Rogelio Hernández‐Pando
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View article: Growth differentiation factor 11 modulates metabolism, mitigating the pro-tumoral behavior provided by M2-like macrophages in hepatocellular carcinoma-derived cells
Growth differentiation factor 11 modulates metabolism, mitigating the pro-tumoral behavior provided by M2-like macrophages in hepatocellular carcinoma-derived cells Open
BACKGROUND Hepatocellular carcinoma (HCC) is one of the most aggressive tumors worldwide. Chronic inflammation contributes to tumor evolution, and the infiltration of tumor-associated macrophages (TAMs), also known as M2-like macrophages, …
View article: Synergistic Effects of Curcumin and Antibiotics Against Drug-Sensitive and Multidrug-Resistant Mycobacterium tuberculosis
Synergistic Effects of Curcumin and Antibiotics Against Drug-Sensitive and Multidrug-Resistant Mycobacterium tuberculosis Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global health challenge, partly due to the prolonged duration and toxicity of standard antibiotic regimens. Adjunctive therapies that enhance antimicrobial efficacy a…
View article: Fenofibrate as a Modulator of the Renin–Angiotensin System in Su/Hx-Induced Pulmonary Arterial Hypertension
Fenofibrate as a Modulator of the Renin–Angiotensin System in Su/Hx-Induced Pulmonary Arterial Hypertension Open
We evaluated the effects of fenofibrate (FF) in a SU5416/hypoxia model of pulmonary arterial hypertension (PAH) with a specific focus on its influence on the renin–angiotensin system (RAS). We assessed right ventricular systolic pressure (…
View article: Early Administration of N-Acetylcysteine Provides Renal and Cardiac Mitochondrial and Redox Protection, Preventing the Development of Cardio-Renal Syndrome Type IV Induced by 5/6NX
Early Administration of N-Acetylcysteine Provides Renal and Cardiac Mitochondrial and Redox Protection, Preventing the Development of Cardio-Renal Syndrome Type IV Induced by 5/6NX Open
Chronic kidney disease (CKD) cardiac impairment is manifested as cardio-renal syndrome type 4 (CRS-IV). The kidneys and heart are highly dependent on mitochondria; thus, bioenergetics and redox and biogenesis alterations are critical in CK…
View article: Portacaval anastomosis promotes fragmentation of mitochondrial network in the cerebellum of male rats
Portacaval anastomosis promotes fragmentation of mitochondrial network in the cerebellum of male rats Open
Portacaval anastomosis (PCA) is a model for hypometabolic liver dysfunction. Spongiform neurodegeneration has been detected in the cerebellum of PCA rats 13 weeks after surgery. This report characterizes the damage associated with spongifo…
View article: The Combination Empagliflozin/Metformin Attenuates the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease in a Diet-Induced Experimental Rat Model
The Combination Empagliflozin/Metformin Attenuates the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease in a Diet-Induced Experimental Rat Model Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses several cardiometabolic risk factors (obesity, insulin resistance, diabetes, and dyslipidemia), in addition to hepatic steatosis. Therefore, treatment is often ch…
View article: Vaccination with a low dose of BCG or BCGΔBCG1419c protects against short-term Mycobacterium tuberculosis HN878 infection in male CB6F1 mice
Vaccination with a low dose of BCG or BCGΔBCG1419c protects against short-term Mycobacterium tuberculosis HN878 infection in male CB6F1 mice Open
View article: The 24p3 receptor is implicated in cadmium-induced distal tubule nephrotoxicity
The 24p3 receptor is implicated in cadmium-induced distal tubule nephrotoxicity Open
Accumulation of toxic metal cadmium (Cd) in the kidney is traditionally associated with proximal tubule (PT) toxicity, but the potential involvement of the distal tubule (DT) remains less explored. A previous study suggested a role of the …
View article: Unveiling the immunomodulatory properties of starch microparticles on alveolar macrophages
Unveiling the immunomodulatory properties of starch microparticles on alveolar macrophages Open
Polysaccharides as immunomodulators are increasingly explored in preclinical studies, showing potential applications for preventing or treating different diseases. Among them is starch, an α-glucan formed by amylose and amylopectin chains.…
View article: Vascular and Glycemic Modulation by Prosthechea livida, an Orchid Used as Traditional Medicine
Vascular and Glycemic Modulation by Prosthechea livida, an Orchid Used as Traditional Medicine Open
Background: Mexico, one of the world’s most biodiverse countries, holds a rich tradition of using medicinal plants to manage chronic diseases such as type 2 diabetes and hypertension. Despite their historical significance, the scientific v…
View article: TGF-β Induced by Allergic Lung Inflammation Enhances Os-Teosarcoma Lung Metastasis in a Mouse Comorbidity Model
TGF-β Induced by Allergic Lung Inflammation Enhances Os-Teosarcoma Lung Metastasis in a Mouse Comorbidity Model Open
TGF-β is a central mediator of pulmonary allergic inflammation recently associated with lung metastasis of osteosarcoma. Given the controversial links between cancer and allergic diseases, this study aimed to evaluate the effects of allerg…
View article: Effect of N-Acetylcysteine in Mitochondrial Function, Redox Signaling, and Sirtuin 3 Levels in the Heart During Cardiorenal Syndrome Type 4 Development
Effect of N-Acetylcysteine in Mitochondrial Function, Redox Signaling, and Sirtuin 3 Levels in the Heart During Cardiorenal Syndrome Type 4 Development Open
Type 4 cardiorenal syndrome (CRS-4) is a pathology in which chronic kidney disease (CKD) triggers the development of cardiovascular disease. CKD pathophysiology produces alterations that can affect the bioenergetics of heart mitochondria, …
View article: Sulforaphane Restores Mitochondrial β-Oxidation and Reduces Renal Lipid Accumulation in a Model of Releasing Unilateral Ureteral Obstruction
Sulforaphane Restores Mitochondrial β-Oxidation and Reduces Renal Lipid Accumulation in a Model of Releasing Unilateral Ureteral Obstruction Open
Obstructive nephropathy (ON), characterized by urine flow disruption, can induce chronic kidney disease (CKD). Although the release of the obstruction is performed as the primary intervention, renal pathology often persists and progresses.…
View article: Increased dietary protein stimulates amino acid catabolism via the gut microbiota and secondary bile acid production
Increased dietary protein stimulates amino acid catabolism via the gut microbiota and secondary bile acid production Open
Excess amino acids from a protein-rich diet are mainly catabolized in the liver. However, it is still unclear to what extent the gut microbiota may be involved in the mechanisms governing this catabolism. Therefore, the aim of this study w…
View article: The Plasma Membrane P-Type ATPase CtpA Is Required for Mycobacterium tuberculosis Virulence in Copper-Activated Macrophages in a Mouse Model of Progressive Tuberculosis
The Plasma Membrane P-Type ATPase CtpA Is Required for Mycobacterium tuberculosis Virulence in Copper-Activated Macrophages in a Mouse Model of Progressive Tuberculosis Open
Background/Objective: Finding new targets to attenuate Mycobacterium tuberculosis (Mtb) is key in the development of new TB vaccines. In this context, plasma membrane P-type ATPases are relevant for mycobacterial homeostasis and virulence.…
View article: P-1787. Tailor Swiftly: Lessons Learned from a Nationwide Implementation of an Antimicrobial Stewardship Program for Asymptomatic Bacteriuria
P-1787. Tailor Swiftly: Lessons Learned from a Nationwide Implementation of an Antimicrobial Stewardship Program for Asymptomatic Bacteriuria Open
Background Overtreatment of asymptomatic bacteriuria (ASB) is a major cause of antibiotic overuse. We are facilitating an implementation of ASB Antimicrobial Stewardship (AS) intervention in 40 Veterans Affairs facilities, with 20 of these…
View article: Fitness costs of Mycobacterium tuberculosis resistant to rifampicin is compensated by rapid Th2 polarization mediated by early and high IL-4 production during mice infection
Fitness costs of Mycobacterium tuberculosis resistant to rifampicin is compensated by rapid Th2 polarization mediated by early and high IL-4 production during mice infection Open
It was a general belief that drug resistance in Mycobacterium tuberculosis (Mtb) was associated with lesser virulence, particularly rifampicin resistance, which is usually produced by mutations in the RNA polymerase Beta subunit (RpoB). In…
View article: Tailor swiftly: lessons learned from a nationwide implementation of an antimicrobial stewardship program for asymptomatic bacteriuria
Tailor swiftly: lessons learned from a nationwide implementation of an antimicrobial stewardship program for asymptomatic bacteriuria Open
Objective: Overtreatment of asymptomatic bacteriuria (ASB) is a major cause of antibiotic overuse. We facilitated a nationwide implementation of an ASB antimicrobial stewardship intervention in 41 Veterans Affairs facilities. Twenty-one si…
View article: Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis Open
Although anti-tuberculous therapy effectively eradicates Mycobacterium tuberculosis (Mtb) infection, it requires prolonged treatment with multiple drugs, often resulting in adverse effects and poor compliance. Therefore, nove…
View article: Mycobacterial EsxG·EsxH (TB9.8·TB10.4) peptides as a subunit vaccine to booster BCG vaccination in an experimental model of pulmonary Tuberculosis
Mycobacterial EsxG·EsxH (TB9.8·TB10.4) peptides as a subunit vaccine to booster BCG vaccination in an experimental model of pulmonary Tuberculosis Open
The attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine is currently the only validated vaccine against tuberculosis (TB). In a previous study, we conducted an in-silico selection of four peptides (G1, G2, H1, and H2) der…
View article: Mast Cell Carboxypeptidase A3 Is Associated with Pulmonary Fibrosis Secondary to COVID-19
Mast Cell Carboxypeptidase A3 Is Associated with Pulmonary Fibrosis Secondary to COVID-19 Open
COVID-19 is an infectious disease caused by SARS-CoV-2; over the course of the disease, a dysregulated immune response leads to excessive inflammation that damages lung parenchyma and compromises its function. One of the cell lineages clas…
View article: Antimycobacterial Activity of Solid Lipid Microparticles Loaded with Ursolic Acid and Oleanolic Acid: In Vitro, In Vivo, and Toxicity Assessments
Antimycobacterial Activity of Solid Lipid Microparticles Loaded with Ursolic Acid and Oleanolic Acid: In Vitro, In Vivo, and Toxicity Assessments Open
Ursolic acid (UA) and oleanolic acid (OA) are hydrophobic triterpenoid isomers with demonstrated anti-mycobacterial (Mtb) and immune-regulatory properties, although their poor solubility limits clinical use. We report the development of so…
View article: Morphological changes in the fetal kidney induced by exposure to fluoride during pregnancy
Morphological changes in the fetal kidney induced by exposure to fluoride during pregnancy Open
To determine if fluoride's established negative impact on adult kidney health begins during gestation, an intergenerational model of Wistar rats was exposed to two doses of fluoride (2.5 or 5.0 mg/kg/day via gavage) 20 days before mating a…
View article: Effect of IL-17A on the immune response to pulmonary tuberculosis induced by high- and low-virulence strains of Mycobacterium bovis
Effect of IL-17A on the immune response to pulmonary tuberculosis induced by high- and low-virulence strains of Mycobacterium bovis Open
Tuberculosis (TB) is an infectious, chronic, and progressive disease occurring globally. Human TB is caused mainly by Mycobacterium tuberculosis ( M . tuberculosis ), while the main causative agent of bovine TB is Mycobacterium bovis ( M .…
View article: Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis Open
Anti-tuberculous therapy successfully eradicates the infection, but it is long-lasting and impose the use of multiple drugs. Therefore, it is required to develop additional immunotherapy approaches to protect and manage human tuberculosis.…
View article: Acute lung injury is prevented by monocyte locomotion inhibitory factor in an experimental severe malaria mouse model
Acute lung injury is prevented by monocyte locomotion inhibitory factor in an experimental severe malaria mouse model Open
Acute lung injury caused by severe malaria (SM) is triggered by a dysregulated immune response towards the infection with Plasmodium parasites. Postmortem analysis of human lungs shows diffuse alveolar damage (DAD), the presence of CD8 lym…
View article: Comparison of the transcriptome, lipidome, and c-di-GMP production between BCGΔBCG1419c and BCG, with Mincle- and Myd88-dependent induction of proinflammatory cytokines in murine macrophages
Comparison of the transcriptome, lipidome, and c-di-GMP production between BCGΔBCG1419c and BCG, with Mincle- and Myd88-dependent induction of proinflammatory cytokines in murine macrophages Open
View article: Negative Regulation of Autophagy during Macrophage Infection by Mycobacterium bovis BCG via Protein Kinase C Activation
Negative Regulation of Autophagy during Macrophage Infection by Mycobacterium bovis BCG via Protein Kinase C Activation Open
Mycobacterium tuberculosis (Mtb) employs various strategies to manipulate the host’s cellular machinery, overriding critical molecular mechanisms such as phagosome-lysosome fusion, which are crucial for its destruction. The Protein Kinase …
View article: Central Nervous System Tuberculosis in a Murine Model: Neurotropic Strains or a New Pathway of Infection?
Central Nervous System Tuberculosis in a Murine Model: Neurotropic Strains or a New Pathway of Infection? Open
Tuberculosis (TB) of the central nervous system (CNS) is a lethal and incapacitating disease. Several studies have been performed to understand the mechanism of bacterial arrival to CNS, however, it remains unclear. Although the interactio…
View article: Effects of Mycobacterium vaccae NCTC 11659 and Lipopolysaccharide Challenge on Polarization of Murine BV-2 Microglial Cells
Effects of Mycobacterium vaccae NCTC 11659 and Lipopolysaccharide Challenge on Polarization of Murine BV-2 Microglial Cells Open
Previous studies have shown that the in vivo administration of soil-derived bacteria with anti-inflammatory and immunoregulatory properties, such as Mycobacterium vaccae NCTC 11659, can prevent a stress-induced shift toward an inflammatory…