Regina Hofmann‐Lehmann
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View article: Novel Neutrophilic Parameters of the Sysmex XN-1000V for the Prediction of Inflammation in Dogs
Novel Neutrophilic Parameters of the Sysmex XN-1000V for the Prediction of Inflammation in Dogs Open
Background: Inflammation is a common reason for dogs to present to veterinary clinics. Early diagnosis of systemic inflammation is important. Acute phase proteins, like C-reactive protein, are useful but not specific to infection. In human…
View article: Feasibility and usefulness of in-hospital and at-home salivary sampling in healthy dogs and trilostane-treated dogs with Cushing’s syndrome: a prospective observational study
Feasibility and usefulness of in-hospital and at-home salivary sampling in healthy dogs and trilostane-treated dogs with Cushing’s syndrome: a prospective observational study Open
Saliva sampling remains challenging in CS dogs. This method needs further refinement before stress-free, at-home salivary cortisol evaluation surpasses current monitoring techniques, such as prepill serum cortisol measurement. Registry: an…
View article: First Detection of Cytauxzoon spp. DNA in Questing Ixodes ricinus Ticks
First Detection of Cytauxzoon spp. DNA in Questing Ixodes ricinus Ticks Open
Feline cytauxzoonosis is an emerging tick-borne disease in Europe. While infections have been reported in different European countries, the tick vector remains unknown. This study investigated 665 ticks collected in 2019 (n = 160), 2022 (n…
View article: Whole blood RNA profiling in cats dissects the host immunological response during recovery from feline infectious peritonitis
Whole blood RNA profiling in cats dissects the host immunological response during recovery from feline infectious peritonitis Open
Feline infectious peritonitis (FIP) is caused by infection with the feline coronavirus (FCoV) and is fatal if left untreated. In most cats, FCoV primarily infects the gastrointestinal tract and remains asymptomatic or causes only mild ente…
View article: Unexpected Clinical and Laboratory Observations During and After 42-Day Versus 84-Day Treatment with Oral GS-441524 in Cats with Feline Infectious Peritonitis with Effusion
Unexpected Clinical and Laboratory Observations During and After 42-Day Versus 84-Day Treatment with Oral GS-441524 in Cats with Feline Infectious Peritonitis with Effusion Open
The nucleoside analogue GS-441524 is a common treatment for cats with feline infectious peritonitis (FIP). In a previous study, 40 cats with FIP with effusion were treated with 15 mg/kg GS-441524 orally once daily for either 42 days or 84 …
View article: Antibody Titer Testing in Dogs: Evaluation of Three Point-of-Care Tests for Canine Core Vaccine Antigens Compared to Virus Neutralization
Antibody Titer Testing in Dogs: Evaluation of Three Point-of-Care Tests for Canine Core Vaccine Antigens Compared to Virus Neutralization Open
Antibody titer testing can be useful in controlling successful puppy immunization and can reduce unnecessary vaccinations in adult dogs. We evaluated three commercially available point-of-care tests (POCTs) for detecting antibodies against…
View article: First detection of <i>Cytauxzoon</i> spp. DNA in questing <i>Ixodes ricinus</i> nymphs
First detection of <i>Cytauxzoon</i> spp. DNA in questing <i>Ixodes ricinus</i> nymphs Open
Feline cytauxzoonosis is an emerging tick-borne disease in Europe. While infections have been reported in different European countries, the tick vector remains unknown. This study investigated 665 ticks collected in 2019 (n= 160), 2022 (n=…
View article: Immune-Mediated Hemolytic Anemia in Cats with Feline Infectious Peritonitis
Immune-Mediated Hemolytic Anemia in Cats with Feline Infectious Peritonitis Open
Feline infectious peritonitis (FIP) is caused by mutated feline coronaviruses. Immune-mediated hemolytic anemia (IMHA) arises due to immune-mediated erythrocyte destruction and can be non-associative or associative with diseases such as FI…
View article: Navigating neurological re-emergence in feline infectious peritonitis: challenges and insights from GS-441524 and remdesivir treatment
Navigating neurological re-emergence in feline infectious peritonitis: challenges and insights from GS-441524 and remdesivir treatment Open
Case summary A 6-month-old male British Longhair cat presented with acute neurological signs, ocular changes, massive ascites and laboratory parameters consistent with feline infectious peritonitis (FIP). Systemic and neurological signs fu…
View article: Myocarditis in Cats with Feline Infectious Peritonitis Can Be Cured with GS-441524 and Symptomatic Cardiovascular Treatment
Myocarditis in Cats with Feline Infectious Peritonitis Can Be Cured with GS-441524 and Symptomatic Cardiovascular Treatment Open
Feline infectious peritonitis (FIP) caused by feline coronavirus (FCoV) is a fatal disease in cats characterized by variable manifestations. Myocarditis represents a less commonly described pathology within the clinical spectrum of FIP. No…
View article: Sysmex <scp>XN</scp>‐V scattergrams in feline mastocythemia and basophilia: Two similar but different cases
Sysmex <span>XN</span>‐V scattergrams in feline mastocythemia and basophilia: Two similar but different cases Open
Scattergram evaluation is an important part of nonstatistical quality control in Veterinary Hematology. In this case report, we present two feline hematological cases with abnormal Sysmex XN‐V scattergrams. Case 1 involved a 16‐year‐old ne…
View article: Navigating Neurological Re-emergence in Feline Infectious Peritonitis: Challenges and Insights from GS-441524 and Remdesivir Treatment
Navigating Neurological Re-emergence in Feline Infectious Peritonitis: Challenges and Insights from GS-441524 and Remdesivir Treatment Open
Case summary A six-month-old male British Longhair cat presented with acute neurological signs, ocular changes, massive ascites and laboratory parameters consistent with feline infectious peritonitis (FIP). Systemic and neurological signs …
View article: Anatomical, functional, and blood-born predictors of severity of brachycephalic obstructive airway syndrome severity in French Bulldogs
Anatomical, functional, and blood-born predictors of severity of brachycephalic obstructive airway syndrome severity in French Bulldogs Open
Brachycephalic breeds suffer from respiratory distress known as brachycephalic obstructive airway syndrome (BOAS) and the multiple comorbidities associated with it. Targeted breeding toward a more BOAS-free phenotype requires accurate and …
View article: Feline Papillomatosis
Feline Papillomatosis Open
Different types of feline papillomaviruses (PVs) are associated with a variety of skin lesions and neoplasia, such as papillomas and cell carcinomas, but the virus can also be found in healthy skin. In this review, the European Advisory Bo…
View article: Dietary Inulin Supplementation Modulates Fecal Microbiota and Vaccine Response in Cats—A Double-Blind Randomized Controlled Pilot Study
Dietary Inulin Supplementation Modulates Fecal Microbiota and Vaccine Response in Cats—A Double-Blind Randomized Controlled Pilot Study Open
Twenty-six cats were fed either a control or an inulin-supplemented diet (0.6%) for six weeks with measurements of fecal short-chain fatty acids (SCFAs) and microbiota. In the second phase, cats were fed their respective diets for another …
View article: Longitudinal assessment of thyroid function in dogs with hypoadrenocorticism: Clinical outcomes and prevalence of autoantibodies
Longitudinal assessment of thyroid function in dogs with hypoadrenocorticism: Clinical outcomes and prevalence of autoantibodies Open
Background Knowledge about primary hypoadrenocorticism coexisting with immune‐mediated thyroiditis (Schmidt's syndrome) in dogs is limited. Objective To evaluate thyroid function in dogs with naturally occurring hypoadrenocorticism before …
View article: Complement Evasion Protects FCoV from Virus Clearance Within Prototypic FIP Lesions
Complement Evasion Protects FCoV from Virus Clearance Within Prototypic FIP Lesions Open
Feline infectious peritonitis (FIP) is a fatal disease in cats caused by infection with feline coronavirus (FCoV). Despite severe inflammatory changes, defense mechanisms fail to achieve virus clearance. Some studies focused on various imm…
View article: Investigations on the Potential Role of Free-Ranging Wildlife as a Reservoir of SARS-CoV-2 in Switzerland
Investigations on the Potential Role of Free-Ranging Wildlife as a Reservoir of SARS-CoV-2 in Switzerland Open
Amid the SARS-CoV-2 pandemic, concerns surfaced regarding the spread of the virus to wildlife. Switzerland lacked data concerning the exposure of free-ranging animals to SARS-CoV-2 during this period. This study aimed to investigate the po…
View article: Antiviral therapy in cats progressively infected with feline leukaemia virus: lessons from a series of 18 consecutive cases from Australia
Antiviral therapy in cats progressively infected with feline leukaemia virus: lessons from a series of 18 consecutive cases from Australia Open
Background It is doubtful that any of the treatments proposed for feline leukaemia virus (FeLV) infection are effective, despite the entity being described 60 years ago. Methods Eighteen pet cats with progressive FeLV infections were recru…
View article: Short Treatment of 42 Days with Oral GS-441524 Results in Equal Efficacy as the Recommended 84-Day Treatment in Cats Suffering from Feline Infectious Peritonitis with Effusion—A Prospective Randomized Controlled Study
Short Treatment of 42 Days with Oral GS-441524 Results in Equal Efficacy as the Recommended 84-Day Treatment in Cats Suffering from Feline Infectious Peritonitis with Effusion—A Prospective Randomized Controlled Study Open
In the past, feline infectious peritonitis (FIP) caused by feline coronavirus (FCoV) was considered fatal. Today, highly efficient drugs, such as GS-441524, can lead to complete remission. The currently recommended treatment duration in th…
View article: Neutrophil Oxidative Burst Profile Is Related to a Satisfactory Response to Itraconazole and Clinical Cure in Feline Sporotrichosis
Neutrophil Oxidative Burst Profile Is Related to a Satisfactory Response to Itraconazole and Clinical Cure in Feline Sporotrichosis Open
Despite the central role of cats in the transmission and amplification of Sporothrix, studies regarding immune response in feline sporotrichosis are scarce. In cats with sporotrichosis, neutrophil-rich lesions are usually associated to goo…
View article: Canine Cerebrospinal Fluid Analysis Using Two New Automated Techniques: The Sysmex XN-V Body Fluid Mode and an Artificial-Intelligence-Based Algorithm
Canine Cerebrospinal Fluid Analysis Using Two New Automated Techniques: The Sysmex XN-V Body Fluid Mode and an Artificial-Intelligence-Based Algorithm Open
Cerebrospinal fluid analysis is an important diagnostic test when assessing a neurological canine patient. For this analysis, the total nucleated cell count and differential cell counts are routinely taken, but both involve time-consuming …
View article: Alpha-1-Acid Glycoprotein Quantification via Spatial Proximity Analyte Reagent Capture Luminescence Assay: Application as Diagnostic and Prognostic Marker in Serum and Effusions of Cats with Feline Infectious Peritonitis Undergoing GS-441524 Therapy
Alpha-1-Acid Glycoprotein Quantification via Spatial Proximity Analyte Reagent Capture Luminescence Assay: Application as Diagnostic and Prognostic Marker in Serum and Effusions of Cats with Feline Infectious Peritonitis Undergoing GS-441524 Therapy Open
Until recently, the diagnosis of feline infectious peritonitis (FIP) in cats usually led to euthanasia, but recent research has revealed that antiviral drugs, including the nucleoside analog GS-441524, have the potential to effectively cur…
View article: Evaluation of a Revised Point-of-Care Test for the Detection of Feline Leukaemia p27 Antigen and Anti-p15E Antibodies in Cats
Evaluation of a Revised Point-of-Care Test for the Detection of Feline Leukaemia p27 Antigen and Anti-p15E Antibodies in Cats Open
The first point-of-care (PoC) test (v-RetroFel®; modified version 2021) determining the presence of FeLV p27 antigen and FeLV anti-p15E antibodies has become recently commercially available to identify different feline leukaemia virus (FeL…
View article: Detection of SARS-CoV-2 RNA in a Zoo-Kept Red Fox (Vulpes vulpes)
Detection of SARS-CoV-2 RNA in a Zoo-Kept Red Fox (Vulpes vulpes) Open
Many different animal species are susceptible to SARS-CoV-2, including a few Canidae (domestic dog and raccoon dog). So far, only experimental evidence is available concerning SARS-CoV-2 infections in red foxes (Vulpes vulpes). This is the…
View article: Long-term surveillance of the feline leukemia virus in the endangered Iberian lynx (Lynx pardinus) in Andalusia, Spain (2008–2021)
Long-term surveillance of the feline leukemia virus in the endangered Iberian lynx (Lynx pardinus) in Andalusia, Spain (2008–2021) Open
Feline leukemia virus (FeLV) infection is considered one of the most serious disease threats for the endangered Iberian lynx ( Lynx pardinus ) Over 14 years (2008–2021), we investigated FeLV infection using point-of-care antigen test and q…
View article: Prospective Investigation of Feline Leukemia Virus Infection in Stray Cats Subjected to a Trap–Neuter–Return Program in Switzerland
Prospective Investigation of Feline Leukemia Virus Infection in Stray Cats Subjected to a Trap–Neuter–Return Program in Switzerland Open
Feline leukemia virus (FeLV) remains a serious concern in some countries despite advances in diagnostics and vaccines. FeLV-infected cats often have reduced lifespans due to FeLV-associated diseases. The infection is transmitted through so…