Nancy R. Manley
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View article: Extrinsic factors significantly influence thymus development in fetal thymus-kidney transplantation 2847
Extrinsic factors significantly influence thymus development in fetal thymus-kidney transplantation 2847 Open
Description The “time-clock” regulates thymus development and growth. While the intrinsic clock hypothesis suggests thymic development is primarily driven by internal mechanisms, external factors may also influence growth. To investigate t…
View article: Insulin-like growth factor 2 as a driving force for exponential expansion and differentiation of the neonatal thymus
Insulin-like growth factor 2 as a driving force for exponential expansion and differentiation of the neonatal thymus Open
Like all organs, the thymus grows in size and function rapidly during development, but this growth comes to a halt after birth. However, the molecular mechanisms behind such a transition in the thymus remain obscure. Using single-cell RNA …
View article: Coordinated changes in thymic stromal and hematopoietic cells that define the perinatal to juvenile transition
Coordinated changes in thymic stromal and hematopoietic cells that define the perinatal to juvenile transition Open
SUMMARY T cells in the perinatal thymus have distinct phenotypes and functions that may be instructed by age-specific features of the microenvironment. We evaluated molecular and cellular profiles of thymic stromal cells, including thymic …
View article: Age-related epithelial defects limit thymic function and regeneration
Age-related epithelial defects limit thymic function and regeneration Open
The thymus is essential for establishing adaptive immunity yet undergoes age-related involution that leads to compromised immune responsiveness. The thymus is also extremely sensitive to acute insult and although capable of regeneration, t…
View article: Mechanisms underlying the direct programming of mouse embryonic fibroblasts to thymic epithelial cells by FOXN1
Mechanisms underlying the direct programming of mouse embryonic fibroblasts to thymic epithelial cells by FOXN1 Open
Thymic epithelial cells (TECs) are crucial to the ability of the thymus to generate T cells for the adaptive immune system in vertebrates. However, no in vitro system for studying TEC function exists. Overexpressing the transcription facto…
View article: Premature thymic involution in young<i>Foxn1<sup>lacz</sup></i>mutant mice causes peripheral T cell phenotypes similar to aging-induced immunosenescence
Premature thymic involution in young<i>Foxn1<sup>lacz</sup></i>mutant mice causes peripheral T cell phenotypes similar to aging-induced immunosenescence Open
The thymus is a primary lymphoid organ generating self-restricted and self-tolerant naïve T-cells. Early in life the thymus starts to involute, resulting in decreased naïve T-cell output which may be more self-reactive, leading to an incre…
View article: Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells
Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells Open
Thymic epithelial cells (TECs) are essential for T cell development in the thymus, yet the mechanisms governing their differentiation are not well understood. Lin28, known for its roles in embryonic development, stem cell pluripotency, and…
View article: The essential roles of Dicer-mediated mTORC1 signaling in parathyroid gland integrity and function: Insights from genetic mouse models and clinical data
The essential roles of Dicer-mediated mTORC1 signaling in parathyroid gland integrity and function: Insights from genetic mouse models and clinical data Open
Secondary hyperparathyroidism (SHP) frequently accompanies chronic kidney disease (CKD), contributing to morbidity and mortality in patients. Our previous findings demonstrated that PT- Dicer -/- mice, with parathyroid specific deletion of…
View article: Learning to live with the thymic roller coaster
Learning to live with the thymic roller coaster Open
The thymus is the primary lymphoid organ responsible for naïve T-cell production, vital for adaptive immunity. Thymus size and T-cell output dynamically change throughout the lifetime. The thymus increases its size and output during the pe…
View article: Novel murine model reveals an early role for pertussis toxin in disrupting neonatal immunity to Bordetella pertussis
Novel murine model reveals an early role for pertussis toxin in disrupting neonatal immunity to Bordetella pertussis Open
The increased susceptibility of neonates to some pathogens has previously been attributed to an underdeveloped immune system. More recent data suggest neonates have effective protection against most pathogens but are particularly susceptib…
View article: <i>Foxn1</i> overexpression promotes thymic epithelial progenitor cell proliferation and mTEC maintenance, but does not prevent thymic involution
<i>Foxn1</i> overexpression promotes thymic epithelial progenitor cell proliferation and mTEC maintenance, but does not prevent thymic involution Open
The transcription factor FOXN1 is essential for fetal thymic epithelial cell (TEC) differentiation and proliferation. Postnatally, Foxn1 levels vary widely between TEC subsets, from low/undetectable in putative TEC progenitors to highest i…
View article: Novel murine model reveals an early role for pertussis toxin in disrupting neonatal immunity to Bordetella pertussis
Novel murine model reveals an early role for pertussis toxin in disrupting neonatal immunity to Bordetella pertussis Open
The increased susceptibility of neonates to specific pathogens has previously been attributed to an underdeveloped immune system. More recent data suggest neonates have effective protection against most pathogens but are particularly susce…
View article: Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection
Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection Open
The generation of a functional, self-tolerant T cell receptor (TCR) repertoire depends on interactions between developing thymocytes and antigen-presenting thymic epithelial cells (TECs). Cortical TECs (cTECs) rely on unique antigen-proces…
View article: Foxn1 overexpression promotes thymic epithelial progenitor cell proliferation and mTEC maintenance, but does not prevent thymic involution
Foxn1 overexpression promotes thymic epithelial progenitor cell proliferation and mTEC maintenance, but does not prevent thymic involution Open
The transcription factor FOXN1 is essential for fetal thymic epithelial cell (TEC) differentiation and proliferation. In the postnatal thymus, Foxn1 levels vary widely between different TEC subsets, from low or undetectable in putative TEC…
View article: Mechanisms underlying the reprogramming of mouse embryonic fibroblasts to thymic epithelial cells
Mechanisms underlying the reprogramming of mouse embryonic fibroblasts to thymic epithelial cells Open
Thymic epithelial cells (TECs) are a critical functional component of the thymus’s ability to generate T cells for the adaptive immune system in vertebrates. However, no in vitro system for studying TEC function exists. Overexpression of t…
View article: Age-related epithelial defects limit thymic function and regeneration
Age-related epithelial defects limit thymic function and regeneration Open
SUMMARY The thymus is essential for establishing adaptive immunity yet undergoes age-related atrophy leading to compromised immune responsiveness. The thymus is also extremely sensitive to acute insult and although capable of regeneration,…
View article: Ovarian cysts and granulosa cell tumors develop after sublethal total body irradiation in mice
Ovarian cysts and granulosa cell tumors develop after sublethal total body irradiation in mice Open
Background Localized and total body irradiation are used to treat certain cancers and also used prior to transplantation of stem cells or organs. However, the use of radiation also induces collateral damage to the cells of healthy tissue. …
View article: NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development
NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development Open
The cortical and medullary thymic epithelial cell (cTEC and mTEC) lineages are essential for inducing T cell lineage commitment, T cell positive selection and the establishment of self-tolerance, but the mechanisms controlling their fetal …
View article: Abstract 4630:<i>In vivo</i>characterization of the Duffy antigen receptor for chemokines (DARC/ACKR1) in breast cancer tumor progression
Abstract 4630:<i>In vivo</i>characterization of the Duffy antigen receptor for chemokines (DARC/ACKR1) in breast cancer tumor progression Open
In studies of the tumor microenvironment (TME), factors that influence immune cell infiltration are of great interest, as these populations can influence disease prognosis, and potential treatment for patients. Through in silico analysis o…
View article: Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment
Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment Open
Thymic epithelial cells (TEC) are essential for thymocyte differentiation and repertoire selection. Despite their indispensable role in generating functional T cells, the molecular mechanisms that orchestrate TEC development from endoderma…
View article: Thymic epithelial cell-derived signals control B progenitor formation and proliferation in the thymus by regulating Let-7 and Arid3a
Thymic epithelial cell-derived signals control B progenitor formation and proliferation in the thymus by regulating Let-7 and Arid3a Open
The postnatal thymus is an efficient microenvironment for T cell specification and differentiation. B cells are also present in the thymus and have been recently shown to impact T cell selection, however, the mechanisms controlling B cell …
View article: Thymic B cell development is controlled by the B potential of progenitors via both hematopoietic-intrinsic and thymic microenvironment-intrinsic regulatory mechanisms
Thymic B cell development is controlled by the B potential of progenitors via both hematopoietic-intrinsic and thymic microenvironment-intrinsic regulatory mechanisms Open
Our findings indicate that the capacity and time course for thymic B-cell production are primarily controlled by the hematopoietic-intrinsic potential for B cells themselves during ontogeny, but that signals from TECs microenvironment also…
View article: Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration Open
BMP4 produced by endothelial cells promotes thymic regeneration after acute damage by activating FOXN1 and its downstream targets.
View article: Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors
Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors Open
Total body irradiation (TBI) damages hematopoietic cells in the bone marrow and thymus; however, the long-term effects of irradiation with aging remain unclear. In this study, we found that the impact of radiation on thymopoiesis in mice v…
View article: Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function
Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function Open
The thymus is essential for proper development and maintenance of a T-cell repertoire that can respond to newly encountered antigens, but its function can be adversely affected by internal factors such as pregnancy and normal aging or by e…
View article: Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate
Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate Open
The thymus and parathyroids develop from third pharyngeal pouch (3rd pp) endoderm. Our previous studies show that Shh null mice have smaller, aparathyroid primordia in which thymus fate specification extends into the pharynx. SHH signaling…