Roberto G. Lucchini
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View article: Polypharmacy and frailty among aging World Trade Center responders
Polypharmacy and frailty among aging World Trade Center responders Open
Background During and after the 9/11 rescue and recovery efforts, World Trade Center (WTC) responders were exposed to environmental hazards that may accelerate aging and increase frailty. This study examines the relationship between polyph…
View article: MRI signature of brain age underlying post-traumatic stress disorder in World Trade Center responders
MRI signature of brain age underlying post-traumatic stress disorder in World Trade Center responders Open
Approximately 23% of the men and women who participated in rescue and recovery efforts at the 9/11 World Trade Center (WTC) site experience persistent, clinically significant post-traumatic stress disorder (PTSD). Recent structural and fun…
View article: Impact of Manganese on Neuronal Function: An Exploratory Multi-Omics Study on Ferroalloy Workers in Brescia, Italy
Impact of Manganese on Neuronal Function: An Exploratory Multi-Omics Study on Ferroalloy Workers in Brescia, Italy Open
Background: There is growing interest in the potential role of manganese (Mn) in the development of Alzheimer’s Disease and related dementias (ADRD). Methods: In this nested pilot study of a ferroalloy worker cohort, we investigated the im…
View article: Exploratory Metabolomic and Lipidomic Profiling in a Manganese-Exposed Parkinsonism-Affected Population in Northern Italy
Exploratory Metabolomic and Lipidomic Profiling in a Manganese-Exposed Parkinsonism-Affected Population in Northern Italy Open
Background/Objectives: Chronic manganese (Mn) exposure is a recognized environmental contributor to Parkinsonian syndromes, including Mn-induced Parkinsonism (MnIP). This study aimed to evaluate whole-blood Mn levels and investigate diseas…
View article: Impact of Manganese on Neuronal Function: An Exploratory MultiOmic Study on Ferroalloy Workers in Brescia, Italy
Impact of Manganese on Neuronal Function: An Exploratory MultiOmic Study on Ferroalloy Workers in Brescia, Italy Open
Interest is growing in the potential role of manganese (Mn) in Alzheimer’s Disease (ADRD). This nested pilot study of a ferroalloy workers cohort was aimed to investigate the effects of long-term occupational Mn exposure on cognitive funct…
View article: Enhancing Bayesian Kernel Machine Regression: A Dynamic Thresholding Framework to Address Variability and Skewness in High-Dimensional Environmental Health Data
Enhancing Bayesian Kernel Machine Regression: A Dynamic Thresholding Framework to Address Variability and Skewness in High-Dimensional Environmental Health Data Open
Bayesian Kernel Machine Regression (BKMR) is widely used in environmental health research to model complex, nonlinear, and interactive relationships in high-dimensional datasets. However, using a fixed posterior inclusion probability (PIP)…
View article: Sociodemographic and Occupational Factors Influencing Pregnant Workers’ Awareness and Utilization of the New York City Pregnant Workers Fairness Act
Sociodemographic and Occupational Factors Influencing Pregnant Workers’ Awareness and Utilization of the New York City Pregnant Workers Fairness Act Open
Background: The New York City (NYC) Pregnant Workers Fairness Act (PWFA) went into effect in January 2014 to provide greater flexibility for pregnant workers’ accommodations, yet no studies to date have evaluated its effectiveness and util…
View article: The development of frailty trajectories in world trade center general responders and the association with World Trade Center Exposure
The development of frailty trajectories in world trade center general responders and the association with World Trade Center Exposure Open
Several sociodemographic and WTC variables were associated with more hazardous frailty trajectories in WTC general responders. This work is beneficial to informing and directing future interventions for those at higher-risk for more hazard…
View article: Mercury Contamination and Co‑exposures in the Amazon Basin: At the Center of the Planetary Environmental Crisis
Mercury Contamination and Co‑exposures in the Amazon Basin: At the Center of the Planetary Environmental Crisis Open
Background: Mercury contamination remains a significant public health concern in the Amazon basin. This review synthesizes recent evidence on mercury exposure, health outcomes, and emerging co-exposures in the Amazon countries. Data were p…
View article: Association between environmental air pollution and olfactory functioning among Italian adolescents and young adults in the province of Brescia, Italy
Association between environmental air pollution and olfactory functioning among Italian adolescents and young adults in the province of Brescia, Italy Open
Olfactory receptor neurons are in direct contact with the ambient air, making olfactory function particularly susceptible to airborne pollutants. This study investigates the relationship between air pollution and olfactory function among a…
View article: Exposure duration and cerebral amyloidosis in the olfactory cortex of World Trade Center responders: A positron emission tomography and magnetic resonance imaging study
Exposure duration and cerebral amyloidosis in the olfactory cortex of World Trade Center responders: A positron emission tomography and magnetic resonance imaging study Open
Background Amyloid-β proteins, a hallmark of Alzheimer's disease, are believed to play an adaptive role in the cerebral immune response. Objective Amyloid is believed to play a role in cerebral immune response and could play a similar role…
View article: MRI signature of brain age underlying post- traumatic stress disorder in World Trade Center responders
MRI signature of brain age underlying post- traumatic stress disorder in World Trade Center responders Open
The men and women involved in rescue and recovery operations at the 9/11 World Trade Center (WTC) site have a greater prevalence (23%) of persistent, clinically significant post- traumatic stress disorder (PTSD). Recent structural and func…
View article: Metabolomic and Lipidomic Analysis of Manganese-Associated Parkinsonism: a Case-Control Study in Brescia, Italy
Metabolomic and Lipidomic Analysis of Manganese-Associated Parkinsonism: a Case-Control Study in Brescia, Italy Open
Background and Objectives Excessive Manganese (Mn) exposure is neurotoxic and can cause Mn-Induced Parkinsonism (MnIP), marked by cognitive and motor dysfunction. Although metabolomic and lipidomic research in Parkinsonism (PD) patients ex…
View article: Sex-specific associations of a ferroalloy metal mixture with motor function in Italian adolescents
Sex-specific associations of a ferroalloy metal mixture with motor function in Italian adolescents Open
Background: Motor function is critical for children’s health, yet remains an understudied neurodevelopmental domain. Exposure to metals has been linked with motor function, but no study has examined the joint effects of metal mixtures. Met…
View article: SS07-04 THE NEED FOR A NEW HOLISTIC APPROACH IN EMERGENCY PREPAREDNESS AND MANAGEMENT
SS07-04 THE NEED FOR A NEW HOLISTIC APPROACH IN EMERGENCY PREPAREDNESS AND MANAGEMENT Open
Introduction Disasters of different types increasingly affect humanity and plans for emergency preparedness and management are still largely insufficient to avoid immediate and long-term impacts on physical/mental health, ecosystem, produc…
View article: Assessing the Risk of Heart Attack: A Bayesian Kernel Machine Regression Analysis of Heavy Metal Mixtures
Assessing the Risk of Heart Attack: A Bayesian Kernel Machine Regression Analysis of Heavy Metal Mixtures Open
Background: The assessment of heavy metals' effects on human health is frequently limited to investigating one metal or a group of related metals. The effect of heavy metals mixture on heart attack is unknown. Methods: This study applied t…
View article: A pilot study to identify factors associated with frailty within the World Trade Center general responder cohort
A pilot study to identify factors associated with frailty within the World Trade Center general responder cohort Open
Background Given the significant exposures experienced by the World Trade Center (WTC) general responders, there is increasing interest in understanding the effect of these exposures on aging in this population. We aim to identify factors …
View article: Fluoride and Manganese
Fluoride and Manganese Open
Children can be exposed to many hazardous metals in the environment, including fluoride and manganese. Sources of exposure may include drinking water, foods and dietary supplements, and metal-containing particles released into the air from…