Lakshmi S. Nair
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View article: Osteoinductive low-dose 3D porous calcium phosphate graphene oxide–integrated matrices enhance osteogenesis and mechanical properties
Osteoinductive low-dose 3D porous calcium phosphate graphene oxide–integrated matrices enhance osteogenesis and mechanical properties Open
Bone regeneration continues to be a challenge due to the complex nature of the tissue. Identifying new materials that stimulate regeneration while providing mechanical properties is an active area of research. One class of promising materi…
View article: A blueprint for precise and fault-tolerant analog neural networks
A blueprint for precise and fault-tolerant analog neural networks Open
Analog computing has reemerged as a promising avenue for accelerating deep neural networks (DNNs) to overcome the scalability challenges posed by traditional digital architectures. However, achieving high precision using analog technologie…
View article: CLIP-Embed-KD: Computationally Efficient Knowledge Distillation Using Embeddings as Teachers
CLIP-Embed-KD: Computationally Efficient Knowledge Distillation Using Embeddings as Teachers Open
Contrastive Language-Image Pre-training (CLIP) has been shown to improve zero-shot generalization capabilities of language and vision models. In this paper, we extend CLIP for efficient knowledge distillation, by utilizing embeddings as te…
View article: Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer
Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer Open
In terms of biomedical tools, nanodiamonds (ND) are a more recent innovation. Their size typically ranges between 4 to 100 nm. ND are produced via a variety of methods and are known for their physical toughness, durability, and chemical st…
View article: Hyaluronic acid–British anti-Lewisite as a safer chelation therapy for the treatment of arthroplasty-related metallosis
Hyaluronic acid–British anti-Lewisite as a safer chelation therapy for the treatment of arthroplasty-related metallosis Open
Cobalt-containing alloys are useful for orthopedic applications due to their low volumetric wear rates, corrosion resistance, high mechanical strength, hardness, and fatigue resistance. Unfortunately, these prosthetics release significant …
View article: Photonic Accelerators for Image Segmentation in Autonomous Driving and Defect Detection
Photonic Accelerators for Image Segmentation in Autonomous Driving and Defect Detection Open
Photonic computing promises faster and more energy-efficient deep neural network (DNN) inference than traditional digital hardware. Advances in photonic computing can have profound impacts on applications such as autonomous driving and def…
View article: A Blueprint for Precise and Fault-Tolerant Analog Neural Networks
A Blueprint for Precise and Fault-Tolerant Analog Neural Networks Open
Analog computing has reemerged as a promising avenue for accelerating deep neural networks (DNNs) due to its potential to overcome the energy efficiency and scalability challenges posed by traditional digital architectures. However, achiev…
View article: Instrumentation and Data Interpretation in Transportation Geotechnics
Instrumentation and Data Interpretation in Transportation Geotechnics Open
Transportation networks on the eastern coast of Australia are often built on or traverse coastal flood plains and marine clays with unfavourable soil conditions. In the past two decades, a significant number of laboratory investigations we…
View article: Creative Problem Solving in Artificially Intelligent Agents: A Survey and Framework (Extended Abstract)
Creative Problem Solving in Artificially Intelligent Agents: A Survey and Framework (Extended Abstract) Open
Creative Problem Solving (CPS) is a sub-area within artificial intelligence that focuses on methods for solving off-nominal, or anomalous problems in autonomous systems. Despite many advancements in planning and learning in AI, resolving n…
View article: INT-FP-QSim: Mixed Precision and Formats For Large Language Models and Vision Transformers
INT-FP-QSim: Mixed Precision and Formats For Large Language Models and Vision Transformers Open
The recent rise of large language models (LLMs) has resulted in increased efforts towards running LLMs at reduced precision. Running LLMs at lower precision supports resource constraints and furthers their democratization, enabling users t…
View article: Sensitivity-Aware Finetuning for Accuracy Recovery on Deep Learning Hardware
Sensitivity-Aware Finetuning for Accuracy Recovery on Deep Learning Hardware Open
Existing methods to recover model accuracy on analog-digital hardware in the presence of quantization and analog noise include noise-injection training. However, it can be slow in practice, incurring high computational costs, even when sta…
View article: Hypoxia induced lactate acidosis modulates tumor microenvironment and lipid reprogramming to sustain the cancer cell survival
Hypoxia induced lactate acidosis modulates tumor microenvironment and lipid reprogramming to sustain the cancer cell survival Open
It is well known that solid hypoxic tumour cells oxidise glucose through glycolysis, and the end product of this pathway is fermented into lactate which accumulates in the tumour microenvironment (TME). Initially, it was proclaimed that ca…
View article: Electroconductivity, a regenerative engineering approach to reverse rotator cuff muscle degeneration
Electroconductivity, a regenerative engineering approach to reverse rotator cuff muscle degeneration Open
Muscle degeneration is one the main factors that lead to the high rate of retear after a successful repair of rotator cuff (RC) tears. The current surgical practices have failed to treat patients with chronic massive rotator cuff tears (RC…
View article: Creative Problem Solving in Artificially Intelligent Agents: A Survey and Framework
Creative Problem Solving in Artificially Intelligent Agents: A Survey and Framework Open
Creative Problem Solving (CPS) is a sub-area within Artificial Intelligence (AI) that focuses on methods for solving off-nominal, or anomalous problems in autonomous systems. Despite many advancements in planning and learning, resolving no…
View article: Transcriptional profiling of neuronal ion channels in dorsal root ganglion–derived immortal cell line (F-11) under different culture conditions
Transcriptional profiling of neuronal ion channels in dorsal root ganglion–derived immortal cell line (F-11) under different culture conditions Open
View article: Poly(cannabinoid)s: Hemp-Derived Biocompatible Thermoplastic Polyesters with Inherent Antioxidant Properties
Poly(cannabinoid)s: Hemp-Derived Biocompatible Thermoplastic Polyesters with Inherent Antioxidant Properties Open
The legalization of hemp cultivation in the United States has caused the price of hemp-derived cannabinoids to decrease 10-fold within 2 years. Cannabidiol (CBD), one of many naturally occurring diols found in hemp, can be purified in high…
View article: Muscle degeneration in chronic massive rotator cuff tears of the shoulder: Addressing the real problem using a graphene matrix
Muscle degeneration in chronic massive rotator cuff tears of the shoulder: Addressing the real problem using a graphene matrix Open
Massive rotator cuff tears (MRCTs) of the shoulder cause disability and pain among the adult population. In chronic injuries, the tendon retraction and subsequently the loss of mechanical load lead to muscle atrophy, fat accumulation, and …
View article: Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells
Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells Open
Adipose-derived stem cells (ADSCs) hold tremendous potential for treating diseases and repairing damaged tissues. Heparan sulfate (HS) plays various roles in cellular signaling mechanisms. The importance of HS in stem cell function has bee…
View article: Internal Instability and Fluidisation of Subgrade Soil under Cyclic Loading
Internal Instability and Fluidisation of Subgrade Soil under Cyclic Loading Open
Rapid globalisation and the rise in population have substantially increased the demand for rail infrastructure which have been critical in transporting passengers and freight across landmasses for over a century. The surge in demand often …
View article: Adaptive Block Floating-Point for Analog Deep Learning Hardware
Adaptive Block Floating-Point for Analog Deep Learning Hardware Open
Analog mixed-signal (AMS) devices promise faster, more energy-efficient deep neural network (DNN) inference than their digital counterparts. However, recent studies show that DNNs on AMS devices with fixed-point numbers can incur an accura…
View article: Creative Problem Solving in Artificially Intelligent Agents: A Survey and Framework
Creative Problem Solving in Artificially Intelligent Agents: A Survey and Framework Open
Creative Problem Solving (CPS) is a sub-area within Artificial Intelligence (AI) that focuses on methods for solving off-nominal, or anomalous problems in autonomous systems. Despite many advancements in planning and learning, resolving no…
View article: Injectable amnion hydrogel-mediated delivery of adipose-derived stem cells for osteoarthritis treatment
Injectable amnion hydrogel-mediated delivery of adipose-derived stem cells for osteoarthritis treatment Open
Significance Osteoarthritis (OA) is a chronic disease affecting millions of people worldwide with no curative solution. In the present study, we developed a minimally invasive injectable system using amnion membrane (AM) from the human pla…
View article: Gender Renaissance: Uncovering Queerness in the Characters of Devdutt Pattanaik’s The Pregnant King
Gender Renaissance: Uncovering Queerness in the Characters of Devdutt Pattanaik’s The Pregnant King Open
View article: Perineural Local Anesthetic Treatments for Osteoarthritic Pain
Perineural Local Anesthetic Treatments for Osteoarthritic Pain Open
View article: Stromal Vascular Fraction for Osteoarthritis of the Knee Regenerative Engineering
Stromal Vascular Fraction for Osteoarthritis of the Knee Regenerative Engineering Open
View article: The Mechanism of Metallosis After Total Hip Arthroplasty
The Mechanism of Metallosis After Total Hip Arthroplasty Open
Metallosis is defined as the accumulation and deposition of metallic particles secondary to abnormal wear from prosthetic implants that may be visualized as abnormal macroscopic staining of periprosthetic soft tissues. This phenomenon occu…
View article: Hair Follicle Stem Cells for Tissue Regeneration
Hair Follicle Stem Cells for Tissue Regeneration Open
With the positive outcomes of various cell therapies currently under preclinical and clinical studies, there is a significant interest in novel stem cell sources with unique therapeutic properties. Studies over the past two decades or so d…
View article: Inductive Materials for Regenerative Engineering
Inductive Materials for Regenerative Engineering Open
Regenerative engineering has pioneered several novel biomaterials to treat critical-sized bone injuries. However, despite significant improvement in synthetic materials research, some limitations still exist. The constraints correlated wit…
View article: Mechanically superior matrices promote osteointegration and regeneration of anterior cruciate ligament tissue in rabbits
Mechanically superior matrices promote osteointegration and regeneration of anterior cruciate ligament tissue in rabbits Open
Significance This paper describes a mechanically superior matrix that enhances the osteointegration and regeneration of ACL tissue in a rabbit model. We show that bone marrow aspirate concentrate enhances the presence of cuboidal cells tha…
View article: Preparation and characterization of amnion hydrogel and its synergistic effect with adipose derived stem cells towards IL1β activated chondrocytes
Preparation and characterization of amnion hydrogel and its synergistic effect with adipose derived stem cells towards IL1β activated chondrocytes Open