Rama Jayaraj
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View article: Optimized PEGylated paclitaxel and 6-gingerol co-loaded liposomes induce G2/M phase arrest and apoptosis in MDA-MB-231 breast and A549 lung cancer cells
Optimized PEGylated paclitaxel and 6-gingerol co-loaded liposomes induce G2/M phase arrest and apoptosis in MDA-MB-231 breast and A549 lung cancer cells Open
The study aimed to optimize and develop novel PEGylated co-loaded nanoliposome entrapped with paclitaxel (PTX) and 6-gingerol (Gn) (PEG-Lipo-PTX-Gn) by response surface methodology (RSM) approach to prevent the diffusion and resistant-rela…
View article: Intraoral scanners in Orthodontics
Intraoral scanners in Orthodontics Open
Rapid advancements in digital technology have changed a number of sectors in recent years. Artificial intelligence (AI) and robotics are two examples of advanced technology that have been adopted into the medical industry. The intraoral sc…
View article: Lymphatic vessels: A highway for metastasis
Lymphatic vessels: A highway for metastasis Open
• Metastasis in cancer progression leads to dismal outcomes and poor overall survival. • The chaotic and open structure of tumor blood vessels suggests that tumor intravasation may be passive. • Cancer has a multiplanar configuration.
View article: Expression of stage-specific Fasciola proteases and their evaluation in vaccination trials
Expression of stage-specific Fasciola proteases and their evaluation in vaccination trials Open
The liver flukes Fasciola hepatica and F. gigantica cause infectious disease in ruminants and humans. The geographical range of these two parasite species (temperate and tropical respectively) ensures that infection can occur worldwide. Al…
View article: Corrigendum: The safety and efficacy of balloon-expandable versus self-expanding trans-catheter aortic valve replacement in high-risk patients
Corrigendum: The safety and efficacy of balloon-expandable versus self-expanding trans-catheter aortic valve replacement in high-risk patients Open
[This corrects the article DOI: 10.3389/fcvm.2023.1130354.].
View article: The roots of cancer: Are we missing the forest for the trees?
The roots of cancer: Are we missing the forest for the trees? Open
The objective of surgical resection is the annihilation of cancer, both gross and microscopic. Surgeons aspire to strike a balance between functional outcomes and a safe oncological clearance in the intricate head and neck anatomical struc…
View article: Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development
Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development Open
Infection with viruses, bacteria, and parasites are thought to be the underlying cause of about 8–17% of the world’s cancer burden, i.e., approximately one in every five malignancies globally is caused by an infectious pathogen. Oncogenesi…
View article: The safety and efficacy of balloon-expandable versus self-expanding trans-catheter aortic valve replacement in high-risk patients with severe symptomatic aortic stenosis
The safety and efficacy of balloon-expandable versus self-expanding trans-catheter aortic valve replacement in high-risk patients with severe symptomatic aortic stenosis Open
Aim Transfemoral Trans-catheter Aortic Valve Replacement (TF-TAVR) is a safe and effective therapy compared with surgical aortic valve replacement (SAVR) in patients across all risk profiles using balloon-expandable valves (BEV) and self-e…
View article: The incidence of male breast cancer: from fiction to reality – correspondence
The incidence of male breast cancer: from fiction to reality – correspondence Open
Mukherjee, Anirban Goutam; Gopalakrishnan, Abilash Valsala PhD; Jayaraj, Rama; Renu, Kaviyarasi; Dey, Abhijit; Vellingiri, Balachandar; Malik, Tabarak Author Information
View article: Cytotoxic Effects of Nanoliposomal Cisplatin and Diallyl Disulfide on Breast Cancer and Lung Cancer Cell Lines
Cytotoxic Effects of Nanoliposomal Cisplatin and Diallyl Disulfide on Breast Cancer and Lung Cancer Cell Lines Open
Dual drug delivery has become the choice of interest nowadays due to its increased therapeutic efficacy in targeting the tumor site precisely. As quoted in recent literature, it has been known to treat several cancers with an acute course …
View article: Clinical Investigation of Chemotherapeutic Resistance and miRNA Expressions in Head and Neck Cancers: A Thorough PRISMA Compliant Systematic Review and Comprehensive Meta-Analysis
Clinical Investigation of Chemotherapeutic Resistance and miRNA Expressions in Head and Neck Cancers: A Thorough PRISMA Compliant Systematic Review and Comprehensive Meta-Analysis Open
Background: Chemoresistance is a significant barrier to combating head and neck cancer, and decoding this resistance can widen the therapeutic application of such chemotherapeutic drugs. This systematic review and meta-analysis explores th…
View article: Trans-radial approach versus trans-femoral approach in patients with acute coronary syndrome undergoing percutaneous coronary intervention: An updated meta-analysis of randomized controlled trials
Trans-radial approach versus trans-femoral approach in patients with acute coronary syndrome undergoing percutaneous coronary intervention: An updated meta-analysis of randomized controlled trials Open
Introduction Trans-radial approach (TRA) is recommended over trans-femoral approach (TFA) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). We intended to study the effect of access on all-…
View article: Bibliometric and Density Visualisation Mapping Analysis of Domestic Violence in Australia Research Output 1984–2019
Bibliometric and Density Visualisation Mapping Analysis of Domestic Violence in Australia Research Output 1984–2019 Open
Domestic violence is highly prevalent in Australia and has serious and complex impacts. This study aimed to analyse research outputs on domestic violence in Australia from the period of 1984 to 2019. Articles relevant to domestic violence …
View article: A Clinical Investigation on the Theragnostic Effect of MicroRNA Biomarkers for Survival Outcome in Cervical Cancer: A PRISMA-P Compliant Protocol for Systematic Review and Comprehensive Meta-Analysis
A Clinical Investigation on the Theragnostic Effect of MicroRNA Biomarkers for Survival Outcome in Cervical Cancer: A PRISMA-P Compliant Protocol for Systematic Review and Comprehensive Meta-Analysis Open
Background: The most often diagnosed malignancy in women worldwide is cancer of the cervix. It is also the most prevalent kind of gynecological cancer in women. This cancer originates in the opening of the cervix and spreads through sexual…
View article: Mapping Research on miRNAs in Cancer: A Global Data Analysis and Bibliometric Profiling Analysis
Mapping Research on miRNAs in Cancer: A Global Data Analysis and Bibliometric Profiling Analysis Open
miRNAs biomarkers are emerging as an essential part of clinical oncology. Their oncogenic and tumour suppressor properties playing a role in malignancy has generated interest in their potential for use in disease prognosis. While several s…
View article: COVID-19 Outcomes in Patients Hospitalised with Acute Myocardial Infarction (AMI): A Protocol for Systematic Review and Meta-Analysis
COVID-19 Outcomes in Patients Hospitalised with Acute Myocardial Infarction (AMI): A Protocol for Systematic Review and Meta-Analysis Open
Background: Patients with cardiovascular disease and risk factors for cardiovascular illness are more likely to acquire severe 2019 novel coronavirus (2019-nCoV) infection (COVID-19). COVID-19 infection is more common in patients with card…
View article: Molecular Investigation of miRNA Biomarkers as Chemoresistance Regulators in Melanoma: A Protocol for Systematic Review and Meta-Analysis
Molecular Investigation of miRNA Biomarkers as Chemoresistance Regulators in Melanoma: A Protocol for Systematic Review and Meta-Analysis Open
Introduction: Melanoma is a global disease that is predominant in Western countries. However, reliable data resources and comprehensive studies on the theragnostic efficiency of miRNAs in melanoma are scarce. Hence, a decisive study or com…
View article: Clinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis Protocol
Clinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis Protocol Open
Background: The microRNAs (miRNAs) are small noncoding single-stranded RNAs typically 19–25 nucleotides long and regulated by cellular and epigenetic factors. These miRNAs plays important part in several pathways necessary for cancer devel…
View article: A Clinical Update on the Prognostic Effect of microRNA Biomarkers for Survival Outcome in Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis
A Clinical Update on the Prognostic Effect of microRNA Biomarkers for Survival Outcome in Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis Open
Background: Nasopharyngeal carcinoma (NPC), a relatively uncommon malignancy in the Western world, is highly prevalent in Southeast Asia where the treatment outcomes are poor. Despite recent improvements in diagnosis and treatment locoregi…
View article: Prognostic Utility of Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Monocyte–Lymphocyte Ratio in Head and Neck Cancers: A Detailed PRISMA Compliant Systematic Review and Meta-Analysis
Prognostic Utility of Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Monocyte–Lymphocyte Ratio in Head and Neck Cancers: A Detailed PRISMA Compliant Systematic Review and Meta-Analysis Open
Inflammation plays a major role in cancer development and progression and has the potential to be used as a prognostic marker in cancer. Previous studies have attempted to evaluate Platelet-to-lymphocyte ratio (PLR), neutrophil–lymphocyte …
View article: Lyophilized Fruit Juice of Citrus sinensis Triggers Mitochondria-mediated Apoptosis via Downregulation of PI3K/AKT in MCF-7 Cell Line
Lyophilized Fruit Juice of Citrus sinensis Triggers Mitochondria-mediated Apoptosis via Downregulation of PI3K/AKT in MCF-7 Cell Line Open
Background: Breast cancer is prevalent cancer among women and a major cause of death worldwide due to various genetic and environmental factors. Citrus sinensis is widely taken fruit juice in most countries that are believed to reduce brea…
View article: EFFECT OF SOCIAL INTELLIGENCE, EMOTIONAL INTELLIGENCE, AND SEXUAL SATISFACTION ON MARITAL ADJUSTMENT OF WORKING WOMEN
EFFECT OF SOCIAL INTELLIGENCE, EMOTIONAL INTELLIGENCE, AND SEXUAL SATISFACTION ON MARITAL ADJUSTMENT OF WORKING WOMEN Open
Introduction: This study was undertaken to find out the effect ofSocial Intelligence (SI), Emotional Intelligence (EI) and Sexual Satisfaction (SS) on Marital Adjustment (MA) of working women of Kerala (India). Method:This descriptive cros…