Keith R. Walley
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View article: Cervical screening approach of self-collection, point-of-care HPV testing, and same-day colposcopy among Aboriginal and Torres Strait Islander women in remote Western Australia (the PREVENT Project): an implementation study
Cervical screening approach of self-collection, point-of-care HPV testing, and same-day colposcopy among Aboriginal and Torres Strait Islander women in remote Western Australia (the PREVENT Project): an implementation study Open
Department of Health's Indigenous Australians' Health Programme Emerging Priorities Grant, Australian Gynaecological Cancer Foundation's Cindy Sullivan Fellowship, Mary Jane Foundation, and National Health and Medical Research Council.
View article: Machine Learning Accurately Predicts Need for Critical Care Support in Patients Admitted to Hospital for Community-Acquired Pneumonia
Machine Learning Accurately Predicts Need for Critical Care Support in Patients Admitted to Hospital for Community-Acquired Pneumonia Open
OBJECTIVES: Hospitalized community-acquired pneumonia (CAP) patients are admitted for ventilation, vasopressors, and renal replacement therapy (RRT). This study aimed to develop a machine learning (ML) model that predicts the need for such…
View article: Low apolipoprotein A-II levels causally contribute to increased mortality in septic shock
Low apolipoprotein A-II levels causally contribute to increased mortality in septic shock Open
Background Lipoproteins and their component apolipoproteins play an important role in sepsis. However, little is known with regard to the association and causal contribution of these proteins to mortality in patients of different ancestrie…
View article: Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity
Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity Open
The results demonstrate that serum metabolomics has diagnostic potential for sTBI and may reflect molecular mechanisms of primary and secondary brain injuries when comparing metabolite profiles between day 1 and day 4 post-injury. These ea…
View article: Complex Thrombo-Inflammatory Responses versus Outcomes of Non-COVID-19 Community-Acquired Pneumonia and COVID-19
Complex Thrombo-Inflammatory Responses versus Outcomes of Non-COVID-19 Community-Acquired Pneumonia and COVID-19 Open
Introduction: The thrombo-inflammatory response and outcomes of community-acquired pneumonia (CAP) due to various organisms (non-COVID-19 CAP) versus CAP due to a single virus, SARS-CoV-2 (i.e., COVID-19) may differ. Methods: Adults hospit…
View article: Community versus academic hospital community-acquired pneumonia patients: a nested cohort study
Community versus academic hospital community-acquired pneumonia patients: a nested cohort study Open
Background Most Canadians receive their care in community hospitals, yet most clinical research is conducted in academic hospitals. This study aims to compare patients with community acquired pneumonia (CAP) treated in academic and communi…
View article: Effects of Losartan on Patients Hospitalized for Acute COVID-19: A Randomized Controlled Trial
Effects of Losartan on Patients Hospitalized for Acute COVID-19: A Randomized Controlled Trial Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) down-regulates angiotensin-converting enzyme 2, potentially increasing angiotensin II. We hypothesized that losartan compared to usual care decreases mortality and is …
View article: CETP inhibition enhances monocyte activation and bacterial clearance and reduces streptococcus pneumonia–associated mortality in mice
CETP inhibition enhances monocyte activation and bacterial clearance and reduces streptococcus pneumonia–associated mortality in mice Open
Sepsis is a leading cause of mortality worldwide, and pneumonia is the most common cause of sepsis in humans. Low levels of high-density lipoprotein cholesterol (HDL-C) levels are associated with an increased risk of death from sepsis, and…
View article: Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis
Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis Open
Background In preclinical studies, mesenchymal stromal cells (MSCs), including umbilical cord-derived MSCs (UC-MSCs), demonstrate the ability to modulate numerous pathophysiological processes related to sepsis; however, a systematic synthe…
View article: Proteomic Evolution from Acute to Post-COVID-19 Conditions
Proteomic Evolution from Acute to Post-COVID-19 Conditions Open
Many COVID-19 survivors have post-COVID-19 conditions, and females are at a higher risk. We sought to determine (1) how protein levels change from acute to post-COVID-19 conditions, (2) whether females have a plasma protein signature diffe…
View article: Metabolomics Analysis of Mesenchymal Stem Cell (MSC) Therapy in a Phase I Clinical Trial of Septic Shock: An Exploratory Study
Metabolomics Analysis of Mesenchymal Stem Cell (MSC) Therapy in a Phase I Clinical Trial of Septic Shock: An Exploratory Study Open
Sepsis is the result of an uncontrolled host inflammatory response to infection that may lead to septic shock with multiorgan failure and a high mortality rate. There is an urgent need to improve early diagnosis and to find markers identif…
View article: Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis
Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis Open
OBJECTIVES: Treatments that prevent sepsis complications are needed. Circulating lipid and protein assemblies—lipoproteins play critical roles in clearing pathogens from the bloodstream. We investigated whether early inhibition of proprote…
View article: Impact of the COVID-19 pandemic on non-COVID-19 community-acquired pneumonia: a retrospective cohort study
Impact of the COVID-19 pandemic on non-COVID-19 community-acquired pneumonia: a retrospective cohort study Open
Background The COVID-19 pandemic could impact frequency and mortality of non-COVID-19 community-acquired pneumonia (CAP). Changes in frequency, patient mix, treatment and organ dysfunction could cascade together to increase mortality of CA…
View article: Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials
Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials Open
US National Institutes of Health.
View article: Outcomes and characteristics of patients hospitalized for COVID-19 in British Columbia, Ontario and Quebec during the Omicron wave
Outcomes and characteristics of patients hospitalized for COVID-19 in British Columbia, Ontario and Quebec during the Omicron wave Open
Patients who were at least double vaccinated had lower mortality than unvaccinated patients hospitalized during the Omicron wave. Patients hospitalized during the Omicron wave had more chronic disease and lower mortality than in the first …
View article: THE IMPACT OF THE COVID-19 PANDEMIC ON NON-COVID-19 COMMUNITY-ACQUIRED PNEUMONIA, A RETROSPECTIVE COHORT STUDY
THE IMPACT OF THE COVID-19 PANDEMIC ON NON-COVID-19 COMMUNITY-ACQUIRED PNEUMONIA, A RETROSPECTIVE COHORT STUDY Open
BACKGROUND The COVID-19 pandemic could impact frequency and mortality of non-COVID-19 community-acquired pneumonia (CAP). Changes in frequency, patient mix, treatment, and organ dysfunction could cascade together to increase mortality of C…
View article: Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1
Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1 Open
Background: Sepsis is associated with significant mortality, yet there are no efficacious therapies beyond antibiotics and supportive care. In adult sepsis studies, PCSK9 loss-of-function (LOF) and inhibition has shown therapeutic promise,…
View article: Hospital Admission and Hospital Course Predictors of Severity of Post-covid-19 Condition
Hospital Admission and Hospital Course Predictors of Severity of Post-covid-19 Condition Open
BACKGROUND Prediction of severity of Post-COVID-19 condition is not clear. We determined whether hospital course variables correlated with objective and subjective outcomes 3- and 6-months post-COVID-19 onset. METHODS Adults admitted to ho…
View article: Use of Mendelian randomization to better understand and treat sepsis
Use of Mendelian randomization to better understand and treat sepsis Open
Discovering novel therapies and defining the causal contribution of genes, proteins and lipids is challenging in sepsis, because sepsis is so heterogeneous; effective therapies in one patient may not be effective in another, explaining in …
View article: Hospital Admission and Hospital Course Predictors of Severity of Post-covid-19 Condition
Hospital Admission and Hospital Course Predictors of Severity of Post-covid-19 Condition Open
BACKGROUND: Prediction of severity of Post-COVID-19 condition is not clear. We determined whether hospital course variables correlated with objective and subjective outcomes 3- and 6-months post-COVID-19 onset. METHODS: Adults admitted to …
View article: Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19*
Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19* Open
OBJECTIVES: To determine whether angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors are associated with improved outcomes in hospitalized patients with COVID-19 according to sex and to report sex-related…