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A-193 It Started with Tape: Empowering Technologists on a Journey of Innovation and Safety in Cryoglobulin Testing Open

Melissa Derksen, Cassandra Poterucha, J. R. Smith, Ashley E. Thompson, Maria Alice V. Willrich · 2025

Background Cryoglobulins are immunoglobulins that precipitate at cold temperatures. They are associated with plasma cell disorders, infectious and autoimmune diseases. Laboratory testing is manual and requires strict temperature control, f…

Coupling IL-2 with IL-10 to mitigate toxicity and enhance antitumor immunity Open

Julie Ahn, Steven Dudics, David Langan, J. R. Smith, Alice H. Hsu , et al. · 2025

Wild-type interleukin (IL)-2 induces anti-tumor immunity and toxicity, predominated by vascular leak syndrome (VLS) leading to edema, hypotension, organ toxicity, and regulatory T cell (Treg) expansion. Efforts to uncouple IL-2 toxicity fr…