Hesham R. El‐Seedi
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View article: Impact of a food supplement containing Citrus limon L. Osbeck and Vitis vinifera L. extracts, hesperidin and chromium in combination with an isocaloric diet on glucose and lipid metabolism in subjects with impaired fasting blood glucose: a single-center, controlled, randomized, parallel-arm, double-blind clinical trial
Impact of a food supplement containing Citrus limon L. Osbeck and Vitis vinifera L. extracts, hesperidin and chromium in combination with an isocaloric diet on glucose and lipid metabolism in subjects with impaired fasting blood glucose: a single-center, controlled, randomized, parallel-arm, double-blind clinical trial Open
Introduction Impaired fasting glycemia (IFG) puts carriers at a significantly higher risk of developing type 2 diabetes and cardiovascular disease. Lifestyle changes, such as increased physical activity and a healthy diet rich in fiber and…
View article: Insights into North African endemic plants and their applications in the food industry with particular emphasis on their quality and safety assessment
Insights into North African endemic plants and their applications in the food industry with particular emphasis on their quality and safety assessment Open
Background The exploration of alternative food sources has gained significant attention mainly to secure the food supply, maintain sustainability and face the environmental, climate and human challenges. North Africa hosts a plethora of en…
View article: RETRACTED: Mahmoud et al. Curcumin-Injected Musca domestica Larval Hemolymph: Cecropin Upregulation and Potential Anticancer Effect. Molecules 2022, 27, 1570
RETRACTED: Mahmoud et al. Curcumin-Injected Musca domestica Larval Hemolymph: Cecropin Upregulation and Potential Anticancer Effect. Molecules 2022, 27, 1570 Open
The journal retracts the article titled “Curcumin-Injected Musca domestica Larval Hemolymph: Cecropin Upregulation and Potential Anticancer Effect” [...]
View article: Recent advances in chemical characterization, emerging applications, and biological activities of tea polysaccharides and their conjugates from leaves and flowers: A review
Recent advances in chemical characterization, emerging applications, and biological activities of tea polysaccharides and their conjugates from leaves and flowers: A review Open
Tea (Camellia sinensis) polysaccharides (TPS) and tea polysaccharide conjugates (TPC) are bioactive compounds found in tea leaves and flowers, attracting growing interest for their biological activities and emerging applications in food, p…
View article: Gut Microbiota‐Bile Acid Metabolism Axis Drive Anti‐Diabetic Effects of <i>Polygonatum cyrtonema</i> Polysaccharide on Glycolipid Metabolism and Intestinal Inflammation
Gut Microbiota‐Bile Acid Metabolism Axis Drive Anti‐Diabetic Effects of <i>Polygonatum cyrtonema</i> Polysaccharide on Glycolipid Metabolism and Intestinal Inflammation Open
Polygonatum cyrtonema polysaccharide (PCP‐80%) is one of the major active ingredients in Polygonatum cyrtonema . By establishing the type 2 diabetes mellitus (T2DM) rat model and applying multi‐omics analysis, the present study aimed to ex…
View article: Rapid Dereplication of Bioactive Compounds in Plant and Food Extracts Using Liquid Chromatography–Electrospray–Tandem Mass Spectrometry
Rapid Dereplication of Bioactive Compounds in Plant and Food Extracts Using Liquid Chromatography–Electrospray–Tandem Mass Spectrometry Open
High‐throughput screening and identification of common phytochemicals are crucial for lead optimization, drug development and investigation of metabolic pathways in complex herbal extracts. The available databases contain a huge number of …
View article: Mechanisms and Genetic Drivers of Resistance of Insect Pests to Insecticides and Approaches to Its Control
Mechanisms and Genetic Drivers of Resistance of Insect Pests to Insecticides and Approaches to Its Control Open
The escalating challenge of resistance to insecticides among agricultural and public health pests poses a significant threat to global food security and vector-borne disease control. This review synthesizes current understanding of the mol…
View article: RETRACTED: El-Garawani et al. In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells: The Role of Anastatica hierochuntica Methanolic Extract. Metabolites 2022, 12, 878
RETRACTED: El-Garawani et al. In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells: The Role of Anastatica hierochuntica Methanolic Extract. Metabolites 2022, 12, 878 Open
The journal Metabolites retracts the article “In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells: The Role of Anastatica hierochuntica Methanolic Extract” [...]
View article: Neurobehavioral Protection by Prebiotic Formulations in a Scopolamine-Induced Cognitive Impaired Zebrafish Model
Neurobehavioral Protection by Prebiotic Formulations in a Scopolamine-Induced Cognitive Impaired Zebrafish Model Open
The present work evaluates the influence of two prebiotic formulations—P1 (ColonX) and P4 (a product containing AnXietate extract), at concentrations of 3 and 6 mg/L—on scopolamine (SCOP, 100 μM)-induced cognitive dysfunction and anxiety-r…
View article: Metabolomic and chemometric profiling of crimson grapes during drying and its impact on antidiabetic activity
Metabolomic and chemometric profiling of crimson grapes during drying and its impact on antidiabetic activity Open
View article: Hypoglycemic effects of goji tea in streptozotocin-induced diabetic mice via IRS1/PI3K/Akt/AMPK pathway
Hypoglycemic effects of goji tea in streptozotocin-induced diabetic mice via IRS1/PI3K/Akt/AMPK pathway Open
View article: Plasma-activated water treatment delayed the lipid oxidation and degradation of golden pompano fillets during storage based on lipidomics
Plasma-activated water treatment delayed the lipid oxidation and degradation of golden pompano fillets during storage based on lipidomics Open
View article: Exploring the Potential of Pyridine Carboxylic Acid Isomers to Discover New Enzyme Inhibitors
Exploring the Potential of Pyridine Carboxylic Acid Isomers to Discover New Enzyme Inhibitors Open
Pyridine carboxylic acid isomers - picolinic acid, nicotinic acid, and isonicotinic acid - have historically resulted in a plethora of drugs against tuberculosis, cancer, diabetes, Alzheimer's, angina, dementia, depression, allergy, respir…
View article: Innovative Pivaloyl Fixed 1,3‐Thiazole‐2‐imines as Multitarget Inhibitors: Synthesis, Enzyme Inhibition, Molecular Docking and Structure Activity Relationship (SAR) Studies
Innovative Pivaloyl Fixed 1,3‐Thiazole‐2‐imines as Multitarget Inhibitors: Synthesis, Enzyme Inhibition, Molecular Docking and Structure Activity Relationship (SAR) Studies Open
A small library of Pivaloyl‐Fixed 1,3‐Thiazole‐2‐imine pharmacophores ( 5a‐j ) was synthesized in three steps, starting with the reaction of pivaloyl chloride with potassium thiocyanate, followed by condensation with p‐toluidine. In the fi…
View article: An Efficient Isolation and Purification of Broad Partition Coefficient Range of Anthraquinones From Seeds of <i>Cassia obtusifolia</i> L. by Linear Gradient Counter‐Current Chromatography Coupled With Inner‐Recycling Mode
An Efficient Isolation and Purification of Broad Partition Coefficient Range of Anthraquinones From Seeds of <i>Cassia obtusifolia</i> L. by Linear Gradient Counter‐Current Chromatography Coupled With Inner‐Recycling Mode Open
Anthraquinones are the main constituents of seeds of Cassia obtusifolia L., which have been used extensively in traditional medicine around the world to cure a variety of illnesses. This work used linear gradient counter‐current chromatogr…
View article: Retraction Note: Anti-proliferative and immunomodulatory potencies of cinnamon oil on Ehrlich ascites carcinoma bearing mice
Retraction Note: Anti-proliferative and immunomodulatory potencies of cinnamon oil on Ehrlich ascites carcinoma bearing mice Open
View article: Improving Irritable Bowel Syndrome (IBS) Symptoms and Quality of Life with Quebracho and Chestnut Tannin-Based Supplementation: A Single-Centre, Randomised, Double-Blind, Placebo-Controlled Clinical Trial
Improving Irritable Bowel Syndrome (IBS) Symptoms and Quality of Life with Quebracho and Chestnut Tannin-Based Supplementation: A Single-Centre, Randomised, Double-Blind, Placebo-Controlled Clinical Trial Open
Background/Objectives: Irritable Bowel Syndrome (IBS) is a disorder of the gut-brain axis for which the gastroenterologist is most often consulted. Gastrointestinal symptoms and decreased quality of life lead to a considerable burden of di…
View article: Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023)
Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023) Open
View article: Correction: Novel pyrimidine linked acyl thiourea derivatives as potent α-amylase and proteinase K inhibitors: design, synthesis, molecular docking and ADME studies
Correction: Novel pyrimidine linked acyl thiourea derivatives as potent α-amylase and proteinase K inhibitors: design, synthesis, molecular docking and ADME studies Open
Correction for ‘Novel pyrimidine linked acyl thiourea derivatives as potent α-amylase and proteinase K inhibitors: design, synthesis, molecular docking and ADME studies’ by Hina Zaman et al. , RSC Adv. , 2024, 14 , 33235–33246, https://doi…
View article: High Internal Phase Pickering Emulsions Stabilized by Arginine-Myosin Microgel Particles for 3d Printing Low Salt Surimi
High Internal Phase Pickering Emulsions Stabilized by Arginine-Myosin Microgel Particles for 3d Printing Low Salt Surimi Open
View article: Three decades of selective product formation <i>via</i> Griesbaum co-ozonolysis: insight and advances (1995–2025)
Three decades of selective product formation <i>via</i> Griesbaum co-ozonolysis: insight and advances (1995–2025) Open
Griesbaum co-ozonolysis enables the synthesis of tetrasubstituted ozonides through the reaction of O -methyl oximes with carbonyl compounds under ozone-mediated conditions.
View article: Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies
Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies Open
Novel guanidines are synthesized as DNA minor groove binders. Spectroscopic and DFT studies revealed that EDGs synergize with halogens to enhance binding affinity, offering promising scaffolds for anticancer drug design.
View article: Multi-Target Biological Activities of Podophyllotoxin-Derived Natural Products
Multi-Target Biological Activities of Podophyllotoxin-Derived Natural Products Open
Podophyllotoxin is a well-studied natural product. Because of its unique structure and ability to inhibit cancer cells, it has been changed in different ways to find out its pharmacological properties. This paper discusses the common chemi…
View article: Migratory Wave due to Conflicts: Risk of Increased Infection From Zoonotic Diseases
Migratory Wave due to Conflicts: Risk of Increased Infection From Zoonotic Diseases Open
Wars have devastating effects on all the components of the One Health approach: humans, animals, and ecosystems. Wars and the resulting migratory waves massively disrupt normal animal health services and surveillance. Among other consequen…
View article: Development of a Tandem Mass Spectral Library for the Detection of Triterpenoids in Plant Metabolome Based on Reference Standards
Development of a Tandem Mass Spectral Library for the Detection of Triterpenoids in Plant Metabolome Based on Reference Standards Open
Plant triterpenoids represent a diverse group of secondary metabolites and are thought to be valuable for therapeutic applications. For drug development, lead optimization, better knowledge of biological pathways, and high-throughput detec…
View article: The Potential Applications of Natural Colostrum in Skin Health
The Potential Applications of Natural Colostrum in Skin Health Open
Skin is a crucial organ for preserving the body’s equilibrium. Like other parts of the body, skin also ages due to extrinsic and intrinsic factors, leading to several signs such as wrinkles, spots, and a decline in elasticity, causing a ra…
View article: Saprophytic fungus (Ganoderma sessile) restrained Treg recruitment in the tumor microenvironment by down-regulating CCL28/CCR10 pathway
Saprophytic fungus (Ganoderma sessile) restrained Treg recruitment in the tumor microenvironment by down-regulating CCL28/CCR10 pathway Open
Ganoderma sessile, a saprophytic fungus, is a traditional Chinese medicinal material used in Chinese folk medicine and cuisine for its potential to enhance cancer patients immunity in clinical practice. However, the underlying mechanisms o…
View article: Bio-fabrication of biologically active copper nanocomposite
Bio-fabrication of biologically active copper nanocomposite Open
View article: Updated Review of Metal Nanoparticles Fabricated by Green Chemistry Using Natural Extracts: Biosynthesis, Mechanisms, and Applications
Updated Review of Metal Nanoparticles Fabricated by Green Chemistry Using Natural Extracts: Biosynthesis, Mechanisms, and Applications Open
Metallic nanoparticles have found wide applications due to their unique physical and chemical properties. Green biosynthesis using plants, microbes, and plant/microbial extracts provides an environmentally friendly approach for nanoparticl…
View article: Retraction Note: A newly isolated strain of Halomonas sp. (HA1) exerts anticancer potential via induction of apoptosis and G2/M arrest in hepatocellular carcinoma (HepG2) cell line
Retraction Note: A newly isolated strain of Halomonas sp. (HA1) exerts anticancer potential via induction of apoptosis and G2/M arrest in hepatocellular carcinoma (HepG2) cell line Open