Rafael Luján
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View article: Neuronal lipofuscinosis caused by Kufs disease/CLN4 DNAJC5 mutations but not by a CSPα/DNAJC5 deficiency
Neuronal lipofuscinosis caused by Kufs disease/CLN4 DNAJC5 mutations but not by a CSPα/DNAJC5 deficiency Open
Kufs disease/CLN4 is an autosomal dominant neurodegenerative disorder caused by unknown mechanisms through Leu 115 Arg and Leu 116 Δ mutations in the DNAJC5 gene that encodes the synaptic vesicle co-chaperone cysteine string protein α (CSP…
View article: Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism
Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism Open
Autism spectrum disorder is a complex neurodevelopmental disease characterized by altered cortical network excitability. Recent genetic studies have identified deep layer V cortical pyramidal neurons in the frontal cortex as central to aut…
View article: Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement
Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement Open
Opioids trigger structural and functional neural adaptations of the reward circuit that lead to dependence. Synaptic cell adhesion molecules (CAMs) play a pivotal role in circuit organization and present prime candidates for orchestrating …
View article: Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease
Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease Open
Niemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to psychiatric alterations. Using an NPC mouse model (Npc1 nmf164 ) we show aberr…
View article: Chronic ethanol exposure in mice evokes pre‐ and postsynaptic deficits in GABAergic transmission in ventral tegmental area GABA neurons
Chronic ethanol exposure in mice evokes pre‐ and postsynaptic deficits in GABAergic transmission in ventral tegmental area GABA neurons Open
Background and purpose GABAergic neurons in mouse ventral tegmental area (VTA) exhibit elevated activity during withdrawal following chronic ethanol exposure. While increased glutamatergic input and decreased GABA A receptor sensitivity ha…
View article: Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by amyloid plaques and cognitive decline, the latter of which is thought to be driven by soluble oligomeric amyloid-β (oAβ). The dysregulation of G protein–g…
View article: Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology
Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology Open
Synaptic dysfunction is an early feature in Alzheimer’s disease (AD) pathogenesis and a major morphological correlate of memory deficits. Given the main synaptic location of N -methyl-D-aspartate receptors (NMDARs), their dysregulation has…
View article: Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles
Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles Open
Members of the synaptophysin and synaptogyrin family are vesicle proteins with four transmembrane domains. In spite of their abundance in synaptic vesicle (SV) membranes, their role remains elusive and only mild defects at the cellular and…
View article: Amyloid-beta pathology–induced nanoscale synaptic disruption: the case of the GABAB–GIRK assembly
Amyloid-beta pathology–induced nanoscale synaptic disruption: the case of the GABAB–GIRK assembly Open
Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks, leading to aberrant homeostatic synaptic plasticity. AD has progressively been recognized as synaptopathy and synaptic dysfunction …
View article: Nanoarchitecture of Ca<sub>V</sub>2.1 channels and GABA<sub>B</sub> receptors in the mouse hippocampus: Impact of APP/PS1 pathology
Nanoarchitecture of Ca<sub>V</sub>2.1 channels and GABA<sub>B</sub> receptors in the mouse hippocampus: Impact of APP/PS1 pathology Open
Voltage‐gated Ca V 2.1 (P/Q‐type) Ca 2+ channels play a crucial role in regulating neurotransmitter release, thus contributing to synaptic plasticity and to processes such as learning and memory. Despite their recognized importance in neur…
View article: Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles
Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles Open
Members of the synaptophysin and synaptogyrin family are vesicle proteins with four transmembrane domains. In spite of their abundance in synaptic vesicle (SV) membranes, their role remains elusive and only mild defects at the cellular and…
View article: Activation of Shh/Smo is sufficient to maintain oligodendrocyte precursor cells in an undifferentiated state and is not necessary for myelin formation and (re)myelination
Activation of Shh/Smo is sufficient to maintain oligodendrocyte precursor cells in an undifferentiated state and is not necessary for myelin formation and (re)myelination Open
Myelination is the terminal step in a complex and precisely timed program that orchestrates the proliferation, migration and differentiation of oligodendroglial cells. It is thought that Sonic Hedgehog (Shh) acting on Smoothened (Smo) part…
View article: Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice
Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice Open
JOURNAL/nrgr/04.03/01300535-202409000-00040/figure1/v/2024-01-30T062302Z/r/image-tiff Plaques of amyloid-β (Aβ) and neurofibrillary tangles are the main pathological characteristics of Alzheimer's disease (AD). However, some older adult pe…
View article: NEURONAL LIPOFUSCINOSIS CAUSED BY KUFS DISEASE/CLN4 DNAJC5 MUTATIONS BUT NOT BY A CSP-ALPHA/DNAJC5 DEFICIENCY
NEURONAL LIPOFUSCINOSIS CAUSED BY KUFS DISEASE/CLN4 DNAJC5 MUTATIONS BUT NOT BY A CSP-ALPHA/DNAJC5 DEFICIENCY Open
View article: Activation of Shh/Smo is sufficient to maintain oligodendrocyte precursor cells in an undifferentiated state but is not necessary for differentiation
Activation of Shh/Smo is sufficient to maintain oligodendrocyte precursor cells in an undifferentiated state but is not necessary for differentiation Open
Myelination is the terminal step in a complex and precisely timed program that orchestrates the proliferation, migration and differentiation of oligodendroglial cells. It is thought that Sonic Hedgehog (Shh) acting on Smoothened (Smo) part…
View article: Neuronal lipofuscinosis caused by Kufs disease/CLN4<i>DNAJC5</i>mutations but not by a CSPα/DNAJC5 deficiency
Neuronal lipofuscinosis caused by Kufs disease/CLN4<i>DNAJC5</i>mutations but not by a CSPα/DNAJC5 deficiency Open
Kufs disease/CLN4 is an autosomal dominant neurodegenerative disorder that affects young adults, caused by mutations in the DNAJC5 gene that encodes the synaptic vesicle co-chaperone Cysteine String Protein α (CSPα/DNAJC5). The Leu115Arg a…
View article: Ethanol-Induced Suppression of G Protein–Gated Inwardly Rectifying K+–Dependent Signaling in the Basal Amygdala
Ethanol-Induced Suppression of G Protein–Gated Inwardly Rectifying K+–Dependent Signaling in the Basal Amygdala Open
View article: Synthesis, characterization, and antibacterial activities of a heteroscorpionate derivative platinum complex against methicillin-resistant Staphylococcus aureus
Synthesis, characterization, and antibacterial activities of a heteroscorpionate derivative platinum complex against methicillin-resistant Staphylococcus aureus Open
Staphylococcus aureus is one of the species with the greatest clinical importance and greatest impact on public health. In fact, methicillin-resistant S. aureus (MRSA) is considered a pandemic pathogen, being essential to develop effective…
View article: Fortification and bioaccessibility of saffron apocarotenoids in potato tubers
Fortification and bioaccessibility of saffron apocarotenoids in potato tubers Open
Carotenoids are C40 isoprenoids with well-established roles in photosynthesis, pollination, photoprotection, and hormone biosynthesis. The enzymatic or ROS-induced cleavage of carotenoids generates a group of compounds named apocarotenoids…
View article: Alteration in the Synaptic and Extrasynaptic Organization of AMPA Receptors in the Hippocampus of P301S Tau Transgenic Mice
Alteration in the Synaptic and Extrasynaptic Organization of AMPA Receptors in the Hippocampus of P301S Tau Transgenic Mice Open
Tau pathology is a hallmark of Alzheimer’s disease (AD) and other tauopathies, but how pathological tau accumulation alters the glutamate receptor dynamics driving synaptic dysfunction is unclear. Here, we determined the impact of tau path…
View article: Editorial: Immunoelectron microscopy: Placing molecular functions within a neuronal context
Editorial: Immunoelectron microscopy: Placing molecular functions within a neuronal context Open
EDITORIAL article Front. Neuroanat., 24 October 2022 Volume 16 - 2022 | https://doi.org/10.3389/fnana.2022.1043371
View article: Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice
Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice Open
View article: Different modes of synaptic and extrasynaptic <scp>NMDA</scp> receptor alteration in the hippocampus of <scp>P301S</scp> tau transgenic mice
Different modes of synaptic and extrasynaptic <span>NMDA</span> receptor alteration in the hippocampus of <span>P301S</span> tau transgenic mice Open
N ‐methyl‐ d ‐aspartate receptors (NMDARs) are pivotal players in the synaptic transmission and synaptic plasticity underlying learning and memory. Accordingly, dysfunction of NMDARs has been implicated in the pathophysiology of Alzheimer …
View article: GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits
GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits Open
View article: Neuron Class and Target Variability in the Three-Dimensional Localization of SK2 Channels in Hippocampal Neurons as Detected by Immunogold FIB-SEM
Neuron Class and Target Variability in the Three-Dimensional Localization of SK2 Channels in Hippocampal Neurons as Detected by Immunogold FIB-SEM Open
Small-conductance calcium-activated potassium (SK) channels are crucial for learning and memory. However, many aspects of their spatial organization in neurons are still unknown. In this study, we have taken a novel approach to answering t…
View article: Overcoming the Challenges of Detecting GPCR Oligomerization in theBrain
Overcoming the Challenges of Detecting GPCR Oligomerization in theBrain Open
G protein-coupled receptors (GPCRs) constitute the largest group of membrane receptor proteins controlling brain activity. Accordingly, GPCRs are the main target of commercial drugs for most neurological and neuropsychiatric disorders. One…
View article: Convergence of adenosine and GABA signaling for synapse stabilization during development
Convergence of adenosine and GABA signaling for synapse stabilization during development Open
Synapse stabilization Early in brain development, neurons connect to each other enthusiastically. With development, an overabundance of synapses is winnowed down to refine efficiently connected circuits. Inactive synapses are prime targets…
View article: Amyloid-Driven Tau Accumulation on Mitochondria Potentially Leads to Cognitive Deterioration in Alzheimer’s Disease
Amyloid-Driven Tau Accumulation on Mitochondria Potentially Leads to Cognitive Deterioration in Alzheimer’s Disease Open
Despite the well-accepted role of the two main neuropathological markers (β-amyloid and tau) in the progression of Alzheimer’s disease, the interaction and specific contribution of each of them is not fully elucidated. To address this ques…
View article: The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer’s Disease
The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer’s Disease Open
G protein-gated inwardly rectifying K+ (GIRK) channels are the main targets controlling excitability and synaptic plasticity on hippocampal neurons. Consequently, dysfunction of GIRK-mediated signalling has been implicated in the pathophys…
View article: Retrograde adenosine/A<sub>2A</sub>receptor signaling facilitates excitatory synaptic transmission and seizures
Retrograde adenosine/A<sub>2A</sub>receptor signaling facilitates excitatory synaptic transmission and seizures Open
Summary Retrograde signaling at the synapse is a fundamental way by which neurons communicate and neuronal circuit function is fine-tuned upon activity. While long-term changes in neurotransmitter release commonly rely on retrograde signal…