Helen Fryer
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View article: Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification
Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification Open
Population-representative estimates of SARS-CoV-2 infection prevalence and antibody levels in specific geographic areas at different time points are needed to optimise policy responses. However, even population-wide surveys are potentially…
View article: Prevalence of persistent SARS-CoV-2 in a large community surveillance study
Prevalence of persistent SARS-CoV-2 in a large community surveillance study Open
Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future outbreaks 1–5 , give rise to highly divergent lineages 6–8 and contribute to cases with post-acute COVID-19 sequelae (long COVID) 9,10 . However, the popul…
View article: Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population
Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population Open
View article: Identifying direct risk factors in UK Biobank with simultaneous Bayesian-frequentist model-averaged hypothesis testing using Doublethink
Identifying direct risk factors in UK Biobank with simultaneous Bayesian-frequentist model-averaged hypothesis testing using Doublethink Open
Big data approaches to discovering non-genetic risk factors have lagged behind genome-wide association studies that routinely uncover novel genetic risk factors for diverse diseases. Instead, epidemiology typically focuses on candidate ris…
View article: Doublethink: simultaneous Bayesian-frequentist model-averaged hypothesis testing
Doublethink: simultaneous Bayesian-frequentist model-averaged hypothesis testing Open
Establishing the frequentist properties of Bayesian approaches widens their appeal and offers new understanding. In hypothesis testing, Bayesian model averaging addresses the problem that conclusions are sensitive to variable selection. Bu…
View article: Lineage replacement and evolution captured by 3 years of the United Kingdom Coronavirus (COVID-19) Infection Survey
Lineage replacement and evolution captured by 3 years of the United Kingdom Coronavirus (COVID-19) Infection Survey Open
The Office for National Statistics Coronavirus (COVID-19) Infection Survey (ONS-CIS) is the largest surveillance study of SARS-CoV-2 positivity in the community, and collected data on the United Kingdom (UK) epidemic from April 2020 until …
View article: Correction: Viral burden is associated with age, vaccination, and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection-related sampling bias
Correction: Viral burden is associated with age, vaccination, and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection-related sampling bias Open
[This corrects the article DOI: 10.1371/journal.ppat.1011461.].
View article: Viral burden is associated with age, vaccination, and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection-related sampling bias
Viral burden is associated with age, vaccination, and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection-related sampling bias Open
In this study, we evaluated the impact of viral variant, in addition to other variables, on within-host viral burden, by analysing cycle threshold (Ct) values derived from nose and throat swabs, collected as part of the UK COVID-19 Infecti…
View article: COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK
COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK Open
View article: Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK
Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK Open
View article: High number of SARS-CoV-2 persistent infections uncovered through genetic analysis of samples from a large community-based surveillance study
High number of SARS-CoV-2 persistent infections uncovered through genetic analysis of samples from a large community-based surveillance study Open
Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may act as viral reservoirs that could seed future outbreaks 1–5 , give rise to highly divergent lineages 6–8 , and contribute to cases with post-acute Coro…
View article: Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway Open
View article: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway Open
View article: SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection
SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection Open
View article: Governing Global Antimicrobial Resistance: 6 Key Lessons From the Paris Climate Agreement.
Governing Global Antimicrobial Resistance: 6 Key Lessons From the Paris Climate Agreement. Open
View article: A mathematical model of antibiotic resistance gene flow from livestock and spread amongst humans
A mathematical model of antibiotic resistance gene flow from livestock and spread amongst humans Open
The evolution and spread of antibiotic resistance poses a major threat to human health. The high level of antibiotic use in the rearing of livestock is contributing to the origin and persistence of antibiotic resistance amongst humans. Und…
View article: Should individuals be paid to participate in mass drug administration to control malaria?
Should individuals be paid to participate in mass drug administration to control malaria? Open
Mass drug administration (MDA) is a malaria control strategy in which antimalarial drugs are offered to a whole community. Although MDA can potentially clear malaria from a community, it is not routinely used in eradication efforts because…
View article: Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines
Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines Open
View article: Lineage replacement and evolution captured by three years of the United Kingdom Covid Infection Survey
Lineage replacement and evolution captured by three years of the United Kingdom Covid Infection Survey Open
The Office for National Statistics COVID-19 Infection Survey (ONS-CIS) is the largest surveillance study of SARS-CoV-2 positivity in the community, and collected data on the United Kingdom (UK) epidemic from April 2020 until March 2023 bef…
View article: Symptoms and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Positivity in the General Population in the United Kingdom
Symptoms and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Positivity in the General Population in the United Kingdom Open
Background “Classic” symptoms (cough, fever, loss of taste/smell) prompt severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) testing in the United Kingdom. Studies have assessed the ability of diffe…
View article: Anti-spike antibody response to natural SARS-CoV-2 infection in the general population
Anti-spike antibody response to natural SARS-CoV-2 infection in the general population Open
View article: Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom
Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom Open
View article: Early analysis of a potential link between viral load and the N501Y mutation in the SARS-COV-2 spike protein
Early analysis of a potential link between viral load and the N501Y mutation in the SARS-COV-2 spike protein Open
A new variant of SARS-CoV-2 has emerged which is increasing in frequency, primarily in the South East of England (lineage B.1.1.7 ( 1 ); VUI-202012/01). One potential hypothesis is that infection with the new variant results in higher vira…
View article: Limited evolution despite years of measurable viremia in a cART-treated seronegative HIV-1 positive individual
Limited evolution despite years of measurable viremia in a cART-treated seronegative HIV-1 positive individual Open
Understanding the role that antibodies play in controlling HIV-1 infection and in the dynamics that underpin the formation of the HIV-1 reservoir are important steps towards combatting this global disease. To address these gaps, we perform…
View article: Increased T cell trafficking as adjunct therapy for HIV-1
Increased T cell trafficking as adjunct therapy for HIV-1 Open
Although antiretroviral drug therapy suppresses human immunodeficiency virus-type 1 (HIV-1) to undetectable levels in the blood of treated individuals, reservoirs of replication competent HIV-1 endure. Upon cessation of antiretroviral ther…
View article: Lorenzo-Redondo et al. reply
Lorenzo-Redondo et al. reply Open
View article: Predicting the extinction of HIV-2 in rural Guinea-Bissau
Predicting the extinction of HIV-2 in rural Guinea-Bissau Open
HIV-2 is predicted go extinct in Caió during the second half of this century.