R. J. E. Grouls
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Author Swipe
View article: Development of a text mining algorithm for identifying adverse drug reactions in electronic health records
Development of a text mining algorithm for identifying adverse drug reactions in electronic health records Open
Objective Adverse drug reactions (ADRs) are a significant healthcare concern. They are often documented as free text in electronic health records (EHRs), making them challenging to use in clinical decision support systems (CDSS). The study…
View article: The Effect of Genotyping on the Number of Pharmacotherapeutic Gene–Drug Interventions in Chronic Kidney Disease Patients
The Effect of Genotyping on the Number of Pharmacotherapeutic Gene–Drug Interventions in Chronic Kidney Disease Patients Open
Patients with chronic kidney disease (CKD) stage 3–5 are polypharmacy patients. Many of these drugs are metabolized by cytochrome P450 (CYP450) and CYP450. Genetic polymorphism is well known to result in altered drug metabolism capacity. T…
View article: Combining text mining with clinical decision support in clinical practice: a scoping review
Combining text mining with clinical decision support in clinical practice: a scoping review Open
Objective Combining text mining (TM) and clinical decision support (CDS) could improve diagnostic and therapeutic processes in clinical practice. This review summarizes current knowledge of the TM-CDS combination in clinical practice, incl…
View article: Contextualized Drug–Drug Interaction Management Improves Clinical Utility Compared With Basic Drug–Drug Interaction Management in Hospitalized Patients
Contextualized Drug–Drug Interaction Management Improves Clinical Utility Compared With Basic Drug–Drug Interaction Management in Hospitalized Patients Open
Drug–drug interactions (DDIs) frequently trigger adverse drug events or reduced efficacy. Most DDI alerts, however, are overridden because of irrelevance for the specific patient. Basic DDI clinical decision support (CDS) systems offer lim…
View article: Identifying adverse drug reactions from free‐text electronic hospital health record notes
Identifying adverse drug reactions from free‐text electronic hospital health record notes Open
Background Adverse drug reactions (ADRs) are estimated to be the fifth cause of hospital death. Up to 50% are potentially preventable and a significant number are recurrent (reADRs). Clinical decision support systems have been used to prev…
View article: Dabigatran trough concentrations in very elderly patients
Dabigatran trough concentrations in very elderly patients Open
Clinicians should be aware of higher dabigatran concentrations in elderly patients despite dose reduction.
View article: Clinical Decision Support System‐Assisted Pharmacy Intervention Reduces Feeding Tube–Related Medication Errors in Hospitalized Patients: A Focus on Medication Suitable for Feeding‐Tube Administration
Clinical Decision Support System‐Assisted Pharmacy Intervention Reduces Feeding Tube–Related Medication Errors in Hospitalized Patients: A Focus on Medication Suitable for Feeding‐Tube Administration Open
Background Administering medication through an enteral feeding tube (FT) is a frequent cause of errors resulting in increased morbidity and cost. Studies on interventions to prevent these errors in hospitalized patients, however, are limit…
View article: Clinical rule‐guided pharmacists' intervention in hospitalized patients with hypokalaemia: A time series analysis
Clinical rule‐guided pharmacists' intervention in hospitalized patients with hypokalaemia: A time series analysis Open
Combining CDSS alerting with a pharmacist evaluation is an effective method to improve response rate, time to supplementation and time to initial improvement, defined as SPL ≥3.0 mmol/L. However, it showed no significant effect on the perc…
View article: The effect of neutropenia on the clinical pharmacokinetics of vancomycin in adults
The effect of neutropenia on the clinical pharmacokinetics of vancomycin in adults Open
View article: A Proof of Principle Study of the Terminal Sterilization of Prefilled Syringes Using A Water Cascade Process
A Proof of Principle Study of the Terminal Sterilization of Prefilled Syringes Using A Water Cascade Process Open
Background A new development in drug compounding is the production of ready-to-administer sterilized prefilled syringes. A challenge with these syringes is the method of terminal sterilization. There is no information available whether wat…