Ricardo R. Lastra
YOU?
Author Swipe
View article: Integration of cell-type resolved spatial proteomics and transcriptomics reveals novel mechanisms in early ovarian cancer
Integration of cell-type resolved spatial proteomics and transcriptomics reveals novel mechanisms in early ovarian cancer Open
High-grade serous carcinoma (HGSC) is the most common ovarian cancer subtype, typically diagnosed at late stages with poor prognosis. Understanding early molecular events driving HGSC progression is crucial for timely detection and develop…
View article: Carboplatin, gemcitabine, and mifepristone for advanced breast and recurrent/persistent epithelial ovarian cancer
Carboplatin, gemcitabine, and mifepristone for advanced breast and recurrent/persistent epithelial ovarian cancer Open
Purpose Preclinical models of glucocorticoid receptor (GR)-positive breast cancer (BC) and ovarian cancer (OC) suggest GR activity inhibits chemotherapy-induced apoptosis, and GR antagonism using mifepristone (Mif) enhances cytotoxicity. W…
View article: Supplementary Table 4 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer
Supplementary Table 4 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer Open
LC-MS based proteomics data of all 144 samples
View article: Supplementary Table 5 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer
Supplementary Table 5 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer Open
Significantly up – and downregulated proteins in the tumor and stroma of synchronous cancers
View article: Supplementary Figures and Legends 1 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer
Supplementary Figures and Legends 1 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer Open
Supplementary Figures and Legends
View article: Supplementary Table 1 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer
Supplementary Table 1 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer Open
Clinico-pathologic patient characteristics
View article: Supplementary Table 6 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer
Supplementary Table 6 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer Open
Top 20 discriminating proteins between dual and single cancers
View article: Supplementary Table 3 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer
Supplementary Table 3 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer Open
Overlap of patients and shared mutations between Anglesio and colleagues and this study
View article: Data from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer
Data from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer Open
Purpose:Increasing genomics-based evidence suggests that synchronous endometrial and ovarian cancer (SEOC) represents clonally related primary and metastatic tumors. A systematic analysis of the global protein landscape of SEOCs, heretofor…
View article: Supplementary Table 2 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer
Supplementary Table 2 from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer Open
Top 30 mutated genes in single (ovary, endometrium) and dual (SEOC) cancers
View article: A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause
A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause Open
View article: Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status
Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status Open
View article: Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma
Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma Open
Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma, associated with poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular mechanism of the origin and development of uLMS is limited. Bromod…
View article: Fate of nondiagnostic thyroid fine needle aspirations
Fate of nondiagnostic thyroid fine needle aspirations Open
Background Thyroid nodules may be detected during the workup of thyroid hormone abnormalities and as incidental findings during unrelated imaging studies. The diagnosis of a thyroid nodule is mainly established by performing fine needle as…
View article: Investigation of selective glucocorticoid receptor modulation in high-grade serous ovarian cancer PDX models
Investigation of selective glucocorticoid receptor modulation in high-grade serous ovarian cancer PDX models Open
The significant improvement in PFS shown in 1 of the 6 models after treatment with a SGRM plus chemotherapy underscores the need to determine predictive biomarkers for SGRM therapy in HGS OvCa and to better identify patient subgroups that …
View article: Deep learning detects premalignant lesions in the Fallopian tube
Deep learning detects premalignant lesions in the Fallopian tube Open
View article: Table S1 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Table S1 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
IPA-derived activation Z-scores in LAPC4 cells
View article: Table S1 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Table S1 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
IPA-derived activation Z-scores in LAPC4 cells
View article: Table S2 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Table S2 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
IPA-derived activation Z-scores in CWR-22Rv1 cells
View article: Figure S6 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Figure S6 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
Overlap of GR DEGs from Arora et al. and the present study
View article: Supplementary figure legends from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Supplementary figure legends from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
Supplementary figure legends
View article: Figure S1 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Figure S1 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
GR-mediated cAMP signaling pathway-related genes with co-treatment of SGRMs
View article: Figure S3 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Figure S3 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
Western blot of PKIB in LAPC4 and CWR-22Rv1 cells
View article: Figure S6 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Figure S6 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
Overlap of GR DEGs from Arora et al. and the present study
View article: Supplementary figure legends from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Supplementary figure legends from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
Supplementary figure legends
View article: Figure S2 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Figure S2 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
GR activation increases PKA substrate phosphorylation events in AR-antagonized CWR-22Rv1 cells
View article: Figure S5 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Figure S5 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
Cyclic AMP pathway expression in GR high vs GR low mCRPC and PDX models
View article: Table S3 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Table S3 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
List of cAMP pathway genes n=224 (based on IPA) used in this study
View article: Table S3 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Table S3 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
List of cAMP pathway genes n=224 (based on IPA) used in this study
View article: Figure S3 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer
Figure S3 from Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer Open
Western blot of PKIB in LAPC4 and CWR-22Rv1 cells