Explanipedia

High-Throughput Label-free Single-Cell Proteomics Enabled by Multicolumn NanoLC with a 5-min Cycle Time Open

Ryan Kelly, Chao Wang, Hsien‐Jung L. Lin, Siqi Huang, Kenneth Triggs , et al. · 2025

Mass spectrometry (MS)-based single-cell proteomics (SCP) enables proteome-wide analysis at single-cell resolution, offering insights into cellular heterogeneity, biological processes, and disease mechanisms. However, conventional nanoLC-M…

The $10 proteome: low-cost, deep and quantitative proteome profiling of limited sample amounts using the Orbitrap Astral and timsTOF Ultra 2 mass spectrometers Open

Siqi Huang, Chao Wang, Hsien‐Jung L. Lin, Ryan Kelly · 2025

Mass spectrometry (MS)-based proteomics remains technically demanding and prohibitively expensive for many large-scale or routine applications, with per-sample costs of hundreds of dollars or more. To democratize access to proteomics and f…

CMG2 interaction with actin is required for growth factor-induced chemotaxis in endothelial cells Open

Fangfang Jiang, Raj Kumar Mongre, Jacob Truman, Rodrigo Carlos de Oliveira, Eugenio Hardy , et al. · 2025

Capillary morphogenesis gene 2 (CMG2/ANTXR2) is a cell surface receptor that contributes to corneal angiogenesis and is essential for orienting endothelial cell chemotaxis in growth factor gradients. However, the mechanism by which CMG2 tr…

Utilization of Fish Meal and Fish Oil from Smoked Salmon By-Products in Juvenile Striped Bass (Morone saxatilis) Feeds: Growth Performance, Nutritional Composition, and Shelf-Life Assessment of Upcycled Ingredients Open

Connor Neagle, Michael Frinsko, Ryan Kelly, Steven Hall, Benjamin J. Reading , et al. · 2025

Fish meal (FM) and fish oil (FO) are vital components commonly used in feed formulations. However, their supply, which generally comes from capture fisheries, is being exhausted, necessitating the exploration of sustainable alternatives. I…

Oocyte mitochondria link maternal environment to offspring phenotype Open

Jason Cooper, Kim Nguyen, Darrick Gates, Emily Wolfrum, Colt Capan , et al. · 2025

During oogenesis and maturation oocytes undergo a recently discovered mitochondrial electron transport chain (ETC) remodeling in flies 1 , frogs 1 , and humans 2 . This conserved oocyte ETC remodeling is regulated by maternal insulin signa…

Non-intrusive radio frequency polarimetry measurements of rotor whirl using artificial neural networks Open

Yoshinari Inoue, Luis E. Perez, Ryan Kelly, Aleksandar Jemcov, Thomas G. Pratt , et al. · 2025

Fault diagnosis in rotating machinery, especially in aviation, is an active research area. RF sensors have the potential to provide on-wing information for fault diagnosis for gas turbine engines. A dual-polarized, distributed RF sensor sy…

WCN25-3425 Severe acute kidney injury with suspected bilateral renal artery stenosis on renal Duplex while on concurrent ACE inhibition – A case for carbon dioxide renal angiography Open

Macaulay Onuigbo, Max W. Breidenstein, Chibundo Onyia, Yetunde Okeowo, Liliana Briones , et al. · 2025

Gradient-Elution Nanoflow Liquid Chromatography Without a Binary Pump: Smoothed Step Gradients Enable Reproducible, Sensitive, and Low-Cost Separations for Single-Cell Proteomics Open

Kei G. I. Webber, Siqi Huang, Hsien‐Jung L. Lin, Tony Hunter, Jeremy Tsang , et al. · 2024

Mass spectrometry-based proteome profiling of trace analytes including single cells benefits from liquid chromatography separations operated at low flow rates (e.g., <50 nl/min). However, high-pressure binary pumps needed to achieve such f…

Boosting the Sensitivity of Quantitative Single-Cell Proteomics with Infrared-Tandem Mass Tags Open

Trenton M. Peters-Clarke, Yiran Liang, Keaton L. Mertz, Kenneth W. Lee, Michael S. Westphall , et al. · 2024

Single-cell proteomics is a powerful approach to precisely profile protein landscapes within individual cells toward a comprehensive understanding of proteomic functions and tissue and cellular states. The inherent challenges associated wi…

Boosting the Sensitivity of Quantitative Single-Cell Proteomics with Activated lon-Tandem Mass Tags (AI-TMT) Open

Trenton M. Peters-Clarke, Yiran Liang, Keaton L. Mertz, Kenneth W. Lee, Michael S. Westphall , et al. · 2024

Single-cell proteomics is a powerful approach to precisely profile protein landscapes within individual cells toward a comprehensive understanding of proteomic functions and tissue and cellular states. The inherent challenges associated wi…

Data for EMSL Project 49531 from January 2024 Open

Keqi Tang, Richard Smith, Ljiljana Paša‐Tolić, Rui Zhao, Desmond Smith , et al. · 2024

Data for EMSL Project 50604 from January 2024 Open

Richard Smith, Scott Baker, Jon Jacobs, Weijun Qian, Ryan Kelly , et al. · 2024

Data for EMSL Project 51636 from March 2024 Open

Mary Lipton, Galya Orr, Scott Baker, Ziyu Dai, Alex Beliaev , et al. · 2024

Data for EMSL Project 49531 from January 2024 Open

Keqi Tang, Richard Smith, Ljiljana Paša‐Tolić, Rui Zhao, Desmond Smith , et al. · 2024

Data for EMSL Project 50604 from January 2024 Open

Richard Smith, Scott Baker, Jon Jacobs, Weijun Qian, Ryan Kelly , et al. · 2024

Data for EMSL Project 49531 from January 2024 Open

Keqi Tang, Richard Smith, Ljiljana Paša‐Tolić, Rui Zhao, Desmond Smith , et al. · 2024

Data for EMSL Project 49531 from January 2024 Open

Keqi Tang, Richard Smith, Ljiljana Paša‐Tolić, Rui Zhao, Desmond Smith , et al. · 2024

Data for EMSL Project 49531 from January 2024 Open

Keqi Tang, Richard Smith, Ljiljana Paša‐Tolić, Rui Zhao, Desmond Smith , et al. · 2024

Data for EMSL Project 49531 from January 2024 Open

Keqi Tang, Richard Smith, Ljiljana Paša‐Tolić, Rui Zhao, Desmond Smith , et al. · 2024

Data for EMSL Project 50604 from January 2024 Open

Richard Smith, Scott Baker, Jon Jacobs, Weijun Qian, Ryan Kelly , et al. · 2024

Data for EMSL Project 49531 from January 2024 Open

Keqi Tang, Richard Smith, Ljiljana Paša‐Tolić, Rui Zhao, Desmond Smith , et al. · 2024

Data for EMSL Project 49531 from January 2024 Open

Keqi Tang, Richard Smith, Ljiljana Paša‐Tolić, Rui Zhao, Desmond Smith , et al. · 2024

Data for EMSL Project 50604 from January 2024 Open

Richard Smith, Scott Baker, Jon Jacobs, Weijun Qian, Ryan Kelly , et al. · 2024

Data for EMSL Project 51636 from March 2024 Open

Mary Lipton, Galya Orr, Scott Baker, Ziyu Dai, Alex Beliaev , et al. · 2024

Data for EMSL Project 50604 from January 2024 Open

Richard Smith, Scott Baker, Jon Jacobs, Weijun Qian, Ryan Kelly , et al. · 2024

Data for EMSL Project 51636 from January 2024 Open

Mary Lipton, Galya Orr, Galya Orr, Scott Baker, Ziyu Dai , et al. · 2024

Data for EMSL Project 49531 from January 2024 Open

Keqi Tang, Richard Smith, Ljiljana Paša‐Tolić, Rui Zhao, Desmond Smith , et al. · 2024

Data for EMSL Project 51636 from March 2024 Open

Mary Lipton, Galya Orr, Scott Baker, Ziyu Dai, Alex Beliaev , et al. · 2024

Data for EMSL Project 51636 from February 2024 Open

Mary Lipton, Galya Orr, Galya Orr, Scott Baker, Ziyu Dai , et al. · 2024

Data for EMSL Project 51636 from March 2024 Open

Mary Lipton, Galya Orr, Scott Baker, Ziyu Dai, Alex Beliaev , et al. · 2024

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