Ruth J. F. Loos
YOU?
Author Swipe
View article: Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas
Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas Open
View article: MagicalRsq-X: A cross-cohort transferable genotype imputation quality metric
MagicalRsq-X: A cross-cohort transferable genotype imputation quality metric Open
View article: Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood
Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood Open
View article: Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing
Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing Open
View article: TOP-LD: A tool to explore linkage disequilibrium with TOPMed whole-genome sequence data
TOP-LD: A tool to explore linkage disequilibrium with TOPMed whole-genome sequence data Open
View article: Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis Open
View article: Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program
Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program Open
View article: Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease
Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease Open
Background Obesity is thought to increase cardiovascular disease (CVD) risk partly through dyslipidemia. Yet, obesity’s effects on dyslipidemia are not uniform. Understanding the shared genetic basis between obesity and lipid traits can pr…
View article: Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations
Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations Open
Clonal hematopoiesis (CH) is defined by the expansion of a lineage of genetically identical cells in blood. Genetic lesions that confer a fitness advantage, such as leukemogenic point mutations or mosaic chromosomal alterations (mCAs), are…
View article: Genome-wide association study provides novel insight into the genetic architecture of severe obesity
Genome-wide association study provides novel insight into the genetic architecture of severe obesity Open
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limi…
View article: Common genetic variants near <i>SLC2A2</i> and glycemic response to glimepiride in the GRADE comparative effectiveness clinical trial
Common genetic variants near <i>SLC2A2</i> and glycemic response to glimepiride in the GRADE comparative effectiveness clinical trial Open
Optimizing second-line therapy for type 2 diabetes is challenging due to interindividual variability in response. We conducted a pharmacogenomic genome-wide association study (GWAS) in the Glycemia Reduction Approaches in Type 2 Diabetes: …
View article: Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease
Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease Open
Background Obesity is thought to increase cardiovascular disease (CVD) risk partly through dyslipidemia. Yet, obesity’s effects on dyslipidemia are not uniform. Understanding the shared genetic basis between obesity and lipid traits can pr…
View article: Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci
Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci Open
Background Genome-wide association studies (GWAS) have identified numerous body mass index (BMI) loci. However, most underlying mechanisms from risk locus to BMI remain unknown. Leveraging omics data through integrative analyses could prov…
View article: Correction to: Elucidating pathways to pediatric obesity: a study evaluating obesity polygenic risk scores related to appetitive traits in children
Correction to: Elucidating pathways to pediatric obesity: a study evaluating obesity polygenic risk scores related to appetitive traits in children Open
View article: Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities Open
Obesity is a heterogeneous condition not adequately captured by a single adiposity trait. We conducted a multi-trait genome-wide association analysis using individual-level data from 452,768 UK Biobank participants to study obesity in rela…
View article: Genome-wide association study provides novel insight into the genetic architecture of severe obesity
Genome-wide association study provides novel insight into the genetic architecture of severe obesity Open
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limi…
View article: Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Open
Introduction: Genetic variants associated with nicotine dependence have previously been identified, primarily in European-ancestry populations. No genome-wide association studies (GWAS) have been reported for smoking behaviors in Hispanics…
View article: Correction to: Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium
Correction to: Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium Open
View article: Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals
Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals Open
This study provides a meta-analysis framework for large-scale whole genome sequence association analyses from diverse population groups, yielding novel rare non-coding variant associations.
View article: Whole-genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia
Whole-genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia Open
In studies of individuals of primarily European genetic ancestry, common and low-frequency variants and rare coding variants have been found to be associated with the risk of bipolar disorder (BD) and schizophrenia (SZ). However, less is k…
View article: An Efficient Lasso Framework for Admixture-Aware Polygenic Scores
An Efficient Lasso Framework for Admixture-Aware Polygenic Scores Open
Polygenic scores (PGS) have promising clinical applications for risk stratification, disease screening, and personalized medicine. However, most PGS are trained on predominantly European ancestry cohorts and have limited portability to ext…
View article: Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans
Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans Open
E-selectin mediates the rolling of circulating leukocytes during inflammatory processes. Previous genome-wide association studies in European and Asian individuals have identified the ABO locus associated with E-selectin levels. Using Tran…
View article: Exposure to per- and poly-fluoroalkyl substances in association to later occurrence of type 2 diabetes and metabolic pathway dysregulation in a multiethnic US population
Exposure to per- and poly-fluoroalkyl substances in association to later occurrence of type 2 diabetes and metabolic pathway dysregulation in a multiethnic US population Open
National Institutes of Health (R01ES033688, P30ES023515, R21ES035148, R35ES030435, R01ES032242, R01ES034521, R01ES029944, R01ES030364, U01HG013288, R21ES037112 and P30ES007048).
View article: A Genome-Wide Association Study Identifies Blood Disorder–Related Variants Influencing Hemoglobin A1c With Implications for Glycemic Status in U.S. Hispanics/Latinos
A Genome-Wide Association Study Identifies Blood Disorder–Related Variants Influencing Hemoglobin A1c With Implications for Glycemic Status in U.S. Hispanics/Latinos Open
OBJECTIVE: We aimed to identify hemoglobin A1c (HbA1c)-associated genetic variants and examine their implications for glycemic status evaluated by HbA1c in U.S. Hispanics/Latinos with diverse genetic ancest…
View article: A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study
A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study Open
Objective To delineate organ-specific and systemic drivers of metabolic dysfunction-associated steatotic liver disease (MASLD), we applied integrative causal inference across clinical, imaging, and proteomic domains in individuals with and…
View article: Body Fluid Proteomic Landscape of Acute Exercise
Body Fluid Proteomic Landscape of Acute Exercise Open
Physical activity improves health, yet the molecular mechanisms remain partially understood. This study presents a high-resolution, time-resolved atlas profiling 10,127 proteins across plasma, saliva, and urine from healthy adults post-acu…
View article: The genomics of childhood eating behaviours
The genomics of childhood eating behaviours Open
View article: Author Correction: The genomics of childhood eating behaviours
Author Correction: The genomics of childhood eating behaviours Open
View article: Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease
Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease Open
View article: Correction to: Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) Study
Correction to: Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) Study Open