Explanipedia

Corrigendum to “Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation” [Mol Metab 18 (2018) 153–163] Open

Sevim Kahraman, Farnaz Shamsi, Lian Yi, Adam Swensen, Yu‐Hua Tseng , et al. · 2025

Author Correction: Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes Open

Dario F. De Jesus, Zijie Zhang, Natalie K. Brown, Xiaolu Li, Jiang Hu , et al. · 2025

Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes Open

Shane S. Kelly, Soumyadeep Sarkar, Elizabeth A. Butterworth, Yumi Kwon, Xiaolu Li , et al. · 2025

Progressive β-cell dysfunction precedes the onset of type 1 diabetes (T1D), yet the molecular mechanisms driving early T1D development remain poorly understood. Although single-cell RNA-sequencing has uncovered transcript-level changes in …

Exploring Size Exclusion Chromatography Columns 20 and 35 nm Pore Size Effect for Isolation of Extracellular Vesicles Open

Balazs Kaszala, Vincenzo Scarsella, Kriti Bomb, John F. Fay, Barbara L. Smith , et al. · 2025

Extracellular vesicles (EVs) have shown great promise as minimally invasive biomarkers for a variety of diseases. However, challenges persist regarding EV isolation, particularly in their co-isolation with impurities such as soluble protei…

Genome-wide CRISPR Screen Identifies Sec31A as a Key Regulator of Alpha Cell Survival Open

Kimitaka Shibue, Sevim Kahraman, Jorge Iván Castillo-Quan, Dario F. De Jesus, Jiang Hu , et al. · 2025

Glucagon, secreted by pancreatic alpha cells, is essential for maintaining normal blood glucose levels. In type 1 and advanced type 2 diabetes, alpha cells often fail to respond to low glucose, yet the mechanisms underlying their stress re…

m 6 A mRNA methylation decorates genes involved in fibrinogen synthesis to regulate liver regeneration in mice Open

Tomohiko Kimura, Dario F. De Jesus, Hyunki Kim, Yi Zhang, Kazuki Fukuda , et al. · 2025

This study uncovers a previously unrecognized mechanism for regulation of the fibrinogen pathway in N 6 -methyladenosine (m 6 A) RNA methylation-mediated liver regeneration.

Regulatory roles of IGF2R in insulin secretion and adaptive β-cell proliferation Open

Jun Shirakawa, Dario F. De Jesus, Takahiro Tsuno, Giorgio Basile, Ryota Inoue , et al. · 2025

Insulin-like growth factor -2 receptor (IGF2R), also known as cation-independent mannose-6-phosphate receptor (CI-MPR), is localized in cytosolic vesicles and is unique in its ability to transport enzymes to the lysosome and to clear IGF2 …

Regulatory roles of IGF2R in insulin secretion and adaptive β-cell proliferation Open

Jun Shirakawa, Dario F. De Jesus, Takahiro Tsuno, Giorgio Basile, Ryota Inoue , et al. · 2025

Insulin-like growth factor -2 receptor (IGF2R), also known as cation-independent mannose-6-phosphate receptor (CI-MPR), is localized in cytosolic vesicles and is unique in its ability to transport enzymes to the lysosome and to clear IGF2 …

Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells Open

Kelly Velasco, Janniche Torsvik, Johanna L. St‐Louis, Sarah Baghestani, Jonas S. G. Silvander , et al. · 2025

Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors Open

Adam Swensen, Paul Piehowski, Jing Chen, X’avia Y. Chan, Shane S. Kelly , et al. · 2025

The LC-MS raw datasets that support the findings of this study have been deposited in the online repository: MassIVE ( https://massive.ucsd.edu/ProteoSAFe/static/massive.jsp ) with accession no. MSV000090212.

Characterization of cytokine treatment on human pancreatic islets by top-down proteomics Open

Ashley N. Ives, Tyler J. Sagendorf, Lorenz Nierves, Tai‐Tu Lin, Ercument Dirice , et al. · 2025

Type 1 diabetes (T1D) results from autoimmune-mediated destruction of insulin-producing β cells in the pancreatic islet. This process is modulated by pro-inflammatory cytokine signaling, which have been previously shown to alter protein ex…

Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism Open

Ling Xiao, Dario F. De Jesus, Cheng‐Wei Ju, Jiangbo Wei, Jiang‐Miao Hu , et al. · 2025

Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression Open

SHOTA OKAGAWA, Masaji Sakaguchi, Yuma Okubo, Yuri Takekuma, Motoyuki Igata , et al. · 2024

9250 carRNA m6A methylation regulates transcription state and chromatin accessibility in human islets in normal physiology and type 2 diabetes Open

Namrata Shukla, Cheng‐Wei Ju, Han Li, Chuan He, Rohit Kulkarni · 2024

Disclosure: N. Shukla: None. C. Ju: None. H. Li: None. C. He: None. R. Kulkarni: Advisory Board Member; Self; Novo Nordisk, Biomea Fusion Inc, REDD Pharma. Grant Recipient; Self; Inversago. Chromatin-associated regulatory RNAs (carRNA), wh…

8182 New Mouse Model Mirrors Human MODY8: Opening Doors to Understanding Exocrine-Endocrine Crosstalk in the Diabetic Pancreas Open

Khadija El Jellas, Valeria Salerno, Liora S. Katz, Jiang Hu, Garrett Fogarty , et al. · 2024

Disclosure: K. El Jellas: None. V. Salerno: None. L.S. Katz: None. J. Hu: None. G. Fogarty: None. A. Mandal: None. A. DiStefano-Forti: None. D. Scott: None. M. Lowe: None. A. Molven: None. R.N. Kulkarni: None. Maturity-onset diabetes of th…

7624 m6A mRNA Methylation in Brown Adipose Tissue Regulates Systemic Insulin Sensitivity via an Inter-Organ Prostaglandin Signaling Axis Open

Ling Xiao, Dario F. De Jesus, Chengwei Ju, Jiangbo Wei, Jiang Hu , et al. · 2024

Disclosure: L. Xiao: None. D. F De Jesus: None. C. Ju: None. J. Wei: None. J. Hu: None. A. DiStefano-Forti: None. T. Tsuji: None. C. Cero: None. V. Männistö: None. S.M. Manninen: None. S. Wei: None. O. Ijaduola: None. M. Blüher: Consulting…

8113 Thyroid Storm in a Patient with Thyroid Nodule on Anticoagulation Open

Rohit Kulkarni, Sathya Krishnasamy, Nandar Mon, Richard K Downs · 2024

Disclosure: R. Kulkarni: None. S.S. Krishnasamy: None. N. Mon: None. R. Downs: None. Background: There are very few case reports related to hyperthyroidism due to anticoagulation use. We describe a case, of a less common cause of hyperthyr…

m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation Open

Sevim Kahraman, Dario F. De Jesus, Jiangbo Wei, Natalie K. Brown, Zhongyu Zou , et al. · 2024

Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases Open

Adam Swensen, Paul Piehowski, Jing Chen, X’avia Y. Chan, Shane S. Kelly , et al. · 2024

Aims/hypothesis Progression to type 1 diabetes (T1D) is associated with genetic factors, the presence of autoantibodies, and a decline in β cell insulin secretion in response to glucose. Very little is known regarding the molecular changes…

Data for EMSL Project 48705 from February 2022 Open

Weijun Qian, Rohit Kulkarni, Marina Gritsenko, Adam Swensen, Tujin Shi , et al. · 2024

Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes Open

Dario F. De Jesus, Zijie Zhang, Natalie K. Brown, Xiaolu Li, Ling Xiao , et al. · 2024

Data for EMSL Project 49531 from January 2024 Open