

First human facial retransplantation: 30-month follow-up Open

Laurent Lantieri, Bernard Cholley, Cédric Lemogne, R. Guillemain, Nicolás Ortonne , et al. · 2020

Scedosporiosis/lomentosporiosis observational study (SOS): Clinical significance of <i>Scedosporium</i> species identification Open

Didier Brönnimann, Dea Garcia‐Hermoso, Françoise Dromer, Fanny Lanternier, Laurence Maulin , et al. · 2020

Scedosporiosis/lomentosporiosis is a devastating emerging fungal infection. Our objective was to describe the clinical pattern and to analyze whether taxonomic grouping of the species involved was supported by differences in terms of clini…

Autoantibodies against granulocyte macrophage colony‐stimulating factor and <i>Nocardia</i> infection in solid organ transplant recipients Open

David Lebeaux, Julien Coussement, Cécile Chauvet, Marie Matignon, Anne Scemla , et al. · 2020

Dear Editors, Nocardiosis is a rare but potentially severe bacterial opportunistic infection that may occur after solid organ transplantation (SOT), typically among thoracic transplant recipients and/or in recipients with a high degree of …

Identification and Characterization of Trajectories of Cardiac Allograft Vasculopathy After Heart Transplantation Open

Alexandre Loupy, Guillaume Coutance, Guillaume Bonnet, Jan Van Keer, Marc Raynaud , et al. · 2020

Background: Cardiac allograft vasculopathy (CAV) is a major contributor of heart transplant recipient mortality. Little is known about the prototypes of CAV trajectories at the population level. We aimed to identify the different evolution…

Exceptional third-time single-lung transplantation in a cystic fibrosis patient with previous pneumonectomy: a case report Open

Françoise Le Pimpec‐Barthes, Giuseppe Mangiameli, C. Pricopi, Alex Arame, A. Hernigou , et al. · 2020

We report for the first time in literature an exceptional case of a third-time lung transplantations (LTx) done on a single lung because of previous pneumonectomy in a cystic fibrosis 22-year-old female. Several hypotheses were advocate to…

Reverse transcriptase multiplex ligation-dependent probe amplification in endomyocardial biopsies for the diagnosis of cardiac allograft rejection Open

Nicolas Adam, Guillaume Coutance, Pierre‐Julien Viailly, Fanny Drieux, Philippe Ruminy , et al. · 2019

Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants Open

Alice Koenig, Chien‐Chia Chen, Antoine Marçais, Thomas Barba, Virginie Mathias , et al. · 2019

Belatacept-based immunosuppression: A calcineurin inhibitor-sparing regimen in heart transplant recipients Open

Manon Launay, Joëlle Guitard, Richard Dorent, Yoann Prevot, Florent Prion , et al. · 2019

Blood CD9+ B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation Open

Carole Brosseau, Richard Danger, Maxim Durand, Eugénie Durand, Aurore Foureau , et al. · 2019

Bronchiolitis obliterans syndrome is the main limitation for long-term survival after lung transplantation. Some specific B cell populations are associated with long-term graft acceptance. We aimed to monitor the B cell profile during earl…

Cumulative radiation dose after lung transplantation in patients with cystic fibrosis Open

Isabelle Fitton, Marie‐Pierre Revel, Pierre‐Régis Burgel, A. Hernigou, V. Boussaud , et al. · 2019

3399Determinants and outcomes of cardiac allograft vasculopathy: major role of donor specific antibody Open

Guillaume Bonnet, Maud Racapé, M.C. Bories, Shaïda Varnous, Philippe Rouvier , et al. · 2018

Background: Neutrophils are able to release their nuclear content into extracellular space by formation of neutrophil extracellular traps (NETs).NETs neutralize pathogens, but have also been implicated in autoimmune and thrombotic diseases…

High circulating CD4+CD25hiFOXP3+ T-cell sub-population early after lung transplantation is associated with development of bronchiolitis obliterans syndrome Open

Maxim Durand, Philippe Lacoste, Richard Danger, Lola Jacquemont, Carole Brosseau , et al. · 2018

Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome Open

Richard Danger, P Royer, Damien Reboulleau, Eugénie Durand, Jennifer Loy , et al. · 2018

Bronchiolitis obliterans syndrome (BOS), the main manifestation of chronic lung allograft dysfunction, leads to poor long-term survival after lung transplantation. Identifying predictors of BOS is essential to prevent the progression of dy…

Posaconazole Tablets in Real-Life Lung Transplantation: Impact on Exposure, Drug-Drug Interactions, and Drug Management in Lung Transplant Patients, Including Those with Cystic Fibrosis Open

Manon Launay, Antoine Roux, L. Beaumont, Benoît Douvry, Lucien Lécuyer , et al. · 2018

Appropriate exposure to posaconazole (PSZ) has been limited until the recent approval of the delayed-release oral tablet formulation. Our goal was to determine the exposure obtained by using the standard dose of 300 mg once a day in lung t…

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